Atmospheric rivers do not explain UK summer extreme rainfall

Extreme rainfall events continue to be one of the largest natural hazards in the UK. In winter, heavy precipitation and floods have been linked with intense moisture transport events associated with atmospheric rivers (ARs), yet no large-scale atmospheric precursors have been linked to summer flooding in the UK. This study investigates the link between ARs and extreme rainfall from two perspectives: 1) Given an extreme rainfall event, is there an associated AR? 2) Given an AR, is there an associated extreme rainfall event? We identify extreme rainfall events using the UK Met Office daily rain-gauge dataset and link these to ARs using two different horizontal resolution atmospheric datasets (ERA-Interim and 20th Century Re-analysis). The results show that less than 35% of winter ARs and less than 15% of summer ARs are associated with an extreme rainfall event. Consistent with previous studies, at least 50% of extreme winter rainfall events are associated with an AR. However, less than 20% of the identified summer extreme rainfall events are associated with an AR. The dependence of the water vapor transport intensity threshold used to define an AR on the years included in the study, and on the length of the season, is also examined. Including a longer period (1900-2012) compared to previous studies (1979-2005) reduces the water vapor transport intensity threshold used to define an AR.

Oxidative stress and growth-regulating intracellular signaling pathways in cardiac myocytes

The toxic effects of oxidative stress on cells (including cardiac myocytes, the contractile cells of the heart) are well known. However, an increasing body of evidence has suggested that increased production of reactive oxygen species (ROS) promotes cardiac myocyte growth. Thus, ROS may be 'second messenger' molecules in their own right, and growth-promoting neurohumoral agonists might exert their effects by stimulating production of ROS. The authors review the principal growth-promoting intracellular signaling pathways that are activated by ROS in cardiac myocytes, namely the mitogen-activated protein kinase cascades (extracellular signal-regulated kinases 1/2, c-Jun N-terminal kinases, and p38-mitogen-activated protein kinases) and the phosphoinositide 3-kinase/protein kinase B (Akt) pathway. Possible mechanisms are discussed by which these pathways are activated by ROS, including the oxidation of active site cysteinyl residues of protein and lipid phosphatases with their consequent inactivation, the potential involvement of protein kinase C or the apoptosis signal-regulating kinase 1, and the current models for the activation of the guanine nucleotide binding protein Ras.

LIMITS OF TILTING MODULES

We study the problem of when a direct limit of tilting modules is still a tilting module.

Surface-enhanced Raman scattering study of alizarin red S

This paper presents the application of surface-enhanced resonance Raman spectroscopy (SERRS) for the structural study of alizarin red S (ARS) and the nature of its interaction with silver nanoparticles. SERRS data for ARS over nanostructured silver electrodes suggest a surface-induced reaction of the adsorbed dye and the formation of an ion stabilized by the dye and alkali ions adsorbed at the metal surface. We found that precoating the SERS active substrate with 1-propanethiol inhibits the surface-induced modification of ARS. In addition to preventing structural modifications of ARS, the coating also concentrates the hydrophobic dye close enough to the SERS active interface enabling the observation of excellent Raman spectra of ARS in aqueous environment at ppm levels. The influence of resonance Raman effect and of the pH on the SERS spectra of ARS was also investigated. (C) 2010 Elsevier B.V. All rights reserved.

Comparing value-at-risk methodologies

In this paper, we compare four different Value-at-Risk (V aR) methodologies through Monte Carlo experiments. Our results indicate that the method based on quantile regression with ARCH effect dominates other methods that require distributional assumption. In particular, we show that the non-robust methodologies have higher probability to predict V aRs with too many violations. We illustrate our findings with an empirical exercise in which we estimate V aR for returns of S˜ao Paulo stock exchange index, IBOVESPA, during periods of market turmoil. Our results indicate that the robust method based on quantile regression presents the least number of violations.

Estudo comparativo da reprodutibilidade de medidas cefalométricas realizadas por radiologistas odontológicos e clínicas de radiologia

A análise cefalométrica é utilizada pelos cirurgiões-dentistas como auxiliar no diagnóstico, planejamento e acompanhamento do tratamento de seus pacientes ortodônticos, cirúrgicos e ortopédicos. No entanto, não é uma ferramenta tão precisa, pois erros significantes estão presentes nas medidas obtidas pelo mesmo ou diferentes examinadores. Assim, faz-se necessário um maior controle dos erros implicados na identificação dos pontos cefalométricos. O objetivo deste estudo foi avaliar a reprodutibilidade de medidas cefalométricas obtidas de cefalogramas realizados por três especialistas em radiologia e compará-la aos resultados obtidos por três clínicas de radiologia odontológica. Para tanto, os examinadores realizaram cefalogramas de 39 telerradiografias pertencentes à amostra de Silveira, 2003. Através do teste ANOVA, verificou-se reprodutibilidade para 17 dos 32 valores dos fatores cefalométricos analisados, o que corresponde a uma concordância em 53,1% dos fatores, enquanto as clínicas de radiologia concordaram em apenas 12,5% destes. A partir dos resultados encontrados, concluiu-se que os três especialistas em radiologia apresentaram maior reprodutibilidade nos traçados cefalométricos do que as clínicas de radiologia estudadas.

A luta do Bispo Dom José de Medeiros Delgado por educação escolar para todos (Caicó-RN, 1941-1951)

The socioeducational program of actions developed by Dom José de Medeiros Delgado, first Bishop of Diocese of Caicó city in Rio Grande do Norte, from 1941 to 1951, is analyzed by the present work in a historical perspective, based upon the school culture refecence.Through this reference point, the general and peculiar school culture proper of catholic schools founded by Dom Delgado was learned.The schools are: the Ginásio Diocesano Seridoense (1942), the Escola Doméstica Popular Darci Vargas (1943, the Prevocacional School of Caicó (1944) and the Santo Cura d ars Seminar (1946). The socioeducational actions of Dom Delgado Bishop affected seven other towns surrounding Caicó. Places where catholic schools were founded and named after Escola do Pobre . In fight for schools for all social segments of city and rural natures, Dom Delgado founded four rural schools in the surroundings of Serra Negra, São João do Sabugi, Jardim do Seridó e Lagoa Nova. It is also part of his beneficial work the creation of rural cooperatives for the parents of the students from such schools

Cobre e zinco no material percolado e no solo com a aplicação de água residuaria de suinocultura em solo cultivado com soja

O objetivo deste trabalho foi avaliar possíveis efeitos da aplicação de taxas de água residuária de suinocultura (ARS), quanto às concentrações de cobre e zinco, tanto no solo quanto na água percolada de lisímetros de drenagem, durante o ciclo da cultura da soja. O experimento foi conduzido em ambiente protegido, onde havia 24 lisímetros de drenagem. Semeou-se soja cultivar CD 202, e foram aplicadas ARS nas seguintes dosagens: 0; 100; 200 e 300 m³ ha-1 no ciclo, combinadas com duas adubações na semeadura (com e sem adição da adubação recomendada na semeadura), em três repetições por tratamento. Foram feitas seis coletas do material percolado durante o ciclo da cultura e realizadas determinações de cobre e zinco. No solo, foram feitas três coletas em cada parcela experimental, para a determinação do pH, da matéria orgânica, da capacidade de troca catiônica, do cobre e do zinco. O delineamento foi em blocos casualizados, num esquema fatorial de 4 x 2. Observou-se que o cobre no solo não apresentou diferenças significativas com a aplicação de ARS e adubação, enquanto as concentrações de zinco no solo foram influenciadas pelas taxas aplicadas de ARS. As transferências de cobre e de zinco por percolação foram pouco expressivas.

Determinação de Ba, Cd, Cr, Cu, Ni, Pb, Sn e Zn em Tainha (Mugil brasiliensis) nos estuários potiguares

Heavy metals can cause problems of human poisoning by ingestion of contaminated food, and the environment, a negative impact on the aquatic fauna and flora. And for the presence of these metals have been used for aquatic animals biomonitoramento environment. This research was done in order to assess the environmental impact of industrial and domestic sewage dumped in estuaries potiguares, from measures of heavy metals in mullet. The methods used for these determinations are those in the literature for analysis of food and water. Collections were 20 samples of mullet in several municipality of the state of Rio Grande do Norte, from the estuaries potiguares. Were analyzed the content of humidity, ash and heavy metals. The data were subjected to two methods of exploratory analysis: analysis of the main components (PCA), which provided a multivariate interpretation, showing that the samples are grouped according to similarities in the levels of metals and analysis of hierarchical groupings (HCA), producing similar results. These tests have proved useful for the treatment of the data producing information that would hardly viewed directly in the matrix of data. The analysis of the results shows the high levels of metallic species in samples Mugil brasiliensis collected in Estuaries /Potengi, Piranhas/Açu, Guaraíra / Papeba / Arês and Curimataú

Stress hormones increase cell proliferation and regulates interleukin-6 secretion in human oral squamous cell carcinoma cells

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Mineral Trioxide Aggregate-based Endodontic Sealer Stimulates Hydroxyapatite Nucleation in Human Osteoblast-like Cell Culture

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Investigation of the Effects of a1-Adrenoceptor Antagonism and L-Type Calcium Channel Blockade on Ejaculation and Vas Deferens and Seminal Vesicle Contractility In Vitro

Introduction. Premature ejaculation is one of the most common male sexual dysfunctions. Current pharmacological treatments involve reduction in penile sensitivity by local anesthetics or increase of ejaculatory threshold by selective serotonin reuptake inhibitors. a1-Adrenoceptors (a1-ARs) and L-type calcium channels are expressed in the smooth muscles of the male reproductive tract, and their activations play an important role in the physiological events involved in the seminal emission phase of ejaculation.Aim. To evaluate if the inhibition of the contractility of the vas deferens and seminal vesicle by alpha(1)-AR antagonism or the L-type calcium channel blockade can delay ejaculation.Methods. The effects of the alpha(1)-AR antagonist tamsulosin and of the L-type calcium channel blockers, nifedipine and (S)-(+)-niguldipine, on contractions induced by norepinephrine in the rat vas deferens and seminal vesicles in vitro and on the ejaculation latency of male rats in behavioral mating tests were evaluated.Main Outcome Measure. Tension development of vas deferens and seminal vesicles in response to norepinephrine in vitro and behavioral mating parameters were quantified.Results. Tension development of vas deferens and seminal vesicle to alpha(1)-AR activation was significantly inhibited by tamsulosin, nifedipine, and (S)-(+)-niguldipine. Tamsulosin displayed insurmountable antagonism of contractions induced by norepinephrine in the rat vas deferens and seminal vesicle. Ejaculation latency of male rats was not modified by tamsulosin, nifedipine, or (S)-(+)-niguldipine; however, both the number and weight of the seminal plugs recovered from female rats mated with male rats treated with tamsulosin were significantly reduced.Conclusion. Seminal emission impairment by inhibition of vas deferens or seminal vesicle contractility by L-type calcium channel blockade or alpha(1)-AR antagonism is not able to delay the ejaculation. de Almeida Kiguti LR and Pupo AS. Investigation of the effects of alpha(1)-adrenoceptor antagonism and L-type calcium channel blockade on ejaculation and vas deferens and seminal vesicle contractility in vitro. J Sex Med 2012; 9: 159-168.