Introdução às linguagens de marcas

Apresenta-se o paradigma de gerenciamento da informação que surgiu com o padrão das linguagens ditas "de marcação" (ou markup languages). Faz-se uma rápida introdução à linguagem SGML, e analisam-se as características e os diferenciais que estão por trás do sucesso da linguagem XML, que promete uma revolução na Web. Mostram-se quais são as bases conceituais de uma nova geração de aplicações das áreas da Informação e da tecnologia da informação que democratizarão ainda mais o acesso à informação organizada na Internet. Aborda-se a evolução das pesquisas em direção à chamada Web Semântica, com o desenvolvimento de ontologias.

Guia d'editor web FCK Editor

Aquesta guia mostra el procés de creació de contingut web de la forma més accessible possible d¿acord amb les restriccions d¿accessibilitat que presenta l¿editor web FCK Editor. Aquest document complementa la Guia de Sakai i la Guia d¿Open CMS explica com formatar i afegir elements al contingut HTML creat amb l¿editor web FCK Editor.

XML y registros electrónicos: principales estándares en la descripción archivística

Describe los principales estándares XML en la descripción archivística concomitantemente con la definición y presentación de las herramientas de XML y conceptos del campo archivístico.

Letter to the Editor : on the value of probability for evaluating results of comparative pattern analyses

This letter to the Editor comments on the article Practical relevance of pattern uniqueness in forensic science by P.T. Jayaprakash (Forensic Science International, in press).

Parametric Approach to Blind Deconvolution of Nonlinear Channels

A parametric procedure for the blind inversion of nonlinear channels is proposed, based on a recent method of blind source separation in nonlinear mixtures. Experiments show that the proposed algorithms perform efficiently, even in the presence of hard distortion. The method, based on the minimization of the output mutual information, needs the knowledge of log-derivative of input distribution (the so-called score function). Each algorithm consists of three adaptive blocks: one devoted to adaptive estimation of the score function, and two other blocks estimating the inverses of the linear and nonlinear parts of the channel, (quasi-)optimally adapted using the estimated score functions. This paper is mainly concerned by the nonlinear part, for which we propose two parametric models, the first based on a polynomial model and the second on a neural network, while [14, 15] proposed non-parametric approaches.

Reply to the letter to the editor "Freedom of choice".

Réponse au commentaire de: Gnädinger M. Freedom of choice. Swiss Med Wkly. 2012 Mar 22;142:0. doi:10.4414/smw.2012.13527. PMID: 22441992.

Robust parametric indirect estimates of the expected cost of a hospital stay with covariates and censored data.

We consider the problem of estimating the mean hospital cost of stays of a class of patients (e.g., a diagnosis-related group) as a function of patient characteristics. The statistical analysis is complicated by the asymmetry of the cost distribution, the possibility of censoring on the cost variable, and the occurrence of outliers. These problems have often been treated separately in the literature, and a method offering a joint solution to all of them is still missing. Indirect procedures have been proposed, combining an estimate of the duration distribution with an estimate of the conditional cost for a given duration. We propose a parametric version of this approach, allowing for asymmetry and censoring in the cost distribution and providing a mean cost estimator that is robust in the presence of extreme values. In addition, the new method takes covariate information into account.

XML y Web Semántica. Diseño y populación semiautomática de ontologías

En el curso y ejecución de este trabajo, ahondaré en el concepto de web semántica, unarealidad cada vez más tangible, que bajo el acrónimo de web 3.0 supondrá el relevo del actual modelo web.Al tratarse de un campo de aplicación muy extenso, centraremos la temática en el diseño y populación semiautomática de ontologías, siendo estas ultimas una pieza clave en el desarrollo y el éxito potencial de las tecnologías semánticas.

Letter to editor: Low Birth Weight And Adult Depression: Eliciting Their Association

Theories supporting fetal origins of adult health and disease are nowadays widely accepted regarding some psychiatric conditions. However, whether genetic or environmental factors disrupting fetal growth might constitute a rick factor for depressive and/or anxious psychopathology remains still controversial.

Pediatric reference intervals for plasma free and total metanephrines established with a parametric approach: Relevance to the diagnosis of neuroblastoma.

BACKGROUND: Urine catecholamines, vanillylmandelic, and homovanillic acid are recognized biomarkers for the diagnosis and follow-up of neuroblastoma. Plasma free (f) and total (t) normetanephrine (NMN), metanephrine (MN) and methoxytyramine (MT) could represent a convenient alternative to those urine markers. The primary objective of this study was to establish pediatric centile charts for plasma metanephrines. Secondarily, we explored their diagnostic performance in 10 patients with neuroblastoma. PROCEDURE: We recruited 191 children (69 females) free of neuroendocrine disease to establish reference intervals for plasma metanephrines, reported as centile curves for a given age and sex based on a parametric method using fractional polynomials models. Urine markers and plasma metanephrines were measured in 10 children with neuroblastoma at diagnosis. Plasma total metanephrines were measured by HPLC with coulometric detection and plasma free metanephrines by tandem LC-MS. RESULTS: We observed a significant age-dependence for tNMN, fNMN, and fMN, and a gender and age-dependence for tMN, fNMN, and fMN. Free MT was below the lower limit of quantification in 94% of the children. All patients with neuroblastoma at diagnosis were above the 97.5th percentile for tMT, tNMN, fNMN, and fMT, whereas their fMN and tMN were mostly within the normal range. As expected, urine assays were inconstantly predictive of the disease. CONCLUSIONS: A continuous model incorporating all data for a given analyte represents an appealing alternative to arbitrary partitioning of reference intervals across age categories. Plasma metanephrines are promising biomarkers for neuroblastoma, and their performances need to be confirmed in a prospective study on a large cohort of patients. Pediatr Blood Cancer 2015;62:587-593. © 2015 Wiley Periodicals, Inc.