1000 resultados para Koskinen, Pirkko K.: Tasa-arvolaki
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Titre uniforme : [Fantaisies. Piano. KV 475. Do mineur]
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Échelle(s) : [1:1 337 000 environ], Lieues de France, de 25 au degré, 30 [= 9,8 cm]
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[Traditions. Asie. Inde. Présidence de Madras [i.e. Chennai]. Ceded Districts]
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[Traditions. Asie. Inde. Présidence de Madras [i.e. Chennai]. Etat du Kerala. Région du Malabar]
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[Traditions. Asie. Inde. Province de Madras [i.e. Chennai]. État du Kérala. Kochi]
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[Traditions. Asie. Inde. Province de Madras [i.e. Chennai]. État de Karnataka. Région du Kanara]
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[Traditions. Asie. Inde. Etat du Maharashtra. Amravati]
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[Traditions. Asie. Inde. Province du Berar. Yavatmal]
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
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Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fasting glucose, fasting insulin and indices of beta-cell function (HOMA-B) and insulin resistance (HOMA-IR) in up to 46,186 nondiabetic participants. Follow-up of 25 loci in up to 76,558 additional subjects identified 16 loci associated with fasting glucose and HOMA-B and two loci associated with fasting insulin and HOMA-IR. These include nine loci newly associated with fasting glucose (in or near ADCY5, MADD, ADRA2A, CRY2, FADS1, GLIS3, SLC2A2, PROX1 and C2CD4B) and one influencing fasting insulin and HOMA-IR (near IGF1). We also demonstrated association of ADCY5, PROX1, GCK, GCKR and DGKB-TMEM195 with type 2 diabetes. Within these loci, likely biological candidate genes influence signal transduction, cell proliferation, development, glucose-sensing and circadian regulation. Our results demonstrate that genetic studies of glycemic traits can identify type 2 diabetes risk loci, as well as loci containing gene variants that are associated with a modest elevation in glucose levels but are not associated with overt diabetes.
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[Traditions. Asie. Inde. Madhya Pradesh. Chhattisgarh]
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[Traditions. Asie. Inde. Madhya Pradesh. Maharashtra]