Alterations of bone microarchitecture in young patients with inflammatory bowel diseases are associated with fracture risk during growth

Aims: Inflammatory bowel diseases (IBD) appearing during childhood and adolescence compromise peak bone mass acquisition and increase fracture risk. The structural determinants of bone fragility in IBD however remain unknown. Methods: We investigated volumetric bone mineral density (vBMD), trabecular and cortical bone microstructure at distal radius and tibia by high-resolution pQCT (XtremeCT, Scanco, Switzerland), aBMD at distal radius, hip and spine and vertebral fracture assessment (VFA) by DXA in 107 young patients (mean age 22.8 yrs, range 12.2-33.7 yrs; 62 females and 45 males) with Crohn's disease (n=75), ulcerative colitis (n=25), undetermined colitis (n=2), and no definitive diagnosis (n=5), and in 389 healthy young individuals. Results: Mean disease duration was 6.1 yrs, 89/107 IBD patients received corticosteroids, 83 other immunomodulators, and 59 vitamin D. Clinical fractures were reported by 38 patients (mean age at 1st fracture, 12.6 yrs), the vast majority of the forearm, arm or hand; 5 had vertebral crush fractures (Grade 1 or 2) and 11 had multiple fractures. As compared to healthy controls (matched 2:1 for age, sex, height and fracture history), the 102 patients with established IBD had similar weight but significantly lower aBMD at all sites, lower trabecular (Tb) BV/TV and number, and greater Tb separation and inhomogeneous Tb distribution (1/SD TbN) at both distal radius and tibia, lower tibia cortical thickness (CTh), but no differences in cortical vBMD nor bone perimeter. Among IBD's, aBMD was not associated with fractures (by logistic regression adjusted for age, age square, sex, height, weight and protein intake). However, radius and tibia Tb BV/TV, thickness and SD 1/TbN, as well as radius Tb separation and perimeter, were significantly associated with fracture risk (fully adjusted as above), whereas cortical vBMD and CTh were not. After adjustment for aBMD at radius, respectively at femur neck, radius SD 1/TbN and tibia BV/TV, TbTh and perimeter remained independently associated with fracture risk. Conclusions: Young subjects with IBD have low bone mass and poor bone microarchitecture compared to healthy controls. Alterations of bone microarchitecture, particularly in the trabecular bone compartment, are specifically associated with increased fracture risk during growth.

Second ESMO consensus conference on lung cancer: pathology and molecular biomarkers for non-small-cell lung cancer.

To complement the existing treatment guidelines for all tumour types, ESMO organises consensus conferences to focus on specific issues in each type of tumour. The Second ESMO Consensus Conference on Lung Cancer was held on 11-12 May 2013 in Lugano. A total of 35 experts met to address several questions on management of patients with non-small-cell lung cancer (NSCLC) in each of four areas: pathology and molecular biomarkers, early stage disease, locally advanced disease and advanced (metastatic) disease. For each question, recommendations were made including reference to the grade of recommendation and level of evidence. This consensus paper focuses on recommendations for pathology and molecular biomarkers in relation to the diagnosis of lung cancer, primarily non-small-cell carcinomas.

Evénements traumatiques et réponses de stress: le rôle de l'ocytocine et de l'attachement [Traumatic events and stress responses: the role of oxytocin and attachement].

Being repeatedly confronted to very difficult situations since childhood influences the way indivuals will later respond to even mildly stressful events. The hypothalamic-pituitary-adrenal axis (HPA) is a complex system implicated in regulating neuroendocrine responses to stress. Its activation produces among others the <stress hormonea, cortisol. However, the regulation of the physiological response to stress depends on psychological factors linked with the representations that individuals develop regarding their close relationships i.e. attachment. Furthermore, attachment representations seem to be associated with oxytocin, a hormone involved both in cortisol reduction and in positive social behaviours.

Atitudes de crianças em relação aos grupos nacionais

In the present study we are going to analyze the development of the ingroup favoritism and outgroup derogation in relation to national groups (Portuguese as ingroup and Cape-Verdeans, Brazilian and Chinese as outgroups) in Portuguese children with ages between 6 and 10 years (60 participants with 6/7 years and 60 participants with 9/10 years). The first aim of this research was to examine whether the ingroup favoritism and outgroup derogation changes according to the age groups. We started from the idea that the age groups would show ingroup preference. However in relation to negativity outgroup it was expected to be less evident. The second aim of this study was to examine if the ingroup favoritism and outgroup derogation would be relatively independent, or if they would be related to each other, so that positive perceptions of national ingroup were associated with negative perceptions of national outgroups (in particular, Cape-Verde, Brazilian and Chinese). In a nut Shell, the results confirmed the hypotheses, and in both age groups, the children showed ingroup preference, the negativism of the outgroup was less obvious in the Brazilian group but not in the others (Cape-Verdeans and Chinese). Regarding the relation between the preference for the ingroup and the negativity of the outgroup we realized that these are relatively independent. As a result, we found that the ingroup favoritism is not related with outgroup derogation, it means that, positive perceptions of the ingroup are not related with negative perceptions of the outgroups.

Atitudes de crianças em relação aos grupos nacionais

In the present study we are going to analyze the development of the ingroup favoritism and outgroup derogation in relation to national groups (Portuguese as ingroup and Cape-Verdeans, Brazilian and Chinese as outgroups) in Portuguese children with ages between 6 and 10 years (60 participants with 6/7 years and 60 participants with 9/10 years). The first aim of this research was to examine whether the ingroup favoritism and outgroup derogation changes according to the age groups. We started from the idea that the age groups would show ingroup preference. However in relation to negativity outgroup it was expected to be less evident. The second aim of this study was to examine if the ingroup favoritism and outgroup derogation would be relatively independent, or if they would be related to each other, so that positive perceptions of national ingroup were associated with negative perceptions of national outgroups (in particular, Cape-Verde, Brazilian and Chinese). In a nut Shell, the results confirmed the hypotheses, and in both age groups, the children showed ingroup preference, the negativism of the outgroup was less obvious in the Brazilian group but not in the others (Cape-Verdeans and Chinese). Regarding the relation between the preference for the ingroup and the negativity of the outgroup we realized that these are relatively independent. As a result, we found that the ingroup favoritism is not related with outgroup derogation, it means that, positive perceptions of the ingroup are not related with negative perceptions of the outgroups.

Early disturbances of gamma band dynamics in mild cognitive impairment.

Recent studies have indicated that gamma band oscillations participate in the temporal binding needed for the synchronization of cortical networks involved in short-term memory and attentional processes. To date, no study has explored the temporal dynamics of gamma band in the early stages of dementia. At baseline, gamma band analysis was performed in 29 cases with mild cognitive impairment (MCI) during the n-back task. Based on phase diagrams, multiple linear regression models were built to explore the relationship between the cognitive status and gamma oscillation changes over time. Individual measures of phase diagram complexity were made using fractal dimension values. After 1 year, all cases were assessed neuropsychologically using the same battery. A total of 16 MCI patients showed progressive cognitive decline (PMCI) and 13 remained stable (SMCI). When adjusted for gamma values at lag -2, and -3 ms, PMCI cases displayed significantly lower average changes in gamma values than SMCI cases both in detection and 2-back tasks. Gamma fractal dimension of PMCI cases displayed significantly higher gamma fractal dimension values compared to SMCI cases. This variable explained 11.8% of the cognitive variability in this series. Our data indicate that the progression of cognitive decline in MCI is associated with early deficits in temporal binding that occur during the activation of selective attention processes.

Atitudes de crianças em relação aos grupos nacionais

No presente estudo vamos analisar o desenvolvimento do favoritismo endogrupal e do “derogation” (desvalorização) exogrupal em relação a grupos nacionais (portugueses como endogrupo e cabo-verdianos, brasileiros e chineses como exogrupos) em crianças portuguesas com idades compreendidas entre os 6 e os 10 anos (60 participantes com 6/7 anos e 60 participantes com 9/10 anos). O primeiro objectivo desta investigação consistiu em examinar se o favoritismo endogrupal e o “derogation” exogrupal variam em função de grupos etários. Partimos da ideia de que os grupos etários evidenciariam preferência endogrupal. Já em relação à negatividade exogrupal era esperado que fosse menos evidente. O segundo objectivo deste estudo foi examinar se o favoritismo endogrupal e o “derogation” exogrupal seriam relativamente independentes, ou se estariam reciprocamente relacionados, de modo que percepções positivas do endogrupo nacional estivessem associadas com percepções negativas dos exogrupos nacionais (em particular, cabo-verdianos, brasileiros e chineses). Os resultados confirmaram as hipóteses, assim em ambos os grupos etários as crianças evidenciaram preferência endogrupal, a negatividade do exogrupo, foi apenas menos evidente para o exogrupo brasileiros e não para os restantes (cabo-verdianos e chineses). Relativamente à relação entre a preferência pelo endogrupo e a negatividade do exogrupo verificou-se que estas são relativamente independentes. Assim verificou-se que o favoritismo endogrupal não está relacionado com a desvalorização exogrupal, ou seja, percepções positivas do endogrupo não estão relacionadas com percepções negativas dos exogrupos.

IFRS introduction and its effect on listed companies in Spain

From the beginning of January 2005 publicly traded companies in the European Union have to comply with the International Financial Reporting Standards (IFRS) for their consolidated accounts, as required by 1606/2002 European Commission Regulation. It had been suggested that the new accounting rules will facilitate not only the process of international harmonization of financial statements, but also efficient performance of financial markets and capital flows worldwide. This study analyzes the first results of IFRS implementation by Spanish non-financial listed companies.

Ctenosciaena peruviana, nov. sp. Una nueva especie de Sciaenidae de la costa del Perú

Presenta el primer registro del género Ctenosciaena peruviana, la cual fue colectada en un crucero de exploración que se realizó para determinar las áreas de abundancia del recurso merluza.

Los estudios de factibilidad de marcaciones de anchoveta

Presenta los estudios de factibilidad de marcaciones de anchoveta, que consistieron en experimentos de transporte y mantenimiento en acuarios, pruebas de marcación en acuarios o viveros flotates o jaulas en el mar, experimentos de recuperación de marcas en las plantas de procesamiento por medio de imanes y estudio de eficiencia, encuesta sobre número, características y localización de imanes en las plantas instaladas en el litoral y marcación experimental y liberación de anchovetas en el mar, en número limitado.

Importance of IL28B gene polymorphisms in hepatitis C virus genotype 2 and 3 infected patients.

BACKGROUND & AIMS: Genetic variation in the interleukin 28B (IL28B) gene has been associated with the response to interferon-alfa/ribavirin therapy in hepatitis C virus (HCV) genotype 1-infected patients. The importance of three IL28B single nucleotide polymorphisms (rs8099917, rs12980275 and rs12979860) for HCV genotype 2/3-infected patients is unknown. METHODS: In patients with chronic hepatitis C genotype 2/3 (n=267), IL28B host genotypes (rs8099917, rs12980275 and rs12979860) were analyzed for associations with sustained virologic response (SVR) to antiviral therapy with (pegylated) interferon-alfa and ribavirin and with respect to epidemiological, biochemical, and virological parameters. For comparison, hepatitis C genotype 1 patients (n=378) and healthy controls (n=200) were included. RESULTS: The rs12979860 CC genotype, lower age, and genotype 2 were significantly associated with SVR in HCV genotype 2/3-infected patients (p=0.01, p=0.03 and p=0.03, respectively). No association was observed for rs8099917 and rs12980275. In addition, an SVR in patients with rapid virologic response (RVR) was associated with the rs12979860 CC genotype (p=0.05), while for non-RVR no association was found. Furthermore, a significant association with a higher baseline viral load was observed for all three IL28B genotypes in genotype 1/2/3-infected patients. Finally, increasing frequencies of the rs12979860 CC genotypes were observed in genotype 1- (33.9%), genotype 3- (38.9%), and genotype 2-infected (51.9%) patients in comparison with healthy controls (49.0%) (p<0.01). CONCLUSIONS: In genotype 2/3-infected patients, rs12979860 was significantly associated with SVR. The frequency of the rs12979860 CC genotype is lower in HCV genotype 1 vs. genotype 2/3 patients. All major IL28B genotypes are associated with HCV-RNA concentration.

L'Academie des princes , où les roys apprennent l'art de regner de la bouche des roys. Ouvrage tiré de l'histoire tant ancienne que nouvelle; et traduit par Pierre Menard

Comprend : Présent royal de Jaques I, roy d'Angleterre... au prince Henry, son fils