998 resultados para Angelico, fra, approximately 1400-1455.
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Sign. : A-D4, E4
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Sign. : [calderon]4, 2[calderon]4, A-B4, C3
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Índice
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Sign.: [calderón]5, A-C4
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Port. con grab. xil
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Sign. : A-Q4
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Induction of phase 2 detoxification enzymes by phenolic antioxidants can account for prevention of tumor initiation but cannot explain why these compounds inhibit tumor promotion. Phase 2 genes are induced through an antioxidant response element (ARE). Although the ARE resembles an AP-1 binding site, we show that the major ARE binding and activating protein is not AP-1. Interestingly, AP-1 DNA binding activity was induced by the phenolic antioxidant tert-butylhydroquinone (BHQ), but the induction of AP-1 transcriptional activity by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) was inhibited by this compound. BHQ induced expression of c-jun, junB, fra-1, and fra-2, which encode AP-1 components, but was a poor inducer of c-fos and had no effect on fosB. Like c-Fos and FosB, the Fra proteins heterodimerize with Jun proteins to form stable AP-1 complexes. However, Fra-containing AP-1 complexes have low transactivation potential. Furthermore, Fra-1 repressed AP-1 activity induced by either TPA or expression of c-Jun and c-Fos. We therefore conclude that inhibitory AP-1 complexes composed of Jun-Fra heterodimers, induced by BHQ, antagonize the transcriptional effects of the tumor promoter TPA, which are mediated by Jun-Fos heterodimers. Since AP-1 is an important mediator of tumor promoter action, these findings may explain the anti-tumor-promoting activity of phenolic antioxidants.
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Son tres los factores que básicamente inciden en la redefinición de la función militar en el área latinoamericana: los cambios en el escenario estratégico global; los procesos de consolidación democrática y la nueva relación entre civiles y militares; y los cambios en la política de EE.UU. hacia la región. Las fuerzas armadas expanden sus funciones a nuevos campos y surge un «neonacionalismo» que torna difícil la desmilitarización. Un debate nacional y regional sobre seguridad y el rol de las fuerzas armadas debería contribuir a una mejor articulación política e institucional del sector.
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no. 104
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Contains Henricus de Friemar's Sermones de tempore (sometimes attributed to his son of the same name) and extracts of Gerardus de Fracheto's Vitae fratrum ordinis praedicatorum, among other sermons, glosses, and an index arranged by subject.
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no. 101-114
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no. 73-75
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no. 93-100