Síntesis de espirobrasinoesteroides análogos de la 6-desoxocastasterona

The synthesis of two new spirostanic analogs of the natural occurring brassinosteroid 6-desoxocastasterone (1) is described. The scheme consists in the formation and elimination of tigogenin mesylate followed by catalytic dihydroxylation of the resulting D2-steroid (3) and acetylation of the 2a, 3a-diol introduced.Treatment diacetate (5) with NaNO2/BF3.Et2O and chromatography in alumina led to a 23-keto (6) which on reduction produced the 23S alcohol (8) as major product. Saponification of the 2a, 3a-diacetoxy-23-keto compound (6) and the 2a,3a-diacetoxy-23-hydroxy compound (8) led to the spirobrasinosteroids (7) and (9).13C NMR and ¹H RMN characteristics derived from substitution at C23 are briefly discussed.

Brain Dopamine and Serotonin Receptors in the Perception of Pain. Positron Emission Tomography Studies in Healthy Subjects

The role of dopamine and serotonin in spinal pain regulation is well established. However, little is known concerning the role of brain dopamine and serotonin in the perception of pain in humans. The aim of this study was to assess the potential role of brain dopamine and serotonin in determining experimental pain sensitivity in humans using positron emission tomography (PET) and psychophysical methods. A total of 39 healthy subjects participated in the study, and PET imaging was performed to assess brain dopamine D2/D3 and serotonin 5-HT_1A receptor availability. In a separate session, sensitivity to pain and touch was assessed with traditional psychophysical methods, allowing the evaluation of potential associations between D2/D3 and 5-HT_1A binding and psychophysical responses. The subjects’ responses were also analyzed according to Signal Detection Theory, which enables separate assessment of the subject’s discriminative capacity (sensory factor) and response criterion (non-sensory factor). The study found that the D2/D3 receptor binding in the right putamen was inversely correlated with pain threshold and response criterion. 5-HT_1A binding in cingulate cortex, inferior temporal gyrus and medial prefrontal cortex was inversely correlated with discriminative capacity for touch. Additionally, the response criterion for pain and intensity rating of suprathreshold pain were inversely correlated with 5-HT_1A binding in multiple brain areas. The results suggest that brain D2/D3 receptors and 5-HT_1A receptors modulate sensitivity to pain and that the pain modulatory effects may, at least partly, be attributed to influences on the response criterion. 5-HT_1A receptors are also involved in the regulation of touch by having an effect on discriminative capacity.

De orthoëpia & orthographia linguae fennicae

Dedicatio: Jac. Tengström.

De sacellis sepulcralibus, in templo cathedrali Aboënsi obviis

Invocatio: I.N.J.C.

De sensibus hominis

Invocatio: Numine trisagio auspice et duce.

Vaticinium Jacobi de Schiloh

Invocatio: [hepreaa].

Examen variarum lectionum, quas ad textum Jesaiae hebraeum Alexandrina versio exhibet

Dedicatio: Jacobus Haartman, Petrus Bonsdordd [kr. runo].

De virtute non senescente

Invocatio: I.N.J.

De legibus necessitati cedentibus

Invocatio: I.N.J.

Dissertatio academica

Arkit: 1 arkintunnukseton lehti, A-C4 D2.

De vulneribus Christi

Invocatio: D.O.M.A.

De genuinis divinae revelationis certitudinem ejusdem apodicticam evincentibus

Dedicatio: Christo favente.

Tanke-försök til närmare utredande af mechaniska häf-tyget

Invocatio: M.G.H.

Reluctante natura

Invocatio: I.N.J.

De praejudiciis interpreti Sacrae Scripturae nocivis

Invocatio: Q.F.F.Q.S.