Report on a review of selected general and application controls over the Iowa Department of Transportation’s Internal Billing System for the period April 6, 2009 through July 31, 2009

Report on a review of selected general and application controls over the Iowa Department of Transportation’s Internal Billing System for the period April 6, 2009 through July 31, 2009

Report on the review of selected general and application controls over the State University of Iowa (University of Iowa) ePro System for the period June 15, 2009 through July 31, 2009

Report on the review of selected general and application controls over the State University of Iowa (University of Iowa) ePro System for the period June 15, 2009 through July 31, 2009

Report on a special investigation of certain driver’s license collections at the Sioux County Treasurer’s Office for the period July 1, 2009 through May 31, 2010

Report on a special investigation of certain driver’s license collections at the Sioux County Treasurer’s Office for the period July 1, 2009 through May 31, 2010

Report on a special investigation of the City of Alburnett for the period January 1, 2006 through December 31, 2009

Report on a special investigation of the City of Alburnett for the period January 1, 2006 through December 31, 2009

Audit report on the Iowa Turkey Marketing Council for the years ended December 31, 2009 and 2008

Audit report on the Iowa Turkey Marketing Council for the years ended December 31, 2009 and 2008

Report on a special investigation of the Region 4 Fusion Office in Atlantic, Iowa for the period March 1, 2006 through August 31, 2009

Report on a special investigation of the Region 4 Fusion Office in Atlantic, Iowa for the period March 1, 2006 through August 31, 2009

The Iowa Perinatal Letter, July, August, September 2010, Vol. 31, no. 3

This newsletter from The Department of Public Health about perinatal health care and statistics.

Rebuild Iowa Office Federal Recovery Framework Recommendations, Updated August 31, 2010.

The Rebuild Iowa Office and its' state and local partners recommendations about improving and streamlining the state and federal disaster recovery framework.

Report on the Department of Commerce, Alcoholic Beverages Division for the month ended May 31, 2010

Report on the Department of Commerce, Alcoholic Beverages Division for the month ended May 31, 2010

Human natural Treg microRNA signature: role of microRNA-31 and microRNA-21 in FOXP3 expression.

Treg are the main mediators of dominant tolerance. Their mechanisms of action and applications are subjects of considerable debate currently. However, a human microRNA (miR) Treg signature has not been described yet. We investigated human natural Treg and identified a signature composed of five miR (21, 31, 125a, 181c and 374). Among those, two were considerably under-expressed (miR-31 and miR-125a). We identified a functional target sequence for miR-31 in the 3' untranslated region (3' UTR) of FOXP3 mRNA. Using lentiviral transduction of fresh cord blood T cells, we demonstrated that miR-31 and miR-21 had an effect on FOXP3 expression levels. We showed that miR-31 negatively regulates FOXP3 expression by binding directly to its potential target site in the 3' UTR of FOXP3 mRNA. We next demonstrated that miR-21 acted as a positive, though indirect, regulator of FOXP3 expression. Transduction of the remaining three miR had no direct effect on FOXP3 expression or on the phenotype and will remain the subject of future investigations. In conclusion, not only have we identified and validated a miR signature for human natural Treg, but also unveiled some of the mechanisms by which this signature was related to the control of FOXP3 expression in these cells.

Report on the City of Truesdale for the period July 1, 2006 through December 31, 2010

Report on the City of Truesdale for the period July 1, 2006 through December 31, 2010

Agreed upon procedures report on the City of Lohrville, Iowa for the period December 1, 2008 through October 31, 2010

Agreed upon procedures report on the City of Lohrville, Iowa for the period December 1, 2008 through October 31, 2010

Iowa Office of the State Medical Examiner Newsletter, October 31, 2007, no. 3

The official newsletter of the Iowa Office of the State Medical Examiner.

Audit report on the Iowa Corn Promotion Board for the years ended August 31, 2010 and 2009

Audit report on the Iowa Corn Promotion Board for the years ended August 31, 2010 and 2009