930 resultados para Calmet, Agustín , Abad de Senones


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Ponencia leída en el Foro de Comunicaciones IkasArt II (BEC Barakaldo, 2010.06.17)

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Poster presentado a la XI Semana de la Ciencia, Tecnología y la Innovación celebrada del 9 al 13 de noviembre de 2011

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The dimorphic fungus Candida albicans is able to trigger a cytokine-mediated pro-inflammatory response that increases tumor cell adhesion to hepatic endothelium and metastasis. To check the intraspecific differences in this effect, we used an in vitro murine model of hepatic response against C. albicans, which made clear that tumor cells adhered more to endothelium incubated with blastoconidia, both live and killed, than germ tubes. This finding was related to the higher carbohydrate/protein ratio found in blastoconidia. In fact, destruction of mannose ligand residues on the cell surface by metaperiodate treatment significantly reduced tumor cell adhesion induced. Moreover, we also noticed that the effect of clinical strains was greater than that of the reference one. This finding could not be explained by the carbohydrate/protein data, but to explain these differences between strains, we analyzed the expression level of ten genes (ADH1, APE3, IDH2, ENO1, FBA1, ILV5, PDI1, PGK1, QCR2 and TUF1) that code for the proteins identified previously in a mannoprotein-enriched pro-metastatic fraction of C. albicans. The results corroborated that their expression was higher in clinical strains than the reference one. To confirm the importance of the mannoprotein fraction, we also demonstrate that blocking the mannose receptor decreases the effect of C. albicans and its mannoproteins, inhibiting IL-18 synthesis and tumor cell adhesion increase by around 60%. These findings could be the first step towards a new treatment for solid organ cancers based on the role of the mannose receptor in C. albicans-induced tumor progression and metastasis.

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El origen es una de las estrategias utilizadas tradicionalmente por parte de los productos agroalimentarios para diferenciar una oferta de otra en el mercado. En nuestro país existen más de 140 Indicaciones de Origen reconocidas por la Comisión Europea que abarcan diferentes alimentos y bebidas. De todas ellas, las seis denominaciones de jamón existentes aportan casi el 15% del valor económico conjunto, aún suponiendo únicamente el 4,26% del total. A partir del análisis cuantitativo, y del desarrollo de un análisis DAFO del sector, se realiza una reflexión acerca del papel que el origen puede jugar como elemento de diferenciación y se ofrecen recomendaciones prácticas para incrementar el conocimiento y la notoriedad de las denominaciones en el mercado

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Artikulu honen helburua da ibilgetu materialeko elementuak erosteko edo norberak eraikitzeko erabakia hartzen duenean, sor daitezkeen aukera ezberdinen azterketa kontablea egitea.

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Especificados los aspectos más sobresalientes de naturaleza económico-financiera de los contratos que regulan las operaciones de arrendamientos, seguidamente procede a comentar desde la optica del arrendatario, las singularidades contables de este tipo de transacciones.

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482 p., [21] p. de lám. - Anejos del Anuario del Seminario de Filología Vasca "Julio de Urquijo" ; 48 - Monumenta Linguae Vasconum : Studia et Instrumenta ; 2

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Este artículo trata sobre las prácticas en empresas. En el caso de la Escuela Universitaria de Estudios Empresariales de San Sebastián son voluntarias. Este carácter facultativo imprime un doble carácter a estas prácticas: por una parte, toda persona que manifiesta su deseo de hacer una práctica es consciente de que su consecución representa un acto de opción por cuanto que precisará de un determinado número de horas en su desarrollo, y por otra, directamente relacionada con la anterior, la convicción de que, entre varias alternativas la de las prácticas, es una vía que les ayuda en su proceso de formación.

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Jada sei urte igaro dira azkeneko hamarkadetan pairatu dugun krisialdi ekonomiko gogorrena iritsi zela eta, kimuak kimu, oraindik ere egundoko sarraskiak sorrarazten dihardu. Urakan bat bailitzan agertu zen gure artean eta guztiongan aparteko eragina izan du: gure kontzientzia ekonomikoa astintzeaz gain orain arte normaltzat ematen genituen hainbat portaera kolokan jarri ditu. Kaltetuen zerrenda luze horretan herritarrengandik gertuen dauden erakunde publikoak agertzen dira: udalak. Artikulu honetan krisiak Gipuzkoako udalen finantza-egoeretan izan duen eragina aztertuko da, eragin negatiboa pairatu zuten lehendabiziko urtetik abiatu (2008) eta aurrekontu likidatuak dauzkagun azkeneko urtera (2012) iritsi arte. Udalen egoera ekonomiko-finantzarioa zein den jakiteko baliagarriak diren, transferentzia arruntekiko menpekotasuna, funtzionamendu gastuak, aurrezki gordina, aurrezki garbia, legezko zorpetze maila, zor bizia eta gastu orokorretarako diruzaintza-gerakina adierazleen egoera eta bilakaerak aurkeztuko dira.

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In this paper, reanalysis fields from the ECMWF have been statistically downscaled to predict from large-scale atmospheric fields, surface moisture flux and daily precipitation at two observatories (Zaragoza and Tortosa, Ebro Valley, Spain) during the 1961-2001 period. Three types of downscaling models have been built: (i) analogues, (ii) analogues followed by random forests and (iii) analogues followed by multiple linear regression. The inputs consist of data (predictor fields) taken from the ERA-40 reanalysis. The predicted fields are precipitation and surface moisture flux as measured at the two observatories. With the aim to reduce the dimensionality of the problem, the ERA-40 fields have been decomposed using empirical orthogonal functions. Available daily data has been divided into two parts: a training period used to find a group of about 300 analogues to build the downscaling model (1961-1996) and a test period (19972001), where models' performance has been assessed using independent data. In the case of surface moisture flux, the models based on analogues followed by random forests do not clearly outperform those built on analogues plus multiple linear regression, while simple averages calculated from the nearest analogues found in the training period, yielded only slightly worse results. In the case of precipitation, the three types of model performed equally. These results suggest that most of the models' downscaling capabilities can be attributed to the analogues-calculation stage.

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Trabajo de Investigación Predoctoral 2006

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Poster presentado en Society for Post-Medieval Archaeology Conference, in St John's, Newfoundland,(Canadá)(June 2010)

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1 carta (mecanografiada) ; 210x270mm. Ubicación: Caja 1 - Carpeta 16

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Background: A new intervention aimed at managing patients with medically unexplained symptoms (MUS) based on a specific set of communication techniques was developed, and tested in a cluster randomised clinical trial. Due to the modest results obtained and in order to improve our intervention we need to know the GPs' attitudes towards patients with MUS, their experience, expectations and the utility of the communication techniques we proposed and the feasibility of implementing them. Physicians who took part in 2 different training programs and in a randomised controlled trial (RCT) for patients with MUS were questioned to ascertain the reasons for the doctors' participation in the trial and the attitudes, experiences and expectations of GPs about the intervention. Methods: A qualitative study based on four focus groups with GPs who took part in a RCT. A content analysis was carried out. Results: Following the RCT patients are perceived as true suffering persons, and the relationship with them has improved in GPs of both groups. GPs mostly valued the fact that it is highly structured, that it made possible a more comfortable relationship and that it could be applied to a broad spectrum of patients with psychosocial problems. Nevertheless, all participants consider that change in patients is necessary; GPs in the intervention group remarked that that is extremely difficult to achieve. Conclusion: GPs positively evaluate the communication techniques and the interventions that help in understanding patient suffering, and express the enormous difficulties in handling change in patients. These findings provide information on the direction in which efforts for improving intervention should be directed.