Análise de propriedades topológicas das redes biológicas integradas da Escherichia coli e da Saccharomyces cerevisiae

Biological processes are complex and possess emergent properties that can not be explained or predict by reductionism methods. To overcome the limitations of reductionism, researchers have been used a group of methods known as systems biology, a new interdisciplinary eld of study aiming to understand the non-linear interactions among components embedded in biological processes. These interactions can be represented by a mathematical object called graph or network, where the elements are represented by nodes and the interactions by edges that link pair of nodes. The networks can be classi- ed according to their topologies: if node degrees follow a Poisson distribution in a given network, i.e. most nodes have approximately the same number of links, this is a random network; if node degrees follow a power-law distribution in a given network, i.e. small number of high-degree nodes and high number of low-degree nodes, this is a scale-free network. Moreover, networks can be classi ed as hierarchical or non-hierarchical. In this study, we analised Escherichia coli and Saccharomyces cerevisiae integrated molecular networks, which have protein-protein interaction, metabolic and transcriptional regulation interactions. By using computational methods, such as MathematicaR , and data collected from public databases, we calculated four topological parameters: the degree distribution P(k), the clustering coe cient C(k), the closeness centrality CC(k) and the betweenness centrality CB(k). P(k) is a function that calculates the total number of nodes with k degree connection and is used to classify the network as random or scale-free. C(k) shows if a network is hierarchical, i.e. if the clusterization coe cient depends on node degree. CC(k) is an indicator of how much a node it is in the lesse way among others some nodes of the network and the CB(k) is a pointer of how a particular node is among several ...(Complete abstract click electronic access below)

O eterno feminino: arquétipos literários em Mujeres de Eduardo Galeano

Le champ littéraire est plein d’oeuvres qui remettent à des mythes. L’ensemble de récits Mujeres, de Eduardo Galeano, a comme thématique la femme et il est composé par des micro-contes, genre narratif qui promeut une condensation maximale d’eléments thématiques et structuraux. Il s’agit des descriptions littéraires où la synthèse est placée ou même niveau que le lyrisme. Ayant pour objectif d’analiser la nature archétypique des mythes sur la féminité, nous avons travaillé spécifiquement les contes de Mujeres où se reconstruisent poétiquement des mythes de la féminité. Méthodologiquement, notre notre étude a pour base la mythocritique et la théorie des structures anthropologiques de l’imaginaire ídéalisées par Gilbert Durand. En partant de ces bases, nous avons réalisé l’analyse des récits qui s’articulent en notre corpus, ayant pour but, celui d’identifier les divers artifices narratifs spécifiques qui y opèrent. Par le moyen des mythèmes présents dans les récits, nous avons révélé les structures archétypiques du texte et nous avons constaté comment elles s’édifient littérairement. En outre, nous avons élucidé la teneur de la représentativité archétypique de la feminité inhérente aux récits et finalement, nous avons rassemblé les situations et les combinatoires qui existent dans l’ensemble de microrécits, traçant les connexions possibles qui y existent. Ainsi, nous avons fait une étude proprement dite, d´analyse mythocritique

Um mundo radicalmente melhor: criatividade, colaboração e padrão de redes como estratégias para o desenvolvimento sustentável

There are substantial evidences that the period experienced by humanity globally is unprecedented and is heading towards a major transformation that results from the Globalization. Totally conditioned to the addictions of the dominant and predatory capitalism, humanity has, for decades, exhausted natural resources, disregarded the nature of its own social existence and walked away from its humanity. It is notable, however, an impressive flow of factors that dialogue and support each other as trends that go towards sustainable development, based on the harmonious integration between Technology, Culture, Society, Environment and Economy. This emerging moment can be seen from the perspectives of the Creative Economy as economic paradigm centered on the subjectivity and the human capacity to undertake innovative services, products and solutions guided by social values. Within this fluid and dynamic global context, initiatives that legitimately intend to act sustainably are gaining space. This socioeconomic moment fosters and is fostered by new kinds of work and organization guided by the Collaboration and social structuring on Network Patterns. These new social models significantly transform the understanding and insights about the Communication flows. The HUB São Paulo, as creative and social organization that operates under the logic of Collaboration through a Network Structure, was the subject of a case study used to sustain the defense of this emerging scenario and also to perform an analysis on the new role of Communication, at perspectives of transformation of mental paradigms towards sustainability and establishment of meaningful connections

O canteiro experimental e o ensino

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Neuróbica, ginástica para o cérebro: levantamento do atual estado da arte deste tema

This paper presents a brief review of theoretical studies on the stimulation and brain development. We also addressed questions about its plasticity, its influence on learning and behavior of the individual in interaction with the environment. Studies clearly show that the brain does not go into decline as we age. In this sense, a new discovery in neuroscience has revealed that the brain maintains the ability to grow and change the pattern of its connections to death. Findings such as these form the basis of neurobics. Demonstrating the importance of a relevant application of appropriate stimuli to change the morphology and function of neurons, the technique can be applied in different ways, ie, clinical, behavioral and neurological. Furthermore it can be applied during all phases of human development

Avaliação do estado emocional associado à catalepsia causada pela administração intraperitoneal de haloperidol

Haloperidol is a dopamine receptor antagonist used to treat schizophrenia. When systemically administered in rodents, haloperidol induces catalepsy, a state of immobility very similar to that seen in Parkinson's disease. It is known that many of Parkinson's disease symptoms are dependent on the emotional state since patients are still able to respond to external triggers such as loud noise or visual signaling. Recent data highlighted the importance of glutamatergic neurotransmission in the inferior colliculus (IC) on the cataleptic state induced by haloperidol in rats. Given the importance of IC in the brain aversion system and its connections to motor pathways, and based on the clinical reports of the emotional influence on the motor aspect of Parkinson's disease, the objective of the present study was to evaluate the emotional aspect related to catalepsy induced by intraperitoneal administration of haloperidol. To this end, we analysed ultrasonic vocalizations (UVs) of 22 kHz (indicative of aversion) in rats during the tests of catalepsy, open field and contextual conditioned fear. Systemic administration of haloperidol affected the motor activity, inducing catalepsy and decreasing exploratory activity in the open field. There were no UVs of 22 kHz resulting from treatment with haloperidol in catalepsy or open field tests. In the contextual conditioned fear test, haloperidol increased freezing when administered before the test, but decreased freezing on test day when administered before training. In this same test, haloperidol decreased the UVs on the day it was administered (training or test). The catalepsy induced by systemic administration of haloperidol seems to have also affected the motor aspect of UVs. In this way, it was not possible to clarify the existence of an aversive emotional state associated haloperidol induced catalepsy

Simulação numérica de fluxo de águas subterrâneas na bacia do Rio Grande (BA)

The Urucuia Aquifer System represents a strategic water source in western Bahia. Its baseflow is responsible for the flow rate of the main tributaries of São Francisco river left bank in the dry season, including the Rio Grande, its main tributary in Bahia state. This river has a hydrological regime heavily affected by groundwater and is located in a region with conflicts about water resources. The aquifers geology is constituted by neocretacious sandstones of Urucuia Group subdivided in Posse Formation and Serra das Araras Formation. The embasement is formed by neoproterozoic rocks of Bambuí Group. This work focuses on an important tool application, the mathematical model, whose function is represent approximately and suitably the reality so that can assist in different scenarios simulations and make predictions. Many studies developed in this basin provided the conceptual model basis including a full free aquifer, lithological and hydraulical homogeneity in entire basin, null flux at plateau borders and aquifer base. The finite element method is the numerical method used and FEFLOW the computational algorithm. The simulated area was discretized in a single layer with 27.357,6 km² (314.432 elements and 320.452 nodes) totaling a 4.249,89 km³ volume. Were utilized 21 observation wells from CERB to calibrate the model. The terrain topography was obtained by SRTM data and the impermeable base was generated by interpolation of descriptive profiles from wells and electric vertical drilling from previous studies. Works in this area obtained mean recharge rates varying approximately from 20% to 25% of average precipitation, thus the values of model recharge zones varying in this range. Were distributed 4 hydraulic conductivity zones: (K1) west zone with K=6x10-5 m/s; (K2) center-east zone with K=3x10-4 m/s; (K3) far east zone with K=5x10-4 m/s; e (K4) east-north zone with K=1x10-5 m/s. Thereby was incorporated to the final conceptual model...

Projeto Taquara: uma experiência na prática de arquitetura

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Relações Públicas: o articulador dos relacionamentos na cultura da convergência

The purpose of this research project is to analyze the Convergence Culture, a term coined by Henry Jenkins, to refer to the cultural transformation we are experiencing - people want to produce their own content, share their stories, expand their experiences and make connections to different platforms media. That is, individuals have changed their position once considered passive and accommodating to sustain an environment of intense involvement, construction and collective pursuit of new experiences. So that we could reach that culture converged, there was a paradigm shift from an asymmetric communication for communication increasingly bilateral. In this new scenario, communication to different audiences is based on a participatory and collaborative model in which organizations do not have absolute control over the media message. Therefore, this study tried to demonstrate what steps to be followed by public relations in convergence culture

Dança indiana e dança do ventre: representantes da cultura oriental e suas influências na cultura brasileira

Este trabalho passa pela grandeza da dança e faz através de uma revisão bibliográfica, uma busca das características que constituem a dança indiana e a dança do ventre, verificando quais destas mesmas característica estão presentes no Brasil. Esta verificação determina o nível de influência que ambas as danças exercem no país. Com isto, verificou-se que o hinduísmo como característica principal da dança indiana está muito presente na vida dos que buscam a arte. O mesmo ocorre com a dança do ventre, que apesar de uma imagem um pouco denegrida, tem seus aspectos vivenciados e apreciados pelas mulheres. Além disso, o trabalho remete ao multiculturalismo e às características do oriente, em que as danças são representantes destas. Com o primeiro, verificou-se que estas artes são um meio de propor mais diálogos, mais conexões entre as culturas, e com o segundo, dão a possibilidade de refletir sobre nossos modos de vida. Desta forma, diante das características que no Brasil estão presentes, é possível crermos que há uma forte influência destas danças, que pode ser refletido simplesmente pela aceitação dos brasileiros, e que faz com que as mesmas continuem crescendo no país.

Ecologia, cultura do consumo e juventude

Neste estudo desenvolvemos algumas reflexões sobre possíveis relações entre ecologia, cultura do consumo e juventude. Partimos da hipótese de que a juventude, estando mais vulnerável às investidas do mercado, em uma sociedade marcada pelo “hiperconsumo”, se encontra em frágeis condições para a formação de atitudes mais saudáveis nas relações com o seu ambiente compreendido nas dimensões física, grupal e da própria subjetividade. As relações entre ecologia, cultura de consumo e juventude são estudadas por meio da coleta dos sentidos produzidos por adolescentes e jovens que se configuram nas chamadas “tribos urbanas”, tais como se expressam em letras de músicas e em discursos colocados em circulação na rede internacional de comunicação. Trazemos para o conjunto de nossas reflexões algumas letras de músicas de grande sucesso compartilhadas entre a juventude, especificamente aquelas intituladas “emocore” ou “hardcore emocional”, que configuram um estilo de grupo em seu viver urbano. Rastreamos nas músicas as marcas de um estilo de vida em suas conexões com modos de consumo e com arranjos de sentidos no dinâmico movimento da cultura. Também colocamos em evidência um conjunto de falas que nos permitem identificar outras marcas de relações entre o jeito de ser jovem e as possíveis buscas de soluções para problemas existenciais por meio da composição de modos de consumo. Deste modo, a abordagem da ecologia sustenta a instituição de um ambiente cultural em que acertos de convívios estabelecidos no interior de um determinado grupo implicam em formas de consumo.

Perfil econômico do lítio nos países sulamericanos e consumo mundial

The lithium industry has changed and the producers of lithium carbonate form South America play a dominant role in the world. This paper discusses the South American geological resources, production and producers of lithium considering the potential growth in lithium consumption for electric vehicle batteries. Taking into account the manufacturing companies and their external connections, their participation in corporate groups and the international market for the stocks of metal, in addition to facts and updates that affect this market and its key growth trends. This inventory of the most important reserves takes into account the geological context of the formation of these deposits, including a description of the types of deposits exploited in the world today. Besides the general description was made a brief description of the South American resources, more exploited by the media (Salar de Atacama, Salar de Hombre Muerto, Salar de Uyuni) and Pegmatites of Província Pegmatítica Oriental do Brasil and Província Seridó-Borborema).

Caracterização dos receptores opióides do núcleo parabraquial lateral envolvidos no controle da ingestão de água e sódio

Nosso organismo constantemente perde água e eletrólitos para o meio ambiente, principalmente pela excreção urinária.Porém, a osmolaridade e o volume de líquidos do organismo devem permanecer dentro de uma pequena faixa de variação para que nossas células funcionem perfeitamente e haja manutenção da pressão arterial. A regulação da osmolaridade e do volume dos líquidos corporais exige que a entrada de água e eletrólitos seja igual à perda pelo corpo e, para tanto, a regulação envolve a ação integrada dos rins e do comportamento de ingestão de água e sódio que é o principal íon extracelular. A ingestão de água e sódio é regulada por mecanismos centrais excitatórios e inibitórios. Os mecanismos excitatórios que desencadeiam a ingestão de água e sódio são ativados principalmente pelo peptídeo angiotensina II (ANG II), cuja produção apresenta-se aumentada em situações de hipovolemia e hipotensão. Por outro lado, destacam-se importantes mecanismos inibitórios da ingestão de água e sódio descobertos recentemente no núcleo parabraquial lateral (NPBL). O NPBL é uma estrutura pontina que recebe projeções aferentes da área postrema (AP) e da porção medial do núcleo do trato solitário (NTSm) e que faz conexões com áreas prosencefálicas envolvidas no controle do balanço hidroeletrolítico. Estudos prévios mostraram que injeções bilaterais do agonista opióide inespecífico β-endorfina no NPBL induziram ingestão de água e sódio em ratos saciados e aumentaram a ingestão de água e sódio induzida pelo tratamento com o diurético furosemida (FURO) combinado com baixas doses do bloqueador da enzima conversora de angiotensina captopril (CAP) injetados subcutaneamente (sc)... (Resumo completo, clicar acesso eletrônico abaixo)

Qualidade de vida dos trabalhadores de enfermagem em UTI adulto: um estudo qualitativo

The quality of life of nursing professionals of character is relevant because the service involves every aspect of workers with personal, social and cultural, so that professionals can result in unproductive and emotionally shaken, and may influence the direct patient care.The aim of this study is to report the quality of life of nursing staff working in the adult ICU of a university hospital.Methodology will be applied to qualitative, through interviews with guiding questions, with the subject all the nursing staff of the Intensive Care Unit - Adult, located in Bauru State Hospital. The survey results were analyzed through content analysis proposed by Bardin. The interviews were divided into categories and subcategories in the sequence. In the category Defining quality of life - hidden connections got four subcategories: happiness, pleasure, interrelation and practice in nursing, which are directly related to the meaning of quality of life. What about the profession as interference in quality of life of nursing staff reached the category A profession in contrast with the quality of life - Connections Exposed that led to the division of four subcategories: proximity to death, absenteeism, double day / salary, shifts, ranking at work and work process. Finally, it concerns the improvement of the profession that can intervene in the quality of life of workers obtained the category Improving occupancy improving the quality of life - Connections to be built, which is subdivided into sub-categories: professional incentive, hierarchy and enhancement of the profession. These categories and subcategories showed significant and important aspects of quality of life of nursing professionals

Bases para criação de um Centro de Voluntariado na UNESP - Guaratinguetá

Volunteering is seen as a form of citizen participation enabling to involve, mobilize, engage and articulate people and institutions around issues of collective interest. Both for the volunteer and for the community involved, voluntary action can promote learning, new experiences and interaction with people previously unknown, as well as create opportunities for professional and personal growth. (CENTRO DE VOLUNTARIADO DE SÃO PAULO, 2012). This work starts from a survey conducted in 2006 by Carvalho, who detected the interest of members of the campus community Guaratinguetá UNESP in performing volunteer work. Its objective is to continue the work mentioned and think of ways to support volunteering in the Guaratinguetá Engineering College, mainly through the creation of connections between stakeholders (individuals and institutions). For this, focused Volunteer Centers and their functional models. Such a center could be the ideal facilitator of relationships between volunteer candidates that integrate FEG / UNESP community and institutions interested in the collaboration of these people. The work highlighted the benefits that voluntary action can bring to those involved in it, and the role that a Volunteer Center at UNESP Guaratinguetá may play, in the promotion and expansion of social activities already undertaken. The study also indicates the need for a validation of the proposals presented here and later detailing way of acting of the Centre in its institutional placement and maintenance costs