Bisphosphonates adherence for treatment of osteoporosis

Background: Osteoporosis is a disease of bone metabolism in which bisphosphonates (BPS) are the most common medications used in its treatment, whose main objective is to reduce the risk of fractures. The aim of this study was to conduct a systematic review on BPs adherence for treatment of osteoporosis. Methods. Systematic review of articles on BPs adherence for treatment of osteoporosis, indexed on MEDLINE (via PubMed) databases, from inception of databases until January 2013. Search terms were Adherence, Medication (MeSH term), Bisphosphonates (MeSH term), and Osteoporosis (MeSH term). Results: Of the 78 identified studies, 27 met the eligibility criteria. Identified studies covered a wide range of aspects regarding adherence and associated factors, adherence and fracture, adherence and BPs dosage. The studies are mostly observational, conducted with women over 45 years old, showing low rates of adherence to treatment. Several factors may influence adherence: socio-economic and cultural, participation of physicians when guidance is given to the patient, the use of bone turnover markers, and use of generic drugs. The monthly dosage is associated with greater adherence compared to weekly dosage. Conclusions: Considering the methodological differences between the studies, the results converge to show that adherence to treatment of osteoporosis with BPs is still inadequate. Further experimental studies are needed to evaluate the adherence and suggest new treatment options. © 2013 Vieira et al.; licensee BioMed Central Ltd.

The influence of topic and systemic administration of copaiba oil on the alveolar wound healing after tooth extraction in rats

The Copaiba oil has been used as an auxiliary treatment of inflammations, skin disorders and stomach ulcers, however, in dentistry, this alternative medicine has not been investigated yet. The purpose of this study was to evaluate the influence of topic and systemic administration of copaiba oil on the alveolar wound healing after tooth extraction. Twenty-eight wistar male rats had their lower first molar teeth extracted. Subsequently, they were divided in four groups, according to the treatment performed: (a) alveolar socket irrigation with copaiba oil; (b) alveolar socket irrigation with physiological serum; (c) daily gavage with copaiba oil or (d) daily gavage with physiological serum. After the sacrifice, the mandibles were removed and processed in order to obtain decalcified histological sections. The results demonstrated high level of epithelial migration, small number of inflammatory cells and vascular enhancement in the animals which received systemic administration of copaiba oil. The rats treated with topic administration of copaiba oil presented ulcerations and large number of inflammatory cells. An increased bone neoformation was observed in both groups treated with copaiba oil when compared with placebo group. It could be concluded that topic or systemic administration of copaiba oil leads to a better alveolar bone healing, however the topic application on connective tissue should be carefully considered, regarding the whole socket wound healing. © Medicina Oral S. L. C.I.F. B 96689336 - eISSN: 1989-5488.

Influência de diferentes tipos de recuperação sobre a modulação autonômica cardíaca, concentração de lactato e proteína C-reativa

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Establishing social statistical databases for evidenced-based social policy formulation in the Caribbean

Includes bibliography

Algunas reflexiones sobre la forma de abordar el tema del Area de Libre Comercio de las Américas = Reflections on ways to approach the topic of the Free Trade Areas of the Americas

Incluye Bibliografía

The use of databases of social and gender statistics in the development of policies and programmes

The unavailability of data to inform policy planning and formulation has been repeatedly cited as the main challenge to economic and social progress in the Caribbean. Furthermore, even in instances when data is produced, broader gaps exist between its production and eventual use for evidence-based policy formulation. Owing to those challenges, this report explores the use of databases of social and gender statistics in the development of policies and programmes in the Caribbean subregion. The report offers a general appraisal of databases against two main considerations: (i) maximizing the use of existing databases in relevant policies and programmes; and (ii) bridging the gaps in data availability of relevant statistical databases and their analyses. The assessment entailed an inventory of social and gender databases maintained by data producers in the region and analysis of the extent to which the databases are used for policy formulation. To that end, a literature search as well as consultations with a number of knowledgeable persons active in the field of statistics and data provision was conducted. Based on the review, a set of recommendations were produced to improve current practices within the region with respect evidence based policy formulation.

Transdisciplinaridade em saúde: uma análise integrativa da literatura

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Delimitação e alinhamento de conceitos lexicalizados no inglês norte-americano e no português brasileiro

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

O comportamento informacional de pós-graduandos da área de Educação

The study of information behavior of graduate students is important because it reveals aspects of the search and information use that will impact the performance of future researchers and other professionals. Earlier studies on the UNESP, campus of Marilia (São Paulo State, Brazil), indicated that the graduate students in the areas of Applied Social Sciences and Humanities little use information sources traditionally used for bibliographic and restricted to the sources indicated by their teachers, contrary to expectations for a student with this level of training. Continuing the theme, we investigate the information behavior of students in postgraduate programs in the field of Education with five and six notes in the latest assessment of the Coordination of Improvement of Higher Education Personnel (CAPES). This research aimed to characterize the information behavior of Brazilian post-graduate in Education; identify factors that may influence the information behavior of the participants; investigate whether there are significant differences in behavior between masters and doctoral students; check the influence of gender in information behavior of post-graduate students. Data collection was performed in two stages: the establishment of a focus group with group of 11 participants for raising subsidies for the next step, which consisted in the application of electronic questionnaire to 16 graduate regular student of programs of excellence in the Brazil. Participated in the survey 493 post-graduates, 54% doctoral students and 46% of masters students and 75% women and 25% of men. The results showed that most subjects did not participate in formal instruction to search in databases. They are open to new ideas and do not restrict your search only to information that confirms their view on the research topic. Respondents are concerned not to overlook details and have the habit of regularly seeking information on their research and were willing to...