Nile River Delta, Egypt, 1785 (Raster Image)

This layer is a georeferenced raster image of the untitled historic paper map: Basse Egypte, E. Giraud, sculp. It was published by Onfroi in 1785. Scale [ca. 1:550,000]. Covers the Nile River Delta, Egypt. Map in French. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Africa Lambert Conformal Conic projected coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, canals, ancient branches of river and canals, cities and other human settlements, monasteries, shoreline features, and more. Relief shown by hachures. This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

South America, 1807 (Image 1 of 7) (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Colombia Prima or South America : in which it has been attempted to delineate the extent of our knowledge of that continent, extracted chiefly from the original manuscript maps of ... Pinto, likewise fom those of João Joaquin da Rocha, João da Costa Ferreira ... Francisco Manuel Sobreviela &c. and from the most authentic edited accounts of those countries, digested & constructed by ... Louis Stanislas D'Arcy Delarochette. It was published by William Faden geographer to His Majesty and to His Royal Highness the Prince of Wales in June 4th, 1807. Scale [ca. 1:3,000,000]. This layer is image 1 of 7 total images of the eight sheet map, representing the southeast portion of the map.The image inside the map neatline is georeferenced to the surface of the earth and fit to the South America Lambert Conformal Conic projected coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, cities and other human settlements, roads, territorial boundaries, shoreline features, mines, tribes, and more. Relief shown by hachures. Includes notes.This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

Die analytische und höhere geometrie in ihren elementen, mit vorzüglicher berücksichtigung der theorie der kegelschnitte...Erste fortsetzung seiner reinen elementar-mathematik.

Added title-page: Algebraische, geometrische und trigonometrische uebungen im gewande einer analytischen geometrie.

A discussion by synthetic methods of two projective pencils of conies

Presented as author's thesis.

Teoremi di Chasles : sopra le proprietà dei sistemi di coniche ([mu], [nu]), che servono di base alla determinazione del numero di queste curve, che soddisfanno a cinque condizioni qualunque :nota /

Includes bibliographical references.

Encyclopaedia of pure mathematics.

Articles reprinted from Encyclopaedia metropolitana.

Vorlesungen über synthetische Geometrie.

v. 1 Die Theorie der Kegelschnitte in elementarer Darstellung. Bearb. von Dr. C. F. Geiser. 3 Aufl.--v. 2 Die Theorie der Kegelschnitte, gestützt auf projectivische Eigenschaften. Bearb. von Dr. Heinrich Schröter. 2 Aufl.

Analytische geometrie der kubischen kegelschnitte,

Available on demand as hard copy or computer file from Cornell University Library.

Researches on curves of the second order, also on cones and spherical conics treated analytically, in which the tangencies of Apollonius are investigated, and general geometrical constructions deduced from analysis; also several of the geometrical conclusions of M. Charles are analytically resolved, together with many properties entirely original.

Available on demand as hard copy or computer file from Cornell University Library.

Die Theorie der Kegelschnitte, gestutzt auf projektivische Eigenschaften.

Mode of access: Internet.

Traité analytique des sections coniques et de leur usage pour la résolution des équations dans les problêmes tant déterminez qu'indéterminez.

Mode of access: Internet.

Compendio delle sezioni coniche d'Apollonio : con aggiunta di nuove proprietá delle medesime seizioni /

Mode of access: Internet.

Constructive geometry of plane curves, with numerous examples,

Mode of access: Internet.

Notes and problems on solid geometry : [Text of C. Smith] /

Author's autograph on fly-leaf.

Patched1 functions as a gatekeeper by promoting cell cycle progression

Mutations in the Hedgehog receptor, Patched 1 (Ptch1), have been linked to both familial and sporadic forms of basal cell carcinoma (BCC), leading to the hypothesis that loss of Ptch1 function is sufficient for tumor progression. By combining conditional knockout technology with the inducible activity of the Keratin6 promoter, we provide in vivo evidence that loss of Ptch1 function from the basal cell population of mouse skin is sufficient to induce rapid skin tumor formation, reminiscent of human BCC. Elimination of Ptch1 does not promote the nuclear translocation of beta-catenin and does not induce ectopic activation or expression of Notch pathway constituents. In the absence of Ptch1, however, a large proportion of basal cells exhibit nuclear accumulation of the cell cycle regulators cyclin D1 and B1. Collectively, our data suggest that Ptch1 likely functions as a tumor suppressor by inhibiting G(1)-S phase and G(2)-M phase cell cycle progression, and the rapid onset of tumor progression clearly indicates Ptch1 functions as a gatekeeper. In addition, we note the high frequency and rapid onset of tumors in this mouse model makes it an ideal system for testing therapeutic strategies, such as Patched pathway inhibitors.