[Letter from John T. Kirkland to Theophilus Parsons,

This folder contains two documents: an original letter presumably in Kirkland's handwriting and a copy of the original in someone else's handwriting.

Letter from John T. Kirkland to Charles Sigourney,

This folder contains a typewritten copy of Kirkland's original letter. The location of the original is unknown.

Bond, Robert, 2 autographed letters signed to John Winthrop; East Hampton, Conn., 1651 March 8-March 10

Correspondence regarding advice Winthrop had given to Bond's family, and requesting he remit instructions for treating an illness of a neighbor's children.

Odell, Richard, 2 autographed letters signed to John Winthrop; Southampton, Long Island, 1652 November 16-1653

Correspondence concerning an illness, which Odell believed was palsy or the King's evil (scrofula), that afflicted his five-year-old daughter. Odell writes that her symptoms included loss of speech and feeling in her right side, and a throat blockage, and he requests advice from Winthrop on the course of treatment the family should pursue. Odell writes again in 1653 thanking Winthrop for the ointment and electuary he had prescribed for the child. Her symptoms had persisted, however, and he requested further advice. Odell adds several lines regarding rumors of an insurrection of a Native American tribe, inquiring if Winthrop has any information regarding "how matters stand & between the Dutch & the English."

Letters from John Hubbard Church to William Jenks, 1795-1798

John Hubbard Church wrote these twelve letters to his friend and classmate William Jenks between 1795 and 1798. Church wrote the letters from Boston, Rutland, Cambridge, and Chatham in Massachusetts and from Somers, Connecticut; they were sent to Jenks in Cambridge and Boston, where for a time he worked as an usher in Mr. Vinall's school and Mr. Webb's school. Church's letters touch on various subjects, ranging from his increased interest in theology and his theological studies under Charles Backus to his seasickness during a sailing voyage to Cape Cod. Church also informs Jenks of what he is reading, including works by John Locke, P. Brydone, James Beattie, John Gillies, Plutarch, and Alexander Pope. He describes his work teaching that children of the Sears family in Chatham, Massachusetts, where he appears to have spent a significant amount of time between 1795 and 1797. Church's letters are at times very personal, and he often expresses great affection for Jenks and their friendship.

An elegie on the deplored decease of that truly pious and religious matron, Mrs. Sara Leveret: relict of the late hon[or]able John Leveret, Esq., sometime governor of his then Majesty's colony of the Massethusets [sic] Bay in New England : manuscript, 1704

Autograph copy, signed.

John Warren's copy of votes from a meeting of the Boston Medical Society, 1784 May 3

This document lists the eleven votes cast at a meeting of the Boston Medical Society on May 3, 1784. It was authorized as a "true coppy" by Thomas Kast, the Secretary of the Society. The following members of the Society were present at the meeting, all of them doctors: James Pecker, James Lloyd, Joseph Gardner, Samuel Danforth, Isaac Rand, Jr., Charles Jarvis, Thomas Kast, Benjamin Curtis, Thomas Welsh, Nathaniel Walker Appleton, and doctors whose last names were Adams, Townsend, Eustis, Homans, and Whitwell. The document indicates that a meeting had been held the previous evening, as well (May 2, 1784), at which the topics on which votes were taken had been discussed. The votes, eleven in total, were all related to the doctors' concerns about John Warren and his involvement with the emerging medical school (now Harvard Medical School), that school's relation to almshouses, the medical care of the poor, and other related matters. The tone and content of these votes reveals anger on the part of the members of the Boston Medical Society towards Warren. This anger appears to have stemmed from the perceived threat of Warren to their own practices, exacerbated by a vote of the Harvard Corporation on April 19, 1784. This vote authorized Warren to apply to the Overseers of the Poor for the town of Boston, requesting that students in the newly-established Harvard medical program, where Warren was Professor of Anatomy and Surgery, be allowed to visit the hospital of the almshouse with their professors for the purpose of clinical instruction. Although Warren believed that the students would learn far more from these visits, in regards to surgical experience, than they could possibly learn in Cambridge, the proposal provoked great distrust from the members of the Boston Medical Society, who accused Warren of an "attempt to direct the public medical business from its usual channels" for his own financial and professional gain.

Knock-out of Arabidopsis metal transporter gene IRT1 results in iron deficiency accompanied by cell differentiation defects

IRT1 and IRT2 are members of the Arabidopsis ZIP metal transporter family that are specifically induced by iron deprivation in roots and act as heterologous suppressors of yeast mutations inhibiting iron and zinc uptake. Although IRT1 and IRT2 are thought to perform redundant functions as root-specific metal transporters, insertional inactivation of the IRT1 gene alone results in typical symptoms of iron deficiency causing severe leaf chlorosis and lethality in soil. The irt1 mutation is characterized by specific developmental defects, including a drastic reduction of chloroplast thylakoid stacking into grana and lack of palisade parenchyma differentiation in leaves, reduced number of vascular bundles in stems, and irregular patterns of enlarged endodermal and cortex cells in roots. Pulse labeling with 59Fe through the root system shows that the irt1 mutation reduces iron accumulation in the shoots. Short-term labeling with 65Zn reveals no alteration in spatial distribution of zinc, but indicates a lower level of zinc accumulation. In comparison to wild-type, the irt1 mutant responds to iron and zinc deprivation by altered expression of certain zinc and iron transporter genes, which results in the activation of ZIP1 in shoots, reduction of ZIP2 transcript levels in roots, and enhanced expression of IRT2 in roots. These data support the conclusion that IRT1 is an essential metal transporter required for proper development and regulation of iron and zinc homeostasis in Arabidopsis.

Ann Barry Allen; Mrs. John Allen

On verso: This was said to be a picture of Ann Isabella Barry McCue Allen. She was born Jan. 22, 1797 daughter of Ihmus Barry (& brother of Andrew) & Ann Isabella Smith of New Kent, Md. The birthplace is given by John McCue at Staunton Va. She died there Nov. 28, 1876 at the home of her daughter Sarah Allen Waddell. Her first husband was Wm McCue M.D. born July 14, 1787 Augusta Co. Va. Died Nov. 7 1818 of flu. Her first husband was a man of prominence & education. She had two children Thomas W. McCue and John McCue

Historical materials in the John Fitzgerald Kennedy Library /

Mode of access: Internet.

Old family letters: copied from the originals for Alexander Biddle.

Mode of access: Internet.