Sínteses e estudos dos diferentes peptídeos de fusão dos flavivirus causadores da dengue

Pós-graduação em Biotecnologia - IQ

Translation, cultural adaptation to Brazil and validation of the venous leg ulcer quality of life questionnaire (VLU-QoL-Br)

Objetivo:traduzir o instrumento Venous legulcer quality of life questionnaire (VLU-QoL), adaptá-lo culturalmente para o português do Brasil e validá-lo com pacientes do Hospital das Clínicas da Faculdade de Medicina de Botucatu (FMB) da Universidade Estadual Paulista (Unesp). Métodos:o questionário foi traduzido por um tradutor profissional e por dois dermatologistas especialistas na área de úlceras venosas (UV), sendo reformulado em reunião com os três tradutores. O constructo (VLU-QoL-Br) foi submetido a pré-entrevista com 10 portadores de UV para a adaptação da linguagem. Posteriormente, foi aplicado em pacientes do HC-Unesp, e como teste-reteste para verificação de sua reprodutibilidade. Resultados:foram avaliados 82 pacientes, sendo 56 (68%) do sexo feminino. A idade média foi de 67,3 anos. O questionário foi traduzido, adaptado e aplicado aos pacientes. O constructo apresentou alta consistência interna (alfa= 0,94) e adequada correlação item-total. Quando avaliados os 32 retestes, observou-se correlação intraclasse para concordância de 0,78 (p < 0,01), indicando boa reprodutibilidade do constructo. A análise fatorial confirmatória corroborou as dimensões do questionário original: atividades, psicológico e sintomas. Escores do VLU-QoL-Br se associaram, independentemente, à área total das úlceras e a menor escolaridade dos sujeitos (p < 0,01). Conclusão:a tradução, a adaptação e a validação do questionário VLU-Qol-Br demonstrou boa performance psicométrica, permitindo seu uso clínico no Brasil. É importante avaliar seu desempenho em outras regiões e em diferentes amostras de indivíduos.

Revendo estudos sobre a assistência domiciliar ao idoso

Home care presents itself as a new modality of care for the elderly, especially in Brazil , and has been inserted into public policies. This study aims to identify scientific productions about home care, in order to ascertain which are the contributions of this social dynamic in the elderly. The research was conducted in the databases MEDLINE and LILACS, with articles published between the years 2001- 2011, in Portuguese and English. The combination of keywords used was home care and elderly , elderly and care, and elderly and caregiver, and correspondents in Portuguese. The discussion highlighted the importance of home care, especially for lonely or neglected elderly. The review revealed few studies concerning the social dynamics in the home care of the elderly and the need to broaden the discussion beyond the field of health.

Qualidade dos estudos clínicos publicados na RBGO ao longo de uma década (1999-2009): aspectos metodológicos, éticos e procedimentos estatísticos

OBJETIVO: Avaliar a evolução metodológica e do delineamento estatístico nas publicações da Revista Brasileira de Ginecologia e Obstetrícia (RBGO) a partir da resolução 196/96. MÉTODOS: Uma revisão de 133 artigos publicados nos anos de 1999 (65) e 2009 (68) foi realizada por dois revisores independentes com formação em epidemiologia clínica e metodologia da pesquisa científica. Foram incluídos todos os artigos clínicos originais, séries e relatos de casos, sendo excluídos os editoriais, as cartas ao editor, os artigos de revisão sistemática, os trabalhos experimentais, artigos de opinião, além dos resumos de teses e dissertações. Características relacionadas com a qualidade metodológica dos estudos foram analisadas por artigo, por meio de check-list que avaliou dois critérios: aspectos metodológicos e procedimentos estatísticos. Utilizou-se a estatística descritiva e o teste do χ2 para comparação entre os anos. RESULTADOS: Observa-se que houve diferença entre os anos de 1999 e 2009 no tocante ao desenho dos estudos e ao delineamento estatístico, demonstrando maior rigor nos respectivos procedimentos com o uso de testes mais robustos, relativamente, entre os anos de 1999 e 2009. CONCLUSÕES: Na RBGO, observou-se evolução metodológica dos artigos publicados entre os anos de 1999 e 2009 e aprofundamento nas análises estatísticas com o uso de testes mais sofisticados, como o uso mais frequente das análises de regressão e da análise multinível, que são técnicas primordiais na produção do conhecimento e planejamento de intervenções em saúde. Isso pode resultar em menos erros de interpretações.

Delineamentos experimentais eficientes para estudos de cinética química

In this paper we show how to obtain efficient designs of experiments for fitting Michaelis-Menten and Hill equations useful in chemical studies. The search of exact D-optimal designs by using local and pseudo-Bayesian approaches is considered. Optimal designs were compared to those commonly used in practice using an efficiency measure and theoretical standard errors of the kinetic parameter estimates. In conclusion, the D-optimal designs based on the Hill equation proved efficient for estimating the parameters of both models. Furthermore, these are promising with respect to practical issues, allowing efficient estimation as well as goodness-of-fit tests and comparisons between some kinetic models.

Peptídeos derivados da toxina ParE: síntese, estrutura e estudos de inibição de DNA topoisomerases

Pós-graduação em Biotecnologia - IQ

Análise dos procedimentos metodológicos utilizados na definição de áreas de influência e níveis de significância em estudos de impacto ambiental de dutovias

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Estudos metabolômicos entre interações da rizosfera de Senna spectabilis e rizobacterias associadas

Pós-graduação em Química - IQ

Desenvolvimento e caracterização de sistemas líquido-cristalinos para aplicação tópica de metotrexato: estudos de liberação, retenção e permeação in vitro

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Concepções dos estudos de usuários na visão dos professores dos cursos de Biblioteconomia brasileiros

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Psychometric Properties of the Oral Health Impact Profile and New Methodological Approach

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Long latency auditory evoked potential in Asperger Syndrome: two case studies

Introduction: Auditory Late Responses (ALR) assess central auditory processing by neuro electric activity of the auditory pathway and analyse the activities involved in cortical abilities of discrimination, attention and integration of the brain. Individuals withAsperger Syndrome experience changes in these skills, so it is important to research these potential this population. The objective of this paper was to describe the auditory late responses of two patients with Asperger Syndrome. Methods: The study included two male patients with Asperger Syndrome, of 7 and 12 years of age, treated in a study centre. The patients did not present any auditory complaint detected by an amnesis. The external auditory canal was inspected and audiological and auditory late responses assessed. After evaluation the components P2, N2 and P3 were analysed. Results: In both patients, the latency of the components P2, N2 and P3 were elongated in both ears. Regarding the amplitude of the P2 component, reduced values were found for the left ear of patient 1 and the right ear of patient 2. The N2 amplitude was reduced for both ears of patient 1 and only the right ear of patient 2. The two patients showed a decrease in the amplitude of the P3 only in the right ear. Conclusion:This study concludes that there were changes in the ALR results in both patients with Asperger Syndrome, suggesting alteration of the auditory function at the cortex level.

A inserção e o impacto internacional da pesquisa brasileira em 'estudos métricos': uma análise na base Scopus

This research aims at analyzing the Brazilian scientific contribution on “metric studies” in the mainstream science through journals indexed in the Scopus basis, intending to visualize its insertion and international impact in the area. Mainly, to diachronically study the researches, the most productive authors and the scientific support network generated among them, as well as to identify the journals in which such production has been disseminated. It is based upon the three main target groups of current bibliometrics, as in Glänzel’s perspective (2003), and upon the impact of Brazilian researches in the international community through the citations received. Were found 263 articles and tables concerning the diachronical study and the highlighted researchers and journals were constructed analyzing the insertion in the target groups, the number of articles, number of citations and the average of citations. As results, researchers from the Federal Universities of Rio de Janeiro and São Paulo have stood out. All the researchers permeate the application of metric studies to several scientific areas, with emphasis on the health and biological sciences. The least contemplated researches were the ones whose objective was to develop and to discuss the bibliometrics as methodology, contributing to its on conceptual-theoreticalmethodological development, as well as those focusing on contributing, assessing and guiding scientific policies. We conclude by suggesting scientific and academic policies which motivate the researchers to publish in journals indexed in international bases in order to internationalize Brazilian science.

Estudos de Análise de Cocitação de Autores: uma abordagem teórico-metodológica para a compreensão de um domínio

This piece of research aims at analyzing the absolute and relative co-citation indicators, especially Salton’s Cosine and comparing the contribution of these indicators to the understanding of a domain, applying them to the universe of "Metric Studies" at the BRAPCI base. It also aims at presenting the co-citation network generated from the absolute frequencies and highlighting the groupings of co-cited authors, depending on the relative values, integrating and explaining the information from the two indexes. The domain analysis, by means of its 11 approaches, including “Bibliometric Studies”, focuses on the science characterization and evaluation, in that it allows us to identify and to analyze the conditions under which the scientific knowledge is constructed and socialized. In these studies, the contribution of citation and co-citation analysis is highlighted. Of the total of 147 articles retrieved at BRAPCI base, the authors cited in at least 11 articles, in a total of 38 researchers, were selected. The 38 x 38 symmetric matrix with the absolute frequencies of co-citation and the matrix with the relative values of Salton’s Cosine were generated. The co-citation network with absolute frequency values were constructed, through Ucinet software. Cluster analysis of data with relative values wer performed, using the SPSS software. Significant differences between the absolute and relative indexes, with some high absolute values of co-citation were observed; when considered in relation to the presence of each author, their significance is decreased. As to the generated network, seven groups were determined, in which only one is established for close themes and comes from co-citations in the original sense of the term. Five groups present closeness in absolute and relative indicators. It can be concluded about the importance of the studies of authors' co-citation analysis, which associate the two indexes, absolute and relative, in order to visualize and understand the underlying structures of a scientific domain.

Atitudes sociais em relação à inclusão: estudos brasileiros

An important component of the Inclusive Education can be the social attitudes toward inclusion presented by teachers, students and other members of the school community. The aim of this paper is to systematize main fidings of some Brazilian studies concerning that theme. The results of studies in which the Likert Scale of Social Attitudes toward Inclusion was used are summarized. Twelve studies were analyzed, examining the relationship between the social attitudes toward inclusion and some subjects characteristics, highlighting the chronological age, formation area, educational experience and previous experience with people with deficiency. The results were not able to demonstrate in a conclusive way the nature of the relationship between each of these variables and the social attitudes toward inclusion. These seem to be affected by a group of complexly related variables of the subjects and of the target of social attitudes.