Immunological protein-protein interactions:a critical reflection

Life, and the biochemistry of which it is ultimately comprised, is built from the interactions of proteins, and the study of protein-protein interactions is fast becoming a central feature of molecular bioscience. This is as true of immunobiology as it is of other areas of the wider biological milieu. Protein-protein interactions within an immunological setting comprise both the kind familiar from other areas of biology and instantiations of protein-protein interactions special to the immune arena. Of the generic kind of protein-protein interaction, co-stimulatory receptors, such as CD28, and the interaction of accessory proteins, such as CD4 or CD8, are amongst the most prevalent and apposite of examples. The key examples of special immunological instantiations of protein-protein interactions are the binding of antigens by antibodies and the formation of peptide-MHC-TCR complexes; both prime examples of vital molecular recognition events mediated by protein-protein interactions. In this brief review, and within the context of this burgeoning field, we examine immunological protein-protein interactions, focussing on the problematic nature of defining such interactions. © 2011 by Nova Science Publishers, Inc. All rights reserved.

Theory and practice in the field of foresight

Purpose – The paper aims to explore the gap between theory and practice in foresight and to give some suggestions on how to reduce it. Design/methodology/approach – Analysis of practical foresight activities and suggestions are based on a literature review, the author's own research and practice in the field of foresight and futures studies, and her participation in the work of a European project (COST A22). Findings – Two different types of practical foresight activities have developed. One of them, the practice of foresight of critical futures studies (FCFS) is an application of a theory of futures studies. The other, termed here as praxis foresight (PF), has no theoretical basis and responds directly to practical needs. At present a gap can be perceived between theory and practice. PF distinguishes itself from the practice and theory of FCFS and narrows the construction space of futures. Neither FCFS nor PF deals with content issues of the outer world. Reducing the gap depends on renewal of joint discourses and research about experience of different practical foresight activities and manageability of complex dynamics in foresight. Production and feedback of self-reflective and reflective foresight knowledge could improve theory and practice. Originality/value – Contemporary practical foresight activities are analysed and suggestions to reduce the gap are developed in the context of the linkage between theory and practice. This paper is thought provoking for futurists, foresight managers and university researchers.

A társadalmi felelősségvállalás vállalati on-line kommunikációjának kritikai elemzése (Critical Analysis of Online CSR Communication in Hungary)

A vállalatok társadalmi felelősségvállalásával (CSR) kapcsolatos alapelvek, kezdeményezések és tevékenységek kommunikációja a vállalati kommunikáció egyik sarkalatos pontjává vált szinte az egész világon. A cégek CSR-kezdeményezéseik bemutatásához egyre többször az internetet is igénybe veszik. Az on-line média használatával párhuzamosan az elmúlt évtizedben egyre többen kutatják a CSR-kommunikáció elektronikus formáit, jóllehet ezek a kutatások többnyire leíró jellegűek, és a CSR-kommunikáció, valamint egyes vállalati jellemzők (méret, iparág és más magyarázó változók) között keresnek kapcsolatot. A szerzők e cikkben a társadalmi felelősségvállalással foglalkozó vállalati weboldalakat kritikai szemüvegen keresztül vizsgálják. Céljuk, hogy feltárják az on-line kommunikációt jellemző belső ellentmondásokat és a vallott és követett értékek közötti különbségeket. _______ Communicating corporate social responsibility (CSR) principles, initiatives, and activities has become a common practice of companies all around the world. It is quite apparent that firms use internet more and more often to communicate their CSR initiatives to their stakeholders. Parallel with the extensive use of the online media, more and more research has been elaborated on the field of online CSR communication in the last decade as well. However, these studies usually have a strong descriptive focus trying to reveal connections between the intensity of online communication of CSR values and activities, and company size, industrial background, and other explanatory variables. In contrast, the authors analysed corporate web pages dedicated to CSR through critical lenses. Their research was designed to explore any dissonances and contradictions within online communication and between communication and real activities of firms from construction, retail, and telecommunication industries in Hungary.

Mi a baj a modern szervezetekkel? – Kritikai menedzsmentelméletek (What is the problem in modern organisations? – Critical Management Studies)

A nemzetközi, elsősorban európai szervezettudományban mára meghatározóvá vált a kritikai megközelítés, a hazai szakirodalomban mégis elvétve találni rá utalásokat. A szerzők írásukban tárgyalják, hogy a kritikai menedzsmentelméletek (KME) szemszögéből miként bírálható a mindenkori szervezeti gyakorlat, és miért bírálandók a főáramú menedzsmentelméletek. A tanulmány fő részében elméleti megkülönböztetéseket tesznek: egyrészt elhatárolják a kritikai megközelítést a főáramú szervezetelméletektől, másrészt több szempontból is különbséget tesznek a különféle – de egyaránt a KME alá tartozó – kritikai megközelítések között. De a kritikai szemlélethez hűen nem csak a puszta elméletismertetés volt a céljuk: e bevezetés és problémafelvető tanulmány – s a későbbiekben tervezett cikksorozat – szándékuk szerint vitaindítóként is szolgál. Abban bíznak, hogy a felvetett kérdésekről valódi, lényegi párbeszédet generálhatnak a hazai menedzsmenttudományban (kutatók, oktatók és elméletalkalmazók körében), mely kihathat a szervezeti gyakorlatra is. _____ Critical Management Studies (CMS) as a field of organization studies (OS) has become central internationally, and especially in Europe. Yet, its appearance is still very rare in the Hungarian OS literature. In this study first the authors discuss how the nowadays dominant organizational practices along with the mainstream management and organization theories are to be criticized from a Critical Management perspective. In the main section, so as to define CMS, they make important theoretical distinctions, first between CMS and mainstream organization theories (in general), and then among the different critical approaches that nevertheless all fall under the broad CMS umbrella. But, in line with a truly critical attitude, they not only go into theoretical discussions but, at least to their intention, the purpose of this introductory paper is also to addresses important problems both in the theory and the practice of organization and management. Therefore, it could serve as an opening of an important debate or dialogue in the Hungarian academic community (researchers, educators and other professionals), a theoretical discussion that could have real influence on organizational practice too.

The development and analysis of a field project model curriculum and its impact on achievement and attitude toward science and the environment with at-risk eleventh and twelfth grade students

This study was an evaluation of a Field Project Model Curriculum and its impact on achievement, attitude toward science, attitude toward the environment, self-concept, and academic self-concept with at-risk eleventh and twelfth grade students. One hundred eight students were pretested and posttested on the Piers-Harris Children's Self-Concept Scale, PHCSC (1985); the Self-Concept as a Learner Scale, SCAL (1978); the Marine Science Test, MST (1987); the Science Attitude Inventory, SAI (1970); and the Environmental Attitude Scale, EAS (1972). Using a stratified random design, three groups of students were randomly assigned according to sex and stanine level, to three treatment groups. Group one received the field project method, group two received the field study method, and group three received the field trip method. All three groups followed the marine biology course content as specified by Florida Student Performance Objectives and Frameworks. The intervention occurred for ten months with each group participating in outside-of-classroom activities on a trimonthly basis. Analysis of covariance procedures were used to determine treatment effects. F-ratios, p-levels and t-tests at p $<$.0062 (.05/8) indicated that a significant difference existed among the three treatment groups. Findings indicated that groups one and two were significantly different from group three with group one displaying significantly higher results than group two. There were no significant differences between males and females in performance on the five dependent variables. The tenets underlying environmental education are congruent with the recommendations toward the reform of science education. These include a value analysis approach, inquiry methods, and critical thinking strategies that are applied to environmental issues. ^

An examination of Lotka's law in the field of Library and Information Studies

The purpose of this study was to test Lotka’s law of scientific publication productivity using the methodology outlined by Pao (1985), in the field of Library and Information Studies (LIS). Lotka’s law has been sporadically tested in the field over the past 30+ years, but the results of these studies are inconclusive due to the varying methods employed by the researchers. ^ A data set of 1,856 citations that were found using the ISI Web of Knowledge databases were studied. The values of n and c were calculated to be 2.1 and 0.6418 (64.18%) respectively. The Kolmogorov-Smirnov (K-S) one sample goodness-of-fit test was conducted at the 0.10 level of significance. The Dmax value is 0.022758 and the calculated critical value is 0.026562. It was determined that the null hypothesis stating that there is no difference in the observed distribution of publications and the distribution obtained using Lotka’s and Pao’s procedure could not be rejected. ^ This study finds that literature in the field of Library and Information Studies does conform to Lotka’s law with reliable results. As result, Lotka’s law can be used in LIS as a standardized means of measuring author publication productivity which will lead to findings that are comparable on many levels (e.g., department, institution, national). Lotka’s law can be employed as an empirically proven analytical tool to establish publication productivity benchmarks for faculty and faculty librarians. Recommendations for further study include (a) exploring the characteristics of the high and low producers; (b) finding a way to successfully account for collaborative contributions in the formula; and, (c) a detailed study of institutional policies concerning publication productivity and its impact on the appointment, tenure and promotion process of academic librarians. ^

Special Education Teachers: What Keeps Them in the Field?

The dilemma of securing a special education teacher supply is a critical issue. Understanding causes of attrition is vital to addressing the problem. This review analyzes literature and identifies factors for teacher retention/attrition while overlaying the concept of Maslow’s hierarchy of needs to understand this phenomenon from a psychological perspective.

A visual critical ethnography of youth develoment in a Rio de Janeiro favela

Favelas are Brazilian informal housing settlements that are areas of concentrated poverty. In Rio de Janeiro, favelas are perceived as areas of heightened criminal activity and violence, and residents experience discrimination, and little access to quality education and employment opportunities. In this context, hundreds of non-formal educational arts and leisure programs work to build the self-esteem and identity of youth in Rio's favelas as a way of preventing the youth from negative local influences. The Morrinho organization, located in the Pereira da Silva favela in Rio, uses art as a way for the local male youth to communicate their lived reality. This study used a visual critical ethnographic methodology to describe the way in which the Morrinho participants interpret living in a favela. Seventeen semi-structured interviews with young men aged 15 to 29, the feature-length documentary film on the organization, 206 researcher produced documentary style photographs of the Morrinho artwork, and the researcher's field notes were analyzed. Truth claims, ways of seeing as communicated through words and actions, were induced through a cyclical process of reconstructive horizon analysis that incorporated the societal context and critical theory. The participants communicated their concerns about life in a favela; however, they did not describe their societal positions in terms of complete marginalization. They named multiple benefits of living in Pereira da Silva, discussed positive and negative experiences in school, and described ways they circumvented discrimination. Morrinho as an organization was described as an enthralling game and a social project that benefited dozens of local youth. Character development was a valuable result of participation at Morrinho. The Morrinho artwork communicates a nuanced vision of both benevolent and violent social actors, and counters the overwhelmingly negative dominant characterization of Rio de Janeiro's favelas. This study has implications for an inclusive critical pedagogy and the use of art as a means to facilitate a transformative education. Further research is recommended to explore terminology used to refer to favelas, and perceptions that favela residents have of their experiences in public education.

Yield of metastable atoms from a rare gas discharge in a longitudinal magnetic field

Atomic beam experiments are limited by intensity. Intensity limitations are specially critical in the measurements of metastable atoms, since their relative population is several order of magnitude smaller than the beam population. This thesis provides a method for increasing the intensity of metastable argon and neon beams effusing from a hot cathode, glow discharge by use of a longitudinal magnetic field. The argon and neon metastable atom intensities have been measured for a range of discharge pressure, voltage, and current for a magnetic field strengths from 0 to 31 mT. For both argon and neon, the metastable atom beam intensity rises to a maximum value about one order of magnitude above the zero field case. A qualitative discussion of the theory of this phenomenon is also presented.

The Significance of Critical Theory for Restorative Justice in Education

Restorative Justice (rj), a distinctive philosophical approach that seeks to replace punitive, managerial structures of schooling with those that emphasize the building and repairing of relationships (Hopkins 2004) has been embraced in the past two decades by a variety of school systems worldwide in an effort to build safe school communities. Early studies indicate rj holds significant promise, however, proponents in the field identify that theoretical and evidence-based research is falling behind practice. They call for further research to deepen the current understanding of rj that will support its sustainability and transformative potential and allow it to move from the margins to the mainstream of schooling (Braithwaite 2006; Morrison & Ahmed 2006; Sherman & Strang 2007).

Using Community Outreach to Build Children’s Resiliency and Critical Literacy through Digital Tools

Grade three students used tablet computers with a pre-selected series of applications over a seven-month period at school and through a community afterschool program. The study determined that these students benefited from differentiated learning in the school environment and online collaborative play in the afterschool centre. Benefits of the exposure to digital tools included: intergenerational learning as children assisted both parents and teachers with digital applications; problem-solving; and enhanced collaborative play for students across environments. Although this study makes a contribution to the field of digital literacy and young learners, the researchers conclude further investigation is warranted, in regards to the inter-relationships between home, school and community as spaces for the learning and teaching of digital technologies.

Efficient numerical methods for the random-field Ising model: Finite-size scaling, reweighting extrapolation, and computation of response functions

It was recently shown [Phys. Rev. Lett. 110, 227201 (2013)] that the critical behavior of the random-field Ising model in three dimensions is ruled by a single universality class. This conclusion was reached only after a proper taming of the large scaling corrections of the model by applying a combined approach of various techniques, coming from the zero-and positive-temperature toolboxes of statistical physics. In the present contribution we provide a detailed description of this combined scheme, explaining in detail the zero-temperature numerical scheme and developing the generalized fluctuation-dissipation formula that allowed us to compute connected and disconnected correlation functions of the model. We discuss the error evolution of our method and we illustrate the infinite limit-size extrapolation of several observables within phenomenological renormalization. We present an extension of the quotients method that allows us to obtain estimates of the critical exponent a of the specific heat of the model via the scaling of the bond energy and we discuss the self-averaging properties of the system and the algorithmic aspects of the maximum-flow algorithm used.

Positionality and Comparisons: Critical Views on Qualitative Research across Asia

Ce cahier est basé sur la réflexion autobiographique de deux chercheuses ayant effectué des recherches qualitatives et ethnographiques, de 2008 à 2014, en Asie centrale et du Sud-­‐Est. Les expériences sur le terrain constituent des moyens de comparaisons dans le présent document. En mettant l’accent sur le positionnement sur le terrain, l’étude montre que, d’abord, il est essentiel de détenir une poste intermédiaire et de parler une langue locale afin de garantir un accès et de mener des activités de recherche sur le terrain. Deuxièmement, différentes régions prédéterminent des contextes culturels et politiques ponctuels qui, à leur tour, façonneraient la recherche en sciences sociales. Troisièmement, le fait d’être une femme présente à la fois des avantages et des inconvénients. Enfin, en termes de méthodologie, les stages et les entrevues se sont avérés des méthodes fiables pour la collecte des données empiriques sur les régions ci-­‐dessus mentionnées, sans pour autant permettre de bâtir la confiance.

Positionality and Comparisons: Critical Views on Qualitative Research across Asia

Ce cahier est basé sur la réflexion autobiographique de deux chercheuses ayant effectué des recherches qualitatives et ethnographiques, de 2008 à 2014, en Asie centrale et du Sud-­‐Est. Les expériences sur le terrain constituent des moyens de comparaisons dans le présent document. En mettant l’accent sur le positionnement sur le terrain, l’étude montre que, d’abord, il est essentiel de détenir une poste intermédiaire et de parler une langue locale afin de garantir un accès et de mener des activités de recherche sur le terrain. Deuxièmement, différentes régions prédéterminent des contextes culturels et politiques ponctuels qui, à leur tour, façonneraient la recherche en sciences sociales. Troisièmement, le fait d’être une femme présente à la fois des avantages et des inconvénients. Enfin, en termes de méthodologie, les stages et les entrevues se sont avérés des méthodes fiables pour la collecte des données empiriques sur les régions ci-­‐dessus mentionnées, sans pour autant permettre de bâtir la confiance.

An Examination of Lotka’s law in the Field of Library and Information Studies

The purpose of this study was to test Lotka’s law of scientific publication productivity using the methodology outlined by Pao (1985), in the field of Library and Information Studies (LIS). Lotka’s law has been sporadically tested in the field over the past 30+ years, but the results of these studies are inconclusive due to the varying methods employed by the researchers. A data set of 1,856 citations that were found using the ISI Web of Knowledge databases were studied. The values of n and c were calculated to be 2.1 and 0.6418 (64.18%) respectively. The Kolmogorov-Smirnov (K-S) one sample goodness-of-fit test was conducted at the 0.10 level of significance. The Dmax value is 0.022758 and the calculated critical value is 0.026562. It was determined that the null hypothesis stating that there is no difference in the observed distribution of publications and the distribution obtained using Lotka’s and Pao’s procedure could not be rejected. This study finds that literature in the field of library and Information Studies does conform to Lotka’s law with reliable results. As result, Lotka’s law can be used in LIS as a standardized means of measuring author publication productivity which will lead to findings that are comparable on many levels (e.g., department, institution, national). Lotka’s law can be employed as an empirically proven analytical tool to establish publication productivity benchmarks for faculty and faculty librarians. Recommendations for further study include (a) exploring the characteristics of the high and low producers; (b) finding a way to successfully account for collaborative contributions in the formula; and, (c) a detailed study of institutional policies concerning publication productivity and its impact on the appointment, tenure and promotion process of academic librarians.