UM Men's Swimming Team, 1942

Top Row: John L. Wiese, Walter V. Stewart, John. Sharemet, Gus Sharemet, Judson Brown, James W. Skinner, John R. Patten, David Levy

Middle Row: Theodore Horlenko, J. Perry Trytten, Richard J. Riedl, head coach Matt Mann, captain William Dobson Burton, assistant coach Harvey Mueller, Robert G. West, Louis P. Kivi

Front Row (divers): Louis W. Haughey, Strother D. Martin, Jr., Alexander Canja

UM Men's Swimming Team, 1960, diving team

Left Row, from front to back: diving coach Dick Kimball, Jozsef Gerlach, Robert D. Webster, Ernest Meissner, Thomas Francis, Ron Jaco.

Second row from left, front to back: Kenneth D. Ware, Edward R. Pongracz, Richard Han, Winston K. Pendleton, William T. Darnton, Jess Brown Jr, Carl T. Wooley.

Third Row From left, front to back: Terry Slonaker, Ronald Clark, Chuck Babcock, James Kerr, Andrew B. Morrow, Frank L. Legacki, John Charles Smith.

Fourth row from left, front to back: Michael Natelson, Thomas B. Bechtel, John D. Pettinger, John Urbanchek, Jerry Reilly, Alejandro Gaxiola, John J. McGuire.

Along the outside at right, front to back: Frederick D. Wolf, J. David Gillanders, Dennis E. Floden, head coach Gus Stager.

UM Men's Swimming Team, 1961, diving team

Back Row: Owen H. Kleinsehmidt, John D. Pettinger, Ken Ware, Robert L. Clark, Dave Heizer, Pete Cox, Richard Han, James Kerr, Paul Cooper, John J. McGuire, Michael G. Reissing, manager Earl Ryan.

Middle Row (starting in center of picture) from left: Terry Slonaker, Ken Ervine, J. Ronald Jaco, John Urbanchek, Michael Natelson, diving coach Dick Kimball; swimming coach Gus Stager.

Front Row: John H. Dumont, J. David Gillanders, Steven D. Thrasher, William T. Darnton, Frederick D. Wolf, Ronald L. Clark, Warren G. Uhler, Alejandro Gaxiola, Robert D. Webster, Winston K. Pendleton.

Left of diving board: Richard F. Nelson, holding NCAA Trophy is captain Frank L. Legacki.

UM Men's Swimming Team, 1962, diving team

Front Row: J. Ronald Jaco, Warren G. Uhler, James Kerr, Pete Cox, William T. Darnton, Richard F. Nelson, Dennis E. Floden, John H. DuMont, Frederick D. Wolf, Michael G. Reissing.

Middle Row: Thomas D. Dudley, Bob Schaefer, Frank W. Berry, Jeffery B. Moore, John F. Baker, Enn Mannard, Geza Bodalay.

Back Row: swimming Gus Stager, diving coach Dick Kimball, Paul A. Attar, Roy D. Burry, Carlos Canepa, Jeffery G. Longstreth, manager Earl Ryan.

UM Men's Swimming Team, 1964,

Top Row: Steven D. Rabinovitch, Thomas Burns, Donald J. Ewing, Edward Haley Boothman, diving coach Dick Kimball

2nd Row: swimming coach Gus Stager, William W. Farley, Richard Grant Walls, Edward C Bartsch, D. Lantz Reppert, Bob Tanner

3rd Row: John Candler, Jon W. Lundin, Thomas D Dudley, Jeffery B. Moore, Jeffery G. Longstreth, Frederick R. Damm, Frank W. Berry, Geza Bodolay.

Front Row: David R. Roadhouse, Rees M. Orland, Geoffrey A. D'Atri, William C. Spann, Bruce P. Brown.

UM Men's Swimming Team, 1989

Front Row: Eric Wunderlich, Robert S. Silverman, Lee C. Michaud, Michael Barrowman, Alejandro Alvizuri, Mats O. Nygren, William T. Hayes, diving coach Dick Kimball

Middle Row: student assistant Alec Campbell, Caldwell B. Esselstyn, Sean Gallagher, Jeffrey Jozwiak, Eric R. Bailey, Eric Namesnik, Michael G. Bayerl, Stephen Hamerski, Richard K. Wilkening, head coach Jon Urbanchek

Back Row: student assistant Bjoern Warland, Gregory B. Varner, Stephen E. Pancratz, David Henkel, Jarrett R. Winter, William J. Harris, Jim A. O'Donnell, Eric W. Wise, Scott Van Appledorn, Brent D. Lang, assistant coach Dave Kerska

UM Men's Swimming Team, 1990,

Front Row (left to right): assistant coach Mark Noetzel, diving coach Dick Kimball, William T. Hayes, Richard K. Wilkening, Brent D. Lang, Michael Barrowman, Eric Wunderlich, swimming coach Jon Urbanchek, assistant coach Bill Kopas

Second Row: Eric Lesser, Noel Strauss, Steven Bigelow, Robert S. Silverman, Gregory Gooch, Thomas Andrew Stabile, Jr., Marc Milobinski, Thomas Hay, trainer Hank Handel

Third Row: James Hume, Brian Gunn, Eric W. Wise, Eric Namesnik, Steve, Duttenhoffer, Stephen Hamerski, Bradley Lambert, William J. Harris

Back Row: Jarrett R. Winter, Richard Mitvalsky, Scott Van Appledorn

1937 UM Track Team

Top Row: Herbert Martens, Harold Davidson, Harvey Clarke, Edward Stanton, William Mitchell, Waldo Abbott, Alan H. Smith, Jerome Friedenberg

3rd Row: Frederick Osberg, James Kinglsey, Charles Miller, John Townsend, William Staehle, William Aigler, Ross Faulkner, William Watson

2nd Row: st. mngr Harrison Church, Fredrerick Martin, Edmond Devine, Raymond Fink, Howard Davidson, Frederick Stiles, Morris Morgan, Paul Pinkerton, asst. coach Ken Doherty

Front Row: Clayton Breslford, Stanley Birleson, Nere Alix, Stevens T. Mason, coach Charles Hoyt, captain Robert Osgood, Harry O'Connell, Sam Stoller, David Hunn, Ben Starr

1938 UM Track Team

Top Row: Fred Culver, Carl Culver, John Kutsche, Sherman Olmsted, Owen Cushing

3rd Row: Ralph Schwartzkopf, Norm Purucker, Francis Hogan, Henry Heyl, Thomas Jester, G. Wesley Allen, Stanley Kelley, st. mngr. William Bourke

2nd Row: asst. coach Ken Doherty, James Clark, Douglas Hayes, Harold Davidson, Waldo Abbott, Elmer Gedeon, William Buchanan, James Kingsley, Ross Faulkner

Front Row: Sanford Farrell, Charles Miller, Walter Stone, Frederick Martin, coach Charles Hoyt, captain William Watson*, John Townsend, William Aigler

* Steve Mason had been elected captain for 1938 but died during the Summer of 1937, Watson served in his place.

A small molecule that walks non-directionally along a track without external intervention

Charge of the light brigade: A molecule is able to walk back and forth upon a five-foothold pentaethylenimine track without external intervention. The 1D random walk is highly processive (mean step number 530) and exchange takes place between adjacent amine groups in a stepwise fashion. The walker performs a simple task whilst walking: quenching of the fluorescence of an anthracene group sited at one end of the track. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Analysis of body composition in individuals with high bone mass reveals a marked increase in fat mass in women but not men

Context: High bone mass (HBM), detected in 0.2% of dual-energy x-ray absorptiometry (DXA) scans, is characterized by raised body mass index, the basis for which is unclear. Objective: To investigate why body mass index is elevated in individuals with HBM, we characterized body composition and examined whether differences could be explained by bone phenotypes, eg, bone mass and/or bone turnover. Design, Setting, and Participants: We conducted a case-control study of 153 cases with unexplained HBM recruited from 4 UK centers by screening 219 088 DXA scans. Atotal of 138 first-degree relatives (of whom 51 had HBM) and 39 spouses were also recruited. Unaffected individuals served as controls. Main Outcome Measures: We measured fat mass, by DXA, and bone turnover markers. Results: Amongwomen, fat mass was inversely related to age in controls (P<.01), but not in HBM cases (P<.96) in whom mean fat mass was 8.9 [95% CI 4.7, 13.0] kg higher compared with controls (fully adjusted mean difference, P<.001). Increased fat mass in male HBM cases was less marked (gender interaction P = .03). Compared with controls, lean mass was also increased in female HBM cases (by 3.3 [1.2, 5.4] kg; P<.002); however, lean mass increases wereless marked than fat mass increases, resulting in 4.5% lower percentage lean mass in HBM cases (P<.001). Osteocalcin was also lower in female HBM cases compared with controls (by 2.8 [0.1, 5.5]μg/L; P = .04). Differences in fat mass were fully attenuated after hip bone mineral density (BMD) adjustment (P = .52) but unchanged after adjustment for bone turnover (P < .001), whereas the greater hip BMD in female HBM cases was minimally attenuated by fat mass adjustment (P<.001). Conclusions: HBM is characterized by a marked increase in fat mass in females, statistically explained by their greater BMD, but not by markers of bone turnover. Copyright © 2013 by The Endocrine Society.

The HIF-1alpha C1772T polymorphism may be associated with susceptibility to clinically localised prostate cancer but not with elevated expression of hypoxic biomarkers

We investigated the role of the C1772T polymorphisms in exon 12 of the Hypoxia-inducible factor-1 alpha (HIF-1alpha) gene C1772T genotype in prostate cancer (PCa) and amplification of the hypoxic response. We identified the heterozygous germline CT genotype as an increased risk factor for clinically localised prostate cancer (Odds ratio = 6.2; p < 0.0001). While immunostaining intensity for HIF-1alpha and VEGF was significantly enhanced in 75% of PCa specimens when compared to matched benign specimens (p < 0.0001), the CT genotype did not modulate the kinetics of HIF-1alpha protein expression in hypoxia in vitro, and was not associated with enhanced expression of hypoxic biomarkers. This study provides the first evidence of an increased risk for clinically localised prostate cancer in men carrying the C1772T HIF-1alpha gene polymorphism. Although our results did not suggest an association between expression of hypoxic biomarkers and genotype status, the correlation may merit further investigation.

Conception, synthèse et diversification de l'azaGly-Pro : un mime de tour beta, outil d'étude structure-activité : application au développement d'un nouvel agent tocolytique

Les accouchements prématurés constituent un problème médical majeur en constante augmentation et ce, malgré tous les efforts mis en œuvre afin de contrer le déclenchement des contractions avant terme. Cette thèse relate du ''design'' rationnel d'un nouvel agent thérapeutique (i.e., tocolytique) qui serait capable de 1) arrêter les contractions, et 2) prolonger la gestation. Pour ce faire, une nouvelle cible, la prostaglandine F2α et son récepteur ont été sélectionnés et le peptidomimétisme a été choisi afin de résoudre cette problématique. L'introduction contient un historique rapide de la conception à la synthèse (''drug design'') du peptide parent, le PDC113, premier peptide a avoir démontré des aptitudes tocolytiques suffisantes pour faire du peptidomimétisme. La deuxième partie de l'introduction présente les concepts du peptidomimétisme appliqués au PDC113 qui ont permis d'accéder au PDC113.824, inhibiteur allostérique du récepteur de la prostaglandine F2α, et explique comment ce mime nous a permis d'élucider les mécanismes de signalisation intracellulaire impliqués dans la contraction musculaire lisse. Cette thèse présente la conception, la synthèse et l'étude structure-activité de mimes de repliement de tour β au sein du mime peptidique original (PDC113.824) dans lequel nous avons remplacé l'azabicycloalkane central (l'indolizidin-2-one) par une série d'autres azabicycloalcanes connus et des acides aza-aminés dont nous avons élaboré la synthèse. Dans un premier temps, une nouvelle stratégie de synthèse en solution de l'aza-glycyl-proline à partir de la diphényle hydrazone et du chloroformate de p-nitrophényle a été réalisée. Cette stratégie a permis d'éliminer les réactions secondaires de cyclisation intramoléculaires communément obtenues lors de l'introduction d'acides aza-aminés avec les protections traditionnelles de type carbamate en présence de phosgène, mais aussi de faciliter l'accès en une étape à des dérivés peptidiques du type aza-glycyle. L'élongation de l'aza-glycyl-proline en solution nous a permis d'accéder à un nouveau mime tetrapeptidique du Smac, un activateur potentiel de l'apoptose au sein de cellules cancéreuses. Par la suite, nous avons développé une stratégie de diversification sélective de l'azote α du résidu azaglycine en utilisant différents types d'halogénures d'alkyle en présence de tert-butoxyde de potassium. Afin de valider le protocole d'alkylation de l'aza-dipeptide, différents halogénures d'alkyle ont été testés. Nous avons également démontré l'utilité des aza-dipeptides résultants en tant que ''building block'' afin d'accéder à une variété d'azapeptides. En effet, l'aza-dipeptide a été déprotégée sélectivement soit en N-terminal soit en C-terminal, respectivement. D'autre part, la libération de l'amine de l'ester méthylique de l'aza-alkylglycyl-proline a conduit à une catégorie de composés à potentiel thérapeutique, les azadicétopipérazines (aza-DKP) par cyclisation intramoléculaire. Enfin, notre intérêt quant au développement d'un nouvel agent tocolytique nous a amené à développer une nouvelle voie de synthèse en solution du PDC113.824 permettant ainsi d'élucider les voies de signalisation intracellulaires du récepteur de la prostaglandine F2α. Afin de valider l'importance de la stéréochimie et d'étudier la relation structure/ activité du mime, nous avons remplacé l'indolizidin-2-one (I2aa) centrale du PDC113.824 par une série d'autres azabicycloalcanes et azadipeptides. Les azabicycloalcanes D-I2aa, quinolizidinone, et indolizidin-9-one ont été synthétisés et incorporés au sein du dit peptide ne donnant aucune activité ni in vitro ni ex vivo, validant ainsi l'importance du tour β de type II' pour le maintien de l'activité biologique du PDC113.824. Finalement, l'insertion d'une série de dérivés aza(alkyl)glycyl-prolyles a mené à de nouveaux inhibiteurs allostériques du récepteur de la PGF2α, l'un contenant l'azaglycine et l'autre, l'azaphénylalanine. Cette thèse a ainsi contribué, grâce à la conception et l'application de nouvelles méthodes de synthèse d'aza-peptides, au développement de nouveaux composés à potentiel thérapeutique afin d'inhiber le travail prématuré.

Evolution of the South Atlantic passive continental margin in southern Brazil derived from zircon and apatite (U-Th-Sm)/He and fission-track data

The area between São Paulo and Porto Alegre in southeastern Brazil plays a key area to understand and quantify the evolution of the South Atlantic passive continental margin (SAPCM) in Brazil. In this contribution, we present new thermochronological data attained by fission-track and (U-Th-Sm)/He analysis on apatites and zircons from metamorphic, sedimentary and intrusive rocks. The zircon fission-track ages range between 108.4 (15.0) and 539.9 (68.4). Ma, the zircon (U-Th-Sm)/He ages between 72.9 (5.8) and 525.1(2.4). Ma, whereas the apatite fission-track ages range between 40.0 (5.3) and 134.7 (8.0). Ma, and the apatite (U-Th-Sm)/He ages between 32.1 (1.5) and 93.0 (2.5). Ma. The spatial distribution of these ages shows three distinct blocks with a different evolution cut by old fracture zones. While the central block exhibits an old stable block, the Northern and especially the Southern block underwent complex post-rift exhumation. The sample of the Northern block shows two distinct cooling phases in the Upper Cretaceous and the Paleogene to Neogene. After sedimentation of the Permian sandstones the samples of the Central block were never heated up over 100. °C with a following moderate to fast cooling phase in Cretaceous to Eocene time and a fast cooling between Oligocene to Miocene. The five thermal models obtained in the Southern block indicate a complex evolution with three cooling phases. The exhumation events of the three blocks correspond with the Paraná-Etendekka event, the alkaline intrusions due to the Trinidad hotspot, and the evolution of the continental rift basins in SE Brazil and are, therefore, most likely to be the major force for the post-rift evolution of the passive continental margin in SE Brazil, which therefore corresponds to the three main phases of the Andean orogeny. © 2013 Elsevier B.V.

Description and performance of track and primary-vertex reconstruction with the CMS tracker

A description is provided of the software algorithms developed for the CMS tracker both for reconstructing charged-particle trajectories in proton-proton interactions and for using the resulting tracks to estimate the positions of the LHC luminous region and individual primary-interaction vertices. Despite the very hostile environment at the LHC, the performance obtained with these algorithms is found to be excellent. For t (t) over bar events under typical 2011 pileup conditions, the average track-reconstruction efficiency for promptly-produced charged particles with transverse momenta of p(T) > 0.9GeV is 94% for pseudorapidities of vertical bar eta vertical bar < 0.9 and 85% for 0.9 < vertical bar eta vertical bar < 2.5. The inefficiency is caused mainly by hadrons that undergo nuclear interactions in the tracker material. For isolated muons, the corresponding efficiencies are essentially 100%. For isolated muons of p(T) = 100GeV emitted at vertical bar eta vertical bar < 1.4, the resolutions are approximately 2.8% in p(T), and respectively, 10 m m and 30 mu m in the transverse and longitudinal impact parameters. The position resolution achieved for reconstructed primary vertices that correspond to interesting pp collisions is 10-12 mu m in each of the three spatial dimensions. The tracking and vertexing software is fast and flexible, and easily adaptable to other functions, such as fast tracking for the trigger, or dedicated tracking for electrons that takes into account bremsstrahlung.