Toxicity of cryoprotectants on Prochilodus lineatus (Valenciennes, 1837) (curimba) embryos in an experimental incubator (Characiformes: Prochilodontidae)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Polimorfismo do gene IL6 candidato à predisposição à rotura prematura de membranas pré-termo e ao trabalho de parto pré-termo

Introduction: Preterm Labor (PTL) and Preterm Premature Rupture of Membranes (PPROM) cause severe complications for both mother and fetus. Among the risk factors associated with preterm labor and PPROM, genetic predisposition has been gaining importance. However, the association between polymorphic genes and the pathogenesis of PTL and PPROM remains elusive. A better understanding of the genetic mechanisms underlying these adverse pregnancy outcomes may enable the identification of high risk patients and allow new approaches to minimize the deleterious effects of prematurity. Aim: To determine the association between maternal IL-6 polymorphism gene and the occurrence of PTL and PPROM. Patients and Methods: The study included 109 patients with prior history of PL and/or PPROM that delivered prematurely at the Obstetrical Unit Care of Botucatu Medical School, UNESP between 2003 and 2012. The control group consisted of 68 patients that delivered at term, matched to the case group by age, ethnicity, and sex of the newborn. Oral swabs (Cath-AllTM – Epicentre Biotechnologies) were collected for analysis of genetic polymorphisms by PCR. Statistical tests were performed to compare genotype, clinical and socio-demographic data from the groups. A p-value of <0.05 was considered significant. Results: The sociodemographic characteristics in both groups were homogeneously distributed. The frequency of the polymorphic allele C, associated with less production of IL-6, and therefore thought to be protective against PTL and PPROM, was 32,5% in the study group and 30,9% in the control group, without statistically significant differences. Conclusion: Considering the sample size included in this study, the frequency of the mutated allele is similar in pregnant women who delivered at term and gestational complications as PTL and PPROM

A leitura na perspectiva de Bakhtin e suas possibilidades na formação do leitor: na educação infantil e no primeiro ano do ensino fundamental

Overall, in Brazilian schools, the concept of reading does not take into account its possibilities and its meaning for life. But read is assigning meaning to something , make sense, interact with the text read. Thus, the present study addresses the mechanical reading, that without contextualization, performed on a technique by joining letters and syllables loose and also reading social use, consisting of statements, dialogism , polyphony and heteroglossy. It is known that the mechanical reading brings undesirable consequences, including learning problems, such as lack of attention, concentration, memory, imagination. When the reading is taught in a systematic way, with only the goal of the code decoding of written language, destroys social perspectives and intellectual development. It is common, when you offer the children a book, there the difficult disinterest of textual interpretation, because there is no attribute meaning to the content, and even the ability to interact with the text. With the interest in studying the dialogic reading this and the statements and genres, the present study was based on several authors: Bakhtin (1988, 2000), Schneuwly and Dolz (2000), Faraco (2009) and Ponzio (2009) Jolibert (1994), Bajard (2002; 2007) Foucambert (1997) Martins ( 1985) and Smith ( 1999). Aim for this study the following research question: what are the contributions of Mikhail Bakhtin's theory to the teaching of reading from kindergarten through the first grade of elementary school? Our hypothesis is that if they are guaranteed to pre -school and elementary school beginners diversified materials and new approaches in teaching reading and encouragement to her, will be developed in children a taste for the act of reading, so that they can assign meaning and significance, making reading part of their lives...

Impact of the medicine Hydroxyurea on reproduction and development, using Drosophila melanogaster as a model organism

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

High efficacy in hyperthermia-associated with polyphosphate magnetic nanoparticles for oral cancer treatment

Nanotherapy applied to cancer treatment is constantly evolving, and new approaches to current techniques, such as magnetohyperthermia, are being implemented to solve and minimize the limitations of conventional therapeutic strategies. The purpose of this study was to investigate the action of polyphosphate-coated maghemite nanoparticles (MNPs) on oral squamous cell carcinoma. Human oral cancer cells (UM-SCC14A) were incubated with MNPs at various concentrations and subjected to cell proliferation tests (MTT), apoptosis assays and transmission electron image analysis. Viability and apoptotic events were time and dose dependent. These in vitro tests showed that at the intermediate concentration tested there is no significant toxicity, as confirmed by transmission electron microscopy. For this reason this MNPs concentration was chosen for the subsequent in vivo tests. Oral tumor induction was performed by applying the carcinogen DMBA to Syrian hamsters. Animals were then treated by magnetohyperthermia using MNPs. No signs of general clinical symptoms of toxicity or abnormal behavioral reactions were observed. However, animals treated with MNPs and exposed to the alternating magnetic field in the hyperthermia procedure exhibited a significant and time dependent cancer regression, as confirmed by histopathological analyses and immunohistochemistry. Actually, in quantitative terms of the magnetotherapy efficacy involving these polyphosphate-coated MNPs, 100% recovery (12/12) was observed in the oral cancer tumor bearing Syrian hamsters seven days after the treatment with the magnetohyperthermia procedure. Data supports the suggestion that the MNPs-mediated hyperthermia represents a promising strategy for the treatment of oral cancer.

Aplicação de princípios do pensamento enxuto no processo de envio e devolução de correspondências em um banco privado

The success obtained by the Toyota Company in implementing the Toyota Production System was a global case of study that generated different new approaches, such as Lean Thinking. This approach was already successfully applied to various sectors, breeding methodologies as Lean Service, Lean Office or Lean IT. In this paper, the main concepts of Lean Thinking were applied in an information flow through an action research, more specifically in the sending and return of mailing process from a bank. The objectives were to create changes that led to the decrease of the mail returning indexes and ultimately to cost reduction and waste elimination. For this purpose the actual situation was mapped, and after data collection and analysis, a future proposed state was generated for the information flow. Alongside, indicators were conceived for managing process control and a set of implemented and proposed improvements were delivered. The applied Lean Thinking concepts were considered efficient for the application, and the proposed objectives were achieved

Identificação de forças de excitação em sistemas rotativos utilizando funções ortogonais

Pós-graduação em Engenharia Mecânica - FEIS

Improvement of gamete quality and its short-term storage: an approach for biotechnology in laboratory fish

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Artificial immune networks Copt-aiNet and Opt-aiNet applied to the reconfiguration problem of radial electrical distribution systems

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Práticas corporais e cristianismo: relações e preceitos

This study, qualitative, aimed to try to understand relations and premises involving bodily practices and Christianity. The study was conducted by means of literature, focusing the themes of religion and the body along with issues involving Christian ethics, through its principles and values, which must be practiced, not only within the church, but even within the society, in sports, in schools. Based on the literature review, it can be seen that the body practices have a direct relationship with the Christian religion, in the aspects involving the ethics of their practices, experiences, thoughts, attitudes, principles and values, in addition to cultural training and body of students from different schools, in which the physical education professional is directly involved with the bodily practices. As conclusions, it was noted the probability of a harmonious and fundamental relationship between religion and bodily practices, along with a productive association between Christianity and society, helping the individual in its ethical and social formation. We suggest new approaches to the formation of the professional of Physical Education, in order take into consideration these aspects involving religiosity

Ferramenta computacional para identificação de micro-organismos com base em assinaturas genômicas

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Entre santos e demônios: a percepção do mal na teologia e hagiografias do Reino Visigodo de Toledo (séculos VI-VII)

Pós-graduação em História - FCLAS

Influência da aplicação de laser de baixa intensidade no recobrimento radicular associado à técnica de enxerto de tecido conjuntivo em indivíduos fumantes: ensaio clínico controlado randomizado

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Mortalidade Materna: uma abordagem atualizada

Purpose: to review literature, highlighting current aspects of maternal mortality.  Method: research initiated through electronic data base PubMed [http:// www.ncbi.nlm.nih.gov/pubmed], limited to the last 10 years. The selected cases which related to pre-defined aspects of interest to the study, such as vulnerable population, risk factors, causes, difficulties in obtaining data, preventive measures e new approaches to the problem, among them, ‘near misses’ and severe maternal morbidity.  Results: maternal death is directly related to the quality of life of the population, with relevant disparities among the different social economic areas. Although maternal mortality is the proper indicator to the female population health, its numbers are presented in unrealistic manners due to the difficulties in identifying the cases through death certificates. Preventive measures associated to early and adequate diagnose and treatment are benefic factors in decreasing those maternal deaths. Apart from these, identification and classification of ‘near misses’ and maternal morbidity are featured in the contemporary approach to the issue.  Final considerations: In spite of advanced technology and recognition of preventive measures, a large number of women die daily due to complications in the pregnancy and puerperal cycle. To decrease such tragedy political, social and economical commitment to Health is necessary, in order to promote the needed reforms in the assistance of such cycle.

Design Participativo para a Sustentabilidade: desenvolvimento de painéis modulares para fechamentos, utilizando bambu associado com terra e resíduos

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)