Chefredaktör Rafael Paasio 18.6.1963 Åbo

Kirje

Magister Raoul Palmgren 18.1.1962 Kemi

Kirje

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.

Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we identified and replicated 28 genome-wide significant loci in association with serum urate concentrations (18 new regions in or near TRIM46, INHBB, SFMBT1, TMEM171, VEGFA, BAZ1B, PRKAG2, STC1, HNF4G, A1CF, ATXN2, UBE2Q2, IGF1R, NFAT5, MAF, HLF, ACVR1B-ACVRL1 and B3GNT4). Associations for many of the loci were of similar magnitude in individuals of non-European ancestry. We further characterized these loci for associations with gout, transcript expression and the fractional excretion of urate. Network analyses implicate the inhibins-activins signaling pathways and glucose metabolism in systemic urate control. New candidate genes for serum urate concentration highlight the importance of metabolic control of urate production and excretion, which may have implications for the treatment and prevention of gout.

Impact and cost of a 2-week community-based screening and awareness program for diabetes and cardiovascular risk factors in a Swiss canton.

BACKGROUND: Community-based diabetes screening programs can help sensitize the population and identify new cases. However, the impact of such programs is rarely assessed in high-income countries, where concurrent health information and screening opportunities are common place. INTERVENTION AND METHODS: A 2-week screening and awareness campaign was organized as part of a new diabetes program in the canton of Vaud (population of 697,000) in Switzerland. Screening was performed without appointment in 190 out of 244 pharmacies in the canton at the subsidized cost of 10 Swiss Francs per participant. Screening included questions on risk behaviors, measurement of body mass index, blood pressure, blood cholesterol, random blood glucose (RBG), and A1c if RBG was >/=7.0 mmol/L. A mass media campaign promoting physical activity and a healthy diet was channeled through several media, eg, 165 spots on radio, billboards in 250 public places, flyers in 360 public transport vehicles, and a dozen articles in several newspapers. A telephone survey in a representative sample of the population of the canton was performed after the campaign to evaluate the program. RESULTS: A total of 4222 participants (0.76% of all persons aged >/=18 years) underwent the screening program (median age: 53 years, 63% females). Among participants not treated for diabetes, 3.7% had RBG >/= 7.8 mmol/L and 1.8% had both RBG >/= 7.0 mmol/L and A1c >/= 6.5. Untreated blood pressure >/=140/90 mmHg and/or untreated cholesterol >/=5.2 mmol/L were found in 50.5% of participants. One or several treated or untreated modifiable risk factors were found in 78% of participants. The telephone survey showed that 53% of all adults in the canton were sensitized by the campaign. Excluding fees paid by the participants, the program incurred a cost of CHF 330,600. CONCLUSION: A community-based screening program had low efficiency for detecting new cases of diabetes, but it identified large numbers of persons with elevated other cardiovascular risk factors. Our findings suggest the convenience of A1c for mass screening of diabetes, the usefulness of extending diabetes screening to other cardiovascular risk factors, and the importance of a robust background communication campaign.

Motor Vehicle Crash Fatalities for Week Ending, April 18, 2008

Motor Vehicle Crash Fatalities

EPI Update, April 18, 2008

Weekly newsletter for Center For Acute Disease Epidemiology of Iowa Department of Public Health.

Informe preliminar del Crucero Unuane 6711. 18 noviembre - 20 diciembre. Primavera 1967

Informe del crucero de primavera 6711 a bordo del Unanue, que formó parte del programa de cruceros del Instituto del Mar del Perú para 1967. El mar fue explorado de Cabo Blanco a Ilo, mediante 19 perfiles perpendiculares a la costa que incluyeron 137 estaciones de observación, con un recorrido de 4870 millas.

Situación del recurso merluza y sus características biológicas en la primavera de 1978 crucero 7811-II TAREQ II (18 de octubre - 8 de noviembre 1978)

Evalúa el stock de la merluza y de otros recursos dermesales, determina la intensidad del desove y la distribución del stock reproductivo, así como las condiciones ambientales que están influyendo en la distribución y concentración del recurso.

Exploración del área marina Supe - Pucusana efectuada durante los periodos 9-13 y 16-18 de agosto de 1965, a bordo del "Explorador"

Describe la exploración bio oceanografía efectuada a bordo del "Explorador" tuvo como principal objetivo el comportamiento de los cardúmenes de anchoveta y determinar desove, relacionándolos con los principales factores abioticos en la zona Supe - Pisco, hasta una distancia de 60 millas náuticas de ka cista, El crucero comprendió un rastreo entre Supe Callao - Pucusana con un total de 49 estaciones distribuidas en 6 perfiles y un zig zag costero.

Budjetti vuodelle 1952 - 18 Pl

Puhe

EPI Update, July 18, 2008

Weekly newsletter for Center For Acute Disease Epidemiology of Iowa Department of Public Health.

Situación del recurso de concha de abanico en el área de Pisco y evaluación de la población en Bahía Independencia (18 de marzo al 06 de abril de 1995). Informe preliminar

Contiene los resultados del monitoreo biológico - pesquero de concha de abanico efectuado en el área de Pisco entre enero y abril de 1995 y de la población en Bahía Independencia entre el 18 de marzo y el 06 de abril del mismo año. Para el estudio, se realizó un muestreo biológico y biométrico de los centros de desembarque a fin de conocer el desarrollo y comportamiento del recurso, así como prospecciones de evaluación para determinar la distribución, concentración y magnitud poblacional en estas áreas.

Fru Marianne Lanamäki 18.4.1958 Vasa

Kirje

[18 phot. de Provence (Basses-Alpes) par Cayol frères, phot. à Marseille, don Elisée Reclus en 1886]

Donateur : Reclus, Élisée (1830-1905)