Efeito de extratos vegetais na parasitemia do Trypanosoma cruzi e na biodistribuição do pertecnetato de sódio (Na99mTcO4)

Artemisia vulgaris (AV) is an antihelmintic and antimalarial drug; Aloe vera(babosa) acts as antidiabetic, laxative and anti-inflammatory; Benznidazole (BZ) is a trypanocidal of Trypanosoma cruzi (TC). Technetium-99m (99mTc) has been used in nuclear medicine to obtain diagnostic images. This study evaluated the plant effects in TC parasitemia and in the biodistribution of 99mTc in mice. Twenty mice were infected by TC. At the peak of parasitemia, 5 mice received babosa; 5 received AV and 5 received BZ. The parasitemia was determined in 0, 2, 4 and 6 h of drugs administration. Five infected mice without drugs, 5 mice without TC and the group treated with AV, received 99mTc. The radioactivity was calculated. Infected mice that received babosa reduced significantly (p<0.05) the parasitemia. The percentage of activity (%ATI) decreased significantly in the AV group. These results indicate that babosa possibly is an anti-TC drug and AV reduces the %ATI probably due to its biological effects

O amor em tempos de internet: as expectativas amorosas na rede social Badoo

This research aims to examine the phenomenon of sexual relations by observing the Social Network Badoo. As a means to achieve this objective, qualitative in-depth interviews were conducted online. The main question is to understand how the amorous expectations in the liquid modernity are configured. Added to that, there is as analysis categories the insight about relationships and the love experiences provided by the use of the Social Network Badoo. There are three initial hypotheses: 1) a time of transition is experienced, in which the liquid love in the proposed terms by Bauman (2004) was gaining ground and, as consequence, the relationships would be presenting themselves shorter, more open and with another interactive proposals for the relations. 2) The consuming practices of the liquid modernity can interpellate the relational practices molding them according to your logic. 3) It is assumed that the reasoning, inherent to the market, of the use followed by the disposal settles itself in the social behavior and this practice is accentuated by technology, through the use of the internet for the establishment of romantic relationships.the empirical analysis shows that both the vision on relationships as the amorous expectations in liquid modernity have as references the model of solid loving relationship, inherent to the traditional modernity. However it also demonstrates that the romantic experiences and practices refer to the liquid relationship model. Therefore, from these statements it is argued that there is in liquid modernity the cohabitation of the liquid and solid models of romantic relationships. In summary, this research aims to understand the contemporary love relationships across the spectrum of relationships that develop on the Internet Social Network: Badoo

Ernst Bloch: esperança e educação em tempos de niilismo

This work aims give evidence of that The hope principle, the philosophical system devised by the German philosopher Ernst Bloch, in which hope assumes an ontological character, offers cognitive support that allows overcoming the void imposed by nihilism today, especially in the field of education. But while it offers cognitive support, it also presents a need that is fulfilled by an educational proposal based on a not-yet-conscious being. An education based on hope has four essential pillars: learning to know, learning to do, learning to be, learning to live together and, most of all, immerging into in the seas of uncertainty. In times when school is a promoter of certainties at the expense of uncertainties, education must not forsake the notion of the unpredictable and immeasurable, nor the need to find ways to enable better understanding of aspect related to the not-yet-be. The employed theoretical and methodological elements in this work paint a corpus through an interactive process in which layers of additional texts are subjected to analysis

Acute phase proteins: a potential approach for diagnosing chronic infection by Trypanosoma vivax

O objetivo do presente estudo foi verificar possíveis alterações nas proteínas de fase aguda em ovinos infectados experimentalmente com Trypanosoma vivax. Para tanto, foram utilizados oito ovinos machos, sendo quatro usados como controle e quatro infectados com 10(5) tripomastigotas de T. vivax. Colheram-se amostras de sangue em dois tempos antes da infecção e, posteriormente, aos 5, 7, 9, 11, 13, 15, 20, 30, 45, 60, 75, 90, 105 e 120 dias após a infecção (dpi); após centrifugação e aliquotização das amostras. As proteínas de fase aguda foram separadas por eletroforese em gel de acrilamida, contendo dodecil sulfato de sódio, e suas concentrações foram determinadas através de densitometria computadorizada. A dosagem de proteína total foi realizada pelo método colorimétrico do biureto. A contagem dos tripanossomas foi realizada diariamente, utilizando-se uma alíquota de 5 µL de sangue disperso em lâmina de microscopia, sob lamínula de 22 × 22 mm, contando-se os parasitos em 100 campos microscópicos, com objetiva de 40×, multiplicados pelo fator de correção do microscópio, e o resultado expresso em parasitos por mL de sangue. Para a análise estatística, empregou-se o teste de Wilcoxon a 5% de probabilidade. Foi observada a diminuição de diversas proteínas de fase aguda e aumento de antitripsina e transferrina que podem ser utilizadas para auxiliar no diagnóstico da infecção por T. vivax, principalmente na fase crônica da infecção.

O progama empregador de última instância: Sua relevância em tempos de crises financeiras e sua aplicabilidade ao Brasil.

This dissertation aims to continue the work developed previously concerning the properties of the employer of last resort program (ELR) that would be able to promote a complete elimination of the involuntary unemployment from the economy, so much of the unemployment generated by structural problems as for problems of the conjuncture, as the present world financial crisis. Besides, it intends to deepen the study concerning the applicability of that program to the Brazilian economy, estimating their potential target population in the country and the cost with the workers' remuneration. It was presented the ELR theoretical-conceptual structure and a debate concerning their economic viability; the program properties that turn it more efficient than the onetary and fiscal policies (PMFs) in the fight against involuntary unemployment in times of financial crises; a study on its applicability to the Brazilian socioeconomic specificities and an estimate of their potential target population and of the annual wage cost in the country, as a whole, and in the specific case of the Northeast region and of the state of Rio Grande do Norte.

Paisagens sonoras, tempos e autoformação

Les sociétés actuelles vivent des temps de vitesse, de l'individualisme, de l'absence d'enracinement historique: en harmonie avec le processus de formation de la civilisation du monde occidental contemporain profondément marqué par le paradigme de la globalisation. La pollution visuelle et sonore des grandes villes est, en même temps, l'expression de la pollution des sens et des affections humaines. En reflétant sur ce processus, la thèse discuter em faveur d'une formation réglée dans la logique du sensible qu'il a dans l'écouter près de la nature (Lévi-Strauss) un de leurs piliers épistémologiques ondamentales. Cette forme de penser et vivre reconnaît dans l'autoformation (Edgar Morin), et dans l'exercice de construction, par le sujet, de leurs propres paysages sonores (Murray Schafer), deux opérateurs cognitifs capables de nourrir les principes de la diversité, complexité, interdépendance et respect à la nature (Fritjof Capra). Dans le parcours argumentatif de la thèse gagnent emphase les savoirs de la tradition, les pratiques et les connaissances produites par les sociétés le plus proche de la nature qui, par des stratégies cognitives ouvertes et des polyphoniques, donnent importance aux facultés sensibles et à la complémentarité des deux itinéraires de la pensée: symbolique/mythologique/magique et empirique/technique/rationnel (Edgar Morin). Proche d'une perspective autobiographique, la thèse se présente dans la forme narrative d'un registre avec des évocations poétiques, philosophiques et musicales germées de l'écouter d'un paysage particulier, la Lagon du Piató, localisé dans la région de l'Assu (Rio Grande do Norte) et, en particulier, des récits et des évocations de mémoire d'un de leurs habitants auxlesquels nous pourrions appeler d'un philosophe de la nature , Francisco Lucas da Silva (Chico Lucas). Ensuite, ils sont décrits non-place (Marc-Augé) des scénarios métropolitains, en discutant ainsi les excès de pollution sonore, visuelle et de l'afection. En ayant comme estimé une éducation complexe ancrée dans non séparation il entre réforme de l'éducation et reforme de la pensée, de la formation et autoformation (Edgar Morin), à la fin, la thèse propose des ateliers d'expérimentation de l'écouter sensible entre des jeunes et des enfants sur le contexte scolaire, en pariant dans les futures générations (Ilya Prigogine) pour la reconstruction d'un monde plus juste et solidaire

Dos tempos de escola aos dias atuais: reminiscências duradouras da experiência escolar

Este estudo trata sobre as marcas da experiência escolar no processo de individuação do sujeito e tem como objetivo geral conhecer de que forma essas experiências, a despeito das questões curriculares e pedagógicas, influenciam esse processo. Buscou-se interpretar as experiências reforçadas durante a escolarização e as trajetórias de enfrentamento das diversas situações vividas na escola. Tentou-se, também, compreender o sentido dos acontecimentos escolares críticos e igualmente como o meio familiar pode influenciar nas escolhas e formação dos sujeitos através do investimento pedagógico. Ademais, refletiu-se sobre os motivos que levaram alguns a permanecerem no ambiente escolar seja como estudante ou mais tarde, do lado de lá, como professor. Para tanto, foi realizada uma pesquisa qualitativa de inspiração fenomenológica utilizando-se de entrevistas narrativas com quatro sujeitos, a partir das quais se identificou as principais características, estrutura, condições de origem, o contexto social, as estratégias escolares, as formas como foram manejadas e suas conseqüências. A análise dos relatos deixou claro dois eixos fundamentais da experiência escolar que se destacam na constituição dos sujeitos: de um lado a dinâmica do ambiente escolar vivido deixou marcas indeléveis na memória que foram determinantes para as escolhas pessoais; por outro lado, a referência familiar, através das suas várias formas de investimento pedagógico, teve uma influência decisiva. As marcas combinadas da escola e da família deixaram um legado importante para formação dos sujeitos e para as escolhas que fizeram durante as suas vidas, especialmente no direcionamento da suas carreiras profissionais. Invariavelmente, percebeu-se na investigação, que muito do aluno que se foi persiste no adulto e profissional de hoje. Assim, o Eu escolar é parte do Eu profissional que existe em cada um. O cidadão, a pessoa e o profissional são derivados dos processos de socialização e individuação, os quais em grande parte se definem durante a vida escolar. E é com o uso desse "capital escolar" , adquirido nos tempos de escola, que temos condições de desenvolver os muitos papéis sociais nos dias atuais.

Biodigestão anaeróbia de dejetos de bovinos leiteiros submetidos a diferentes tempos de retenção hidráulica

Utilizando-se biodigestores contínuos, abastecidos com dejetos de bovinos leiteiros e operados sob três tempos de retenção hidráulica, avaliou-se o efeito do processo de digestão anaeróbia sobre o número de microrganismos indicadores de poluição fecal, sobre a ocorrência de ovos e larvas de helmintos parasitas de ruminantes, analisando-se também os teores de sólidos totais e voláteis do afluente e dos efluentes, bem como a produção e a qualidade do biogás produzido. Verificou-se que vinte dias de retenção hidráulica foram suficientes para reduzir significativamente o número de microorganismos indicadores de poluição fecal e a quantidade de ovos de helmintos parasitas de ruminantes. Os resultados obtidos nas análises de sólidos totais e voláteis, bem como a produção de biogás (m³/dia), permitem concluir que o biodigestor modelo Chinês operado com 20 dias de tempo de retenção hidráulica, apresentou mais eficiência. Vale ressaltar que vinte dias de retenção foram insuficientes para impedir a sobrevivência de larvas de helmintos parasitas de ruminantes.

Dos tempos de escola aso dias atuais reminiscências duradousras da experiência escolar

This study it treats on the marks of the school experience in the individuation process of the subject and has as general aim to know of that it forms these experiences, the spite of the curricular and pedagogical questions, influences this process. It searched to interpret the experiences strengthened during the school education and the trajectories of confrontation of the diverse situations lived in the school. It was tried,also,to understand the direction of the critical school events and equally as the familiar way can influence in the choices and formation of the citizens through the pedagogical investment. Furthermore, it was reflected on the reasons that had taken some to remain in the school environment are as student or, later, of the side of there ,as teacher. For in such a way, it realized a qualitative research with a phenomenological inspiration using narratives interviews carried with four subjects, from which if it identified the main characteristics, structure, conditions of origin, the social context, the school strategies, the forms as they had been managed and its consequences. The analysis of the stories clearly left two basic axles about the school experience that if detach in the constitution of the subjects: in a hand, the dynamics of the lived school environment left undeleted marks in the memory that had been determinative for the personal choices; on the other hand,the familiar reference, through its different forms of pedagogical investment,had a decisive influence. The agreed marks of the school and the family had left an important legacy for formation of the subjects and the choices that had made during their lives, especially in the aiming of its professional careers. Invariably, it was perceived in the inquiry, that much of the pupil who if was persists in the adult and professional of today. Thus, the school I it s part of professional I that it exists in each one. The citizen, the person and the professional are derived from the processes of socialization and individuation, which to a large extent are defined during the school life. And it s with the use of this school capital , acquired in the school times, that we have conditions to develop the many social roles in the current days

Atributos físicos nos tempos de adoção de manejos em Latossolo cultivado com soja

A condução das operações de preparo de forma inadequada ocasiona sérios problemas de conservação do solo, destacando-se a compactação, que acarreta a redução do espaço poroso, principalmente dos macroporos, e altera os atributos físico-hídricos. Este trabalho teve como objetivo verificar a influência dos diferentes sistemas e tempos de adoção de manejos em Latossolo Vermelho de Jaboticabal, Estado de São Paulo, por meio da densidade máxima, e correlacioná-la com a produtividade da soja, a densidade relativa e a umidade crítica de compactação. O delineamento experimental foi o inteiramente casualizado com parcelas subdivididas (cinco sistemas de uso e três camadas), com quatro repetições. Os cinco sistemas de uso foram: plantio direto por cino anos (SPD5), plantio direto por sete anos (SPD7), plantio direto por nove anos (SPD9), preparo convencional (SPC) e uma área adjacente de mata nativa (MN). As camadas do solo avaliadas foram as de 0-0,10, 0,10-0,20 e 0,20-0,30 m, nas quais foram determinados a densidade máxima do solo (Ds máx), a umidade crítica de compactação (Ugc), a densidade relativa do solo (Dsr), a composição granulométrica, a porosidade e o teor de matéria orgânica do solo. Os resultados mostraram que o comportamento das curvas de compactação do solo foi o mesmo em todas as camadas dos diferentes manejos e que os teores de matéria orgânica não justificaram as pequenas alterações da Ds máx. Para o Latossolo Vermelho, as operações mecanizadas nos sistemas de manejo podem ser executadas na faixa de 0,13 a 0,19 kg kg-1 de umidade sem causar degradação física. Verificou-se que a Dsr ótima e a umidade crítica de compactação foram de 0,86 e 0,15 kg kg-1, respectivamente, embora os diferentes sistemas e tempos de adoção de manejo tenham apresentado comportamento semelhante quanto à produtividade da soja.

Frações Nitrogenadas, Glicídicas e Amônia Liberada pela Cama de Frangos de Corte em Diferentes Densidades e Tempos de Confinamento

O presente trabalho foi conduzido com o objetivo de estudar a liberação de amônia pela cama de frangos de corte, bem como o teor de umidade e de compostos glicídicos (carboidratos redutores) e nitrogenados (nitrogênio total, nitrogênio solúvel total e nitrato) presentes na mesma, em função da densidade populacional, tempo de confinamento e sexo das aves. Realizou-se o experimento em delineamento inteiramente casualizado. A cama de frango foi submetida às densidades de 10; 14; 18 e 22 aves/m² de piso, para ambos os sexos, e analisada em três épocas diferentes (24, 38 e 42 dias de idade das aves), utilizando-se de esquema fatorial 4x2x3 (densidades x sexos x épocas). de modo geral, observou-se que o sexo não influenciou o comportamento das variáveis estudadas. O aumento da densidade e o avanço da época de amostragem induziram a aumentos da quantidade de amônia liberada, do teor de umidade e dos teores de nitrogênio total e de nitrogênio solúvel, bem como diminuição do teor de carboidratos redutores. Estes resultados sugerem a necessidade de um controle rigoroso da amônia no ar dos galpões, principalmente em densidades elevadas e no período final de criação.

Avaliação de duas variedades de cana-de-açúcar submetidas a diferentes tempos de armazenamento

Foram estudadas duas variedades de cana-de-açúcar (CO 413 e RB 72 454), com o objetivo de verificar o efeito do armazenamento pós-corte sobre suas características tecnológicas e bromatológicas. As variedades foram cortadas e armazenadas durante zero, 1,5, 3,0 e 4,5 dias. Utilizou-se o delineamento inteiramente casualizado em esquema fatorial 2 x 4 . A variedade RB 72 454 apresentou melhor maturação que a variedade CO 413. O armazenamento proporcionou aumento no teor de açúcares redutores (P<0,01) e diminuição no teor protéico (P<0,01) das variedades de cana em estudo. A variedade RB 72 454 apresentou maior teor de matéria seca (P<0,01). Ambas as variedades, quando armazenadas durante 4,5 dias, apresentaram queda de 14,66 e 4,04% nos teores de proteína bruta e energia bruta, respectivamente.

Metodologia estatística na solução do problema do caixeiro viajante e na avaliação de algoritmos : um estudo aplicado à transgenética computacional

The problems of combinatory optimization have involved a large number of researchers in search of approximative solutions for them, since it is generally accepted that they are unsolvable in polynomial time. Initially, these solutions were focused on heuristics. Currently, metaheuristics are used more for this task, especially those based on evolutionary algorithms. The two main contributions of this work are: the creation of what is called an -Operon- heuristic, for the construction of the information chains necessary for the implementation of transgenetic (evolutionary) algorithms, mainly using statistical methodology - the Cluster Analysis and the Principal Component Analysis; and the utilization of statistical analyses that are adequate for the evaluation of the performance of the algorithms that are developed to solve these problems. The aim of the Operon is to construct good quality dynamic information chains to promote an -intelligent- search in the space of solutions. The Traveling Salesman Problem (TSP) is intended for applications based on a transgenetic algorithmic known as ProtoG. A strategy is also proposed for the renovation of part of the chromosome population indicated by adopting a minimum limit in the coefficient of variation of the adequation function of the individuals, with calculations based on the population. Statistical methodology is used for the evaluation of the performance of four algorithms, as follows: the proposed ProtoG, two memetic algorithms and a Simulated Annealing algorithm. Three performance analyses of these algorithms are proposed. The first is accomplished through the Logistic Regression, based on the probability of finding an optimal solution for a TSP instance by the algorithm being tested. The second is accomplished through Survival Analysis, based on a probability of the time observed for its execution until an optimal solution is achieved. The third is accomplished by means of a non-parametric Analysis of Variance, considering the Percent Error of the Solution (PES) obtained by the percentage in which the solution found exceeds the best solution available in the literature. Six experiments have been conducted applied to sixty-one instances of Euclidean TSP with sizes of up to 1,655 cities. The first two experiments deal with the adjustments of four parameters used in the ProtoG algorithm in an attempt to improve its performance. The last four have been undertaken to evaluate the performance of the ProtoG in comparison to the three algorithms adopted. For these sixty-one instances, it has been concluded on the grounds of statistical tests that there is evidence that the ProtoG performs better than these three algorithms in fifty instances. In addition, for the thirty-six instances considered in the last three trials in which the performance of the algorithms was evaluated through PES, it was observed that the PES average obtained with the ProtoG was less than 1% in almost half of these instances, having reached the greatest average for one instance of 1,173 cities, with an PES average equal to 3.52%. Therefore, the ProtoG can be considered a competitive algorithm for solving the TSP, since it is not rare in the literature find PESs averages greater than 10% to be reported for instances of this size.

Análise estatística das emissões de CO e HC produzidas por gases da exaustão veicular oriundos de gasolina, GNV e mistura álcool/gasolina

The vehicles are the main mobile sources of carbon monoxide (CO) and unburned hydrocarbons (HC) released into the atmosphere. In the last years the increment of the fleet of vehicles in the municipal district of Natal-RN it is contributing to the increase of the emissions of those pollutants. The study consisted of a statistical analysis of the emissions of CO and HC of a composed sample for 384 vehicles with mechanization Gasoline/CNG or Alcohol/Gasoline/CNG of the municipal district of Natal-RN. The tests were accomplished in vehicles submitted to Vehicular Safety's Inspection, in the facilities of INSPETRANS, Organism of Vehicular Inspection. An partial gases analyzer allowed to measure, for each vehicle, the levels of CO and HC in two conditions of rotation of the motor (900 and 2500 rpm). The statistical analysis accomplished through the STATISTICA software revealed a sensitive reduction in the efficiency of the converters catalytic after 6 years of use with emission average it is of 0,78% of CO and 156 (ppm) of HC, Which represents approximately 4 (four) times the amount of CO and the double of HC in comparison with the newest vehicles. The result of a Student s t-test, suggests strongly that the average of the emissions of HC (152 ppm), at 900 rpm, is 40% larger than at 2500 rpm, for the motor without load. This result reveals that the efficiency of the catalytic conversion is limited kinetically in low engine speeds. The Study also ends that when comparing the emissions of CO and HC considering the influence of the fuels, it was verified that although the emissions of CO starting from CNG are 62% smaller than arising from the gasoline, there are not significant differences among the emissions of HC originating from of CNG and of the gasoline. In synthesis, the results place the current criteria of vehicular inspection, for exhaust gases, in doubt, leading the creation of emission limits of pollutant more rigorous, because the efficiency of the converters catalytic is sensibly reduced starting from 6 years of use. It is also raised the possibility of modifications in the test conditions adopted by the current norms, specifically in the speed engine, have seen that in the condition without load the largest emission indexes were registered in slow march. That fact that allows to suggest the dismissal of the tests in high speed engine, reducing the time of inspection in half and generating economy of fuel