Validation of Two Methods of Data Collection of Self-Reported Medicine Use Among the Elderly

The accuracy of medicine use information was compared for a telephone interview and mail questionnaire, using an in-home medicine check as the standard of assessment The validity of medicine use information varied by data source, level of specificity of data, and respondent characteristics. The mail questionnaire was the more valid source of overall medicine use information. Implications for both service providers and researchers are provided.

Structural analysis of B-Box 2 from MuRF1: identification of a novel self-association pattern in a RING-like fold

The B-box motif is the defining feature of the TRIM family of proteins, characterized by a RING finger-B-box-coiled coil tripartite fold. We have elucidated the crystal structure of B-box 2 (B2) from MuRF1, a TRIM protein that supports a wide variety of protein interactions in the sarcomere and regulates the trophic state of striated muscle tissue. MuRF1 B2 coordinates two zinc ions through a cross-brace alpha/beta-topology typical of members of the RING finger superfamily. However, it self-associates into dimers with high affinity. The dimerization pattern is mediated by the helical component of this fold and is unique among RING-like folds. This B2 reveals a long shallow groove that encircles the C-terminal metal binding site ZnII and appears as the defining protein-protein interaction feature of this domain. A cluster of conserved hydrophobic residues in this groove and, in particular, a highly conserved aromatic residue (Y133 in MuRF1 B2) is likely to be central to this role. We expect these findings to aid the future exploration of the cellular function and therapeutic potential of MuRF1.

Demo Abstract: Disseminating WMSN Data by Using Social Network and Web

For smart cities applications, a key requirement is to disseminate data collected from both scalar and multimedia wireless sensor networks to thousands of end-users. Furthermore, the information must be delivered to non-specialist users in a simple, intuitive and transparent manner. In this context, we present Sensor4Cities, a user-friendly tool that enables data dissemination to large audiences, by using using social networks, or/and web pages. The user can request and receive monitored information by using social networks, e.g., Twitter and Facebook, due to their popularity, user-friendly interfaces and easy dissemination. Additionally, the user can collect or share information from smart cities services, by using web pages, which also include a mobile version for smartphones. Finally, the tool could be configured to periodically monitor the environmental conditions, specific behaviors or abnormal events, and notify users in an asynchronous manner. Sensor4Cities improves the data delivery for individuals or groups of users of smart cities applications and encourages the development of new user-friendly services.

THEORETICAL STUDIES ON THE METHODS OF RECONSTRUCTING PHYLOGENETIC TREES FROM DNA SEQUENCE DATA (MOLECULAR EVOLUTION, HOMINOID EVOLUTION, COMPUTER SIMULATION)

(1) A mathematical theory for computing the probabilities of various nucleotide configurations is developed, and the probability of obtaining the correct phylogenetic tree (model tree) from sequence data is evaluated for six phylogenetic tree-making methods (UPGMA, distance Wagner method, transformed distance method, Fitch-Margoliash's method, maximum parsimony method, and compatibility method). The number of nucleotides (m*) necessary to obtain the correct tree with a probability of 95% is estimated with special reference to the human, chimpanzee, and gorilla divergence. m* is at least 4,200, but the availability of outgroup species greatly reduces m* for all methods except UPGMA. m* increases if transitions occur more frequently than transversions as in the case of mitochondrial DNA. (2) A new tree-making method called the neighbor-joining method is proposed. This method is applicable either for distance data or character state data. Computer simulation has shown that the neighbor-joining method is generally better than UPGMA, Farris' method, Li's method, and modified Farris method on recovering the true topology when distance data are used. A related method, the simultaneous partitioning method, is also discussed. (3) The maximum likelihood (ML) method for phylogeny reconstruction under the assumption of both constant and varying evolutionary rates is studied, and a new algorithm for obtaining the ML tree is presented. This method gives a tree similar to that obtained by UPGMA when constant evolutionary rate is assumed, whereas it gives a tree similar to that obtained by the maximum parsimony tree and the neighbor-joining method when varying evolutionary rate is assumed. ^

Territorio, ambiente y actores. Aportes metodológicos para la formulación de Códigos urbanos : Caso Paraná, Entre Ríos. Area de la Bajada

El tema central se vincula con el Ordenamiento territorial y su correlato en herramientas y metodologías de intervención y gestión urbanas, desde una visión del saber ambiental. A partir de los conceptos categoriales de territorio, actores y ambiente se propone aportar, por un lado metodologías para la comprensión, explicación y análisis del territorio y sus lugares, por el otro mecanismos de gestión para una normativa basada en la inteligencia territorial. Desde estos conceptos se pretende entonces, realizar una vinculación conceptual y normativa para la gestión sustentable del territorio que logre salvar las diferencias entre el estatismo normativo y la dinámica socio-espacial. El área objeto de estudio, es el aquella denominada aquí Area de La Bajada. Así, para un abordaje integral y conceptual del territorio se trabaja desde lo metodológico con los métodos Territorii y Stlocus. Incluyendo mecanismos participativos, como talleres y encuestas que aporten a la comprensión del territorio real, pensado, legal, vivido y posible, propuestos por Territorii que estructura el proceso de lectura y comprensión del lugar. Por su parte el método Stlocus en su ensamble con Territorii permite indagar y analizar el lugar, desde el reconocimiento de patrones de ocupación del lugar, apropiación territorial y vocaciones. Conceptos que llevarán a incoporar a la normativa categorías y dimensiones de urbanístico-territoriales. Desde lo ambiental, se cree de gran importancia el desarrollo del riesgo (vulnerabilidad + amenazas) como concepto operativo para la obtención de dos objetivos: la inclusión de los actores a la dinámica de gestión y la operativización de acciones ambientales directas sobre el territorio. Finalmente, luego del proceso de comprensión y análisis iniciado se arriba a tres cuestiones fundamentales: los métodos propuestos son herramientas flexibles que aportan a la comprensión del territorio desde conceptos categoriales de espacio se torna fundamental, los actores pueden ser incluidos en esta indagación en cualquier etapa del proceso. Sin embargo, aquí aparece la terca línea fundamental: la participación y la gestión de territorios sustentables. Para ello es necesario iniciar un proceso de gobernanza que logre minimizar los impactos de los procesos distorsivos del mercado mediante un Estado proactivo que regule de manera inclusiva, para reducir al mínimo las diferentes dinámicas entre los cuerpos normativos, y su vinculación directa con el territorio deseado por todos los ciudadanos a través de una normativa urbana con inteligencia territorial