Effects of a treatment gap during adjuvant chemotherapy in node-positive breast cancer: results of International Breast Cancer Study Group (IBCSG) Trials 13-93 and 14-93.

BACKGROUND: The International Breast Cancer Study Group (IBCSG) conducted two complementary randomized trials to assess whether a treatment-free gap during adjuvant chemotherapy influenced outcome. PATIENTS AND METHODS: From 1993 to 1999, IBCSG Trials 13-93 and 14-93 enrolled 2215 premenopausal and postmenopausal women with axillary node-positive, operable breast cancer. All patients received cyclophosphamide (Cytoxan, C) plus either doxorubicin (Adriamycin, A) or epirubicin (E) for four courses followed immediately (No Gap) or after a 16-week delay (Gap) by classical cyclophosphamide, methotrexate, and fluorouracil (CMF) for three courses. The median follow-up was 7.7 years. RESULTS: The Gap and No-Gap groups had similar disease-free survival (DFS) and overall survival (OS). No identified subgroup showed a statistically significant difference, but exploratory subgroup analysis noted a trend towards decreased DFS for Gap compared with No Gap for women with estrogen receptor (ER)-negative tumors not receiving tamoxifen, especially evident during the first 2 years. CONCLUSIONS: A 16-week gap between adjuvant AC/EC and CMF provided no benefit and may have increased early recurrence rates in patients with ER-negative tumors.

Lottery Action, Vol. 15, no. 14 July 12-August 3, 2008

Iowa Lottery Authority Newsletter For Lottery Retailers

Kansanedustaja Pertti Salolainen 14/4 1971

Kirje 14.4.1971

EPI Update, November 14, 2008

Weekly newsletter for Center For Acute Disease Epidemiology of Iowa Department of Public Health.

Fil. dr Johannes Salminen 14.2.1967 Härstädes

Kirje

Evaluación de la contaminación marina en la Bahía Ferrol, Chimbote. 14 - 18 Julio 1994

Evalúa la calidad del medio marino en la Bahía de Ferrol, Chimbote; donde se realizó un muestreo simultáneo por mar y playa, durantre una época de intensa actividad industrial pesquera. Los resultados del análisis concluyen en que la bahía presenta signos serios de deterioro ambiental, con el desarrollo de procesos eutróficos que conllevan a una pérdida de condiciones ambientales apropiadas, en perjuicio de los recursos hidrobiológicos costeros.

Maaherra Urho Kiukas 14/6 1966

Kirje 14.6.1966

Executive Order Number Twelve, April 14, 2009

This Executive Order made the creation of the Iowa Accountability and Transparency Board and the report of the State of Iowa's efforts to implement the AARA

Operación Eureka XXXII, 14-15 febrero, 1975

Expone los resultados de la Operación Eureka XXXII, realizado a fin de obtener información sobre el reclutamiento 1975, así como otros aspectos biológicos y de medio ambiente, que como parte del sistema de monitoreo del recurso anchoveta realizó el Instituto del Mar del Perú.