Mecanismos financieros de la Asociación Latinoamericana de Integración (ALADI) y la expansión del comercio intrarregional

Incluye Bibliografía

Analyzing the dependence structure of microarray data: a copula–based approach

The main aim of this Ph.D. dissertation is the study of clustering dependent data by means of copula functions with particular emphasis on microarray data. Copula functions are a popular multivariate modeling tool in each field where the multivariate dependence is of great interest and their use in clustering has not been still investigated. The first part of this work contains the review of the literature of clustering methods, copula functions and microarray experiments. The attention focuses on the K–means (Hartigan, 1975; Hartigan and Wong, 1979), the hierarchical (Everitt, 1974) and the model–based (Fraley and Raftery, 1998, 1999, 2000, 2007) clustering techniques because their performance is compared. Then, the probabilistic interpretation of the Sklar’s theorem (Sklar’s, 1959), the estimation methods for copulas like the Inference for Margins (Joe and Xu, 1996) and the Archimedean and Elliptical copula families are presented. In the end, applications of clustering methods and copulas to the genetic and microarray experiments are highlighted. The second part contains the original contribution proposed. A simulation study is performed in order to evaluate the performance of the K–means and the hierarchical bottom–up clustering methods in identifying clusters according to the dependence structure of the data generating process. Different simulations are performed by varying different conditions (e.g., the kind of margins (distinct, overlapping and nested) and the value of the dependence parameter ) and the results are evaluated by means of different measures of performance. In light of the simulation results and of the limits of the two investigated clustering methods, a new clustering algorithm based on copula functions (‘CoClust’ in brief) is proposed. The basic idea, the iterative procedure of the CoClust and the description of the written R functions with their output are given. The CoClust algorithm is tested on simulated data (by varying the number of clusters, the copula models, the dependence parameter value and the degree of overlap of margins) and is compared with the performance of model–based clustering by using different measures of performance, like the percentage of well–identified number of clusters and the not rejection percentage of H0 on . It is shown that the CoClust algorithm allows to overcome all observed limits of the other investigated clustering techniques and is able to identify clusters according to the dependence structure of the data independently of the degree of overlap of margins and the strength of the dependence. The CoClust uses a criterion based on the maximized log–likelihood function of the copula and can virtually account for any possible dependence relationship between observations. Many peculiar characteristics are shown for the CoClust, e.g. its capability of identifying the true number of clusters and the fact that it does not require a starting classification. Finally, the CoClust algorithm is applied to the real microarray data of Hedenfalk et al. (2001) both to the gene expressions observed in three different cancer samples and to the columns (tumor samples) of the whole data matrix.

Prevalence and determinants of colonic polyps in children undergoing colonoscopy: A large hospital-based cross-sectional study

Background. Colorectal polyps are abnormal growths in the wall of the colon including the rectum. The study aims to estimate the prevalence and type of colonic polyps in children undergoing colonoscopic examination at Texas Children's Hospital (TCH) in Houston, Texas during 2000-2007. Also, to examine the factors associated with colonic polyps and the potential determinants of colonic polyps in children undergoing colonoscopy and compare those who had colonic polyps with those who did not on colonoscopy, and determine the significant risk factors of colonic polyps in these children. ^ Methods. We conducted a cross sectional study to analyze data collected at TCH. We obtained demographic, clinical, and histopathology information on consecutive patients who underwent colonoscopy during 2000-2007 from endoscopic records contained in the PEDS-CORI registry (Pediatric Endoscopy Database System-Clinical Outcomes Research Initiative), and abstracted data from the accompanying histopathology reports. ^ Results. We identified 2,693-unique patients, under 18 years of age, who underwent colonoscopy. Approximately 65.5% were white non-Hispanic, and 10.8% African-American. The mean age was 8.7 years and 51.8% were female patients. Polyps were present in 174 patients (6.5%). The most common two histological types were juvenile (60.6%), inflammatory (17.4%). We found that the prevalence of polyps was higher in younger aged children (12.9% in 0-5 years) than in older aged children (4% in 15-17 years), and slightly higher in males than in females (7.9% and 5.4% respectively). For males only, the odds of polyps were statistically significantly higher in Blacks and Hispanics compared to white non Hispanics (OR of 2.2 and 2.1, respectively, and 95% CI of 1.3, 3.9 and 1.3, 3.5 respectively). The indications for colonoscopy were different for children with polyps compared to those without polyps, i.e., 47.0% vs. 19.8% respectively for lower GI bleeding, 2.7% vs. 21.4% respectively for abdominal pain/bloating, and, or 0.9% vs. 9.6% respectively for diarrhea. ^ Conclusion. Colorectal polyps occur in about 1 in 15 children and adolescents undergoing first colonoscopy. The demographic variable of younger age is strongly associated with having polyps irrespective of ethnicity. Lower GI bleeding is strongly related to the presence of colorectal polyps in children and adolescents undergoing colonoscopy.^

El progreso de microrregionalización como estrategia del desarrollo local : Un estudio de la provincia de Chaco

El artículo analiza la experiencia de desarrollo llevada a cabo por el gobierno del Chaco, Argentina, entre los años 2000 y 2007 mediante la organización del territorio provincial en microrregiones. El énfasis ha sido puesto en los aspectos participativos y en el sentido que el proceso adquirió para sus propios actores. La noción de territorio, en su vinculación con el término ?campo? de Bourdieu, constituyó un concepto relevante a los efectos del análisis. En primer lugar, se explicitan los ejes teóricos del discurso oficial que origina y promueve el proceso: la opción por el desarrollo sustentable, la perspectiva de integración de lo económico con lo social y la generación de espacios participativos para la gestión de las políticas públicas. En la descripción de la experiencia se identifican las tensiones, actores y lógicas subyacentes: iniciativas y razones para la creación de cada microrregión, modalidad de la participación, consecuencias y obstáculos. El análisis muestra que la tensión entre los intereses económicos de los sectores productivos más estabilizados y las expectativas sociales de los sectores vulnerados no logra dirimirse, por lo cual la voluntad asociativa discurre en el marco de esta lógica. El Estado no puede ser un actor prescindente. Estos procesos deben contribuir a afirmar la identidad cultural y el sentido de pertenencia desde una perspectiva que reconozca la diversidad pero no legitime la desigualdad. En este contexto, se destaca la importancia de abrir espacios que permitan nuclear a la población de las distintas jurisdicciones para la discusión de ejes, la definición de políticas y la construcción de consensos que incluyan el reconocimiento del otro como igual, fortaleciendo los mecanismos de cohesión social

El progreso de microrregionalización como estrategia del desarrollo local : Un estudio de la provincia de Chaco

El artículo analiza la experiencia de desarrollo llevada a cabo por el gobierno del Chaco, Argentina, entre los años 2000 y 2007 mediante la organización del territorio provincial en microrregiones. El énfasis ha sido puesto en los aspectos participativos y en el sentido que el proceso adquirió para sus propios actores. La noción de territorio, en su vinculación con el término ?campo? de Bourdieu, constituyó un concepto relevante a los efectos del análisis. En primer lugar, se explicitan los ejes teóricos del discurso oficial que origina y promueve el proceso: la opción por el desarrollo sustentable, la perspectiva de integración de lo económico con lo social y la generación de espacios participativos para la gestión de las políticas públicas. En la descripción de la experiencia se identifican las tensiones, actores y lógicas subyacentes: iniciativas y razones para la creación de cada microrregión, modalidad de la participación, consecuencias y obstáculos. El análisis muestra que la tensión entre los intereses económicos de los sectores productivos más estabilizados y las expectativas sociales de los sectores vulnerados no logra dirimirse, por lo cual la voluntad asociativa discurre en el marco de esta lógica. El Estado no puede ser un actor prescindente. Estos procesos deben contribuir a afirmar la identidad cultural y el sentido de pertenencia desde una perspectiva que reconozca la diversidad pero no legitime la desigualdad. En este contexto, se destaca la importancia de abrir espacios que permitan nuclear a la población de las distintas jurisdicciones para la discusión de ejes, la definición de políticas y la construcción de consensos que incluyan el reconocimiento del otro como igual, fortaleciendo los mecanismos de cohesión social

El progreso de microrregionalización como estrategia del desarrollo local : Un estudio de la provincia de Chaco

El artículo analiza la experiencia de desarrollo llevada a cabo por el gobierno del Chaco, Argentina, entre los años 2000 y 2007 mediante la organización del territorio provincial en microrregiones. El énfasis ha sido puesto en los aspectos participativos y en el sentido que el proceso adquirió para sus propios actores. La noción de territorio, en su vinculación con el término ?campo? de Bourdieu, constituyó un concepto relevante a los efectos del análisis. En primer lugar, se explicitan los ejes teóricos del discurso oficial que origina y promueve el proceso: la opción por el desarrollo sustentable, la perspectiva de integración de lo económico con lo social y la generación de espacios participativos para la gestión de las políticas públicas. En la descripción de la experiencia se identifican las tensiones, actores y lógicas subyacentes: iniciativas y razones para la creación de cada microrregión, modalidad de la participación, consecuencias y obstáculos. El análisis muestra que la tensión entre los intereses económicos de los sectores productivos más estabilizados y las expectativas sociales de los sectores vulnerados no logra dirimirse, por lo cual la voluntad asociativa discurre en el marco de esta lógica. El Estado no puede ser un actor prescindente. Estos procesos deben contribuir a afirmar la identidad cultural y el sentido de pertenencia desde una perspectiva que reconozca la diversidad pero no legitime la desigualdad. En este contexto, se destaca la importancia de abrir espacios que permitan nuclear a la población de las distintas jurisdicciones para la discusión de ejes, la definición de políticas y la construcción de consensos que incluyan el reconocimiento del otro como igual, fortaleciendo los mecanismos de cohesión social

Co-design: setting relational domains for deep sustainability

This paper draws mainly on the work of Elizabeth Sanders who has being practising, thinking and mapping participatory design research for over 25 years, connecting it to insights from Maturana (1984), Capra (2002), Jovchelovitch (1995, 2000, 2007) and Preece (2011), to propose that the process of design per se is a relational domain of cocreativity that is essential to construct a way toward deeper sustainability.

‘Neutral, native-like or authentic’ : Investigating attitudes and beliefs of expanding circle speakers of English

The status of English as the language of international communication is by now well-established. However, in the past 16 years, research has tried to emphasize the fact that the English spoken in international contact situations and between people with other first languages than English has different needs than the English spoken locally amongst native speakers, resulting in the emergence of English as a lingua franca (ELF) as a scholarly field. However, the impact of findings in ELF has so far only led to a moderate shift in English language teaching. Especially in expanding circle countries, where ELF should have the biggest impact, change is only gradually becoming palpable. Accent and pronunciation, as one of the biggest factors on both identity and mutual intelligibility (Jenkins 2000; 2007) are at the root of discussion. The scope of this study is therefore to examine accent choices and the extent to which native speaker ideology informs the preferences of ten speakers of ELF and 27 German natives with experience in international communication. Both ethnographical and sociolinguistic methods, as well as auditory analysis have been applied and conducted. The auditory analysis of six variables in the recorded speech production of the ten speakers suggests that there is no significant preference of one norm-giving variety over the other. Rather, speakers tend to mix-and-match General American- and Standard Southern British English-like features in their pronunciation. When reporting their accent ideals, the idea of a ‘neutral’ English accent is mentioned by four participants. Neutral accents seem to have been understood as ‘unmarked accents’. Expressed beliefs on their own English pronunciation show a comparatively high level of reflection on and confidence in their own production. Results from a rating task and a survey given to 27 German participants reveal attitudes that are more negatively stacked. While Germans reported openness towards NNS (non-native speaker) accents and showed awareness of the priority of intelligibility over accent choice in both their own and others’ pronunciation, they still largely reported NS accent preference. The ratings of the production from ten ELF speakers confirmed this and showed that ‘neutral’ is equated with native-like. In the light of these findings, issues are discussed that ultimately relate to the influence of NS Englishes, identity and the development of English as an international language.

Sexual Behavior Patterns and Condom Use in Newly Sexually Active Female University Students

Thesis (Master's)--University of Washington, 2016-06

Currículo escolar e inclusão de estudantes com deficiência: diálogos com uma escola pública

This work of qualitative approach, has as its study object the school curriculum, resulting from the implementation of public policies for inclusion in the Brazilian educational field and of the teaching organization in State School Despertar. While we acknowledge advances in government discussions and proposals related to school inclusion in our country, it is still important to develop studies and interventions in the context of basic education focused on the curriculum. With methodological basis in collaborative-critical action research and contribution by Barbier, the survey was conducted in 2013, in a state school in the Natal - Rio Grande do Norte - school system, and aimed to analyze the curriculum of the State School Despertar, in particular issues related to the inclusion of students with disabilities in common teaching classes expressed in the school and in collective situations of continuing education with teachers and interpreter of Brazilian Sign Language (Libras). The school was previously chosen because it had already been locus of research in a study conducted by a professor at the Federal University of Rio Grande do Norte promoting the knowledge of their formative needs. The study subjects were 26 teachers in the early years and the end of elementary school and a Libras interpreter. The instruments were direct observation, semi-structured interviews, document analysis and a proposal for continuing education called Collaborative Group on School Inclusion (GCEI), established with the participating subjects and the other research collaborators. The analyzed data showed eight dialogues built with the State School Despertar, being basic the contributions of Goffman (1988) on stigma and of Forquin (1993) on school culture. As a theoretical framework, there were important contributions on School Curriculum (SACRISTÁN, 2000; 2007; APPLE, 2006; 2008), School Inclusion (BUENO, 2008), Continuing Education (NÓVOA, 2002; GATTI, 2003) and the existing studies on the dialogues between Curriculum and Special Education (MAGALHÃES, 2002; SILVA, 2008; 2010; OLIVEIRA, 2004; VIEIRA, 2012). The study highlighted the importance of extending the dialogue, the theoretical deepening of GCEI for the understanding of school curriculum and the specifics of any students, with or without disability. It will be necessary to revisit the school teaching practices that do not correspond to the students, for instance the formation of classes made in classrooms. It is also important to consider the organization of the school day and its interface with the pedagogical functions of each member of the school in building curriculum practices consistent with the diversity of modes and learning styles. Subliminal aspects of the curriculum should be reviewed, given its implications in the context of the classroom and management. However, significant changes identified in the practices of some teachers, such as the use of audio description, stimulus to the participation of students with disabilities and use of images, favored the development of other students, who benefit of more exciting and participatory classes. Based on the conducted research, we conclude on the importance of collectively discuss the conditions for / in schooling of different students and the (re)thinking of curriculum practices in the school as a whole, and therein lies a paradox because, on the one hand, it is not about minimizing the specific knowledge in dealing with the needs of students with disabilities, on the other, we are not interested in distancing these needs from those inherent in human nature, therefore peculiar to the other students. The questioning of our own practices is the challenge imposed, not to special education, or its target audience, but this is undoubtedly task of education.

Currículo escolar e inclusão de estudantes com deficiência: diálogos com uma escola pública

This work of qualitative approach, has as its study object the school curriculum, resulting from the implementation of public policies for inclusion in the Brazilian educational field and of the teaching organization in State School Despertar. While we acknowledge advances in government discussions and proposals related to school inclusion in our country, it is still important to develop studies and interventions in the context of basic education focused on the curriculum. With methodological basis in collaborative-critical action research and contribution by Barbier, the survey was conducted in 2013, in a state school in the Natal - Rio Grande do Norte - school system, and aimed to analyze the curriculum of the State School Despertar, in particular issues related to the inclusion of students with disabilities in common teaching classes expressed in the school and in collective situations of continuing education with teachers and interpreter of Brazilian Sign Language (Libras). The school was previously chosen because it had already been locus of research in a study conducted by a professor at the Federal University of Rio Grande do Norte promoting the knowledge of their formative needs. The study subjects were 26 teachers in the early years and the end of elementary school and a Libras interpreter. The instruments were direct observation, semi-structured interviews, document analysis and a proposal for continuing education called Collaborative Group on School Inclusion (GCEI), established with the participating subjects and the other research collaborators. The analyzed data showed eight dialogues built with the State School Despertar, being basic the contributions of Goffman (1988) on stigma and of Forquin (1993) on school culture. As a theoretical framework, there were important contributions on School Curriculum (SACRISTÁN, 2000; 2007; APPLE, 2006; 2008), School Inclusion (BUENO, 2008), Continuing Education (NÓVOA, 2002; GATTI, 2003) and the existing studies on the dialogues between Curriculum and Special Education (MAGALHÃES, 2002; SILVA, 2008; 2010; OLIVEIRA, 2004; VIEIRA, 2012). The study highlighted the importance of extending the dialogue, the theoretical deepening of GCEI for the understanding of school curriculum and the specifics of any students, with or without disability. It will be necessary to revisit the school teaching practices that do not correspond to the students, for instance the formation of classes made in classrooms. It is also important to consider the organization of the school day and its interface with the pedagogical functions of each member of the school in building curriculum practices consistent with the diversity of modes and learning styles. Subliminal aspects of the curriculum should be reviewed, given its implications in the context of the classroom and management. However, significant changes identified in the practices of some teachers, such as the use of audio description, stimulus to the participation of students with disabilities and use of images, favored the development of other students, who benefit of more exciting and participatory classes. Based on the conducted research, we conclude on the importance of collectively discuss the conditions for / in schooling of different students and the (re)thinking of curriculum practices in the school as a whole, and therein lies a paradox because, on the one hand, it is not about minimizing the specific knowledge in dealing with the needs of students with disabilities, on the other, we are not interested in distancing these needs from those inherent in human nature, therefore peculiar to the other students. The questioning of our own practices is the challenge imposed, not to special education, or its target audience, but this is undoubtedly task of education.

Redes Sociais da Família Multiproblemática ou Família Multidesafios

Esta investigação surge no âmbito do Mestrado de Psicologia Clínica – Família e Intervenção Sistémica, da Escola Superior de Altos Estudos, do Instituto Superior Miguel Torga. A dissertação de mestrado intitulada As Rede Sociais da Família Multiproblemática ou Família Multidesafios – Estudo Exploratório, trata-se de um estudo exploratório e versa sobre as principais características das redes sociais destas famílias, seus principais problemas e particularidades, contemplando uma leitura macrosistémica (Bronfenbrenner, 1986; Fuster & Ochoa, 2000; Navarro, 2004; Rojano, 2004; Rosello, 2004). Foram exploradas as características estruturais, as características funcionais e os atributos do vínculo das redes sociais (Guay, 1984; Guédon, 1984; Barrón, 1996; Sluzki, 1996, 2000, 2007; Guadalupe, 2003, 2009; Alarcão & Sousa, 2007) das famílias multiproblemáticas ou multidesafios, concluindo-se que estas possuem maioritariamente redes de tamanho reduzido, de densidade média (redes fragmentadas). Os quadrantes das relações familiares, das relações institucionais e das relações de amizade assumem um peso significativo. As redes sociais demonstram ser localizadas, nos quadrantes anteriormente mencionados e no quadrante das relações de trabalho ou estudo constatamos uma ausência de relações. Foram analisadas as características funcionais, como o apoio emocional, o apoio informativo, e o apoio material e instrumental, concluindo-se que o apoio é reconhecido de forma positiva, pelas famílias. Relativamente, aos atributos do vínculo, a totalidade da amostra percepciona trocas equitativas do apoio (reciprocidade) e ao nível da frequência de contactos, as famílias referem contactos frequentes. Ao tentarmos identificar os principais problemas das famílias (Costa, 1998; Sousa, Hespanha, Rodrigues & Grilo, 2007) concluímos que se encontram em diferentes áreas e são percepcionados de forma diferente por famílias e profissionais.

Auswirkungen von Traumata auf Entstehung und Verlauf von somatoformen Beschwerden sowie die Wirksamkeit von psychodynamischer Psychotherapie bei dieser Patientengruppe

Zusammenhänge zwischen Trauma und Somatisierung wurden empirisch vielfach belegt. Zur Erklärung des Zusammenhangs bestehen verschiedene Theorien, u.a. die der unterbrochenen Handlung (Fischer, 2000, 2007), der unterbrochenen Informationsverarbeitung (Bering, 2011), der Dissoziation (Nijenhuis, 2004) und der Alexithymie (Krystal, 1979). Unklar ist, welche Art der Therapie traumatisierten, somatisierenden Patienten hilft, da die Psychosomatik als Outcome in der Traumatherapieforschung bislang häufig vernachlässigt wurde. In der vorliegenden Promotion wurde der Zusammenhang von Trauma und somatoformen Beschwerden sowie die Wirksamkeit psychodynamischer Psychotherapie bei dieser Patientengruppe untersucht. Hierzu wurde eine klinische, naturalistische Längsschnittstudie mit Prätest-Posttest-Design an einer Stichprobe ambulanter Psychotherapiepatienten durchgeführt. Die Ergebnisse (N = 248) zeigen, dass zwei Drittel der Somatisierungsvarianz mittels Traumata (insbesondere vor dem 6. Lj.), posttraumatischer und dissoziativer Symptomatik aufgeklärt werden können. Physische und sexuelle Gewalt sind die Subformen, die die stärksten Zusammenhänge mit Somatisierung aufweisen. Der Zusammenhang zwischen traumatischen Ereignissen und Somatisierung wird insbesondere durch PTBS-Symptomatik moderiert und durch Dissoziation partiell mediiert. Die längsschnittlichen Ergebnisse (n = 83) zeigen, dass nach psychodynamischer Psychotherapie (durchschnittlich 79 Std.) moderate bis große Effekte bezüglich der Verbesserung des Funktionsniveaus, der Reduktion der posttraumatischen, alexithymen, allgemeinpsychopathologischen, somatoformen und dissoziativen Symptome vorliegen. Entgegen der Hypothese liegt keine signifikante Veränderung der Inanspruchnahme des Gesundheitssystems vor. Negative Prädiktoren des Therapieverlaufs im Hinblick auf die Somatisierung sind Traumata (insbesondere vor dem 6. Lj.) sowie tendenziell starke Dissoziation und Alexithymie zu Therapiebeginn. Die Therapiedosis erweist sich als positiver, jedoch nicht signifikanter Prädiktor des Therapieerfolgs. Die Ergebnisse zeigen, dass somatoforme Symptome als Folge von Traumatisierung eher die Regel als die Ausnahme darstellen und durch Traumatherapie beeinflusst werden können. Sie verweisen zudem auf die Relevanz der Psychosomatik als Outcome in der Traumatherapieforschung. Zu diskutierende Limitationen der Untersuchung sind die reduzierte interne Validität des Feldstudiendesigns, das Fehlen einer Kontrollgruppe, die Auswahl der Outcome-Variablen inklusive des weitgehenden Fehlens multimodaler Bewertungen.