Reflexões sobre a influência de Maquiavel na educação e na formação do Estado Moderno

Este texto tem como objetivo analisar algumas formulações de Nicolau Maquiavel sobre a teoria política, bem como refletir sobre a contribuição de suas ideias, expostas na obra O Príncipe, para a formação do Estado Moderno Absoluto. Essa obra foi resultado de suas reflexões sobre os problemas do seu tempo: séculos XV e XVI, na Itália. O Príncipe expressava o desenvolvimento dos Estados Nacionais, a dessacralização do político, a independência do poder temporal em relação ao poder religioso e a primazia do Estado frente à religião. Consideramos que a obra de Maquiavel é de suma relevância para a história das ideias, principalmente, no campo da ciência política. Dessa forma, destacamos a importância do estudo de seu pensamento sob a perspectiva da Educação, o qual nos possibilita a compreensão dos fundamentos políticos da modernidade e, por conseguinte, o entendimento da formação do homem político-moderno.

Usable work of macro-scale cavities in liquids

It is shown that the generation of cavities in a liquid can produce usable work, which is illustrated by the stretching of a string. This work is done during the expansion of the cavity, and not with its collapse. Basic equations are presented for the movement of a device moved by the so called cavity events. A theoretical solution is also proposed, which uses polynomial functions relating the so called "excess of pressure" in the cavity and time. Evaluations of the force generated during the expansion of the cavity showed a mean peak value of about 58 N for the moving container, while measurements with the container fixed to a support showed a peak value of 476 N, considered somewhat overestimated, because high frequency oscillations seem to superpose the mean behavior. Simultaneous phenomena occurring during the cavity events are also described. Series of pictures of the experiments are presented.

Upstream clopidogrel, prasugrel, or ticagrelor for patients treated with primary angioplasty: Results of an angiographic randomized pilot study.

OBJETIVES The main objective of the present randomized pilot study was to explore the effects of upstream prasugrel or ticagrelor or clopidogrel for patients with ST-segment-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). BACKGROUND Administration of clopidogrel "as soon as possible" has been advocated for STEMI. Pretreatment with prasugrel and ticagrelor may improve reperfusion. Currently, the angiographic effects of upstream administration of these agents are poorly understood. METHODS A total of 132 patients with STEMI within the first 12 hr of chest pain referred to primary angioplasty were randomized to upstream clopidogrel (600 mg), prasugrel (60 mg), or ticagrelor (180 mg) while still in the emergency room. All patients underwent protocol-mandated thrombus aspiration. RESULTS Macroscopic thrombus material was retrieved in 79.5% of the clopidogrel group, 65.9% of the prasugrel group, and 54.3% of the ticagrelor group (P = 0.041). At baseline angiography, large thrombus burden was 97.7% vs. 87.8% vs. 80.4% in the clopidogrel, prasugrel, and ticagrelor groups, respectively (P = 0.036). Also, at baseline, 97.7% presented with an occluded target vessel in the clopidogrel group, 87.8% in the prasugrel group and 78.3% in the ticagrelor group (P = 0.019). At the end of the procedure, the percentages of patients with combined TIMI grade III flow and myocardial blush grade III were 52.3% for clopidogrel, 80.5% for prasugrel, and 67.4% for ticagrelor (P = 0.022). CONCLUSIONS In patients with STEMI undergoing primary PCI within 12 hr, upstream clopidogrel, prasugrel or ticagrelor have varying angiographic findings, with a trend toward better results for the latter two agents. © 2015 Wiley Periodicals, Inc.

A importância do amor para a apreensão do divino em De docta ignorantia

En el presente artículo tenemos como soporte el Libro III del De docta ignorantia de Nicolás de Cusa (1401-1464) y buscamos mostrar como el referido texto ya demonstra el necesario equilíbrio entre affectus y intellectus, poniendo en relieve, sin embargo, la importancia del amor como instancia importante para el ser humano a buscar Dios.