PPAR-mediated activity of phthalates: A link to the obesity epidemic?

The endocrine disruption hypothesis asserts that exposure to small amounts of some chemicals in the environment may interfere with the endocrine system and lead to harmful effects in wildlife and humans. Many of these chemicals may interact with members of the nuclear receptor superfamily. Peroxisome proliferator-activated receptors (PPARs) are such candidate members, which interact with many different endogenous and exogenous lipophilic compounds. More particularly, the roles of PPARs in lipid and carbohydrate metabolism raise the question of their activation by a sub-class of pollutants, tentatively named "metabolic disrupters". Phthalates are abundant environmental micro-pollutants in Europe and North America and may belong to this class. Mono-ethyl-hexyl-phthalate (MEHP), a metabolite of the widespread plasticizer di-ethyl-hexyl-phthalate (DEHP), has been found in exposed organisms and interacts with all three PPARs. A thorough analysis of its interactions with PPARgamma identified MEHP as a selective PPARgamma modulator, and thus a possible contributor to the obesity epidemic.

13/11/19, affiches électorales [panneaux électoraux dans la rue pour les élections législatives du 16 novembre 1919] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 56908

RTM mould design and construction for a DN 50 PN 16 flansch

The objective of this project consists of designing and constructing a RTM mould for a loose flange of glass fibre reinforced plastic (GRP). The design phase has the mission to realise a quality and simple design of the RTM mould, with the objective to obtain an easy and economic phase of construction and the more possible great characteristics of the loose flange. In fact this RTM mould will be a mould prototype, which will be developed in the future to obtain an RTM mould able to support a loose flange production. Therefore when more steps are developed in this project, then the future objective will be near

ABD e-News, May 16, 2003

Newsletter for State of Iowa Alcoholic Beverages Division

Tools and Trends, July 2001, Issue 16

Newsletter for Ecnonmic Development

Général Maud'huy [16-1-20, cour du Sénat, vote préparatoire à l'élection présidentielle] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57669

Lottery Action, August 19-September 8, 2002 Vol. 9, no. 16

Iowa Lottery Authority Retailer Information Newsletter

Lottery Action, December 16, 2002-January 5, 2003, Vol. 9, no. 24

Newsletter for Iowa Lottery

Lottery Action, August 11-24, 2003, Vol. 10 no. 16

Iowa Lottery Authority Retailer Information Newsletter

Lottery Action, June 16-29, 2003, Vol. 10, no. 12

Newsletter for Iowa Lottery

M.Dubois [Louis] ministre du Commerce [16-1-20, cour du Sénat, vote préparatoire à l'élection présidentielle] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57668

Missing Persons Summary, June 16, 2003

Missing person report

Missing Persons Summary, December 16, 2002

Missing person report