334 resultados para 1343
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O conflito trabalho-família é um fenômeno freqüente nas sociedades atuais em que homens e mulheres dividem responsabilidades familiares e profissionais. A sua direção pode ser unidirecional ou bidirecional, ou seja, da família para o trabalho, do trabalho para a família ou simultaneamente de uma esfera para outra, afetando sensivelmente as relações familiares e as relações nas organizações, sendo possível afetar diretamente o bem-estar dos indivíduos. Este é um estudo de natureza quantitativa e com desenho transversal. O critério para a escolha de participantes foi o de conveniência. O objetivo geral desta pesquisa foi analisar as relações entre conflito trabalho-família (CTF), bem-estar subjetivo (BES) e bem-estar no trabalho (BET). O estudo contou com a participação de 174 trabalhadores em uma amostra diversificada de profissionais do segmento privado, público e de ONG, sendo 52,9% do sexo feminino, com idade média de 38,29 anos (DP=11,22). Para a obtenção dos dados optou-se por um questionário abrangendo as três variáveis do estudo contendo duas escalas para aferir as dimensões de BES, uma escala para aferir BET e uma escala para aferir CTF/CFT. Para a análise dos dados foi usado o SPSS, versão 20. Foram calculadas frequências, percentuais, médias, desvios-padrão, e índices de correlação, bem como índices de precisão das medidas usadas (Alpha de Cronbach). Os resultados apontaram para uma maior interferência do trabalho na família do que da família no trabalho. Essa interferência foi significativa tanto para o bem-estar no trabalho, quanto para o bem-estar subjetivo, alterando o envolvimento com o trabalho e gerando sentimentos de infelicidade, desânimo e angústia em relação as suas realizações pessoais, e ao futuro. Quanto maior o conflito trabalho-família, menor é o bem-estar no trabalho e menor é o bem-estar subjetivo desses participantes.
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Raf kinase inhibitory protein (RKIP) is a physiologic inhibitor of c-RAF kinase and nuclear factor ?B signaling that represses tumor invasion and metastasis. Glycogen synthase kinase-3ß (GSK3ß) suppresses tumor progression by downregulating multiple oncogenic pathways including Wnt signaling and cyclin D1 activation. Here, we show that RKIP binds GSK3 proteins and maintains GSK3ß protein levels and its active form. Depletion of RKIP augments oxidative stress-mediated activation of the p38 mitogen activated protein kinase, which, in turn, inactivates GSK3ß by phosphorylating it at the inhibitory T390 residue. This pathway de-represses GSK3ß inhibition of oncogenic substrates causing stabilization of cyclin D, which induces cell-cycle progression and ß-catenin, SNAIL, and SLUG, which promote epithelial to mesenchymal transition. RKIP levels in human colorectal cancer positively correlate with GSK3ß expression. These findings reveal the RKIP/GSK3 axis as both a potential therapeutic target and a prognosis-based predictor of cancer progression.
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Cross-cultural researchers have questioned the extent to which European–American management practices can be transported to major markets in Asia, such as the People's Republic of China. Applying employee involvement theory, we examined the relationships between climate for autonomy, work demands climate, employee stress and organizational productivity in a cross-national study of 51 UK and 104 Chinese manufacturing organizations. We predicted and found that climate for autonomy was positively and negatively related to stress in the Chinese and UK contexts, respectively. The interaction of climate for autonomy and work demands climate was significant: climate for autonomy was positively related to organizational productivity only when work demands climate was low.
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AMS Subj. Classification: 90C57; 90C10;
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Substitution of branded medicine with a generic equivalent is already common. Robin Ferner, Warren Lenney, and John Marriott argue that concerns about UK plans to let pharmacists make the decision are unwarranted.
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Az új választási törvény egyik célja a korábbinál igazságosabb választási körzetek kialakítása. Ezt a Velencei Bizottság választási kódexében megfogalmazott ajánlásokhoz hasonló, bár azoknál némileg megengedőbb szabályok révén biztosítja. A szabályok rögzítik a körzetek számát, illetve hogy a körzetek nem oszthatnak ketté kisebb településeket, és nem nyúlhatnak át a megyehatárokon. Tanulmányunkban belátjuk, hogy a szabályok betartása mellett a körzetek kialakítása matematikailag lehetetlen. Javaslatot teszünk a probléma optimális megoldására elvi alapon is, vizsgáljuk a módszer tulajdonságait, majd az általunk megfogalmazott hatékony algoritmussal, a 2010. évi országgyűlési választások adatainak felhasználásával meghatározzuk a körzetek megyék közti elosztásának legjobb megoldását. Végül kitérünk a demográfiai változások várható hatásaira, és több javaslatot teszünk a korlátok hosszú távú betartására: javasoljuk a választási körzetek számának körülbelül 130-ra növelését; egy-egy felülvizsgálat alkalmával a választási körzetek számának megváltoztathatóságát; illetve a körzetek megyék helyett régiók szerinti szervezését. _______ One of the aims of the new electoral law of Hungary has been to apportion voters to voting districts more fairly. This is ensured by a set of rules rather more permissive than those put forward in the Code of Good Practice in Electoral Matters issued by the Venice Commission. These rules fix the size of the voting districts, and require voting districts not to split smaller towns and villages and not to cross county borders. The article shows that such an apportionment is mathematically impos-sible, and makes suggestions for a theoretical approach to resolving this problem: determine the optimal apportionment by studying the properties of their approach, and use the authors efficient algorithm on the data for the 2010 national elections. The article also examines the expected effect of demographic changes and formulates recommendations for adhering to the rules over the long term: increase the number of voting districts to about 130, allow the number of voting districts to change flexibly at each revision of the districts, and base the districts on regions rather than counties.
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The Visegrad Countries (VC)2 joined the European Union in 2004, which has offered several possibilities and challenges for their agriculture. The aim of the paper is to evaluate the status of the sector in the light of latest available data as well as to identify the factors lying behind different country performances. Results suggest that EU accession has had a diverse impact on the Visegrad Countries’ agriculture and member states capitalised their possibilities in a different manner, due to initial conditions and pre- and post-accession policies.
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Robert M. Jams, editor-in-chief, Benedict on Admiralty: Cruise Ships (New York: Matthew Bender & Company Inc. Lexis Publishing, March 2000), www.bender.com, ISBNO- 8205-4392-6 Binder, 312 pp. (Appendices, Index) $200.
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The definition and nomenclature used in queer theory have become distorted from their initial meanings and intents.
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Vol. 22, Issue 11, 12 pages
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Florida International University Commencement Ceremony April 26,2010 at US Century Bank Arena ( Session 1) Colleges graduated: School of Hospitality and Tourism Management School of Journalism and Mass Communication College of Education
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Approaches to quantify the organic carbon accumulation on a global scale generally do not consider the small-scale variability of sedimentary and oceanographic boundary conditions along continental margins. In this study, we present a new approach to regionalize the total organic carbon (TOC) content in surface sediments (<5 cm sediment depth). It is based on a compilation of more than 5500 single measurements from various sources. Global TOC distribution was determined by the application of a combined qualitative and quantitative-geostatistical method. Overall, 33 benthic TOC-based provinces were defined and used to process the global distribution pattern of the TOC content in surface sediments in a 1°x1° grid resolution. Regional dependencies of data points within each single province are expressed by modeled semi-variograms. Measured and estimated TOC values show good correlation, emphasizing the reasonable applicability of the method. The accumulation of organic carbon in marine surface sediments is a key parameter in the control of mineralization processes and the material exchange between the sediment and the ocean water. Our approach will help to improve global budgets of nutrient and carbon cycles.
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http://digitalcommons.fiu.edu/fce_lter_photos/1343/thumbnail.jpg
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The indigenous people of Greenland, the Inuit, have lived for a long time in the extreme conditions of the Arctic, including low annual temperatures, and with a specialized diet rich in protein and fatty acids, particularly omega-3 polyunsaturated fatty acids (PUFAs). A scan of Inuit genomes for signatures of adaptation revealed signals at several loci, with the strongest signal located in a cluster of fatty acid desaturases that determine PUFA levels. The selected alleles are associated with multiple metabolic and anthropometric phenotypes and have large effect sizes for weight and height, with the effect on height replicated in Europeans. By analyzing membrane lipids, we found that the selected alleles modulate fatty acid composition, which may affect the regulation of growth hormones. Thus, the Inuit have genetic and physiological adaptations to a diet rich in PUFAs.