960 resultados para Barber, Francis, d.1801.


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Sign.: [calderon]-3[calderon]4, A--Z4, 2A-2Z4, 3A-3Z4, 4A-4G4, 4H2

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Sign.: [ ]2, [calderon]2, A-Z4, 2A-2Z4, 3A-3Z4, 4A-4E4

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Resumen: Descripción: retrato de 3/4 de figura del Obispo de Heliópolis con mirada frontal. Viste muceta y crucifijo al cuello. Fué uno de los primeros vicarios apostólicos nombrados por propaganda Fidei. Fundador del seminario en misiones extranjeras en París

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Resumen: Descripción: San Vicente de pie y de frente acompañado por dos niños arrodillados. Viste hábito de dominico. Filacteria en la parte superior con la inscripción: "Timete Deum et date illi honorem"

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Resumen: Descripción: retrato del Patriarca Ribera barbado, sedente, de tres cuartos de figura y ligeramente de perfil hacia la derecha. Viste muceta y capisayo. En mano derecha "Plano del Seminario de Corpus Christi"

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Inscripción en parte sup.: "Pl. 103"

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Gp180, a duck protein that was proposed to be a cell surface receptor for duck hepatitis B virus, is the homolog of metallocarboxypeptidase D, a mammalian protein thought to function in the trans-Golgi network (TGN) in the processing of proteins that transit the secretory pathway. Both gp180 and mammalian metallocarboxypeptidase D are type I integral membrane proteins that contain a 58-residue cytosolic C-terminal tail that is highly conserved between duck and rat. To investigate the regions of the gp180 tail involved with TGN retention and intracellular trafficking, gp180 and various deletion and point mutations were expressed in the AtT-20 mouse pituitary corticotroph cell line. Full length gp180 is enriched in the TGN and also cycles to the cell surface. Truncation of the C-terminal 56 residues of the cytosolic tail eliminates the enrichment in the TGN and the retrieval from the cell surface. Truncation of 12–43 residues of the tail reduced retention in the TGN and greatly accelerated the turnover of the protein. In contrast, deletion of the C-terminal 45 residues, which truncates a potential YxxL-like sequence (FxxL), reduced the protein turnover and caused accumulation of the protein on the cell surface. A point mutation of the FxxL sequence to AxxL slowed internalization, showing that this element is important for retrieval from the cell surface. Mutation of a pair of casein kinase II sites within an acidic cluster showed that they are also important for trafficking. The present study demonstrates that multiple sequence elements within the cytoplasmic tail of gp180 participate in TGN localization.