Comparison of a Novel Biodegradable Polymer Sirolimus-Eluting Stent With a Durable Polymer Everolimus-Eluting Stent: Results of the Randomized BIOFLOW-II Trial.

BACKGROUND Biodegradable polymers for release of antiproliferative drugs from drug-eluting stents aim to improve vascular healing. We assessed noninferiority of a novel ultrathin strut drug-eluting stent releasing sirolimus from a biodegradable polymer (Orsiro, O-SES) compared with the durable polymer Xience Prime everolimus-eluting stent (X-EES) in terms of the primary end point in-stent late lumen loss at 9 months. METHODS AND RESULTS A total of 452 patients were randomly assigned 2:1 to treatment with O-SES (298 patients, 332 lesions) or X-EES (154 patients, 173 lesions) in a multicenter, noninferiority trial. The primary end point was in-stent late loss at 9 months. O-SES was noninferior to X-EES for the primary end point (0.10±0.32 versus 0.11±0.29 mm; difference=0.00063 mm; 95% confidence interval, -0.06 to 0.07; Pnoninferiority<0.0001). Clinical outcome showed similar rates of target-lesion failure at 1 year (O-SES 6.5% versus X-EES 8.0%; hazard ratio=0.82; 95% confidence interval, 0.40-1.68; log-rank test: P=0.58) without cases of stent thrombosis. A subgroup of patients (n=55) underwent serial optical coherence tomography at 9 months, which demonstrated similar neointimal thickness among lesions allocated to O-SES and X-EES (0.10±0.04 mm versus 0.11±0.04 mm; -0.01 [-0.04, -0.01]; P=0.37). Another subgroup of patients (n=56) underwent serial intravascular ultrasound at baseline and 9 months indicating a potential difference in neointimal area at follow-up (O-SES, 0.16±0.33 mm(2) versus X-EES, 0.43±0.56 mm(2); P=0.04). CONCLUSIONS Compared with durable polymer X-EES, novel biodegradable polymer-based O-SES was found noninferior for the primary end point in-stent late lumen loss at 9 months. Clinical event rates were comparable without cases of stent thrombosis throughout 1 year of follow-up. CLINICAL TRIAL REGISTRATION URL http://www.clinicaltrials.gov. Unique identifier: NCT01356888.

Jacob Abraham und Abraham Abramson : 55 Jahre Berliner Medaillenkunst 1755 - 1810

von Tassilo Hoffmann

Measurement of the neutrino-oxygen neutral-current interaction cross section by observing nuclear deexcitation γ rays

We report the first measurement of the neutrino-oxygen neutral-current quasielastic (NCQE) cross section. It is obtained by observing nuclear deexcitation γ rays which follow neutrino-oxygen interactions at the Super-Kamiokande water Cherenkov detector. We use T2K data corresponding to 3.01 × 1020 protons on target. By selecting only events during the T2K beam window and with well-reconstructed vertices in the fiducial volume, the large background rate from natural radioactivity is dramatically reduced. We observe 43 events in the 4–30 MeV reconstructed energy window, compared with an expectation of 51.0, which includes an estimated 16.2 background events. The background is primarily nonquasielastic neutral-current interactions and has only 1.2 events from natural radioactivity. The flux-averaged NCQE cross section we measure is 1.55 × 10−38 cm2 with a 68% confidence interval of ð1.22; 2.20Þ × 10−38 cm2 at a median neutrino energy of 630 MeV, compared with the theoretical prediction of 2.01 × 10−38 cm2.

Ms. hebr. oct. 55 - Beʼur le- sefer ha-higayon

Vorbesitzer: Abraham Merzbacher

Ueber die Robotablösung: Ueber die Robotablösung enthält der Aufsatz der Prager Zeitung in Nr. 55 vom 6ten April 1848 mehrere sehr praktische Ansichten und Vorschläge ...

Welsch (Projektbearbeiter): Diskussion über die Aufhebung der Robot (Fronarbeit) am Beispiel Böhmens. Die grundsätzliche Notwendigkeit dieses Schrittes wird bejaht, eine entschädigungslose Ablösung jedoch abgelehnt

Kundmachung: Anton Heizerath, von Wien gebürtig, 55 Jahre alt, katholisch ...

Welsch (Projektbearbeiter): Verurteilung des ehemaligen Amtsschreibers und Bauaufsehers Heizerath (in Umwandlung der zuvor ausgesprochenen Todesstrafe) zu fünfjähriger Zwangsarbeit wegen Aufruhrs

Notizen aus Dernschwams Tagebuch einer Reise nach Konstantinopel (1533/55)

Nathan Porges

Die Schreiberfamilien: I. Chronik 2, 55

Samuel Klein

Ms. germ. qu. 55 - Deutsches Evangelistar

Vorbesitzer: Johann Maximilian zum Jungen

Ms. Barth. 55 - Postilla super quattuor evangelia

Vorbesitzer: Bartholomaeusstift Frankfurt am Main

Ms. Praed. 55 - Commentarius in Evangelium S. Johannis

Vorbesitzer: Dominikanerkloster Frankfurt am Main

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 430 - Bemerkungen zu Kants theoretischer und praktischer Vernunft

veröffentlicht in: Der handschriftliche Nachlaß / Arthur Schopenhauer. Hrsg. von Arthur Hübscher - Frankfurt am Main, Bd. 2, S 302-304