ERPN, Enterprise Resource Planning Newsletter, May/June 2001, Vol.1, no.4

Newsletter for Information Technology Department

Iowa 100% E News, May/June 2001, Vol.1, no.4

Newsletter for Information Technology Department

3-amino-1,2,4-triazole inhibits macrophage NO synthase.

Murine macrophages activated by interferon-gamma and lipopolysaccharide become leishmanicidal through a process involving L-arginine-derived nitrogen oxidation products. Both nitrite secretion and parasite killing by activated macrophages were inhibited by 3-amino-1,2,4-triazole as well as the related compound, 3-amino-1,2,4-triazine. Moreover, NO synthase activity in cytosolic extracts of activated cells was inhibited by both compounds. 4-amino-1,2,4-triazole, an isomer of 3-amino-1,2,4-triazole, was without effect. Our results suggest that besides its known inhibitory effect on catalases and peroxidases, 3-amino-1,2,4-triazole is an inhibitor of NO synthase. The resemblance between the tautomeric form of 3-amino-1,2,4-triazole and the guanidino group of L-arginine, the natural substrate for NO synthase, might be responsible for the observed inhibition.

Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation.

Engagement of TNF receptor 1 by TNFalpha activates the transcription factor NF-kappaB but can also induce apoptosis. Here we show that upon TNFalpha binding, TNFR1 translocates to cholesterol- and sphingolipid-enriched membrane microdomains, termed lipid rafts, where it associates with the Ser/Thr kinase RIP and the adaptor proteins TRADD and TRAF2, forming a signaling complex. In lipid rafts, TNFR1 and RIP are ubiquitylated. Furthermore, we provide evidence that translocation to lipid rafts precedes ubiquitylation, which leads to the degradation via the proteasome pathway. Interfering with lipid raft organization not only abolishes ubiquitylation but switches TNFalpha signaling from NF-kappaB activation to apoptosis. We suggest that lipid rafts are crucial for the outcome of TNFalpha-activated signaling pathways.

The Security Blanket, December 2001, Vol.1, no.4

Newsletter for Information Technology Department

Innovative Outstanding Weatherization Assistance News, October 2003. Vol.1, no.4

Quarterly newsletter from the Division of Cimmunity Action Agenices, part of the Department of Human Rights.

Iowa Department of Elder Affairs Legislative Update, January 28, 2005, Vol. 1, no. 4

Iowa Department of Elder Affairs provides a brief summation of a Departmental program or other important Departmental information in each Legislative Update. The Legislative Update is produced for informational and educational purposes only.

Archives parlementaires de 1787 à 1860 ; 2-7. États généraux ; Cahiers des sénéchaussées et bailliages. Série 1 / Tome 4 / impr. par ordre du Sénat et de la Chambre des députés ; sous la dir. de MM. Jules Mavidal et Emile Laurent,...

Collection : Les archives de la Révolution française ; 3.1

Oeuvres / Spinoza ; 1. Oeuvres. 4 / Spinoza ; trad. et notes par Charles Appuhn

Collection : GF-Flammarion

Healthy Aging Update, June 2, 2006, Vol. 1, no. 4

This bimonthly electronic newsletter will provide information and resources on nutrition and health promotion and disease prevention. The Healthy Aging Update is produced for informal and educational purposes only. The newsletter will be distributed electronically and posted on the Department’s website at www.state.ia.us/elderaffairs.

Johne’s Disease–Beef, Spring 2010, Vol. 1, no. 4

Newsletter about controlling animal diseases, tips and techniques on how prevention works and the transportation of livestock.

Johne’s Disease–Dairy, Spring 2010, Vol. 1, no. 4

Newsletter about controlling animal diseases, tips and techniques on how prevention works and the transportation of livestock.

Fonction ventriculaire gauche après revascularisation pour occlusion d'une coronaire d'une durée de 1-2 heures [Left ventricular function following revascularization for occlusion of a coronary artery lasting 1 to 2 hours].

The time-lag between coronary occlusion and irreversible damage to the myocardium is ill-defined in man. In 10 patients the changes in left ventricular function have been studied after coronary occlusion during diagnostic or therapeutic cardiac catheterization of 1-2 hours' duration. Revascularization was achieved either surgically or through intracoronary streptokinase infusion. The interval between occlusion and onset of extracorporal circulation or reopening was 61 to 119 minutes. Despite enzyme elevation (CPK, CK-MB, SGOT) and appearance of Q-waves in 5 patients, no significant alteration of left ventricular function was noted on repeat cardiac catheterization 10 to 230 days after the accident. These observations, suggest that coronary occlusion of 1-2 hours' duration fails to produce significant irreversible damage to the myocardium despite electrocardiographic and enzymatic signs of myocardial infarction.