Alice, grand duchess of Hesse,

Mode of access: Internet.

The state of the Church of England laid open in a conference between Diotrephes a bishop. Tertullus a papist. Demetrius a usurer, Pandechus an innkeeper, and Paul a preacher of the word of God. April 1588.

With reproduction of t.p. of original (1588) ed.

Plant lore, legends, and lyries. Embracing the myths, traditions, superstitions, and folk-lore of the plant kingdom.

"Principal works referred to": p. [v]-vi.

Researches on the chemical origin of various lines in solar and stellar spectra : being the results of investigations made at the Solar physics observatory, South Kensington, after discussion /

At head of title: Solar physics committee.

The critical role of tryptophan-116 in the catalytic cycle of dimethylsulfoxide reductase from Rhodobacter capsulatus

In dimethylsulfoxide reductase of Rhodobacter capsulatus tryptophan-116 forms a hydrogen bond with a single oxo ligand bound to the molybdenum ion. Mutation of this residue to phenylalanine affected the UV/visible spectrum of the purified Mo-VI form of dimethylsulfoxide reductase resulting in the loss of the characteristic transition at 720 nm. Results of steady-state kinetic analysis and electrochemical studies suggest that tryptophan 116 plays a critical role in stabilizing the hexacoordinate monooxo Mo-VI form of the enzyme and prevents the formation of a dioxo pentacoordinate Mo-VI species, generated as a consequence of the dissociation of one of the dithiolene ligands of the molybdopterin cofactor from the Mo ion. (C) 2004 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.

Quantification of the pathological changes in the temporal lobe of patients with a novel neurofilamentopathy: neurofilament inclusion disease (NID)

Objective: To quantify the densities of neurofilament inclusions (NI), swollen achromatic neurons, surviving neurons and glial cells in a novel neurofilamentopathy neurofilament inclusion disease (NID). Material: Sectionsof temporal lobe from 4 cases of NID stained with an antibody raised to neurofilament proteins. Method: Densities of the pathological changes were estimated in the various gyri of the temporal lobe, hippocampus and dentate gyrus. Results: Densities of the NI and swollen achromatic neurons (SN) were greater in the cerebral cortical gyri than in the hippocampus and dentate gyrus. Lesion density was relatively constant between gyri and between the CA sectors of the hippocampus. In cortical gyri, the density of the NI, SN and glial cell nuclei was greater in laminae II/III than laminae V/VI. Densities of the NI were negatively correlated with the surviving neurons and positively correlated with the glial cell nuclei. The density of the SN was positively correlated with that of the surviving neurons. Conclusion: The pathology of NID morphologically resembles that of Pick's disease (PD) and corticobasal degeneration (CBD), but there are distinct differences between NID and these disorders supporting the hypothesis that NID is a novel and unique type of neurodegenerative disease.

4-hydroxy estradiol-induced oxidant-mediated signaling is involved in the development of breast cancer

Breast cancer is a disease associated with excess exposures to estrogens. While the mode of cancer causation is unknown, others have shown that oxidative stress induced by prolonged exposure to estrogens mediates renal, liver, endometrial and mammary tumorigenesis though the mechanism(s) underling this process is unknown. In this study, we show that 4-hydroxyl 17β-estradiol (4-OHE2), a catechol metabolite of estrogen, induces mammary tumorigenesis in a redox dependent manner. We found that the mechanism of tumorigenesis involves redox activations of nuclear respiratory factor-1 (NRF1); a transcriptions factor associated with regulation of mitochondria biogenesis and oxidative phosphorylation (OXPHOS), as well as mediation of cell survival and growth of cells during periods of oxidative stress. Key findings from our study are as follows: (i) Prolonged treatments of normal mammary epithelial cells with 4-OHE2, increased the formation of intracellular reactive oxygen species (ROS). (ii) Estrogen-induced ROS activates redox sensitive transcription factors NRF1. (iii) 4-OHE2 through activation of serine-threonine kinase and histone acetyl transferase, phosphorylates and acetylate NRF1 respectively. (iv) Redox mediated epigenetic modifications of NRF1 facilitates mammary tumorigenesis and invasive phenotypes of breast cancer cells via modulations of genes involved in proliferation, growth and metastasis of exposed cells. (v) Animal engraftment of transformed clones formed invasive tumors. (vi) Treatment of cells or tumors with biological or chemical antioxidants, as well as silencing of NRF1 expressions, prevented 4-OHE2 induced mammary tumorigenesis and invasive phenotypes of MCF-10A cells. Based on these observations, we hypothesize that 4-OHE2 induced ROS epigenetically activate NRF1 through its phosphorylation and acylation. This, in turn, through NRF1-mediated transcriptional activation of the cell cycle genes, controls 4-OHE2 induced cell transformation and tumorigenesis.^

HATWALK/ Guerilla Millinery/ Part of the Cultural Olympiad

Stealth Visor for the Duke of Wellington Project HATWALK The 2012 Cultural Olympiad would not have been representative of London's creative industries without fashion design. Sponsored by the Mayor of London brought milliners to organise an alternative to the catwalk format , the designers brought together a Hatwalk, uniting landmark heritage statues, classical and modern, to be crowned with a new bespoke design piece each. Together forming a pedestrian navigation through the Jubilee city, the hats also invited twenty one milliners to consider the specificity of working for the great outdoors. Rigorously tested in wind tunnel laboratory to withstand hurricane wind speeds and squally shows the designs aim to bring the 'exclusive' culture of fashion accessories to the inclusive culture of international festival. Working with new technologies of engineering, such as laser measuring tools, and crane for assemblage and fitting, McLean brings new meaning to the familiar figures of national public authority. Since the storming of the Bastille in revolutionary France it has been traditional for the new order to symbolize change through attacking public statuary. In a similar vein, Hatwalk, invites spectators to reconsider the relationship between distant and lofty personages of power and the sartorial insignia through which their power is signified. Crowned with a revolutionary red ' large plexi punk neon number' the Duke of Wellington, at Wellington arch is the first in the Hatwalk exhibition. The originality of this research consists in the effects of surprise and Brechtian 'de familiarisation' resulting from the unexpected. The effects of this structural carnivalesque inversion of authorities can involve a range of reactions from the disdain of the offended to the laughter and pleasure of the surprised. This strategy of bringing the ludic element of play to the formalised authority of legitimised power is also signified through the conscious use of materials and colour in a monochrome and uniform culture of statuary. Here the difference in materials and visible surface of the design signifies the differences that need to be included within a socio political order before it may takes its place in history as being representative of the people it is entrusted to lead. This research output continues the work that led to the Hat Anthology exhibition (output 1), the Fifty Hats that Changed the World (output 2), the Jamaican Olympic team headwear design ( output 4), and is continued in the design, merchandise, accessories and avant garde artefacts of the House of Flora ( see website). The iterative process of the research brings innovation within continuity to McLean's work. It is difficult to theorise the 'rigour' that is undeniably present in a creative design praxis except in that McLean;s research outputs are always surprising and unexpected.

The Participation of Townspeople Making Music in Public Events in the Low Countries in the Fifteenth Century

Musicians, rhetoricians and crossbowmen, all of them employed by the city of Brussels, acted, sang and played instruments during the "Ommegang" procession in the 15th century in the main square, some of them during other processions, too. In Bruges, instrumentalists and singers took part in the representation of biblical scenes on street corners, which were part of the entry of Philip III the Good, Duke of Burgundy, into the city around the year 1440. The members of the clergy who knew music sang plainchant in all of these three roles, and independent musicians probably participated, too, even though the documents don't name them or describe their function. Except for the disabled, who marched in a procession on their own, the "common people" were only spectators of these events, which were planned in advance. The evidence that remains indicates that the voices of the "common people" remained hidden in these events, which were intended to promote civic unity.

The romances of Alexandre Dumas.

4. The count of Monte Cristo / illustrated by Edmund H. Garrett -- 5. Agénor de Mauléon : a romance of the reign of Charles V. of France / illustrated by J. Wagrez -- 6. Agénor de Mauléon : a romance of the reign of Charles V. of France / illustrated by J. Wagrez -- 7. The Brigand : a romance of the reign of Don Carlos and Black the story of a dog / illustrated by Eugéne Grivaz -- 8. Ascanio : a romance of the reign of Francis First / illustrated by Evert Van Muyden -- 9. The two Dianas : a romance of the reign of Henry ll. / illustrated by Evert Van Muyden -- 10. The two Dianas : a romance of the reign of Henry ll. / illustrated by Evert Van Muyden -- 11. The page of the Duke of Savoy : a romance of the reign of Henry ll. / illustrated by Frank T. Merrill -- 12. The horoscope : a romance of the reign of Francois ll. and tales of the caucasus / illustrated by Eugéne Grivaz -- 13. Marguerite de Valois : a romance of the reign of Charles lX. / illustrated by Félix Oudart -- 14. La Dame de Monsoreau : a romance of the reign of Henry lll. / illustrated by Eugéne Courboin -- 15. The fourty-five : a romance of the reign of Henri lll. / illustrated by Eugéne Courboin -- 16. The Three Musketeers : a romance of the reign of Louis Xlll. / illustrated by E. Abot, Gustave Doré, Félix Oudart and Edmund H. Garrett -- 17. The Three Musketeers : a romance of the reign of Louis Xlll. / illustrated by E. Abot, Gustave Doré, Félix Oudart and Edmund H. Garrett -- 20. The Vicomte de Bragelonne or, Ten years later : a romance of the reign of Louis XlV. in which are included the stories of "Louise de La Valliére" and "The Iron Mask" / illustrated by Evert Van Muyden, Félix Oudart and Edmund H. Garrett -- 21. The Vicomte de Bragelonne or, Ten years later : a romance of the reign of Louis XlV. in which are included the stories of "Louise de La Valliére" and "The Iron Mask" / illustrated by Evert Van Muyden, Félix Oudart and Edmund H. Garrett -- 22. The Vicomte de Bragelonne or, Ten years later : a romance of the reign of Louis XlV. in which are included the stories of "Louise de La Valliére" and "The Iron Mask" / illustrated by Félix Oudart and Edmund H. Garrett --23. The Vicomte de Bragelonne or, Ten years later : a romance of the reign of Louis XlV. in which are included the stories of "Louise de La Valliére" and "The Iron Mask" / illustrated by Evert Van Muyden, Félix Oudart and Edmund H. Garrett -- 24. Sylvandire : a romance of the time of Louis XlV. and The Woman with the Velvet Necklace : a romance of the Revolution / illustrated by J. Wagrez -- 25. The war of women : a romance of the Fronde / illustrated by Eugéne Grivaz -- 26. Le Chevalier D'Harmental : a romance of the regency of Philippe, Duc D'Orléans / illustrated by Evert Van Muyden -- 27. The Regents daughter and the black tulip / illustrated by Evert Van Muyden, Félix Oudart and Edmund H. Garrett -- 28. Olympe de Cléves and Chauvelin's will : romances of the reign of Louis XV. / illustrated by Evert Van Muyden -- 29. Olympe de Cléves and Chauvelin's will : romances of the reign of Louis XV. illustrated by Evert Van Muyden -- 30. Memoirs of a physician : a romance of the reign of Louis XV. / illustrated by Félix Oudart, Evert Van Muyden and Eugéne Courbion -- 31. Memoirs of a physician : a romance of the reign of Louis XV. / illustrated by Félix Oudart, Evert Van Muyden and Eugéne Courbion -- 32. Memoirs of a physician : a romance of the reign of Louis XV. / illustrated by Félix Oudart, Evert Van Muyden and Eugéne Courbion -- 33. The Queens necklace : a romance of the reign of Louis XVl. / illustrated by Eugéne Courbion, Félix Oudart and Evert Van Muyden -- 34. The Queens necklace : a romance of the reign of Louis XVl. / illustrated by Eugéne Courbion, Félix Oudart and Evert Van Muyden -- 35. Ange Pitou and Blanche de Beaulieu : romances of the French Revolution / illustrated by Eugéne Courbion and Evert Van Muyden -- 36. Ange Pitou and Blanche de Beaulieu : romances of the French Revolution / illustrated by Eugéne Courbion and Evert Van Muyden -- 37. La Comtesse de Charny : a romance of the French Revolution / illustrated by Félix Oudart, Eugéne Courbion and Evert Van Muyden -- 38. La Comtesse de Charny : a romance of the French Revolution / illustrated by Félix Oudart, Eugéne Courbion and Evert Van Muyden -- 39. La Comtesse de Charny : a romance of the French Revolution / illustrated by Félix Oudart, Eugéne Courbion and Evert Van Muyden -- 40. The Chevalier de Maison-Rouge : a romance of the French Revolution / illustrated by E. Abot -- 41. The companions of Jehu : a romance of the consulate under Napoleon / illustrated by Evert Van Muyden and F. T. Merrill -- 42. The whites and the blues : a romance of the directory / illustrated by Félix Oudart, Eugéne Courbion and Evert Van Muyden -- 43.The whites and the blues : a romance of the directory / illustrated by Félix Oudart, Eugéne Courbion and Evert Van Muyden -- 44. The She-Wolves of Machecoul : a romance of the Last Vendée to which are added The Corsican Brothers / illustrated by Evert Van Muyden, Félix Oudart and Edmund H. Garrett -- 45. The She-Wolves of Machecoul : a romance of the Last Vendée to which are added The Corsican Brothers / illustrated by Evert Van Muyden, Félix Oudart and Edmund H. Garrett.

EFFECTS OF BUBBLE-FACILITATED VOC TRANSPORT FROM LNAPL SMEAR ZONES ON VAPOR INTRUSION

Light non-aqueous phase liquid (LNAPL) sources can pose a significant threat to indoor air through vapour intrusion (VI). Most conceptual and numerical models of VI assume that the transport of volatile organic compounds (VOCs) is a diffusion-limited process. Recently, alternate conditions have been identified that could lead to faster transport, including the presence of preferential pathways and methanogenic gas production. In this study, an additional mechanism that could lead to faster transport was investigated: bubble-facilitated VOC transport from LNAPL smear zones. A laboratory investigation was preformed using pentane in one-dimensional laboratory columns and two-dimensional visualization experiments. Results of the column experiments showed that average VOC mass fluxes in the bubble-facilitated columns were over two orders of magnitude greater than in the diffusion-limited columns. In addition, the flux signal was intermittent, consistent with expectations of bubble-facilitated transport as bubbles expand, mobilize and are released to the vadose zone at various times during the test. The results from the visualization experiments showed gas fingers growing and mobilizing over time, which supports the findings of the column experiments. In conclusion, these results demonstrate the potential for bubble-facilitated VOC transport to affect mass transfer in LNAPL smear zones, and lead to increased indoor air concentrations by VI.

Green buildings : a framework for social sustainability

Despite the ongoing debate surrounding climate change, sustainability is increasingly a key consideration for building owners and tenants with the ‘triple bottom line’ as desired outcomes. The triangulated social, economic and environmental goals of sustainability are now the mantra of many businesses. While much has been written of the benefits of green buildings to its occupants, comparatively fewer studies have been devoted to investigating the perceived drawbacks and measures to improve the social sustainability factor, i.e., user satisfaction. Therefore, the purpose of this paper is to consider the impacts of green buildings on its occupants by drawing together past empirical findings and summarizing the results. In addition, the paper will also present a case study of the Institute of Sustainable Development and Architecture, which is Australia’s first 6-green star, rated educational building. Through these methods, the paper will identify gaps between green building performance and user satisfaction. Thereafter, it will introduce a social sustainability framework that seeks to improve the social performance of green buildings. The 6-P model is a holistic framework targeting the following factors that can influence user satisfaction of green buildings. These factors are: public perception, price, policies, psychological, physical and personal.

Using upper bounds on attainable discrimination to select discrete valued features

Selection of features that will permit accurate pattern classification is a difficult task. However, if a particular data set is represented by discrete valued features, it becomes possible to determine empirically the contribution that each feature makes to the discrimination between classes. This paper extends the discrimination bound method so that both the maximum and average discrimination expected on unseen test data can be estimated. These estimation techniques are the basis of a backwards elimination algorithm that can be use to rank features in order of their discriminative power. Two problems are used to demonstrate this feature selection process: classification of the Mushroom Database, and a real-world, pregnancy related medical risk prediction task - assessment of risk of perinatal death.

Chinese Street

A frieze-like composition depicting storefronts with mixed English and Chinese language signs, as well as activities of shopkeepers and shoppers.