976 resultados para Clive, Mrs. (Catherine), 1711-1785.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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The corpus of this study is the novel Mrs. Dalloway, by Virginia Woolf, published in 1925. According to the writer Harold Bloom, while writing Mrs. Dalloway, Woolf thought of an order structure such that each scene would establish the idea of the character of Clarissa. The heroine's subjective universe is constructed scene by scene through the hours that run in London one day apparently common. The day that begins at ten am and ends at 3 am the other, involves not only personal and important findings deepen the understanding of his own human condition. The objective of this paper is to show how, in Mrs. Dalloway, the progression of hours in the space of one day, get through the poetic narrative and the use of psychological and chronological time, clearing the mind of the characters - focusing on single Clarissa Dalloway's character - culminating in his personal growth and social, is to understand the reason for their existence or, after all, considered a key and important in the world, finding motivations for why they live
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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The Mrs. J. Palmer Lockwood Journal consists of a 76 page journal kept by Mrs. J. Palmer (Leize) Lockwood concerning how the poem Carolina by Henry Timrod became the South Carolina state song. There is also a description of how Mrs. Lockwood worked to popularize the song, three copies of Timrod’s poem, and a copy of a poem titled “Carolina” by Mary Frances Wickliffe, Winthrop faculty member from 1895 to 1919.
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The Mrs. W. E. Cochran Papers consist of histories, constitutions, bylaws, reports, memoranda, minutes, membership lists, newsletters, handbooks, brochures, manuals, newspaper clippings and photographs, relating to her involvement with the South Carolina Extension Homemakers’ Council (1936-1976), the National Home Demonstration Council (1960-1976), the Associated Country Women of the World (1947-1976), the Master Farm Homemakers’ Guild (1964-1976), and the South Carolina Council for the Common Good (1968-1972).
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Duchenne muscular dystrophy (DMD) is a recessive X-linked form of muscular dystrophy characterized by progressive and irreversible degeneration of the muscles. The mdx mouse is the classical animal model for DMD, showing similar molecular and protein defects. The mdx mouse, however, does not show significant muscle weakness, and the diaphragm muscle is significantly more degenerated than skeletal muscles. In this work, magnetic resonance spectroscopy (MRS) was used to study the metabolic profile of quadriceps and diaphragm muscles from mdx and control mice. Using principal components analysis (PCA), the animals were separated into groups according to age and lineages. The classification was compared to histopathological analysis. Among the 24 metabolites identified from the nuclear MR spectra, only 19 were used by the PCA program for classification purposes. These can be important key biomarkers associated with the progression of degeneration in mdx muscles and with natural aging in control mice. Glutamate, glutamine, succinate, isoleucine, acetate, alanine and glycerol were increased in mdx samples as compared to control mice, in contrast to carnosine, taurine, glycine, methionine and creatine that were decreased. These results suggest that MRS associated with pattern recognition analysis can be a reliable tool to assess the degree of pathological and metabolic alterations in the dystrophic tissue, thereby affording the possibility of evaluation of beneficial effects of putative therapies. (C) 2012 Elsevier Inc. All rights reserved.
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Magnetic Resonance Spectroscopy (MRS) is an advanced clinical and research application which guarantees a specific biochemical and metabolic characterization of tissues by the detection and quantification of key metabolites for diagnosis and disease staging. The "Associazione Italiana di Fisica Medica (AIFM)" has promoted the activity of the "Interconfronto di spettroscopia in RM" working group. The purpose of the study is to compare and analyze results obtained by perfoming MRS on scanners of different manufacturing in order to compile a robust protocol for spectroscopic examinations in clinical routines. This thesis takes part into this project by using the GE Signa HDxt 1.5 T at the Pavillion no. 11 of the S.Orsola-Malpighi hospital in Bologna. The spectral analyses have been performed with the jMRUI package, which includes a wide range of preprocessing and quantification algorithms for signal analysis in the time domain. After the quality assurance on the scanner with standard and innovative methods, both spectra with and without suppression of the water peak have been acquired on the GE test phantom. The comparison of the ratios of the metabolite amplitudes over Creatine computed by the workstation software, which works on the frequencies, and jMRUI shows good agreement, suggesting that quantifications in both domains may lead to consistent results. The characterization of an in-house phantom provided by the working group has achieved its goal of assessing the solution content and the metabolite concentrations with good accuracy. The goodness of the experimental procedure and data analysis has been demonstrated by the correct estimation of the T2 of water, the observed biexponential relaxation curve of Creatine and the correct TE value at which the modulation by J coupling causes the Lactate doublet to be inverted in the spectrum. The work of this thesis has demonstrated that it is possible to perform measurements and establish protocols for data analysis, based on the physical principles of NMR, which are able to provide robust values for the spectral parameters of clinical use.