Observationes ad cognitionem mei et aliorum: Januar 1740 - Juli 1742

Handschrift

Wissenschaft und Glauben bei Michael Polanyi

For Michael Polanyi, religion and science fight abreast to protect the occidental culture from totalitarian threat. Both are belief-based endeavors, Polanyi is convinced. While this is not surprising at all regarding religion, it is surely a provocation regarding science. The article tries to explore this original thought of Polanyi and to examine how it is rooted in his personal convictions and beliefs. Special emphasis is given to Polanyi’s critique of contemporary biology, as expressed in his article on “Science and Religion”, in some ways a response to Paul Tillich’s theology. Contemporary biology’s findings undermine exactly what Polanyi is fighting for, hence he is convinced that its findings are somewhat flawed. This should however not lead to the false conclusion that Polanyi had anything to do with creationism or would have favored Intelligent Design in our days.

Worte der Trauer, gesprochen am 20. October 1871 am Sarge des verewigten Herrn Gotthelf Michael Binge

von N. Brüll und H. Bärwald

Oberrabbiner Michael Scheuer als Kritiker seiner Zeit

Isak Unna

Oberrabbiner Michael Scheuer als Kritiker seiner Zeit

Berthold Rosenthal

Probing the effect of minor groove interactions on the catalytic efficiency of DNAzymes 8–17 and 10–23

DNAzymes (Dz) 8–17 and 10–23 are two widely studied and well-characterized RNA-cleaving DNA catalysts. In an effort to further improve the understanding of the fragile interactions and dynamics of the enzymatic mechanism, this study examines the catalytic efficiency of minimally modified DNAzymes. Five single mutants of Dz8–17 and Dz10–23 were prepared by replacing the adenine residues in the corresponding catalytic cores with 3-deazaadenine units. Kinetic assays were used to assess the effect on the catalytic activity and thereby identify the importance of hydrogen bonding that arises from the N3 atoms. The results suggest that modifications at A15 and A15.0 of Dz8–17 have a significant influence and show a reduction in catalytic activity. Modification at each location in Dz10–23 results in a decrease of the observed rate constants, with A12 appearing to be the most affected with a reduction of ∼80% of kobs and ∼25% of the maximal cleavage rate compared to the wild-type DNAzyme. On the other hand, modification of A12 in Dz8–17 showed an ∼130% increase in kobs, thus unraveling a new potential site for the introduction of chemical modifications. A pH-profile analysis showed that the chemical cleavage step is rate-determining, regardless of the presence and/or location of the mutation. These findings point towards the importance of the N3-nitrogens of certain adenine nucleotides located within the catalytic cores of the DNAzymes for efficient catalytic activity and further suggest that they might directly partake in maintaining the appropriate tertiary structure. Therefore, it appears that minor groove interactions constitute an important feature of DNAzymes as well as ribozymes.

Segens-Spruch des Rabbiner Dr. Michael Sachs über die Opfer des 18. und 19. März: An ihren Särgen gesprochen den 22. März 1848: Im Namen jenes uralten Bekenntnisses, das als lebendiger Zeuge der Weltgeschichte und Weltgeschicke ...

Welsch (Projektbearbeiter): Veröffentlichung der anläßlich der Einsegnung der Märzgefallenen von dem Berliner Rabbiner Dr. Sachs gesprochenen Trauerworte

Michael Scheuer : Eine Erwiderung

Isak Unna

Zur Geschichte der Juden in Franken : (1772 - 1775)

Leopold Löwenstein