The Political and Judicial Life of Metadata: Digital Rights Ireland and the Trail of the Data Retention Directive. CEPS Paper in Liberty and Security No. 65, May 2014

This paper examines the challenges facing the EU regarding data retention, particularly in the aftermath of the judgment Digital Rights Ireland by the Court of Justice of the European Union (CJEU) of April 2014, which found the Data Retention Directive 2002/58 to be invalid. It first offers a brief historical account of the Data Retention Directive and then moves to a detailed assessment of what the judgment means for determining the lawfulness of data retention from the perspective of the EU Charter of Fundamental Rights: what is wrong with the Data Retention Directive and how would it need to be changed to comply with the right to respect for privacy? The paper also looks at the responses to the judgment from the European institutions and elsewhere, and presents a set of policy suggestions to the European institutions on the way forward. It is argued here that one of the main issues underlying the Digital Rights Ireland judgment has been the role of fundamental rights in the EU legal order, and in particular the extent to which the retention of metadata for law enforcement purposes is consistent with EU citizens’ right to respect for privacy and to data protection. The paper offers three main recommendations to EU policy-makers: first, to give priority to a full and independent evaluation of the value of the data retention directive; second, to assess the judgment’s implications for other large EU information systems and proposals that provide for the mass collection of metadata from innocent persons, in the EU; and third, to adopt without delay the proposal for Directive COM(2012)10 dealing with data protection in the fields of police and judicial cooperation in criminal matters.

New insights into the pharmacokinetics and pharmacodynamics of natalizumab treatment for patients with multiple sclerosis, obtained from clinical and in vitro studies.

BACKGROUND The monoclonal antibody natalizumab (NAT) inhibits the migration of lymphocytes throughout the blood-brain barrier by blocking very late antigen (VLA)-4 interactions, thereby reducing inflammatory central nervous system (CNS) activity in patients with multiple sclerosis (MS). We evaluated the effects of different NAT treatment regimens. METHODS We developed and optimised a NAT assay to measure free NAT, cell-bound NAT and VLA-4 expression levels in blood and cerebrospinal fluid (CSF) of patients using standard and prolonged treatment intervals and after the cessation of therapy. RESULTS In paired CSF and blood samples of NAT-treated MS patients, NAT concentrations in CSF were approximately 100-fold lower than those in serum. Cell-bound NAT and mean VLA-4 expression levels in CSF were comparable with those in blood. After the cessation of therapy, the kinetics of free NAT, cell-bound NAT and VLA-4 expression levels differed. Prolonged intervals greater than 4 weeks between infusions caused a gradual reduction of free and cell-bound NAT concentrations. Sera from patients with and without NAT-neutralising antibodies could be identified in a blinded assessment. The NAT-neutralising antibodies removed NAT from the cell surface in vivo and in vitro. Intercellular NAT exchange was detected in vitro. CONCLUSIONS Incorporating assays to measure free and cell-bound NAT into clinical practice can help to determine the optimal individual NAT dosing regimen for patients with MS.

Discrimination against minorities and women in pensions and health, life, and disability insurance.

Includes bibliographical references.

Demonstration of ultrafiltration and carbon adsorption for treatment of industrial laundering wastewater /

Mode of access: Internet.

Development of methods and techniques for final treatment of combined municipal and textile wastewater, including sludge utilization and disposal /

Issued Dec. 1979.

Effects of suspended solids and sediment on reproduction and early life of warmwater fishes : a review /

Mode of access: Internet.

The secret of a long and active life and how to enjoy it ... presenting the condensed views, advices and counsel of qualified biologists, physicians, dieticians and specialists, consulted;

On cover: By Frank Linden.

Christian ethics in history and modern life,

"An elaboration of a course of lectures delivered on the Stanton foundation in the University of Cambridge."--Pref.

Plutarch's Lives : translated from the Greek with notes, critical and historical and a life of Plutarch /

Includes index.

Housing discrimination study : incidence and severity of unfavorable treatment /

"HUD-1327-PDR"--Cover p. 4.

Instructions and notes on the treatment and training of disabled men.

Mode of access: Internet.

Home and family life in a changing civilization : held by the United States Office of Education in cooperation with the State University of Iowa and the Iowa State College of Agriculture and Mechanic Arts at Ames, Iowa, November 10 and 11, 1930 /

"January, 1931."

A list of books on farming, homemaking and rural life; for farmers and homemakers.

Annotated and classified list.

Process design and cost estimating algorithms for the computer assisted procedure for design and evaluation of wastewater treatment systems (CAPDET) /

"PB 82-190455."

The great mother, a gospel of the eternally-feminine; occult and scientific studies and experiences in the sacred and secret life,

Mode of access: Internet.