APR e FMEA em trocador de calor de bomba

The modernization of the world made the speed, accuracy and reliability of all existing processes become increasingly necessary. For this evolution to occur every day, the evolution of the equipment was strategic, but not as much as needed. It is necessary for such equipment to ensure its function and, in case of failure, an early diagnosis to prevent loss. Therefore the evolution of maintainability and reliability in equipment is also paramount. Thus, the growth of forms of maintenance was driven by this scenario, forming maintenance philosophies. Among many, there is the RCM, which have its focus on the identification, parameters development and performance preview. One of those methodologies from this idea is the FMEA, process that has been studied and implemented this work, aiming the anticipation of failure modes and guidance for the use of a heat exchanger and a pump. This implementation has the aid of another process of RCM, the PHA, which was also shown and implemented, these results being used to start the FMEA process. The results show the activities with the highest chance of failure, presenting also the measures to be taken to avoid or minimize them. It is shown, in this paper, concern with the valves because they maintain control and system security, and its flaws related to accidents with possible danger to people and the whole system, emphasizing the priority of action

Boa colocação da equação do calor semilinear em L^p-fraco

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Considerações sobre concepções de calor e sistema termodinâmico para o ensino médio.

Este trabalho parte da ideia de que para ocorrer significativo avanço na compreensão das leis da termodinâmica pelos estudantes é necessário promover, inicialmente, discussões sobre diversas concepções de calor e de sistemas. É nessa direção que este trabalho aponta, ao procurar responder à questão: Como possibilitar, no ensino médio, a compreensão de diferentes concepções de calor antes da apresentação das leis da termodinâmica? Para isso apresenta subsídios que poderão ser utilizados na elaboração de estratégias, mostrando a atitude dos cientistas frente a situações nas quais concepções aceitas sobre calor revelaram-se inadequadas; destaca-se aqui a importância que teve a introdução do conceito de sistema na elaboração das teorias da termodinâmica. Para isso selecionou-se de uma pesquisa anterior, algumas ideias comuns e persistentes entre estudantes do ensino médio e do nível superior que já passaram pelo ensino formal da termodinâmica como as de Calor como “quente” e “frio”. Consideraram-se também fragmentos de trabalhos originais de Carnot e de Clausius que tocam nesses conteúdos. Com isso pretende-se despertar, nos estudantes, a percepção de que suas concepções baseadas em sensações bem como ideias “substancialistas” precisam ser redimensionadas, juntamente com adoção de elementos teóricos adotados pela termodinâmica. Espera-se dos professores o planejamento de atividades que propiciem o encontro dessas ideias.

Determinación de la variabilidad estacional del transporte de masa, calor y agua dulce en la cuenca este del Giro Subtropical del Atlántico Norte mediante el uso de perfiladores lagrangianos

Premio extraordinario de doctorado y premio a la mejor tesis doctoral por el Área de Ciencias Experimentales, 2007.

Variabilidad espacio temporal de la Corriente de Canarias, del afloramiento costero al noroeste de África y de los intercambios atmósfera-océano de calor y agua dulce

Programa de Doctorado en Oceanografía

Análisis crítico de potencialidades y limitaciones de la transición energética en el sector turístico canario: producción sostenible de calor/frío

Directores: Matías González y Carmelo León. Programa de doctorado: Turismo, economía y gestión

Actividad física y síndrome metabólico en adultos de Canarias

Programa de doctorado: Actividad Física, Salud y Rendimiento Deportivo

Chemotherapy for isolated locoregional recurrence of breast cancer (CALOR): a randomised trial.

BACKGROUND Patients with isolated locoregional recurrences (ILRR) of breast cancer have a high risk of distant metastasis and death from breast cancer. We aimed to establish whether adjuvant chemotherapy improves the outcome of such patients. METHODS The CALOR trial was a pragmatic, open-label, randomised trial that accrued patients with histologically proven and completely excised ILRR after unilateral breast cancer who had undergone a mastectomy or lumpectomy with clear surgical margins. Eligible patients were enrolled from hospitals worldwide and were centrally randomised (1:1) to chemotherapy (type selected by the investigator; multidrug for at least four courses recommended) or no chemotherapy, using permuted blocks, and stratified by previous chemotherapy, oestrogen-receptor and progesterone-receptor status, and location of ILRR. Patients with oestrogen-receptor-positive ILRR received adjuvant endocrine therapy, radiation therapy was mandated for patients with microscopically involved surgical margins, and anti-HER2 therapy was optional. The primary endpoint was disease-free survival. All analyses were by intention to treat. This study is registered with ClinicalTrials.gov, number NCT00074152. FINDINGS From Aug 22, 2003, to Jan 31, 2010, 85 patients were randomly assigned to receive chemotherapy and 77 were assigned to no chemotherapy. At a median follow-up of 4·9 years (IQR 3·6-6 ·0), 24 (28%) patients had disease-free survival events in the chemotherapy group compared with 34 (44%) in the no chemotherapy group. 5-year disease-free survival was 69% (95% CI 56-79) with chemotherapy versus 57% (44-67) without chemotherapy (hazard ratio 0·59 [95% CI 0·35-0·99]; p=0·046). Adjuvant chemotherapy was significantly more effective for women with oestrogen-receptor-negative ILRR (pinteraction=0·046), but analyses of disease-free survival according to the oestrogen-receptor status of the primary tumour were not statistically significant (pinteraction=0·43). Of the 81 patients who received chemotherapy, 12 (15%) had serious adverse events. The most common adverse events were neutropenia, febrile neutropenia, and intestinal infection. INTERPRETATION Adjuvant chemotherapy should be recommended for patients with completely resected ILRR of breast cancer, especially if the recurrence is oestrogen-receptor negative. FUNDING US Department of Health and Human Services, Swiss Group for Clinical Cancer Research (SAKK), Frontier Science and Technology Research Foundation, Australian and New Zealand Breast Cancer Trials Group, Swedish Cancer Society, Oncosuisse, Cancer Association of South Africa, Foundation for Clinical Research of Eastern Switzerland (OSKK), Grupo Español de Investigación en Cáncer de Mama (GEICAM), and the Dutch Breast Cancer Trialists' Group (BOOG).

Adipocitoquinas y síndrome metabólico : rol de la vistafina en la patogenia de enfermedad cardiovascular

La enfermedad cardiovascular es la primera causa de morbi-mortalidad en los países industrializados. El síndrome metabólico, caracterizado por hipertensión, dislipidemia, obesidad e hiperglucemia, constituye el principal factor de riesgo para la enfermedad cardiovascular. El tejido adiposo visceral juega un papel fundamental en este proceso, dado que secreta una variedad de sustancias biológicamente activas denominadas adipoquinas o adipocitoquinas, tales como leptina, resistina, adiponectina, factor de necrosis tumoral alfa (TNFa), y visfatina entre otras. La visfatina es una citoquina descubierta recientemente y su rol en la enfermedad cardiovascular es controversial y aún no ha sido completamente dilucidado. Estudios realizados en humanos y en modelos experimentales en animales sugieren que la visfatina tendría un papel muy importante en las patologías asociadas a la enfermedad cardiovascular. Esta revisión intenta mostrar los últimos avances sobre el rol de la visfatina y las principales adipocitoquinas en las patologías cardiovasculares y el síndrome metabólico.