Dějiny královského krajského města Písku nad Otavou /

Includes index.

Archiv český.

"Čili, staré písemné památky české i moravské, sebrané z archivů domácích i cizích."

Di Marco Polo e degli altri viaggiatori veneziani più illustri dissertazioni del P. Ab. D. Placido Zurla, con appendice sulle antiche mappe idro-geografiche lavorate...

v. 1. Dei viaggi di Marco Polo.--v. 2. Dei viaggi di Nicoló ed Antonio Zeni. Dei viaggi di Alvise da Cá da Mosto. Dei viaggi di Nicoló Conti e di altri Veneziani. Appendice sulle antiche mappe idrogeografiche lavorate in Venezia.

Hai kuan yü yen pi hsü = An Anglo-Chinese glossary for customs and commercial use.

Mode of access: Internet.

Le vite de' più eccellenti pittori, scultori ed architettori scritte /

Tome 8 lacks set t.-p.

Novum Testamentum graece et latine : expressum ad binas editiones a Leone X. P.M. adprobatas complutensium scilicet et Erasmi Roterod. : additae sunt recensionum Roberti Stephani, C. F. de Matthaei et J. J. Griesbachii variantes lectiones graecae : una cum Vulgata latina, editionis Clementinae ... /

Errata page included.

C. Plinii Caecilii Secundi Epistolae et Panegyricus Trajano dictus ... /

Includes index of recipients of the letters.

Collezione di elogi storici dei militari più celebri nati negli stati della r. casa di Savoia,

F.E. di Savoia Carignano.--Pietro Micca.

Das Glaubens-Bekenntnis : welches die Stände und Gemeinen, so in Pohlen, Preussen und Litthauen der U.A.C. zugethan seyn, im Liebreichen Friedens-Gespräch, so zu Thorn A. 1645. gehalten worden, zuförderst der Königl. Maj. in Pohlen, Vladislai IV. Gesandten, Herrn Georgio Ossalinski, nachgehends dem Grossmächtigsten Könige selbst übergeben haben, von neuen, nach dem Leipziger Exemplar von A. 1655. zum Druck befördert durch Samuel Günthern...

Signatures: pi⁴ A-Q⁴ R².

The experienced English house-keeper : for the use and ease of ladies, house-keepers, cooks, &c. : wrote purely from practice and dedicated to the Hon. Lady Elizabeth Warburton ... : consisting of near 800 original receipts, most of which never appeared in print .../

Includes index.

A communication from Sir Charles Brisbane, K.C.B. governor of Saint Vincent : to the House of Assembly of that colony, dated 17th of August, 1826. Enclosing certain bills for meliorating the condition of, and for emancipating the slave population of the colonies: transmitted by the Earl Bathurst ... with the joint reply of the council and assembly thereto.

Not in Lib. Company. Afro-Americana.

Pamiętnik wzniesienia i odsłonięcia pomników Tadeusza Kościuszki i Kazimierza Pułaskiego : tudzież połączonego z tą uroczystością Pierwszego kongresu narodowego polskiego w Waszyngtonie, D.C., stolicy Stanów Zjednoczonych Ameryki Północnej, w maju, 1910 roku; poprzedzony krótkim zarysem historycznym emigracyi i rozwoju polonii amerykańskiej i ozdobiony illustracyami /

Mode of access: Internet.

A phase I biological and pharmacologic study of the heparanase inhibitor PI-88 in patients with advanced solid tumors

Purpose: PI-88 is a mixture of highly sulfated oligosaccharides that inhibits heparanase, an extracellular matrix endoglycosidase, and the binding of angiogenic growth factors to heparan sulfate. This agent showed potent inhibition of placental blood vessel angiogenesis as well as growth inhibition in multiple xenograft models, thus forming the basis for this study. Experimental Design: This study evaluated the toxicity and pharmacokinetics of PI-88 (80-315 mg) when administered s.c. daily for 4 consecutive days bimonthly (part 1) or weekly (part 2). Results: Forty-two patients [median age, 53 years (range, 19-78 years); median performance status, 1] with a range of advanced solid tumors received a total of 232 courses. The maximum tolerated dose was 250 mg/d. Dose-limiting toxicity consisted of thrombocytopenia and pulmonary embolism. Other toxicity was generally mild and included prolongation of the activated partial thromboplastin time and injection site echymosis. The pharmacokinetics were linear with dose. Intrapatient variability was low and interpatient variability was moderate. Both AUC and C-max correlated with the percent increase in activated partial thromboplastin time, showing that this pharmacodynamic end point can be used as a surrogate for drug exposure, No association between PI-88 administration and vascular endothelial growth factor or basic fibroblast growth factor levels was observed. One patient with melanoma had a partial response, which was maintained for >50 months, and 9 patients had stable disease for >= 6 months. Conclusion: The recommended dose of PI-88 administered for 4 consecutive days bimonthly or weekly is 250 mg/d. PI-88 was generally well tolerated. Evidence of efficacy in melanoma supports further evaluation of PI-88 in phase II trials.