John Fitzgerald Letter

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Methadone maintenance treatment and St. John's Wort - a case report.

St. John's wort, a popular over-the-counter drug for treatment of depression, might reduce concentrations of drugs such as cyclosporin and indinavir and lead to drug resistance and treatment failure. No studies as yet have examined its influence on methadone plasma levels. The trough methadone plasma levels were measured in four patients (2 males, median age: 31 years; range 19 - 40 years) in methadone maintenance treatment just before the introduction of St. John's wort (900 mg/d) and after a median period of 31-day treatment (range 14 - 47). The study was proposed to addict patients about to start an antidepressant therapy. Introduction of St. John's wort resulted in a strong reduction of (R,S)-methadone concentration-to-dose ratios in the four median patients included, with a median decrease to 47 % of the original concentration (range: 19 % - 60 % of the original concentration). Two patients reported symptoms that suggested a withdrawal syndrome. Thus, prescription of St. John's wort might decrease methadone blood levels and induce withdrawal symptoms which, if not correctly identified and handled (by changing the antidepressant or by increasing the methadone dose), might cause unnecessary discomfort to the patient, lead to resumption of illicit drug uses, or be a risk factor for discontinuation of the methadone or antidepressant treatment.

Josep Pallach, vist des del Govern Civil de Girona (1967-1976)

Fa dotze anys l'autor d'aquest article va donar a conèixer la documentació dels anys 1944-1946 que, procedent dels arxius governatius i de les presons gironines, feia referència a la vida clandestina i de represaliat del polític i professor Josep Pallach (Figueres 1920-l’Hospitalet de Llobregat 1977), antic militant del Bloc Obrer i Camperol i del Partit Obrer d’Unificació Marxista (POUM). Aquest article del 2005 complementa aquella recerca amb la recuperació d’una documentació similar, relativa al temps final del franquisme i al període inicial de la transició, els quals es corresponen també amb els darrers anys del periple vital del protagonista d’aquestes pàgines

Select works of the emperor Julian, and some pieces of the sophist Libanius, translated from the Greek, with notes from Petau, La Bleterie, Gibbon, etc., to which is added the History of the emperor Jovian from the French of the abbé de La Bleterie, by John Duncombe...

Comprend : The History of the emperor Jovien

[3 phot. des mines de Monteponi en Sardaigne, en août 1878, don Demaffey en 1886]

Donateur : Demaffey (18..-1...)

[Phot. de la maison de Kronenberg à Varsovie en 1878, don de Maurice Chaudoir en 1886]

Donateur : Chaudoir, Maurice (18..-18..?)