906 resultados para Baer, Raymond


Relevância:

10.00% 10.00%

Publicador:

Resumo:

(Résumé de l'ouvrage) " Le livre de Raymond Brown sur la mort du Messie est un chef-d'eouvre monumental de l'exégèse historique. Il fait le point de la recherche historicocritique appliquée à la Passion de Jésus et en magnifie les résultats. Dans ce livre se dépose plus d'un siècle de critique textuelle, d'interrogation philologique, de comparaison littéraire, de vérification historique - un siècle d'enquêtes minutieuses, attachées à sonder les récits évangéliques sur la souffrance et la mort de Jésus le Nazôréen. La visée de cette somme exégétique est très clairement énoncée par l'auteur : "Expliquer en détail ce que les évangélistes ont voulu dire et ont transmis à leur auditoire par leurs récits de la Passion et de la mort de Jésus." (...) Les questions qui guident l'enquête sont aussi bien littéraires qu'historiques et théologiques. Quel regard les évangélistes posent-ils sur cette tragédie? Leurs récits sont-ils historiquement plausibles? D'où proviennent leurs informations? Que sait-on des pratiques judiciaires et religieuses de ce temps-la? Comment démêler les faits de l'interprétation dont ils sont enrobés? Peut-on recosntruire le scénario des événements? ". Daniel Marguerat

Relevância:

10.00% 10.00%

Publicador:

Resumo:

Creació d'una empresa que el seu producte principal es un programa amb una llicencia de programari lliure. L'empresa generarà una base del programa, robust i estable. Després s'alliberarà amb una llicencia lliure per a que la comunitat de programari lliure s'afegeixi al desenvolupament i el faci créixer i convertir-ho en un producte de qualitat i superior als actuals productes privatius. Per aconseguir el objectiu, l'empresa gestionarà el producte amb metodologies empresarials. El benefici, s'obtindrà de les SaaS (Software As a Service). El model de negoci i l'estratègia empresarial es basarà segons el model Hecker i Raymond.

Relevância:

10.00% 10.00%

Publicador:

Resumo:

Estimates have recently been made of the incidence of cancers in the countries of the European Community. Similar estimates are given for Switzerland, based on data from the six Swiss cantonal cancer registries, all of which have been operating for at least 12 years. These registries cover Basel, Geneva, Neuchatel, St Gall and Appenzell, Vaud and Zurich, which account for about 50% of the Swiss population as a whole. Two different methods were used to extrapolate from the incidences observed in the regions covered by cancer registration to the entire country. The first method is based solely on the distribution of populations according to the country's main linguistic groups, whereas the second relies on mortality data. Estimates obtained by the second approach are presented and their reliability is discussed. Comparison of the age incidence curve with that of Denmark tends to confirm the validity of the estimations. Estimated standardised rates (world population) for all sites except nonmelanomatous skin cancer are 294.3 for males and 214.2 for females. Comparisons with other European countries show that in males, lung cancer is relatively less common in Switzerland, whereas in females, breast cancer is relatively more frequent.

Relevância:

10.00% 10.00%

Publicador:

Resumo:

Sand flies within the genus Lutzomyia serve as the vectors for all species of the protozoan parasite Leishmania in the New World. In this paper, we present a summary of the 29 species of Lutzomyia and one of Brumptomyia previously reported for Nicaragua and report results of our recent collections of 565 sand flies at eight localities in the country from 2001-2006. Lutzomyia longipalpis was the predominant species collected within the Pacific plains region of western Nicaragua, while Lutzomyia cruciata or Lutzomyia barrettoi majuscula were the species most frequently collected in the central highlands and Atlantic plains regions. The collection of Lutzomyia durani (Vargas & Nájera) at San Jacinto in July 2001 is a new record for Nicaragua. Leishmaniasis is endemic to Nicaragua and occurs in three forms: cutaneous, mucocutaneous and visceral leishmaniasis. Cutaneous infections are the most prevalent type of leishmaniasis in Nicaragua and they occur in two different clinical manifestations, typical cutaneous leishmaniasis and atypical cutaneous leishmaniasis, depending on the species of the infecting Leishmania parasite. The distribution of sand flies collected during this study in relation to the geographic distribution of clinical forms of leishmaniasis in the country is also discussed.

Relevância:

10.00% 10.00%

Publicador:

Resumo:

Only one drug is currently available for the treatment and control of schistosomiasis and the increasing risk of selecting strains of schistosome that are resistant to praziquantel means that the development of new drugs is urgent. With this objective we have chosen to target the enzymes modifying histones and in particular the histone acetyltransferases and histone deacetylases (HDAC). Inhibitors of HDACs (HDACi) are under intense study as potential anti-cancer drugs and act via the induction of cell cycle arrest and/or apoptosis. Schistosomes like other parasites can be considered as similar to tumours in that they maintain an intense metabolic activity and rate of cell division that is outside the control of the host. We have shown that HDACi can induce apoptosis and death of schistosomes maintained in culture and have set up a consortium (Schistosome Epigenetics: Targets, Regulation, New Drugs) funded by the European Commission with the aim of developing inhibitors specific for schistosome histone modifying enzymes as novel lead compounds for drug development.

Relevância:

10.00% 10.00%

Publicador:

Relevância:

10.00% 10.00%

Publicador:

Resumo:

Référence bibliographique : Lhéritier, 38