Materialien zur Geschichte der Juden in Böhmen

von M. H. Friedländer

Jüdische Alterthümer in Worms und Speier

von A. Epstein

Tiferet Jisrael : Schilderungen aus dem inneren Leben der Juden in Mähren in vormärzlichen Zeiten : ein Beitrag zur Cultur- und Sittengeschichte

von M. H. Friedländer

Die Vertreibung der Juden aus Brünn im Jahre 1454

von G. Deutsch

Early development of human lymphomas in a prostate cancer xenograft program using triple knock-out immunocompromised mice

BACKGROUND There is an urgent need for preclinical models of prostate cancer; however, clinically relevant patient-derived prostate cancer xenografts (PDXs) are demanding to establish. METHODS Sixty-seven patients who were undergoing palliative transurethral surgery or radical prostatectomy for histologically confirmed, clinically relevant prostate cancer were included in the study. Fresh prostate cancer tissue was identified by frozen analysis in 48 patients. The cancer tissue was transplanted subcutaneously and under the renal capsule of NSG and NOG mice supplemented with human testosterone. All growing PDXs were evaluated by histology and immunohistochemistry. RESULTS Early assessment of the animals at least three months after transplantation included 27/48 (56.3%) eligible PDX cohorts. PDX growth was detected in 10/27 (37%) mouse cohorts. Eight of the ten PDXs were identified as human donor derived lymphomas, including seven Epstein Barr virus (EBV)-positive diffuse large B-cell lymphomas and one EBV-negative peripheral T-cell lymphoma. One sample consisted of benign prostatic tissue, and one sample comprised a benign epithelial cyst. Prostate cancer was not detected in any of the samples. CONCLUSIONS Tumors that arise within the first three months after prostate cancer xenografting may represent patient-derived EBV-positive lymphomas in up to 80% of the early growing PDXs when using triple knockout NSG immunocompromised mice. Therefore, lymphoma should be excluded in prostate cancer xenografts that do not resemble typical prostatic adenocarcinoma. Prostate 9999: XX-XX, 2014. © 2015 Wiley Periodicals, Inc.

The splenic autoimmune response to ADAMTS13 in thrombotic thrombocytopenic purpura contains recurrent antigen-binding CDR3 motifs.

Acquired thrombotic thrombocytopenic purpura (TTP) is the consequence of a severe ADAMTS13 deficiency resulting from autoantibodies inhibiting ADAMTS13 or accelerating its clearance. Despite the success of plasma exchange the risk of relapse is high. From 2 patients (A and B), splenectomized for recurrent episodes of acquired TTP, the splenic B-cell response against ADAMTS13 was characterized through generation of human monoclonal anti-ADAMTS13 autoantibodies (mAbs) by cloning an immunoglobulin G (IgG)4κ- and IgG4λ-Fab library using phage display technology and by Epstein-Barr virus transformation of switched memory B cells (CD19+/CD27+/IgG+). Sequence analysis of the anti-ADAMTS13 IgGs of both patients revealed that the VH gene use was limited in our patients to VH1-3 (55%), VH1-69 (17%), VH3-30 (7%), and VH4-28 (21%) and contained 8 unique and thus far not reported heavy-chain complementarity determining region 3 motifs, of which 4 were shared by the 2 patients. The discovery of several highly similar anti-ADAMTS13 autoantibodies in 2 unrelated TTP patients suggests that the autoimmune response is antigen driven, because the probability that such similar immunoglobulin rearrangements happen by chance is very low (< 10(-9)).

Mein Weg von Ost nach West : Erinnerungen

von Jehudo Epstein

Die hervorragendsten jüdische Religionsphilosophen und Dichter im Mittelalter

von M. H. Friedländer

Chachme hadorot : Geschichtsbilder aus d. nachtalmudischen Zeit : (500-1500)

nach d. Quellen bearb. von M. H. Friedländer

Expression of the vault RNA protects cells from undergoing apoptosis

Non-protein-coding RNAs are a functionally versatile class of transcripts exerting their biological roles on the RNA level. Recently, we demonstrated that the vault complex-associated RNAs (vtRNAs) are significantly upregulated in Epstein-Barr virus (EBV)-infected human B cells. Very little is known about the function(s) of the vtRNAs or the vault complex. Here, we individually express latent EBV-encoded proteins in B cells and identify the latent membrane protein 1 (LMP1) as trigger for vtRNA upregulation. Ectopic expression of vtRNA1-1, but not of the other vtRNA paralogues, results in an improved viral establishment and reduced apoptosis, a function located in the central domain of vtRNA1-1. Knockdown of the major vault protein has no effect on these phenotypes revealing that vtRNA1-1 and not the vault complex contributes to general cell death resistance. This study describes a NF-κB-mediated role of the non-coding vtRNA1-1 in inhibiting both the extrinsic and intrinsic apoptotic pathways.

Sēfer ʿEṣ ḥayyîm : we-hû sēfer qiṣṣûr Šenê lûḥôt hab-berît ... mir hobin eś matik giwen oif ivri-ṭaiṭš

[Jechiel Michel Ben-Abraham Epstein. Übers.: Wolf Gerschels aus Prag

Sēfer ʿEṣ ḥayyîm : doś kesṭlichi sefer Qiṣṣîr Šenê lûḥôt hab-berît oif ṭaiṭš gšṭelṭ

[Jechiel Michel Ben-Abraham Epstein. Übers.: Wolf Gerschels aus Prag]

Sēfer ʿEṣ ḥayyîm : doś iz dś kesṭlichi sefer Qiṣṣûr Šenê lûḥôt hab-berît oif ṭaiṭš gšṭelṭ

[Jechiel Michel Ben-Abraham Epstein. Übers.: Wolf Gerschels aus Prag]

Sēfer Śimḥat han-nefeš : dem heiligen sefer hoṭ meḥaber giwen ... ke-de jeder menṭš zol kenin zain nefeš meśameaḥ zain ... divre musar ... mešolim un maiśes ...

[Elchanan Haendel Kirchhahn] ...

Sēfer ʿEṣ ḥayyîm : hû han-niqrā Qiṣṣûr Šenê lûḥôt hab-berît ...

[Jechiel Michel Ben-Abraham Epstein. Übers.: Wolf Gerschels aus Prag