Granuloma periférico de células gigantes: relato de caso

The peripheral giant cell granuloma (GPCG) is defined as a benign disorder of uncertain etiopathogenesis and proliferative reaction of the fibrous connective tissue or periosteum, which is characterized histologically by the presence of multinucleated giant cells. The purpose of this study is to report a case of GPCG in a 56-year-old white woman presenting a bleeding nodule on palpation, a red color with small whitish ulcerated areas, defined limits, resilient consistency, a pedicled base 2.0 cm in diameter, asymptomatic, involving the permanent lower left third molar, which presented mobility. Radiographically there was significant bone loss in this tooth region, whose initial diagnosis was pyogenic granuloma. The definitive diagnosis was obtained after excisional biopsy the microscopic examination of which identified the presence of multinucleated giant cells. The clinical postoperative follow-up revealed a favorable cicatricial repair of the operated area with no recurrence after 9 months of monitoring.

Programa de diagnóstico e prevenção de câncer da boca: uma estratégia simples e eficaz

The program of diagnosis and prevention of oral cancer of Univag - University Center aims to increase preventive and early oral diseases with emphasis on oral cancer, aiming to reduce the morbidity and mortality through educative actions, spreading of the auto-examination, performed by dental students of UNIVAG since the second half of 2005 to the present day. The dental students of 1st, 2nd, 3rd and 4th semesters were trained using practice-theoretical classes, for realization the exams preventives and diagnostics, such as self-examination, exfoliative cytology and biopsy of oral mucosa, and even present educative actions. Analyzing the preliminary results were observed increase in the number of diagnoses and referral of diagnosed with oral cancer for treatment in referral services. It was concluded that the program of diagnosis and prevention of oral cancer can make possible early diagnosis and adoption of preventive measures, consequently improving survival rates and life quality in population.

Granuloma Periférico de Células Gigantes: Relato de caso com acompanhamento de 2 anos

The peripheral giant cell granuloma (GPCG) is defined as a benign disorder of uncertain etiopathogenesis, and proliferative reaction of the fibrous connective tissue or the periosteum, which is characterized histologically by the presence of multinucleated giant cells. The purpose of this study is report a case of GPCG in a white women, with 56 years old, presenting nodule bleeding to the touch, red and white with small ulcerated areas, defined limits, resilient consistency, pedicled base with 2.0 cm diameter, asymptomatic, involving the permanent lower left third molar, that it was presented with mobility. Radiographically there was significant bone loss in this tooth region, whose initial diagnosis was pyogenic granuloma. The definitive diagnosis was obtained after excisional biopsy in which microscopic examination it was identified e presence of multinucleated giant cells. The clinical postoperative presented favorable cicatricial repairing of the operated area without recurrence after two years of monitoring.

Perfil epidemiológico dos participantes do Programa de diagnóstico e prevenção do câncer de boca em Mato Grosso

To determine the profile of the patients who participated in the program of oral cancer diagnosis and prevention in Mato Grosso, from 2008 to 2009. Materials and Methods: The medical records of the treated patients were examined. Results: 1.293 records were analyzed, with a predominance of female patients (60%) and a greater participation of patients from 10 to 19 years of age (20%). Reports of pre-existing illnesses amounted to 302 recorded cases. In addition, 292 variations of normality could be also identified. During the period, 25 participants were recommended for exfoliative cytology and 133 for biopsy, as they presented oral lesions that raised the suspicion of malignancy. Conclusions: Campaigns to raise awareness of and prevent oral cancer are very important and should be extended to the entire population of the state of Mato Grosso, either by means of the local University Center (UNIVAG), or by other agencies and health institutions.

Carcinoma de lábio com prognóstico sombrio devido conduta médica inadequada

The Squamous Cell Carcinoma is what more happens among the oral cancers, being considered sweats incidence in more than 90%. As important prognostic factor competes the early diagnosis and the immediate institution of the treatment, that it can involve radiotherapy and chemotherapy besides the surgery. The initial lesions don’t offer great diagnostic difficulties and now complemental laboratory exams define the diagnosis quickly, In the present report, the initial medical conduct was inadequate, with incomplete interpretation of the laboratorial result and adoption of inadequate therapeutic conduct, what resulted in constant evolution of the lesion. The patient came to the consultation with that medical history, after six months of the first attendance accomplished in another center. To the physical exam, infiltrative ulcerated lesion was observed in the lower lip, with having accentuated tissue loss superficially. The patient accused spontaneous pain and she did use an ointment, recommended six months ago for occasion of the first attendance. As diagnostic conduct was indicated the accomplishment of cytology and biopsy, being defined the diagnosis of Squamous Cell Carcinoma. The patient was immediately guided to the medical service of its municipal district for manegement of the specialized oncologic treatment. The patient was submitted the surgery followed by radiotherapy, being verified involvement of another structures by contiguity. Now, the patient meets abed, without viable perspectives of cure. The present report emphasizes the importance of the clinical knowledge and professional responsibility in attendance of cases of that nature.

Lesão fibro-óssea na mandíbula associada à osteomielite

A displasia cemento-óssea é o tipo mais comum dentre as lesões fibro-ósseas, podendo apresentar-se de 3 maneiras: periapical, focal e florida. Paciente parda, de 53 anos, compareceu com queixa de “secreção na gengiva” e histórico de exodontia na região há 8 meses. À inspeção apresentou uma leve tumefação na região vestibular posterior esquerda da mandíbula e uma pequena fístula drenando pus. Realizou-se uma radiografia panorâmica, que revelou uma lesão de radiopacidade mista na região de molares inferiores direitos, medindo 2 cm de diâmetro; outra lesão radiopaca na região de pré-molares esquerdos, de 6mm de diâmetro - ambas bem delimitadas; e outra área radiolúcida com radiopacidade central, com halo radiopaco na região infectada, medindo 1,5 cm de diâmetro. O diagnóstico presuntivo foi de displasia cemento-óssea infectada, cisto periapical infectado associado à displasia e osteomielite. Após antibioticoterapia, realizou-se biópsia e curetagem da área. Microscopicamente apresentou áreas de tecido cemento-ósseo em forma trabecular e no local onde deveria haver tecido fibroso, presença de biofilme bacteriano, conteúdo hemorrágico e restos necróticos. No tecido de granulação removido observou-se intenso infiltrado inflamatório e áreas de calcificação cementóide. As características microscópicas juntamente com os achados clínicos e radiográficos levaram ao diagnóstico de osteomielite aguda supurativa secundária a lesão fibro-óssea, sugestiva de displasia cemento-óssea florida.

Perfil de acidentes envolvendo risco biológico em profissionais de saúde de Araçatuba-SP: uma caracterização dos envolvidos

Each year individuals have sought a better quality of life and work, in this case, the science of Bio-insurance needs to keep up with technological advances and the needs of society to minimize or eliminate the risks of accidents. This study evaluated the most common accidents involving health staff from 2007 to 2011 in Araçatuba-SP. 478 accidents were recorded, and 78.7% with percutaneous involvement, 9% with intact skin, 4% with no skin intact, with 7.3 mucous and 1.05% other types of exposures. Most accidents were caused by needles with lumen (68.0%), followed by other agents (14.1%), accidents with blades (8.5%) or needles without lumen (5.5%); 3.7% did not answer and 0.2% were accidents with glasses. When checking the condition in which the accident occurred, 26.0% did not specify, 25.1% occurred in the disposal and / or handling sharp objects, 12.0% at the time of drug administration, 6.9% puncture, 3.7% occurred during recapping the needle. These data show that the most common accidents are those involving needles with lumen and / or sharp objects and due to these factors, the industry of health materials have sought alternatives to minimize such accidents as needles with protective, vacuum collection . Thus, it appears that reporting accidents is important for the development of technical and / or safer materials for patients and health workers.

Anestesia peridural com lidocaína em um potro: relato de caso

Um equino macho, raça Manga Larga, de 20 dias de idade, pesando 55 kg foi atendido no Hospital Veterinário “Luiz Quintiliano de Oliveira” com histórico de queda no dia anterior, apresentando impotência funcional e desvio do eixo ósseo do membro pélvico esquerdo (MPE). Ao exame radiográfico, constatou-se uma fratura classificada como Salter- Harris tipo II, na região distal da tíbia esquerda, com indicação para osteossíntese. Ao exame físico geral, observou-se frequência cardíaca (FC) de 82 batimentos.min-1, frequência respiratória (f) de 60 movimentos.min-1, mucosas róseas, tempo de preenchimento capilar de dois segundos, temperatura retal (ToC) de 38,5oC e hidratação adequada. Como medicação pré-anestésica, administrou-se xilazina (0,5 mg.kg-1) IV. A indução foi realizada por meio da administração de midazolam (0,1mg.kg-1) e cetamina (2mg.kg-1) IV. Seguiu-se a intubação orotraqueal com sonda n o 12 conectando-se a um circuito anestésico com reinalação parcial de gases, e a manutenção foi realizada com isofluorano em fluxo diluente de oxigênio a 100%, sob ventilação espontânea. Realizou-se a técnica de anestesia peridural com o paciente em decúbito lateral direito, introduzindo uma agulha 30x8 percutaneamente até atingir o espaço peridural entre as vértebras L6 e S1, onde se administrou lidocaína a 2% (2,2mg.kg-1) com vasoconstritor, perfazendo um volume de 6 mLs. Adicionalmente foi realizado o bloqueio perineural dos nervos tibial e fibular do membro acometido, com administração de 5 mLs de lidocaína a 2% com vasoconstritor em cada ponto. A administração de anestésicos locais pela via peridural na região L6 – S1 não é rotineiramente usada em equinos, uma vez que provoca ataxia ou perda do tônus muscular, aumentando os riscos relacionados à intervenção anestésica. No entanto, a recuperação do potro nesse relato de caso foi rápida e isenta de complicações, provalvelmente proporcionando anestesia multimodal e consequentemente menor depressão cardiovascular. A associação da anestesia peridural e bloqueio dos nervos tibial e fibular à anestesia geral, pode ser uma alternativa para intervenções cirúrgicas em membros pélvicos de potros, uma vez que demonstrou ser efetiva e de fácil execução.

Influência do veículo na remoção da pasta tri antibiótica do canal radicular

Pós-graduação em Ciência Odontólogica - FOA

Avaliação da resposta inflamatória local após aplicação de células tronco mesenquimais alogênicas em tendão flexor digital superficial de equinos

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Critérios citológicos associados ao fenótipo luminal do carcinoma de mama

Pós-graduação em Patologia - FMB

Efeito de um tratamento com auriculoterapia na dor, funcionalidade e mobilidade de adultos com dor lombar crônica

Pós-graduação em Desenvolvimento Humano e Tecnologias - IBRC

Influência da vitamina D sérica na adiponectina, visfatina e resistina nas alterações histológicas no fígado de pacientes com doença hepática gordurosa não alcoólica

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

A análise morfométrica para avaliar a taxa de progressão da fibrose hepática na hepatite C crônica após o transplante renal: uma série de casos

The real role of renal transplantation in hepatic fi brosis progression caused by hepatitis C virus is still unpredictable. Histological evaluation of the liver is the best form to estimate fi brosis evolution, although semiquantitative analysis carries important limitations. Objective: To apply a morphometric quantitative assay on hepatic fi brosis progression in renal recipients with hepatits C. Methods: Thirty patients were initially evaluated, but only seven were included. They underwent the fi rst biopsy near the transplantation date and the second biopsy at least 4 years later. The immunosuppressant therapy adopted in all cases was azatioprine and micofenolate. Fibrosis progression rate (FPR) was calculated before and after the surgery date in each patient according to Metavir score and morphometric analysis. Results: The FPR calculated by Metavir score showed no statistical difference between pre- and post-transplantation (p=0.9). The FPR calculated by the morphometric analysis was 0.58 ± 0.78 before transplantation and 3.0 ± 3.3 after the surgery, with statistical signi- fi cance between these values (p=0.0026). Conclusion: In the sample assessed, the progression of hepatic fi brosis was documented and quantifi ed only by the morphometric analysis, which is as a promising approach to histological evaluation of these patients.

Pancreatic hemangioma manifesting as variceal gastroesophageal bleeding during pregnancy: case report

There are only 10 reported cases of pancreatic hemangiomas in adults, only one of them causing digestive bleeding. We present a case of variceal bleeding and portal hypertension caused by a pancreatic hemangioma. The patient had 19 year-old and was received at her 16th week of pregnancy. She had massive hematemesis, controlled after variceal band ligation. Her image exams revealed a cystic lesion of 164 cm³ in the pancreas tail and signs of portal hypertension. Two months after, the ultrassonographic exam documented the lesion growth, achieving 200 cm³ at that time. The patient was submitted to distal pancreatectomy, and the histopathological analysis revealed a pancreatic hemangioma of 11 x 9 x 8 cm. Therefore, we report the second case of digestive bleeding caused by a pancreatic hemangioma, which had a well documented growth during the pregnancy. Additionally, we review the previous reports of pancreatic hemangiomas and discuss the hypothesis of hormonal infl uence on the natural history of these tumors.