Quantitative integration of high-resolution hydrogeophysical data through Monte-Carlo-type conditional simulations

Geophysical techniques can help to bridge the inherent gap with regard to spatial resolution and the range of coverage that plagues classical hydrological methods. This has lead to the emergence of the new and rapidly growing field of hydrogeophysics. Given the differing sensitivities of various geophysical techniques to hydrologically relevant parameters and their inherent trade-off between resolution and range the fundamental usefulness of multi-method hydrogeophysical surveys for reducing uncertainties in data analysis and interpretation is widely accepted. A major challenge arising from such endeavors is the quantitative integration of the resulting vast and diverse database in order to obtain a unified model of the probed subsurface region that is internally consistent with all available data. To address this problem, we have developed a strategy towards hydrogeophysical data integration based on Monte-Carlo-type conditional stochastic simulation that we consider to be particularly suitable for local-scale studies characterized by high-resolution and high-quality datasets. Monte-Carlo-based optimization techniques are flexible and versatile, allow for accounting for a wide variety of data and constraints of differing resolution and hardness and thus have the potential of providing, in a geostatistical sense, highly detailed and realistic models of the pertinent target parameter distributions. Compared to more conventional approaches of this kind, our approach provides significant advancements in the way that the larger-scale deterministic information resolved by the hydrogeophysical data can be accounted for, which represents an inherently problematic, and as of yet unresolved, aspect of Monte-Carlo-type conditional simulation techniques. We present the results of applying our algorithm to the integration of porosity log and tomographic crosshole georadar data to generate stochastic realizations of the local-scale porosity structure. Our procedure is first tested on pertinent synthetic data and then applied to corresponding field data collected at the Boise Hydrogeophysical Research Site near Boise, Idaho, USA.

High-Resolution Mass Spectrometry applied to the identification of new metabolites and transformation products of quinolones in chicken muscle tissues

The aim of this work was the identification of new metabolites and transformation products (TPs) in chicken muscle from Enrofloxacin (ENR), Ciprofloxacin (CIP), Difloxacin (DIF) and Sarafloxacin (SAR), which are antibiotics that belong to the fluoroquinolones family. The stability of ENR, CIP, DIF and SAR standard solutions versus pH degradation process (from pH 1.5 to 8.0, simulating the pH since the drug is administered until its excretion) and freeze-thawing (F/T) cycles was tested. In addition, chicken muscle samples from medicated animals with ENR were analyzed in order to identify new metabolites and TPs. The identification of the different metabolites and TPs was accomplished by comparison of mass spectral data from samples and blanks, using liquid chromatography coupled to quadrupole time-of-flight (LC-QqToF) and Multiple Mass Defect Filter (MMDF) technique as a pre-filter to remove most of the background noise and endogenous components. Confirmation and structure elucidation was performed by liquid chromatography coupled to linear ion trap quadrupole Orbitrap (LC-LTQ-Orbitrap), due to its mass accuracy and MS/MS capacity for elemental composition determination. As a result, 21 TPs from ENR, 6 TPs from CIP, 14 TPs from DIF and 12 TPs from SAR were identified due to the pH shock and F/T cycles. On the other hand, 14 metabolites were identified from the medicated chicken muscle samples. Formation of CIP and SAR, from ENR and DIF, respectively, and the formation of desethylene-quinolone were the most remarkable identified compounds.

High-resolution mass spectrometry applied to the study of metabolome modifications in various chicken tissues after amoxicillin administration

The performance of high resolution accurate mass spectrometry (HRMS) operating in full scan MS mode was investigated for the quantitative determination of amoxicillin (AMX) as well as qualitative analysis of metabolomic profiles in tissues of medicated chickens. The metabolomic approach was exploited to compile analytical information on changes in the metabolome of muscle, kidney and liver from chickens subjected to a pharmacological program with AMX. Data consisting of m/z features taken throughout the entire chromatogram were extracted and filtered to be treated by Principal Component Analysis. As a result, it was found that medicated and non-treated animals were clearly clustered in distinct groups. Besides, the multivariate analysis revealed some relevant mass features contributing to this separation. In this context, recognizing those potential markers of each chicken class was a priority research for both metabolite identification and, obviously, evaluation of food quality and health effects associated to food consumption.

1.° Fratris Bernardi de Virduno, ordinis Minorum, liber super totam astrologiam. — 2.° Liber de compositione et practica instrumenti astronomici, quod dicitur Turketus. — 3.° Tractatus de almanach : authore anonymo. — 4.° Theorica planetarum : authore Gerardo Carmonensi. — 5.° Liber Thebit de motu octavae sphaerae. — 6.° Ejusdem liber de iis quae indigent expositione antequam legatur almagestum Ptolemaei. — 7.° Ejusdem liber de imaginatione sphaerae et circulorum ejus diversorum. — 8.° Ejusdem liber de quantitatibus stellarum et planetarum.

Colbertinus

1.° Hilperici tractatus de arte calculatoria : praemittitur fragmentum de calendario. — 2.° Interrogationes et responsiones de computo. — 3.° Bedae liber de sex aetatibus mundi. — 4.° Adalbaldi, Episcopi Trajectensis, opusculum super illud Boëtii : O qui perpetua mundum ratione gubernas. — 5.° Anicii Manlii Severini Boëtii libri quinque de musica. — Hujusce codicis pars duodecimo, pars decimo tertio saeculo videtur exarata.

Colbertinus

1.° Hilperici tractatus de arte calculatoria : praemittitur calendarium ad usum Cisterciensium. — 2.° Ratio Gaii Caesaris de ordine anni per duodecim menses. — 3.° Bedae opusculum de loquela digitorum. — 4.° Expositio tabulae de luna quotidiè per rationem epactarum invenienda. — 5.° Excerptum ex etymologiis Isidori, de coelo ejusque luminaribus. — 6.° Carmen de temporibus anni. — 7.° Ratio epactarum. — 8.° Anonymi expositio super tabulam Dionysii Exigui, Abbatis. — 9.° Fragmentum Macrobii de mensura terrae. — 10.° Anonymi figurata expositio duodecim signorum zodiaci. — 11.° Scholium de temporibus et aetatibus mundi. — 12.° Alcuini opusculum de vita Antichristi. — 13.° Hieronymus de quindecim signis praecedentibus diem judicii. — 14.° Beda de die judicii. — 15.° Anonymi chronicon in epitomen contractum, et à mundi creatione ad Leonis III. imperium productum. — 16.° Provincialis Romanae Ecclesiae fragmentum.

Colbertinus

Scripta diversa super scientiam mathematicam et physicam

1.° Practica geometriae, ordinata per Magistrum Dominicum de Mastinario Clanaxio. — 2.° Tractatus brevis et utilis de proportionalitate motuum coelestium : authore Nicolao Oresme, Normanno. — 3.° Anonymi fragmentum de quadratura circuli. — 4.° Euclidis liber de speculis : initium desideratur. — 5.° Ejusdem perspectiva. — 6.° Anonymi liber de crepusculis. — 7.° Liber Jordanis de triangulis. — 8.° Ejusdem liber de ponderibus. — 9.° Libri duo de musica. — 10.° Joannis de Lineriis canones primi mobilis. — 11.° Canones minutiarum, sive fractionum arithmetica. — 12.° Magistri Leonis, Hebraei, tractatus de harmonicis numeris. — 13.° Ars novae musicae. — 14.° Ars cujusvis compositionis de motetis, compilata à Philippo de Vitry, Magistro in musica. — 15.° Magister Leo, Judaeus, Prognosticatio super conjunctione Saturni, Jovis et Martis. — 16.° Johannes de Muris Prognosticatio super eodem argumento. — 17.° Firminus de Bellavalle Prognosticatio de eodem argumento. — 18.° Planisphaerium Nicolai Jude. — 19.° Tractatus brevis de compositione et usu cylindri. — 20.° Epistola Petri Peregrini de Maricourt ad Sigermum de Foucaucourt, de magnete : ibi reperias delineationem veteris pyxidis nauticae. — 21.° Compositio tabulae quae saphea dicitur, sive astrolabium Arzachelis. — 22.° Tractatus de optica, dioptrica et catoptrica. — 23.° Canones astrolabii. — 24.° Variae receptae medicinales. — 25.° Plantarum usitatarum nomina, ordine alphabetico disposita. — 26.° Anonymi fragmentum de visione. — 27.° Propositiones notabiles octo librorum Aristotelis de physica auscultatione. — 28.° Dicta super libros de coelo et mundo Aristotelis. Decimo quarto saeculo videtur exaratus.

1.° Canones in Gerlandi tabulam de computo. — 2.° Scriptum Magistri Joannis Alemanni super computum manualem absque cifra. — 3.° Scriptum super compotum Magistri Joannis de Sacrobosco. — 4.° Statuta Magistri Roberti de Sorbona. — 5.° Tabulae astronomicae : praemittuntur canones.

Colbertinus, antea Jacobi Augusti Thuani

Scripta diversa super rhetoricam et grammaticam. Carmina.

Catalogus codicum manuscriptorum Bibliothecae regiae. Pars tertia. Tomus tertius (-quartus), Parisiis : ex typographia regia, 1744 : "1.° Anonymi grammatica, in qua de verborum conjugatione. — 2.° Bedae, Presbyteri, de arte metrica liber ad Gutbertum. — 3.° Ejusdem de schematibus et tropis liber ad eundem. — 4.° Claudii Marii Victoris Massiliensis, de Genesi libri tres : carmine heroïco ; porro hi libri iidem prorsus cum illis qui commentariorum in Genesim in editis titulum prae se ferunt : praemittitur Victoris precatio ad Deum, oratione soluta. — 5.° Sancti Paulini carmina ad Ausonium. — 6.° Ausonii, qui in hoc codice sanctus appellatur, carmina ad Paulinum. — 7.° Anonymi carmen in laudem sancti Joannis Baptistae. — 8.° Anonymi carmen cujus is est titulus : laudes Domini cum miraculo quod accidit in Aedrico. — 9.° Anonymi carmen in laudem Christi Domini ; incipit : Jam mihi polliceor. — 10.° Bebiani carmen de uxore sua morti proxima, è variis versuum generibus contextum ; incipit : ô vir beatus cui remissa iniquitas. — 11.° Drepanii Flori Diaconi Lugdunensis, carmen de cereo paschali. — 12.° Hymnus in solemnitate S. Michaëlis, Archangeli. — 13.° Drepanii Flori, Diaconi Lugdunensis, epistola ad Modoinum, Episcopum Augustodunensem. — 14.° Servii Honorati de ultimarum syllabarum natura liber ad Aquilinum. — 15.° Anonymi grammatica. — 16.° Epigrammata quorumdam psalmorum, sive potiùs, psalmi XXII. XXVI. XXVII. versibus haeroïcis expositi ; authore Drepanio Floro. — 17.° Canticum trium puerorum, versibus heroïcis : eodem authore. — 18.° Anonymi cohortatio ad Wlfinum, Aurelianensem Grammaticum. — 19.° Sedulii carmen elegiacum de incarnatione Christi. Saeculo nono videtur exaratus."

1.° Opus cujus is est titulus : tractatus instrumenti astronomici Magistri Leonis Judaei de Balneolis, ad summum Pontificem Clementem VI. ex hebraïca lingua in latinam anno Incarnationis 1342. conversus. — 2.° Anonymi tractatus de Deo ab aeterno, sive pars operis theologici majoris. — 3.° Anonymi postillae in epistolam ad Romanos ; et considerationes super passione Domini et Scriptura sacra.

Colbertinus

1.° Instrumenti cujusdam astronomici descriptio, compositio et usus : accedunt figurae. — 2.° Anonymi arithmetica de rerum ac numerorum proportionibus. — 3.° Messahallach tractatus de compositione et usu astrolabii. — 4.° Canones super tabulas Alphonsinas : authore Joanne de Saxonia. — 5.° Tabulae astronomicae Alphonsi, Regis Castellae. — 6.° Canones Joannis de Ligneriis, aliàs, de Lineriis. — 7.° Tractatus de eclipsibus Solis.

Colbertinus