Selected topics in probiotics and prebiotics: meeting report for the 2004 international scientific association for probiotics and prebiotics

On August 2931, 2004, 84 academic and industry scientists from 16 countries gathered in Copper Mountain, Colorado USA to discuss certain issues at the forefront of the science of probiotics and prebiotics. The format for this invitation only meeting included six featured lectures: engineering human vaginal lactobacilli to express HIV inhibitory molecules (Peter Lee, Stanford University), programming the gut for health (Thaddeus Stappenbeck, Washington University School of Medicine), immune modulation by intestinal helminthes (Joel Weinstock, University of Iowa Hospitals and Clinics), hygiene as a cause of autoimmune disorders (G. A. Rook, University College London), prebiotics and bone health (Connie Weaver, Purdue University) and prebiotics and colorectal cancer risk (Ian Rowland, Northern Ireland Centre for Food and Health). In addition, all participants were included in one of eight discussion groups on the topics of engineered probiotics, host-commensal bacteria communication, 'omics' technologies, hygiene and immune regulation, biomarkers for healthy people, prebiotic and probiotic applications to companion animals, development of a probiotic dossier, and physiological relevance of prebiotic activity. Brief conclusions from these discussion groups are summarized in this paper.

Emerging hybrid practices in construction design work: role of mixed media

Information technologies are used across all stages of the construction process, and are crucial in the delivery of large projects. Drawing on detailed research on a construction megaproject, we take a practice-based approach to examining the practical and theoretical tensions between existing ways of working and the introduction of new coordination tools in this paper. We analyze the new hybrid practices that emerge, using insights from actor-network theory to articulate the delegation of actions to material and digital objects within ecologies of practice. The three vignettes that we discuss highlight this delegation of actions, the “plugging” and “patching” of ecologies occurring across media and the continual iterations of working practices between different types of media. By shifting the focus from tools to these wider ecologies of practice, the approach has important managerial mplications for the stabilization of new technologies and practices and for managing technological change on large construction projects. We conclude with a discussion of new directions for research, oriented to further elaborating on the importance of the material in understanding change.

IT implementation in the construction organization

Organizational issues are inhibiting the implementation and strategic use of information technologies (IT) in the construction sector. This paper focuses on these issues and explores processes by which emerging technologies can be introduced into construction organizations. The paper is based on a case study, conducted in a major house building company that was implementing a virtual reality (VR) system for internal design review in the regional offices. Interviews were conducted with different members of the organization to explore the introduction process and the use of the system. The case study findings provide insight into the process of change, the constraints that inhibit IT implementation and the relationship between new technology and work patterns within construction organizations. They suggest that (1) user-developer communications are critical for the successful implementation of non-diffused innovations in the construction industry; and (2) successful uptake of IT requires both strategic decision-making by top management and decision-making by technical managers.

Using HIT to deliver integrated care for the frail elderly in the UK: current barriers and future challenges

In this paper we briefly describe the results of a 3 year project examining the use of Health Information Technologies (e.g., electronic patient record systems) to deliver integrated care. In particular, we focus on one group of patient (the frail elderly) and efforts to design an e-health supported healthcare pathway (the frail elderly pathway – FEP). The aim of FEP is to bring together clinicians and staff from health and social care and allow them to share patient information. Our findings show that progress in delivering a fully-supported and working FEP has been slow, not least because of the difficulties experienced by healthcare staff in using current IT systems. In addition, there are many strategic and technical issues which remain unresolved (e.g., systems interoperability).

Optimal frame length for keeping normalized goodput with lowest requirement on BER

This paper presents an adaptive frame length mechanism based on a cross-layer analysis of intrinsic relations between the MAC frame length, bit error rate (BER) of the wireless link and normalized goodput. The proposed mechanism selects the optimal frame length that keeps the service normalized goodput at required levels while satisfying the lowest requirement on the BER, thus increasing the transmission reliability. Numerical results are provided and show that an optimal frame length satisfying the lowest BER requirement does indeed exist. The performance of BER requirement as a function of the MAC frame length is evaluated and compared for transmission scenarios with and without automatic repeat request (ARQ). Furthermore, issues related to the MAC overhead length are also discussed to illuminate the functionality and performance of the proposed mechanism.

Cloud computing in e-science: research challenges and opportunities

SOA (Service Oriented Architecture), workflow, the Semantic Web, and Grid computing are key enabling information technologies in the development of increasingly sophisticated e-Science infrastructures and application platforms. While the emergence of Cloud computing as a new computing paradigm has provided new directions and opportunities for e-Science infrastructure development, it also presents some challenges. Scientific research is increasingly finding that it is difficult to handle “big data” using traditional data processing techniques. Such challenges demonstrate the need for a comprehensive analysis on using the above mentioned informatics techniques to develop appropriate e-Science infrastructure and platforms in the context of Cloud computing. This survey paper describes recent research advances in applying informatics techniques to facilitate scientific research particularly from the Cloud computing perspective. Our particular contributions include identifying associated research challenges and opportunities, presenting lessons learned, and describing our future vision for applying Cloud computing to e-Science. We believe our research findings can help indicate the future trend of e-Science, and can inform funding and research directions in how to more appropriately employ computing technologies in scientific research. We point out the open research issues hoping to spark new development and innovation in the e-Science field.

Development of on-line courses focusing on quality

The purpose of this paper is to show by which means quality in on-line education is achieved at Dalarna University. As a leading provider of online university courses in northern Europe, both in terms of number of students conducting their studies entirely on-line compared to the whole student body, (approximately 70% on-line students all subjects included), Dalarna University has acquired de facto extensive practical experience in the field of information technologies related to distance education. It has been deemed essential, to ensure that the quality of teaching reflects the principles governing the assessment of learning so that on-line education is deemed as comparative to campus education, both from a legal and cognitive point-of-view. Dalarna University began on-line courses in 2002 and it soon became clear that the interaction between the teacher and the student should make its mark in all stages of the learning process in order to both maintain the learners' motivation and ensure the assimilation of knowledge. We will illustrate these aspects by giving examples of what has been done in the recent years in on-line teaching of languages. As this method of teaching is not limited to learning basic language skills, but also to the study of literature, social issues and the language system of the various cultures, our presentation will offer a broad range of areas where the principles of quality in education are provided on a daily basis.

Kvinnors behov av stöd vid bröstcancer : - En litteraturöversikt

Bakgrund Bröstcancer är den vanligaste typen av cancer hos kvinnor över hela världen. De som drabbas av bröstcancer har olika förutsättningar att hantera sin situation. Många av kvinnorna upplever en emotionell kris i samband med diagnosen och med hjälp av stöd från sjukvården kan patienten finna mening i sin situation. Syfte Syftet är att sammanställa aktuell forskning om bröstcancerdrabbade kvinnors effekter av stöd under diagnosperioden. Metod En litteraturöversikt som sammanställer aktuell forskning inom det valda omvårdnadsområdet. Resultat I resultatet framkom att kvinnorna behöver ett stöd i form av kommunikation, information samt ett emotionellt stöd från vårdpersonal. Stödet ska utformas efter patientens unika situation och när sjukvården är tillgänglig för patienterna minskas deras stress. Patienterna upplevde stöd under diagnosperioden då sjuksköterskan erhöll god förmåga att bemöta och kommunicera på ett adekvat sätt. Slutsats Studien visar att det krävs en god relation mellan bröstcancer drabbade kvinnor och vårdaren för att kvinnorna ska känna stöd.

An Environmental Analysis Corroborating PDA and the Winthrop Example

Libraries seek active ways to innovate amidst macroeconomic shifts, growing online education to help alleviate ever-growing schedule conflicts as students juggle jobs and course schedules, as well as changing business models in publishing and evolving information technologies. Patron-driven acquisition (PDA), also known as demand-driven acquisition (DDA), offers numerous strengths in supporting university curricula in the context of these significant shifts. PDA is a business model centered on short-term loans and subsequent purchases of ebooks resulting directly from patrons' natural use stemming from their discovery of the ebooks in library catalogs where the ebooks' bibliographic records are loaded at regular intervals established between the library and ebook supplier. Winthrop University's PDA plan went live in October 2011, and this article chronicles the philosophical and operational considerations, the in-library collaboration, and technical preparations in concert with the library system vendor and ebook supplier. Short-term loan is invoked after a threshold is crossed, typically number of pages or time spent in the ebook. After a certain number of short-term loans negotiated between the library and ebook supplier, the next short-term loan becomes an automatic purchase after which the library owns the ebook in perpetuity. Purchasing options include single-user and multi-user licenses. Owing to high levels of need in college and university environments, Winthrop chose the multi-user license as the preferred default purchase. Only where multi-user licenses are unavailable does the automatic purchase occur with single-user title licenses. Data on initial use between October 2011 and February 2013 reveal that of all PDA ebooks viewed, only 30% crossed the threshold into short-term loans. Of all triggered short-term loans, Psychology was the highest-using. Of all ebook views too brief to trigger short-term loans, Business was the highest-using area. Although the data are still too young to draw conclusions after only a few months, thought-provoking usage differences between academic disciplines have begun to emerge. These differences should be considered in library plans for the best possible curricular support for each academic program. As higher education struggles with costs and course-delivery methods libraries have an enduring lead role.

Os impactos da utilização da internet e outras tecnologias da informação sobre o setor industrial: uma análise de empresas do Estado de São Paulo

Este projeto de pesquisa teve por objetivo aprofundar o conhecimento acadêmico sobre a maneira como as empresas estão se utilizando da Internet e outras tecnologias da informação para agregar valor e/ou reduzir custos para os seus clientes, com foco na possibilidade de virtualização dos produtos/serviços oferecidos e dos processos utilizados na sua obtenção, incluindo o relacionamento com fornecedores e outros parceiros comerciais. O estudo foi realizado com base em dados levantados a partir de pesquisa de campo, com aplicação de questionário, e na utilização de métodos quantitativos para a análise das informações obtidas. O objetivo principal foi verificar se o modelo preliminar proposto explicava o comportamento das empresas industriais de São Paulo, permitindo uma reflexão sobre eventuais discrepâncias e o aprimoramento do modelo, além da recomendação de linhas de ação para as empresas. Procurou-se, ainda, determinar se os usos feitos da Internet pelas empresas envolvidas na pesquisa, assim como as transformações por elas realizadas em seu ambiente empresarial em virtude da disponibilização das novas tecnologias, eram extensíveis a outros segmentos do mercado, além dos que representaram o objeto de estudo imediato deste trabalho.

O Estado organizacional dos grandes escritórios de advocacia do Brasil: dois estudos de caso

The objective of this study was to identify the real organizational status of major law firms in Brazil compared to fordism and post-fordism organizational economic paradigms. In order to fulfill the objectives, an exploratory-explanatory research was carried out through case studies. The two major Brazilian law firms, according the study developed by the newspaper Gazeta Mercantil (PANORAMA SETORIAL ¿ ESCRITÓRIOS DE ADVOCACIA, 2002), Pinheiro Neto Advogados (PN) and Tozzini, Freire, Teixeira e Silva Advogados (TFTS), were researched. The case study was based on multiple evidence analysis: semi-structured interviews, documents and records analysis, and direct observations. The report of the research was structured by presenting a detailed introduction about lawyer and the law firms, including their historics main characteristics and factors which lead up to the constitution of these firms, showing the relationship among information technologies, globalizations and the need of strategic recontextualization of law firms. The data collected showed how these aspects presented in the studied unities. It was concluded through this research that PN and TFTS present an organizational development compatible to what is frequently practised in the organizations as far as contemporary organizational techniques and tools are concerned; neither fordism nor the transitional process to post-fordism, intensified the division of work of the lawyer; the new information technologies are essential for the maintenance of the sustained competitive advantage within the post-fordism scenario.

Os impactos da utilização da internet e outras tecnologias da informação sobre o setor industrial: uma análise de empresas de manufatura do estado de São Paulo

Esta tese tem por objetivo aprofundar o conhecimento acadêmico sobre a maneira como as empresas do setor industrial estão se utilizando da Internet e outras tecnologias da informação para agregar valor para os seus clientes e/ou reduzir seus próprios custos, com foco na possibilidade de virtualização dos produtos/serviços oferecidos e dos processos utilizados na sua obtenção, incluindo o relacionamento com os parceiros comerciais. O estudo foi realizado com base em dados levantados a partir de pesquisa de campo, com aplicação de questionário, e na utilização de métodos quantitativos para a análise das informações obtidas. Responderam ao questionário 665 empresas industriais do estado de São Paulo.

Smartphones e profissionais: amigos e inimigos

A utilização de artefatos de Tecnologias da Informação Móveis e Sem Fio (TIMS) traz consigo alguns paradoxos tecnológicos associados, já identificados na literatura. O aumento do uso de TIMS e suas evoluções acabam por permitir novos tipos de uso e interação junto aos usuários. Tendo como base teorias sobre a existência de paradoxos associados ao uso de equipamentos tecnológicos, mormente TIMS, este estudo buscou aprofundar a relação entre smartphones e profissionais. A partir da coleta de dados por meio de questionário estruturado, esta pesquisa utilizou a análise quantitativa e teve como objetivo determinar a presença e medir a intensidade dos paradoxos tecnológicos, identificados na literatura, quando do uso profissional de smartphones. Outro ponto observado no presente trabalho foi a associação estatística entre esses paradoxos tecnológicos e, ainda, a identificação de fatores que poderiam impactar a percepção desses paradoxos associados ao uso do smartphone pelos profissionais que os utilizam. A análise dos dados permitiu verificar quais dos quatorze paradoxos tecnológicos apresentados por Mick e Fournier (1998), Jarvenpaa e Lang (2005) e Mazmanian et al. (2006) foram percebidos por mais respondentes, com destaque para o paradoxo de autonomia e vício, que foi vivenciado por mais de 85% daqueles que responderam à pesquisa. Usando como base o percentual de respondentes que percebem os paradoxos tecnológicos e considerando suas intensidades, esta dissertação também apresenta um ranking das forças dos paradoxos, determinado pela taxa relativa da força dos paradoxos. Esse ranking traz nas primeiras posições as seguintes ambiguidades: autonomia / vício, engajamento / desengajamento e liberdade / escravidão, respectivamente. Outro apontamento dessa pesquisa foi que nenhum dos paradoxos analisados é estatisticamente independente. Por fim, a realização de uma regressão logística ordinal levou à conclusão que apenas dois dos paradoxos em questão sofrem impacto das variáveis independentes observadas.

Estudo exploratório sobre indústrias criativas no Brasil e no Estado de São Paulo

As indústrias criativas são hoje um tema de intenso debate na literatura acadêmica internacional e nas organizações públicas e governamentais. Essas indústrias nasceram como um conceito conciliador entre as indústrias culturais tradicionais, as artes criativas e as novas tecnologias de informação. O objetivo desta pesquisa foi fazer um levantamento bibliográfico sobre o tema e um mapeamento de um core dessas indústrias no país e no Estado de São Paulo. Para a realização deste mapeamento, utilizou-se de informações provenientes de fontes secundárias, como de relatórios de institutos de pesquisa, listas telefônicas e órgãos de classe. Os resultados apontam para um desenvolvimento mais pronunciado das indústrias criativas focadas em produção de bens culturais de massa, como Televisão e rádio, bem como, menos expressivamente porém, em audiovisual. No Estado de São Paulo, apenas 1,0% do PIB está associado às atividades das indústrias criativas, com esperada concentração na capital e região metropolitana. Este relatório aponta ainda algumas linhas de pesquisas futuras sobre o tema.