Moderate Exercise Reduces Food Consumption in Obese Mice for Activate Jak-2/Stat-3 Pathway in the Hypothalami

It is very known that due to inflammatory processes the obesity leads to resistance to leptin, it reduces phosphorylation via JAK-2/STAT-3, which generates lower STAT-3 activity in the cell nucleus, and it leads to decrease the number of transcription of anorexigenic neurons (POMC/CART) and allowing transcription of orexigenic (NPY/AgRP). PURPOSE: The present study aimed to evaluate the effects of moderate aerobic training on food intake of obese mice through analysis of activity of hypothalamic proteins JAK-2/STAT-3. METHODS: It were used 30 Swiss mice (30 days old) divided into 3 groups: Control Group (C): sedentary animals fed with balanced diet ; Obese (OB) sedentary animals fed with high-fat diet throughout the experiment and Trained Obese (TOB) : animals fed with high fat diet throughout the experiment , kept sedentary during the first half of the experiment (8 weeks) and submitted to physical training protocol during the second half of the experiment (8 weeks). The exercise program consisted of treadmill running 1h, 5 days/week during 8 weeks at a speed equivalent to 60 % of maximum potency determined at the beginning of training period. To assess the leptin resistance, after rats were deprived of food for 6h with free access to water, they received i.p injection with leptin (2.0µl, 10-6M), after this, the chow was returned and food intake was determined by measuring the quantity and Kcal consumed at the end of 2h. The hypothalami was removed for determination of JAK-2 and STAt-3 activity. RESULTS: Our results showed that moderate physical exercise was effective in improving the JAK/STAT signaling pathway in the hypothalamus of obese animals. This has made these obese animals had reduced food intake and consequently lower body mass gain. CONCLUSION: It can be concluded that physical exercise, for restoring leptin signaling in the hypothalamus, controls the synthesis of neurons responsible for appetite and thus is an important tool in the treatment of obesity.

Prevalence of physical activity through the practice of sports among adolescents from Portuguese speaking countries

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Inquérito de suplementação nutricional e experiência no treinamento resistido entre jovens do interior e litoral paulista

To the practitioners of resistance exercise, a better performance is associated with nutritional habits and the help of nutritional supplements. Whatever, this use has been made improperly and without foundation, advised by persons not trained, leading to misuse. To analyze the profile of practitioners in the knowledge of and access to supplements, as well as knowledge about the sport and the need to use additional food resources. A questionnaire will be used to youths aged 15 to 21 consumers of nutritional supplements on the sports, the substance used, why the substance used, who appointed her, which substances have been used, satisfaction with that product, and socioeconomic characteristics of the individual. The data will be correlated by Pearson's correlation coefficient. It is expected that the abuse of supplements is associated with ease by socioeconomic status and experience in the sport for the little progress with the adoption of a routine training exercise in the circumstances only. The major difference compared to the goal of practice, was the motivation for the improvement of physical fitness (Guaruja 21% and Bauru 9.6%), with the intention of increasing muscle mass response occurring closer (Guaruja 22% and Bauru 19.2%) among respondents, and reported more emphasis on the Interior Health (17.3%). The use of supplements is somewhat similar to trends involving body aesthetics and fitness for participation in sports, in the Coast (hypertrophy: 33% body fat reduction, improved endurance and improved performance in sports: 20%), and beauty, fitness and health, the Interior (hypertrophy: 41% increase in strength: 22%, and quality of life: 15%). Interest in the use of supplements is mostly aimed at the improvement of overload training (Guaruja 67% and Bauru 56%) but the sources of information on the use of supplements have become more secure among the respondents of the Interior (gym teacher: 20%, Conferences and Symposia: 12%, and the...

Excess body weight and gait influence energy cost of walking in older adults

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

A influência da orientação motivacional durante o treinamento de atletas iniciantes no tênis de campo

The motivation in the sport has been one of the most studied subjects nowadays, as much that some authors say that the motivation is the base for the success of an athlete, that is, the psychological part must also well be stimulated so that if it reaches the maximum level of concentration during a game it will obtains the expected result. Tennis is one of the sports that more grew in recent years, and together with this fast ascension also increased the number of interested in researching in this area of the Psychology of the Sport. The present study has as objective to begin the adaptation and validation of the interest scale and to analyze the influence of the motivational orientation of the athletes in the sportive performance of the Tennis through the application of scale Teosq – Task and Ego Orientation in Sport Questionnaire (DUDA, 1992), translated, adapted and validated by Hirota and De Marco (2006), where we can identify if the individual is guided for a task or an ego’s goal. This research was carried through in a situated academy of Tennis in the City of Cotia – SP – Brazil, counting on the participation of 20 citizens with age between 09 and 18 years of both the practicing sexes of Tennis. The calculation of the Alpha Coefficient of Cronbach was adopted as statistical method, in order to identify the trust worthy and validity of the instrument beyond the average of each orientation, to be able to verify the athlete’s motivational orientation. For the analysis of the results, the Alpha Coefficient was observed high, compared with previous studies, reaching values of orientation for the ego of 0,90, and 0,70 of orientation for task. They had been registered the following averages, 4,20 (+0,93) and 2,42 (+0,85), respectively of orientation for task and ego. With those results we can point that, the scale applied with the proposal to identify the motivational orientation of the athletes of Tennis, revealed efficiency, and trust worthy in its application, and in accordance with the results, the athletes are guided for task, revealing self-determination, selfconfident, more creative and they judge its success for the quality of the carried through work.