Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

Most psychiatric disorders are moderately to highly heritable. The degree to which genetic variation is unique to individual disorders or shared across disorders is unclear. To examine shared genetic etiology, we use genome-wide genotype data from the Psychiatric Genomics Consortium (PGC) for cases and controls in schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD). We apply univariate and bivariate methods for the estimation of genetic variation within and covariation between disorders. SNPs explained 17-29% of the variance in liability. The genetic correlation calculated using common SNPs was high between schizophrenia and bipolar disorder (0.68 +/- 0.04 s.e.), moderate between schizophrenia and major depressive disorder (0.43 +/- 0.06 s.e.), bipolar disorder and major depressive disorder (0.47 +/- 0.06 s.e.), and ADHD and major depressive disorder (0.32 +/- 0.07 s.e.), low between schizophrenia and ASD (0.16 +/- 0.06 s.e.) and non-significant for other pairs of disorders as well as between psychiatric disorders and the negative control of Crohn's disease. This empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders.

Hanukkah lamp from Theresienstadt Coin

Obverse: 1 Sheqel silver coin, number one designed to remind striped clothing of the inmates of concentration camps. Reverse: Hanukkah lamp from Theresienstadt.

Hanukkah lamp from Theresienstadt Coin

Obverse: 2 Sheqalim silver coin, number one designed to remind striped clothing of the inmates of concentration camps. Reverse: Hanukkah lamp from Theresienstadt.

Taxonomy and redescription of the Swamp Antechinus, Antechinus minimus (E. Geoffroy) (Marsupialia: Dasyuridae)

We provide a taxonomic redescription of the dasyurid marsupial Swamp Antechinus, Antechinus minimus (Geoffroy, 1803). In the past, A. minimus has been classified as two subspecies: the nominate A. minimus minimus (Geoffroy, 1803), which is found throughout much of Tasmania (including southern Bass Strait islands) and A. minimus maritimus (Finlayson, 1958), which is found on mainland Australia (as well as some near-coastal islands) and is patchily distributed in mostly coastal areas between South Gippsland (Victoria) and Robe (South Australia). Based on an assessment of morphology and DNA, we conclude that A. minimus is both distinctly different from all extant congeners and that the two existing subspecies of Swamp Antechinus are appropriately taxonomically characterised. In our genetic phylogenies, the Swamp Antechinus was monophyletic with respect to all 14 known extant congeners; moreover, A. minimus was well-positioned in a large clade, together with all four species in the Dusky Antechinus complex, to the exclusion of all other antechinus. Within A. minimus, between subspecies there were subtle morphological differences (A. m. maritimus skulls tend to be broader, with larger molar teeth, than A. m. minimus, but these differences were not significant); there was distinct, but only moderately deep genetic differences (3.9–4.5% at mtDNA) between A. minimus subspecies. Comparatively, across Bass Strait, the two subspecies of A. minimus are morphologically and genetically markedly less divergent than recently recognised species pairs within the Dusky Antechinus complex, found in Victoria (A. mimetes) and Tasmania (A. swainsonii) (9.4–11.6% divergent at mtDNA)

Molecular cloning and expression pattern of a Cubitus interruptus homologue from the mulberry silkworm Bombyx mori

A homologue of the segment polarity gene Cubitus interruptus from Bombyx Mori, (BmCi) has been cloned and characterized. This region harbouring Zn2+ finger motif is highly conserved across species. In B. Mori, BmCi RNA expression was first detected at stage 6 of embryogenesis, which reached maximum levels at stage 21C and was maintained until larval hatching. The segmentally reiterated striped pattern of transcript distribution in stage 21C embryos was in conformity with its predicted segment polarity nature. BmCi was expressed in the fore- and hind-wing discs, ovaries, testes and gut during fifth larval intermolt, reminiscent of its expression domains in Drosophila. Besides, BmCi expression was seen in the. anterior part of the middle silkglands in late embryonic stages, and this pattern was maintained during larval development. The transition from third to fourth and fifth larval intermolts was accompanied by an increase in the transcript levels in the middle silkglands. Our results demonstrate the presence of a novel expression domain for Ci in Bombyx. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

Averting biodiversity collapse in tropical forest protected areas

The rapid disruption of tropical forests probably imperils global biodiversity more than any other contemporary phenomenon(1-3). With deforestation advancing quickly, protected areas are increasingly becoming final refuges for threatened species and natural ecosystem processes. However, many protected areas in the tropics are themselves vulnerable to human encroachment and other environmental stresses(4-9). As pressures mount, it is vital to know whether existing reserves can sustain their biodiversity. A critical constraint in addressing this question has been that data describing a broad array of biodiversity groups have been unavailable for a sufficiently large and representative sample of reserves. Here we present a uniquely comprehensive data set on changes over the past 20 to 30 years in 31 functional groups of species and 21 potential drivers of environmental change, for 60 protected areas stratified across the world's major tropical regions. Our analysis reveals great variation in reserve `health': about half of all reserves have been effective or performed passably, but the rest are experiencing an erosion of biodiversity that is often alarmingly widespread taxonomically and functionally. Habitat disruption, hunting and forest-product exploitation were the strongest predictors of declining reserve health. Crucially, environmental changes immediately outside reserves seemed nearly as important as those inside in determining their ecological fate, with changes inside reserves strongly mirroring those occurring around them. These findings suggest that tropical protected areas are often intimately linked ecologically to their surrounding habitats, and that a failure to stem broad-scale loss and degradation of such habitats could sharply increase the likelihood of serious biodiversity declines.

A simulation-based algorithm for optimal pricing policy under demand uncertainty

We propose a simulation-based algorithm for computing the optimal pricing policy for a product under uncertain demand dynamics. We consider a parameterized stochastic differential equation (SDE) model for the uncertain demand dynamics of the product over the planning horizon. In particular, we consider a dynamic model that is an extension of the Bass model. The performance of our algorithm is compared to that of a myopic pricing policy and is shown to give better results. Two significant advantages with our algorithm are as follows: (a) it does not require information on the system model parameters if the SDE system state is known via either a simulation device or real data, and (b) as it works efficiently even for high-dimensional parameters, it uses the efficient smoothed functional gradient estimator.

Spectrophone measurements in sulfur-hexafluoride

The optoacoustic signal generated by pulsed 10.6 c infrared radiation incident upon a test cell filled with gaseous SF6 has been analyzed in detail. The effects ofm icroscopic energy transfer from the absorbing vibrational degrees of freedom, spontaneous emission, thermal conduction, and acoustic wave propagation are included. This complete treatment explains the experimental observations including a negative pressure response following irradiation at low gas pressure.

Annual report 2004 - North Pacific Marine Science Organization (PICES). Thirteenth meeting, Honolulu, Hawaii, U.S.A., October 14-24, 2004

Report of Opening Session (pdf 0.07 Mb) Report of Governing Council (pdf 0.2 Mb) Report of the Finance and Administration Committee (pdf 0.08 Mb) Reports of Science Board and Committees Science Board inter-sessional meeting (pdf 0.05 Mb) Science Board (pdf 0.1 Mb) Biological Oceanography Committee (pdf 0.1 Mb) Fishery Science Committee (pdf 0.04 Mb) Marine Environmental Quality Committee (pdf 0.04 Mb) Physical Oceanography and Climate Committee (pdf 0.04 Mb) Technical Committee on Data Exchange (pdf 0.04 Mb) Reports of Sections, Working and Study Groups Harmful Algal Blooms Section (pdf 0.03 Mb) Working Group 17 on Biogeochemical data integration and synthesis (pdf 0.03 Mb) Working Group 18 on Mariculture in the 21st century - The intersection between ecology, socio-economics and production (pdf 0.06 Mb) Study Group on Ecosystem-based management science and its application to the North Pacific (pdf 0.04 Mb) Reports of the Climate Change and Carrying Capacity Program Implementation Panel on the CCCC Program (pdf 0.04 Mb) BASS Task Team (pdf 0.04 Mb) CFAME Task Team (pdf 0.04 Mb) MODEL Task Team (pdf 0.04 Mb) MONITOR Task Team (pdf 0.03 Mb) REX Task Team (pdf 0.04 Mb) Reports of Advisory Panels Advisory Panel on Continuous Plankton Recorder Survey in the North Pacific (pdf 0.4 Mb) Advisory Panel on Iron Fertilization Experiment in the Subarctic Pacific Ocean (pdf 0.03 Mb) Advisory Panel on Marine Birds and Mammals (pdf 0.04 Mb) Advisory Panel on Micronekton Sampling Inter-Calibration experiment (pdf 0.04 Mb) Summary of Scientific Sessions and Workshops (pdf 0.2 Mb) Membership List (pdf 0.07 Mb) List of Participants (pdf 0.09 Mb) List of Acronyms (pdf 0.03 Mb)

Annual report 2003 - North Pacific Marine Science Organization (PICES). Twelfth meeting, Seoul, Republic of Korea, October 9-18, 2003

Report of Opening Session (pdf 58 KB) Report of Governing Council Meeting (pdf 244 KB) Report of 2003 interim Governing Council meeting Tenth Anniversary PICES Organization Review Report of the Finance and Administration Committee (pdf 102 KB) 2002 Auditor's report to the Organization Review of PICES Publication Program Reports of Science Board and Committees: Science Board/Governing Council interim meeting (pdf 81 KB) Science Board (pdf 95 KB) Study Group on PICES Capacity Building Biological Oceanography Committee (pdf 65 KB) Advisory Panel on Micronekton sampling gear intercalibration experiment Advisory Panel on Marine birds and mammals Fishery Science Committee (pdf 41 KB) Working Group 16 on Climate change, shifts to fish production, and fisheries management Marine Environmental Quality Committee (pdf 76 KB) Working Group 15 on Ecology of Harmful Algal Blooms (HABs) in the North Pacific Physical Oceanography and Climate Committee (pdf 70 KB) Working Group 17 on Biogeochemical data integration and synthesis Advisory Panel on North Pacific Data Buoy Technical Committee on Data Exchange (pdf 32 KB) Implementation Panel on the CCCC Program (pdf 64 KB) Nemuro Experimental Planning Team (NEXT) BASS Task Team (pdf 35 KB) Advisory Panel on Iron Fertilization Experiment MODEL Task Team (pdf 29 KB) MONITOR Task Team (pdf 30KB) REX Task Team (pdf 25 KB) Documenting Scientific Sessions (pdf 164 KB) List of Participants (pdf 60 KB) List of Acronyms (pdf 21 KB)

Annual report 2002 - North Pacific Marine Science Organization (PICES). Eleventh meeting, Qingdao, People's Republic of China, October 18-16, 2002

Report of Opening Session (pdf 51 KB) Report of Governing Council Meeting(pdf 136 KB) Report of the Finance and Administration Committee (pdf 48 KB) Reports of Science Board and Committees: Science Board (pdf 71 KB) Biological Oceanography Committee (pdf 66 KB) Working Group 14: Effective sampling of micronekton Marine Birds and Mammals Advisory Panel Fishery Science Committee (pdf 36 KB) Working Group 16: Climate change, shifts to fish production, and fisheries management Marine Environmental Quality Committee (pdf 39 KB) Working Group 15: Ecology of Harmful Algal Blooms (HABs) in the North Pacific Physical Oceanography and Climate Committee (pdf 49 KB) North Pacific Data Buoy Advisory Panel Working Group 17: Biogeochemical data integration and synthesis Technical Committee on Data Exchange (pdf 29 KB) Implementation Panel on the CCCC Program (pdf 43 KB) BASS Task Team (pdf 30 KB) Iron Fertilization Experiment Advisory Panel MODEL Task Team (pdf 28 KB) MONITOR Task Team (pdf 34 KB) Summary of Continuous Plankton Recorder activities in 2002 REX Task Team (pdf 21 KB) Documenting Scientific Sessions (pdf 140 KB) List of Participants (pdf 59 KB) List of Acronyms (pdf 21 KB)

Annual report 2001 - North Pacific Marine Science Organization (PICES). Tenth meeting, Victoria, B.C., Canada, October 5-13, 2001

Report of Opening Session (pdf 42 KB) Report of Governing Council Meeting (pdf 89 KB) Reports of Science Board and Committees: Science Board (pdf 88 KB) Study Group on North Pacific Ecosystem Status Report and Regional Analysis Center Biological Oceanography Committee (pdf 57 KB) Working Group 14: Effective sampling of micronekton Advisory Panel on Marine Birds and Mammals Fishery Science Committee (pdf 37 KB) Working Group 16: Climate change, shifts to fish production, and fisheries management Marine Environmental Quality Committee (pdf 62 KB) Working Group 15: Ecology of Harmful Algal Blooms (HABs) in the North Pacific Physical Oceanography and Climate Committee (pdf 34 KB) Working Group 13: CO2 in the North Pacific Technical Committee on Data Exchange (pdf 24 KB) Implementation Panel on the CCCC Program (pdf 39 KB) BASS Task Team (pdf 32 KB) Advisory Panel on Iron Fertilization Experiment MODEL Task Team (pdf 22 KB) MONITOR Task Team (pdf 32 KB) Advisory Panel on Continuous Plankton Recorder Survey in the North Pacific REX Task Team (pdf 21 KB) Report of the Finance and Administration Committee (pdf 53 KB) List of Participants (pdf 67 KB) List of Acronyms (pdf 13 KB)

Annual report 2000 - North Pacific Marine Science Organization (PICES). Ninth meeting, Hakodate, Hokkaido, Japan, October 20-28, 2000

Report of Opening Session (pdf 42 KB) Report of Governing Council Meetings (pdf 70 KB) Reports of Science Board and Committees: Science Board (pdf 57 KB) Biological Oceanography Committee (pdf 43 KB) Working Group 14: Effective Sampling of Micronekton Advisory Panel on Marine birds and mammals Fishery Science Committee (pdf 31 KB) Working Group 16 on Implications of Climate change to Fisheries Management Marine Environmental Quality Committee (pdf 47 KB) Working Group 8: Practical Assessment Methodology Working Group 15 on Ecology of Harmful Algal Blooms (HABs) in the North Pacific Physical Oceanography and Climate Committee (pdf 41 KB) Working Group 13: CO2 in the North Pacific Implementation Panel on the CCCC Program (pdf 120 KB) BASS Task Team Advisory Panel on Iron Fertilization Experiment MODEL Task Team MONITOR Task Team Advisory Panel on Continuous Plankton Recorder Survey in the North Pacific REX Task Team Technical Committee on Data Exchange (pdf 24 KB) Finance and Administration: Report of the Finance and Administration Committee (pdf 49 KB) Assets on 31st of December, 1999 Income and Expenditures for 1999 Budget for 2001 Report of the Fund-Raising Committee (pdf 20 KB) Composition of the Organization (pdf 27 KB) List of Participants (pdf 94 KB) List of Acronyms (pdf 13 KB)

PICES-GLOBEC International Program on Climate Change and Carrying Capacity

Introduction [pdf, 0.27 MB] Methods [pdf, 0.15 MB] Results and discussion [pdf, 2.1 MB] Conclusions [pdf, 0.12 MB] Appendix A: Data gathering review, results and balancing [pdf, 0.3 MB] Appendix B: Data tables [pdf, 0.35 MB] Appendix C: BASS Workshop on the "Development of a conceptual model of the subarctic Pacific Basin ecosystems" [pdf, 0.16 MB] Appendix D: BASS/MODEL Workshop on "Higher trohic level modeling" [pdf, 0.24 MB] Appendix E: BASS/MODEL Workshop to review ecosystem models for the subarctic Pacific gyres [pdf, 4.39 MB] Appendix F: BASS/MODEL Workshop on "Perturbation analysis" on subarctic Pacific gyre ecosystem models using ECOPATH/ECOSIM" [pdf, 0.37 MB] Appendix G: Proposal for a BASS Workshop on "Linkages between open and coastal systems" [pdf, 0.15 MB] References [pdf, 0.14 MB] (97 page document)

Observations of the biological communities at Bolsa Chica artificial reef

Bolsa Chica Artificial Reef (BCAR) was constructed in November 1986 with 10,400 tons of concrete rubble and eight concrete and steel barges. Prior to any additional augmentation of BCAR, the u.s. Army Corps of Engineers and the California Coastal Commission required the California Department of Fish and Game (CDFG) to survey the bioloqical communities on and around BCAR. In April 1992, qualitative surveys of the biological communities were conducted on one of the eight modules at BCAR and at a nearby sand-only site. One of the modules, Module D, located in 90 feet of water (MLLW), was surveyed for fish, macroinvertebrates, and turf community organisms (small plants and sessile animals). Twelve species of fish were observed, including kelp bass (Paralabrax clathratus) and barred sand bass (P. nebulifer). Eight macroinvertebrate species were observed, rock scallops (Crassedoma giganteum) being the most abundant. The turf community was comprised of thirteen invertebrate taxa, among which erect ectoprocts (Bugula spp.) were the most numerous. Two species of foliose red algae (Rhodymenia pacifica and Anisocladella pacifica) were also observed. The reef has reached an advanced stage of successional development with fish and invertebrate communities diverse and well established. However, due,.to its depth and the turbidity of surrounding waters, this reef is not likely to ever support a diverse algal community. The diversity and abundance of fish and macroinvertebrates were, as to be expected, much lower in the nearby sand-only site. Only two species of fish and seven macroinvertebrate species were observed. Of these, only the sea pen, Stylatula elongata, was common. Overall, when compared to nearby sand-only habitats, Bolsa Chica Artificial Reef appears to contribute substantially to the local biological productivity. In addition, the concrete rubble used in BCAR' s construction appears to be performing as well as the quarry rock used in all of CDFG's experimental reefs. (Document pdf contains 22 pages)