462 resultados para LEACH
Resumo:
The nuclear spin polarization of 129Xe can be enhanced by several orders of magnitude by using optical pumping techniques. The increased sensitivity of xenon NMR has allowed imaging of lungs as well as other in vivo applications. The most critical parameter for efficient delivery of laser-polarized xenon to blood and tissues is the spin-lattice relaxation time (T1) of xenon in blood. In this work, the relaxation of laser-polarized xenon in human blood is measured in vitro as a function of blood oxygenation. Interactions with dissolved oxygen and with deoxyhemoglobin are found to contribute to the spin-lattice relaxation time of 129Xe in blood, the latter interaction having greater effect. Consequently, relaxation times of 129Xe in deoxygenated blood are shorter than in oxygenated blood. In samples with oxygenation equivalent to arterial and venous blood, the 129Xe T1s at 37°C and a magnetic field of 1.5 T were 6.4 s ± 0.5 s and 4.0 s ± 0.4 s, respectively. The 129Xe spin-lattice relaxation time in blood decreases at lower temperatures, but the ratio of T1 in oxygenated blood to that in deoxygenated blood is the same at 37°C and 25°C. A competing ligand has been used to show that xenon binding to albumin contributes to the 129Xe spin-lattice relaxation in blood plasma. This technique is promising for the study of xenon interactions with macromolecules.
Resumo:
We thank Karim Gharbi and Urmi Trivedi for their assistance with RNA sequencing, carried out in the GenePool genomics facility (University of Edinburgh). We also thank Susan Fairley and Eduardo De Paiva Alves (Centre for Genome Enabled Biology and Medicine, University of Aberdeen) for help with the initial bioinformatics analysis. We thank Aaron Mitchell for kindly providing the ALS3 mutant, Julian Naglik for the gift of TR146 cells, and Jon Richardson for technical assistance. We thank the Genomics and Bioinformatics core of the Faculty of Health Sciences for Next Generation Sequencing and Bioinformatics support, the Information and Communication Technology Office at the University of Macau for providing access to a High Performance Computer and Jacky Chan and William Pang for their expert support on the High Performance Computer. Finally, we thank Amanda Veri for generating CaLC2928. M.D.L. is supported by a Sir Henry Wellcome Postdoctoral Fellowship (Wellcome Trust 096072), R.A.F. by a Wellcome Trust-Massachusetts Institute of Technology (MIT) Postdoctoral Fellowship, L.E.C. by a Canada Research Chair in Microbial Genomics and Infectious Disease and by Canadian Institutes of Health Research Grants MOP-119520 and MOP-86452, A.J. P.B. was supported by the UK Biotechnology and Biological Sciences Research Council (BB/F00513X/1) and by the European Research Council (ERC-2009-AdG-249793-STRIFE), KHW is supported by the Science and Technology Development Fund of Macau S.A.R (FDCT) (085/2014/A2) and the Research and Development Administrative Office of the University of Macau (SRG2014-00003-FHS) and R.T.W. by the Burroughs Wellcome fund and NIH R15AO094406. Data availability RNA-sequencing data sets are available at ArrayExpress (www.ebi.ac.uk) under accession code E-MTAB-4075. ChIP-seq data sets are available at the NCBI SRA database (http://www.ncbi.nlm.nih.gov) under accession code SRP071687. The authors declare that all other data supporting the findings of this study are available within the article and its supplementary information files, or from the corresponding author upon request.
Resumo:
O presente trabalho trata do gênero de porcelanídeos Megalolobrachium Stimpson, 1858 e está organizado em três partes: (1) uma revisão taxonômica das espécies atualmente atribuídas a Megalobrachium Stimpson, 1858; (2) uma revisão da diversidade morfológica do gênero em um contexto maior dentro de Porcellanidae; e (3) uma análise cladística a partir de dados morfológicos com o intuito de testar o monofiletismo de Megalobrachium e propor a primeira hipótese filogenética para o gênero. A revisão taxonômica se baseou no estudo de material abundante de diferentes localidades do Pacífico oriental e Atlântico ocidental. Uma nova espécie de Megalobrachium é descrita com base no material das costas pacíficas do Panamá e Colômbia, totalizando 13 espécies em Megalobrachium. Para a análise filogenética, foram obtidos 151 caracteres; o grupo-externo foi composto por quatro espécies de três gêneros: Pachycheles Stimpson, 1858, Pisidia Leach, 1820, e Porcellana Lamarck, 1801. Uma única árvore (314 passos; IC: 64; IR: 80) foi obtida, com dois clados. O primeiro clado inclui espécies com lobos da fronte marcadamente flexionados, flagelo da antena curto, com artículos longos, patas ambulatórias curtas e robustas, abdome subtriangular em machos, pleópodo feminino iv com três segmentos, e urópodos curtos. O segundo clado contém espécies com lobos da fronte não flexionados, flagelo da antena longo, com artículos curtos, patas ambulatórias longas e delgadas, abdome sub-retangular, pleópodo feminino iv com dois segmentos, urópodos longos. O primeiro clado corresponde a Porcellanopsis Rathbun, 1910 (espécie-tipo P. festae (Nobili, 1901)), previamente tratado como sinônimo de Megalobrachium. Contudo, a combinação de diferenças morfológicas entre Megalobrachium e Porcellanopsis justifica a revalidação de Porcellanopsis. Três espécies foram erroneamente registradas no Pacífico oriental (M. mortenseni Haig, 1962, P. rosea (Rathbun, 1900) e P. soriata (Say, 1818)); essas espécies são exclusivamente distribuídas no Atlântico ocidental.
Resumo:
Paired analyses of Os isotope composition and concentration of bulk sediment and leachable Os in a metalliferous pelagic clay sequence from the North Pacific, ODP Site 886C, are used to reconstruct the marine Os isotope record and the particulate meteoritic Os flux between 65.5 and 78 Ma. Measured 187Os/188Os of bulk sediments ranges from approximately 0.64 to 0.32 and those of leach analyses are very similar to bulk analyses. Hydrogenous Os dominates the sedimentary Os inventory throughout most of the studied interval. As a result the measured 187Os/188Os of leachable Os approximates that of contemporaneous seawater. The ODP 886C record shows rising 187Os/188Os in the deepest portion of the core, with a local maximum of 0.66 close to 74 Ma. The 67-72 Ma portion of the record is characterized by nearly constant 187Os/188Os ratios close to 0.6. The structure of the marine Os isotope record from ODP 886C differs markedly from the seawater 87Sr/86Sr curve, which rises monotonically throughout the time interval studied here. Calculated particulate meteoritic Os fluxes are between 0.5 and 2 pg/cm**2/kyr throughout most of the studied interval. Two discrete intervals of the core (one of which is within Cretaceous Tertiary, boundary KTB interval) are characterized by higher fluxes of meteoritic Os. Excluding these two intervals, the average background flux of particulate meteoritic Os is roughly half of that estimated from analyses of Cenozoic marine sediments. These are the first Os isotope data to provide evidence of resolvable temporal variations in the background flux of particulate meteoritic material to the Earth.
Resumo:
The circulation and internal structure of the oceans exert a strong influence on Earth's climate because they control latitudinal heat transport and the segregation of carbon between the atmosphere and the abyss (Sigman et al., 2010, doi:10.1038/nature09149). Circulation change, particularly in the Atlantic Ocean, is widely suggested (Bartoli et al., 2005, doi:10.1016/j.epsl.2005.06.020; Haug and Tiedemann, 1998, doi:10.1038/31447; Woodard et al., 2014, doi:10.1126/science.1255586; McKay et al., 2012, doi:10.1073/pnas.1112248109) to have been instrumental in the intensification of Northern Hemisphere glaciation when large ice sheets first developed on North America and Eurasia during the late Pliocene, approximately 2.7 million years ago (Bailey et al., 2013, doi:10.1016/j.quascirev.2013.06.004). Yet the mechanistic link and cause/effect relationship between ocean circulation and glaciation are debated. Here we present new records of North Atlantic Ocean structure using the carbon and neodymium isotopic composition of marine sediments recording deep water for both the Last Glacial to Holocene (35-5 thousand years ago) and the late Pliocene to earliest Pleistocene (3.3-2.4 million years ago). Our data show no secular change. Instead we document major southern-sourced water incursions into the deep North Atlantic during prominent glacials from 2.7 million years ago. Our results suggest that Atlantic circulation acts as a positive feedback rather than as an underlying cause of late Pliocene Northern Hemisphere glaciation. We propose that, once surface Southern Ocean stratification (Sigman, et al., 2004, doi:10.1038/nature02357) and/or extensive sea-ice cover (McKay et al., 2012, doi:10.1073/pnas.1112248109) was established, cold-stage expansions of southern-sourced water such as those documented here enhanced carbon dioxide storage in the deep ocean, helping to increase the amplitude of glacial cycles.
Resumo:
Back Row: Chris Grieves, Bob Franks, Gregg Willner, Dave Goldwaithe, Mark Slaughter, John Mandich, Pat Watts, James Blue, Nick Labun, Tony Woodford, C. Newhof, Jeff Lawley
9th Row: Steve Knickerbocker, Kyron Williams, Stacy Johnson, John Weisenburger, Bob Hollway, Chip Pederson, Dale Keitz, Tim Malinak, Leon Richardson, Rock Lindsay, Lewis Smith, Woody Brown
8th Row: Scott Smith, Mark Braman, Bob Patek, Jon Giesler, Mark Torzy, Curtis Greer, William Jackson, Jerry Meter, Rick Leach, Dave Stavale, Tom Melita
7th Row: Mike Smith, Tom Seabron, Mark DeSantis, Frank Bell, Harlan Huckleby, Gene Johnson, Mark Schmerge, Russell Davis, John Arbeznik, Andy Jackson, Dennis Richardson
6th Row: Joe Holland, Steve Nauta, Kevin King, Max Richardson, Dave Harding, Mike Kenn, Dominic Tedesco, Jim Pickens, Ray Johnson, Phil Brown, Ken Bush, Roger Bettis
5th Row: Roger Szafranski, Dwight Hicks, Scott Corbin, Mark Donahue, Bill Dufek, Rex Mackall, John Anderson, Derek Howard, Greg Bartnick, Walt Downing, Terry Stefan, Asst. Coach Bill McCartney
4th Row: Asst. Coach Paul Schudel, Curt Stephenson, Rob Carian, Phil Andrews, Eric Phelps, Steve Graves, Gerry Szara, Jim Hackett, Pete Traber, Steve Anderson, Bob Wood, Darrell Truitt, Phil Brumbaugh, Asst. Coach Jack Harbaugh
3rd Row: Asst. Coach Gary Moeller, Asst. Coach Tom Reed, Asst. Coach Jed Hughes, Jerry Zuver, Rick White, Jim Hall, Mike Strabley, Jerry Vogele, Jim Smith, Rob Lytle, John Hennessy, Bob Lang, Jim Bolden, John Ceddia, A. Miller, Asst. Coach Dennis Brown
2nd Row: Asst. Coach Tirrel Burton, Asst. Coach Jerry Hanlon, Greg Morton, Tom Jensen, George Przygodski, Mike Holmes, Co-Captain Kirk Lewis, Jeff Perlinger, Steve King, Dan Jilek, Jim Czirr, Bill Hoban, Calvin O'Neal, Chuck Randolph, Asst. Coach Chuck Stobart
Front Row: Mark Elzinga, Jerry Collins, Kurt Kampe, Rick Koschalk, Dave Devich, Co-captain Gordon Bell, Co-Captain Don Dufek, Tim Davis, Keith Johnson, Les Miles, Dave Whiteford, Greg Strinko, Head Coach Bo Schembechler
Resumo:
Back Row: Assistant Coaches: Larry Gustafson, Bob Thornbladh, Jerry Hanlon, Tirrel Burton, Dennis Brown, Chuck Stobart, Paul Schudel, Gary Moeller, Bill McCartney, Jack Harbaugh, Tom Reed, Dave Elliott, Tim Davis, Lou Angelo, Eqp. Mgr. Jon Falk, Trainer Lindsy McLean
8th Row: Roger Gaudette, Jim Kozlowski, Virgil Williams, Chris Godfrey, Ron Pratl, Dick Novak, Doug Marsh, Irvin Johnson, Keith Gilmore, Jim Humphries, * , Dan Murray, * , Dave Angood
7th Row: Mike Harden, Mel Owens, Michael Davis, George Lilja, Mark Kochanski, John Powers, Chuck Hetts, Bob Taylor, Garrett Quinn, Mike Jolly, Ralph Clayton, John Wangler, David Payne
6th Row: Gerald Diggs, Gary Weber, Lawrence Reid, Gene Bell, Ron Simpkins, Roosevelt Smith, Lewis Smith, William Jackson, Stacy Johnson, Jeff Bednarek, Mike Leoni, Tony Leoni, Jay Allen, Larry Crockett
5th Row: Woody Brown, Gregg Willner, Chris Grieves, Tim Malinak, Mark Braman, * , Jon Giesler, Dave Kadela, Kyron Williams, * , * , Nick Labun, Tom Keller, * .
4th Row: Mgr. Bob Brown, Chip Pederson, Bob Patek, Dale Keitz, Curtis Greer, Tom Seabron, Jerry Meter, John Arbeznik, Mark DeSantis, Bob Hollway, Tom Melita, Mark Torzy, Rock Lindsay, Ed Kasparek
3rd Row: Roger Bettis, * , Dave Harding, Kevin King, Steve Nauta, Max Richardson, Dom Tedesco, Mark Schmerge, Gene Johnson, Russell Davis, Rick Leach, Greg Bartnick, Harlan Huckleby, Mike Smith, Ray Johnson, * .
2nd Row: Roger Szafranski, Jim Pickens, Dwight Hicks, Mark Donahue, Walt Downing, Steve Anderson, Eric Phelps, Rick White, Curt Stephenson, Phil Andrews, Steve Graves, John Anderson, Bill Dufek, Mike Kenn, Derek Howard, Rex Mackall
Front Row: Jim Hackett, Gerry Szara, Jerry Zuver, John Hennessy, Greg Morton, Co-Capt. Calvin O'Neal, Co-Capt. Kirk Lewis, Co-Capt. Rob Lytle, Jim Smith, Bob Wood, Jim Bolden, Bob Lang, Jerry Vogele, John Ceddia, Head Coach Bo Schembechler
* = left the team
Resumo:
Back Row: Asst. coaches Bob Thornbladh, Tom Reed, Jerry Hanlon, Tirrel Burton, Tim Davis, Bill McCartney, Jack Harbaugh, Paul Schudel, Dennis Brown, Don Nehlen, Barry Pierson, Jerry Zuver, Eqp. Mgr. Jon Falk, Trainer Lindsy McLean
8th Row: Marcus Bond, Chuck Christian, Greg Wunderli, Kurt Becker, Tony Osbun, Dan Kwiatkowski, Tom Wandersleben, Fred Motley, Andy Cannavino, Mike Kligis, Jim Breaugh, Oliver Johnson
7th Row: Kirk Yearian, B.J. Dickey, Alan Mitchell, Rodney Feaster, Stanley Edwards, Mike Trgovac, Dave Nicolau, Jeff Jackson, Neal Ginley, Kelley Keough, John Prepolec, Ben Needham, Stuart Harris, Rick Jones
6th Row: Derek Williams, Tony Woodford, Jay Allen, James Humphries, David Payne, Tom Keller, Ron Pratl, Rich Novak, David Angood, Craig Page, Dan Murray, Thomas Moss, Larry Jones, Brian Virgil
5th Row: Roger Gaudette, Virgil Williams, Gerald Diggs, Gene Bell, Dave Kadela, Gary Quinn, Ralph Clayton, Chuck Hetts, Mel Owens, Gary Weber, John Wangler, Keith Gilmore, Irvin Johnson, Tony Leoni, Jim Kozlowski
4th Row: Sr. Mgr. Don DiPaolo, Nick Labun, Mike Harden, Michael Davis, Lawrence Reid, Mike Jolly, John Powers, Chris Godfrey, Jeff Bednarek, George Lilja, Mike Leoni, Doug Marsh, Ron Simpkins, Roosevelt Smith, Gregg Willner, Tim Malinak
3rd Row: Ed Kasparek, Mark Braman, Bob Patek, Stacy Johnson, Dale Keitz, John Arbeznik, Curtis Greer, Jon Giesler, Chip Pederson, Mark DeSantis, Mark Torzy, Rock Lindsay, William Jackson, Bob Hollway, Tom Melita
2nd Row: Max Richardson, Curt Stephenson, Derek Howard, Steve Graves, John Anderson, Bill Dufek, Mark Donahue, Co-captain Walt Downing, Garry Szara, Mike Kenn, Rick White, Dominic Tedesco, Jim Pickens, Kevin King, Co-captain Dwight Hicks, Head Coach Bo Schembechler
Front Row: Raymond Johnson, Roger Bettis, Mike Smith, Russell Davis, Tom Seabron, Gene Johnson, Steve Nauta, Rex Mackall, Greg Bartnick, Dave Harding, Mark Schmerge, Jerry Meter, Rick Leach, Harlan Huckleby, Woody Brown
Resumo:
Back Row: Coaches Bob Patek, Jerry Zuver, Mike Gittleson, Milan Vooletich, Dennis Brown, Jack Harbaugh, Bill McCartney, Jerry Hanlon, Don Nehlen, Tirrel Burton, Paul Schudel, Bob Thornbladh, Barry Pierson, Mike Smith, Curt Stephenson, Trainer Lindsy McLean, Eqp. Mgr. Jon Falk.
9th Row: Kevin Smith, Doug Agnew, * , Mike Butts, Steve Zarnata, Brad Fischer, Kevin Gilligan, * , Karl Tech, Jerome Jelinek, Bill Welch, * , Vince Shaw, Mgr. Nick Uriah
8th Row: Marion Body, Dave Brewster, Rich Strenger, Sanford Washington, Steve Reilly, Tom Neal, Norm Betts, Mike Petsch, Mike Lemirande, Gary Snell, Jeff Reeves, Tony Jackson, Jeff Felten, Tony Kelsie
7th Row: Mike Webster, Butch Woolfolk, Cedric Coles, Bubba Paris, Chuck Rowland, Ed Muransky, Mark Warth, Tom Garrity, Robert Thompson, Jim Paciorek, Gary Lee, Zeke Wallace, Brian Carpenter, John Sandberg
6th Row: Tom Moss, Tim Carrier, Jay Allen, Jim Breaugh, Larry Jones, David Angood, Tom Wandersleben, Fred Motley, Dave Payne, Rod Vaughn, Gasper Calindrino, Kevin Long, Bryan Virgil, *
5th Row: Brad Bates, Irvin Johnson, Kelly Keough, Tom Keller, Rick Novak, Ben Needham, Oliver Johnson, Jeff Jackson, Dan Kwiatkowski, John Prepolec, Greg Wunderli, Kurt Becker, Tony Osbun, Mike Kligis, Chuck Christian
4th Row: Craig Page, B.J. Dickey, Rodney Peaster, Dan Murray, Andy Cannavino, Dave Nicolau, Stanley Edwards, Michael Davis, Mike Trgovac, Stuart Harris, Roger Gaudette, Jim Kozlowski, Alan Mitchell, Rick Jones, Head Coach Bo Schembechler
3rd Row: Gerald Diggs, Tony Leoni, Roosevelt Smith, Gary Weber, Lawrence Reid, Mel Owens, George Lilja, John Powers, Chris Godfrey, John Wangler, Gene Bell, Michael Harden, Mike Leoni, Gary Quinn, Jim Humphries
2nd Row: Gregg Willner, William Jackson, Mike Jolly, Ralph Clayton, Chip Pederson, Rock Lindsay, John Arbeznik, Ron Simpkins, Doug Marsh, Dale Keitz, Tom Melita, Mark Torzy, Tim Malinak, Ed Kasparek, Chuck Netts
Front Row: Mark Braman, Mark DeSantis, Mark Schmerge, Curtis Greer, Greg Bartnick, Harlan Huckleby, Co-Captain Russell Davis, Bill Dufek, Rick Leach, Co-Captain Jerry Meter, Gene Johnson, Jon Giesler, Tom Seabron, Steve Nauta, Bob Hollway
* = left the team
Resumo:
Top Row: John Estates, Ron Brewer, Ihor Debryn, Ross Laser
Middle Row: Mark Mees, Tom Haney, Rodd Schreiber, Mike Swaney
Bottom Row: Dan McLaughlin, Mike Leach, Matt Horwitch, Coach Brian Eisner
