Bigdê Kohanîm id est vestitus sacerdotum Hebræorum, sive commentarius amplissimus in Exodi cap. XXVIII. ac XXXIX. & Levit. cap. XVI. aliaque loca s. scripturae quamplurima : cum indicibus locupletissimis & tabulis aeneis elegantissimis

auctore Johanne Braunio, Palatino

Virus-like particle-mediated intracellular delivery of mRNA cap analog with in vivo activity against hepatocellular carcinoma.

UNLABELLED Adenovirus dodecahedron (Dd), a nanoparticulate proteinaceous biodegradable virus-like particle (VLP), was used as a vector for delivery of an oncogene inhibitor to hepatocellular carcinoma (HCC) rat orthotopic model. Initiation factor eIF4E is an oncogene with elevated expression in human cancers. Cell-impermeant eIF4E inhibitor, cap structure analog (cap) and anti-cancer antibiotic doxorubicin (Dox) were delivered as Dd conjugates. Dd-cap and Dd-dox inhibited cancer cell culture proliferation up to 50 and 84%, respectively, while with free Dox similar results could be obtained only at a 5 times higher concentration. In animal HCC model the combination treatment of Dd-cap/Dd-dox caused 40% inhibition of tumor growth. Importantly, the level of two pro-oncogenes, eIF4E and c-myc, was significantly diminished in tumor sections of treated rats. Attachment to Dd, a virus-like particle, permitted the first demonstration of cap analog intracellular delivery and resulted in improved doxorubicin delivery leading to statistically significant inhibition of HCC tumor growth. FROM THE CLINICAL EDITOR Adenovirus dodecahedron, a nanoparticulate proteinaceous biodegradable virus-like particle was used in this study as a vector for the concomitant delivery of cap structure analog and doxorubicine to hepatocellular carcinoma in a rat model, resulting in significant inhibition of tumor growth.

Aus dem Kohelet-Kommentar des Tanchum Jeruschalmi : Cap. I - VI ; mit Einl. u. Anmerkungen

Leipzig, Univ., Diss. 1888

Das Spruchbuch nach Saadja : ein Auszug aus Saadja's Kitab ṭalab al-ḥikma, Cap. 1-9 : als Beitrag zur Geschichte der Bibelauslegung

Halle-Wittenberg, Univ., Diss., 1888

Ueber die Stelle Jud. Cap. 11, 30 bis Ende

H. Werner

Commentarius critico-typicus de Tabernaculo Mosis, ad Exod. Cap. XXV.-XXX.

Vorlage d. Digitalisats aus d. Besitz d. Theol. Hochschule St. Georgen

Seder 'Olam (Cap. 1-10) nach Handschriften, und Druckwerken hrsg., übersetzt und erklärt

Königsberg i. Pr., Univ., Diss., 1903

Ms. lat. oct. 22 - Annotationes in primum librum Partitionum dialecticarum Joannis Sturmii, cap. 2 - 19

Vorbesitzer: Andreas Santher; Heinrich Kellner; Johann Maximilian Zum Jungen

Passionsmusik nach dem Evangelium Matthäi : Cap. 26 und 27

von Johann Sebastian Bach

Passionsmusik nach dem Evangelium Matthäi : Cap. 26 und 27

von Johann Sebastian Bach

Carbonate saturation in the water column of station M8_056 off Cap Sao Vincente, Portugal (Table 1)

Changes in the dissolved oxygen content, the alkalinity, and the pH in sea water near the ocean floor are interpreted in terms of chemical and biochemical processes at the sediment water interface. A simple model provides a plausible explanation of the observed phenomena. Special emphasis is given to the importance of borate corrections in the calculation of the solution effects of calcium carbonate.