Carbon- and nitrogen-quality signaling to translation are mediated by distinct GATA-type transcription factors

The target of rapamycin (Tor) proteins sense nutrients and control transcription and translation relevant to cell growth. Treating cells with the immunosuppressant rapamycin leads to the intracellular formation of an Fpr1p-rapamycin-Tor ternary complex that in turn leads to translational down-regulation. A more rapid effect is a rich transcriptional response resembling that when cells are shifted from high- to low-quality carbon or nitrogen sources. This transcriptional response is partly mediated by the nutrient-sensitive transcription factors GLN3 and NIL1 (also named GAT1). Here, we show that these GATA-type transcription factors control transcriptional responses that mediate translation by several means. Four observations highlight upstream roles of GATA-type transcription factors in translation. In their absence, processes caused by rapamycin or poor nutrients are diminished: translation repression, eIF4G protein loss, transcriptional down-regulation of proteins involved in translation, and RNA polymerase I/III activity repression. The Tor proteins preferentially use Gln3p or Nil1p to down-regulate translation in response to low-quality nitrogen or carbon, respectively. Functional consideration of the genes regulated by Gln3p or Nil1p reveals the logic of this differential regulation. Besides integrating control of transcription and translation, these transcription factors constitute branches downstream of the multichannel Tor proteins that can be selectively modulated in response to distinct (carbon- and nitrogen-based) nutrient signals from the environment.

Propagation, structural similarity and image quality

Póster presentado en SPIE Photonics Europe, Brussels, 16-19 April 2012.

Patient safety in the operating room and documentary quality related to infection and hospitalization

Objective: To describe the documentary quality of two records related to patient safety in the operating room and to identify differences between information related to infection and hospitalization. Methods: Comparative study based on two cross sections, conducted with 3,033 patients who had been hospitalized for more than 24 hours in an Orthopedics and Traumatology Center. Sociodemographic and clinical data, as well as information provided in forms were compared. Postoperative infection was identified as an adverse event. Results: There was a significant correlation between hospitalization days and the total number of diagnoses collected (Pearson=0.328; p<0.001). When diagnoses and infections were grouped together, a significant value was found between closed fractures and infection (p=0.001). Conclusion: Differences in the degree of completion were observed between the two records. There were no differences between adverse events.

Prediction of blackwood wood and pulp quality parameters using NIR-PLS-R spectral modelling : wavenumber ranges and smoothing points

Só está disponível o resumo.

Costs and water quality impacts of reducing agricultural nonpoint source pollution : an analysis methodology /

Aug. 1979.

Livestock grazing management and water quality protection : (state of the art reference document) /

Mode of access: Internet.

Forest chemicals and water quality.

Mode of access: Internet.

Irrigated agriculture and water quality management.

Mode of access: Internet.

Colonies of insects, mites, ticks, and spiders maintained in laboratories of the Entomology Research and Market Quality Research Divisions of the Agricultural Research Service, U. S. Dept. of Agriculture.

Mode of access: Internet.

Colonies of insects, mites, ticks, and spiders maintained in laboratories of the Entomology Research and Market Quality Research Divisions of the Agricultural Research Service, U. S. Dept. of Agriculture.

Mode of access: Internet.

Colonies of insects, mites, and ticks maintained in laboratories of the Entomology Research and Market Quality Research Divisions of the Agricultural Research Service, U. S. Dept. of Agriculture,

Cover title.

Effects of the proposed Prosperity Reservoir on ground water and water quality in lower Center Creek basin, Missouri /

Mode of access: Internet.

Productivity and the quality of working life /

"Updates Personnel bibliography no. 86."

Aerodynamics and air quality management of highway tunnels : R. N. Schlaug, T. J. Carlin.

Mode of access: Internet.