521 resultados para Tripartite synapse


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Pós-graduação em Educação Matemática - IGCE

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Pós-graduação em Letras - IBILCE

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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The length of the post-partum anoestrous interval affects reproductive efficiency in many tropical beef cattle herds. In this study, results from genome-wide association studies (Experiment 1: GWAS) and gene expression (Experiment 2: microarray) were combined in a systems approach to reveal genetic markers, genes and pathways underlying the physiology of post-partum anoestrus in tropically adapted cattle. The microarray study measured the expression of 13,964 genes in the hypothalamus of Brahman cows. A total of 366 genes were differentially expressed (DE) in the post-partum period, when acyclic cows were compared to cows that had resumed ovarian cycles. Associated markers (P < 0.05) from a high density GWAS pointed to 2829 genes that were associated with post-partum anoestrous interval (PPAI) in two populations of beef cattle: Brahman and Tropical composite. Together the experiments provided evidence for 63 genes that are likely to influence the resumption of ovulation post-partum in tropically adapted beef cattle. Functional annotation analysis revealed that some of the 63 genes have known roles in hormonal activity, energy balance and neuronal synapse plasticity. Polymorphisms within candidate genes identified by this systems approach could have biological significance in post-partum anoestrus and help select Zebu (Bos indicus) influenced cattle with genetic potential for shorter post-partum anoestrus. Crown Copyright (C) 2014 Published by Elsevier B.V. All rights reserved.

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In birds, neurons of the isthmo-optic nucleus (ION), as well as ''ectopic'' neurons, send axons to the retina, where they synapse on cells in the inner nuclear layer (INL). Previous work has shown that centrifugal axons can be divided into two anatomically distinct types depending on their mode of termination: either ''convergent'' or ''divergent'' (Ramon y Cajal, 1889; Maturana and Frenk, 1965). We show that cytochrome-oxidase histochemistry specifically labels ''convergent'' centrifugal axons and target neurons which appear to be amacrine cells, as well as three ''types'' of ganglion cells: two types found in the INL (displaced ganglion cells) and one in the ganglion cell layer. Labeled target amacrine cells have distinct darkly labeled ''nests'' of boutons enveloping the somas, are associated with labeled centrifugal fibers, and are confined to central retina. Lesions of the isthmo-optic tract abolish the cytochrome-oxidase labeling in the centrifugal axons and in the target amacrine cells but not in the ganglion cells. Cytochromeoxidase-labeled ganglion cells in the INL are large; one type is oval and similar to the classical displaced ganglion cells of Dogiel, which have been reported to receive centrifugal input; the other type is rounder. Rhodamine beads injected into the accessory optic system results in retrograde label in both types of cells, showing that two distinct types of displaced ganglion cells project to the accessory optic system in chickens. The ganglion cells in the ganglion cell layer that label for cytochrome oxidase also project to the accessory optic system. These have proximal dendrites that ramify in the outer inner plexiform layer. Neither the target amacrine cells nor either of the displaced ganglion cells are immunoreactive for the inhibitory transmitter gamma aminobutyric acid. At least some of the target amacrine cells may, however, be cholinoceptive: we found that the antibody to the alpha-7 subunit of the nicotinic ACh receptor labels a population of cells in the INL that are similar in location, size, and the presence of labeled bouton-like structures to those we find labeled with cytochrome oxidase. This antibody also labels neurons in the ION proper but not ectopic cells. In conclusion, it appears that cytochrome oxidase may be a marker for ''convergent'' centrifugal axons and at least one of their target cells in the INL.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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To assess the influence of anatomic location on the relationship between computed tomography (CT) number and X-ray attenuation in limited and medium field-of-view (FOV) scans. Materials and Methods Tubes containing solutions with different concentrations of K2HPO4 were placed in the tooth sockets of a human head phantom. Cone-beam computed tomography (CBCT) scans were acquired, and CT numbers of the K2HPO4 solutions were measured. The relationship between CT number and K2HPO4 concentration was examined by linear regression analyses. Then, the variation in CT number according to anatomic location was examined. Results The relationship between K2HPO4 concentration and CT number was strongly linear. The slopes of the linear regressions for the limited FOVs were almost 2-fold lower than those for the medium FOVs. The absolute CT number differed between imaging protocols and anatomic locations. Conclusion There is a strong linear relationship between X-ray attenuation and CT number. The specific imaging protocol and anatomic location of the object strongly influence this relationship.

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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tabula tabular tachyauxesis tachyblastic tachygen tachygenesis tachytelic tactic tactile tactoreceptors taenia taeniate taenidium taenioglossate tagma tagmata tagmosis tail tailfan Takakura's talon talus tandem tangent tangoreceptor tanylobous tapetal tapetum tapinoma-odor Tardigrada tardigrades tarsal tarsation tarsite tarsomere tarsungulus tarsus taste tautonomy tautonym taxa taxes taxis taxis taxodont taxometrics taxon taxonomic taxonomist taxonomy tectiform tectostracum tectum teeth teges tegillum tegmen tegmentum tegula tegular tegulum tegumen tegument tegumentary tela telaform telamon telegonic teleiochrysalis telenchium teleoconch teleodont teleology teleotrocha telepod telescope telescopic teletrophic telioderma teliophan telmophage telocentric telodendria telofemur telogonic telolecithal telomitic telophase telophragma telopod telopodite telorhabdions telosonic telostome telosynapsis telosyndesis telotarsus telotaxis telotroch telson template temporal tenacipeds tenaculum tenent teneral tensor tentacle tentacular tentaculocyst tentaculozooid tentilla tentorial tentorium tenuous teratocyte teratogen teratogenesis teratogyne teratology terebella terebra terebrant terebrate teres terete terga tergal tergite tergolateral tergopleural tergopore tergum tergum termen terminal terminalia termitarium termitophile terranes terrestrial terricolous territory tertiary tertibrach tertibrachial tessellate test testaceology testaceous test-cross testes testis testisac testudinate tetanus tetany tetractinal tetractine tetrad tetradelphic tetramerous tetramorphic tetraploid tetrapod tetrapterous tetrasomic tetrathyridial tetrathyridium tetraxon tetraxonid thalassophilous thallus thamnophilous thanatocoenosis thanatosis theca thecae thecal thecate thelycum thelygenesis thelygenous thelyotokous thelyotoky theory thermocline thermophile thermophobe thermoreceptor thermotaxis thickness thigmotactic thigmotaxis thigmotropism third-form thoraces thoracic thoracomere thoracopod(ite) thorax thoraxes thread thylacium thylacogen thyridial thyridium thyroid thysanuriform tibia tibial tibiotarsal tibiotarsus Tiedemann's tiled timbal tinctorial tine tissue tissue titilla titillae titillator tocopherol tocospermal tocospermia tocostome tokostome tomentose tomentum Tomosvary tone tonic tonofibrillae tonus topochemical topogamodeme topomorph topomorphic toponym topotype tori torma tormogen tornote tornus torose torpid torqueate torsion tortuose torulose torus totipotent totomount toxa toxicognath toxicology toxin toxinosis toxoglossate toxoid trabecula trabeculate trabeculated trachea tracheae tracheal tracheate tracheoblast tracheolar tracheoles trachychromatic tract Tragardh's tragus transad transcoxa transcurrent transect transection transformation transient transitional translocation translucent transmission transposed transscutal transstadial transtilla transverse trapeziform trapezium trapezoid trema tremata Trematoda trenchant trepan triact triactinal triad triaene triage triangle triangular triangulate triaulic triaxial triaxon tribe tribocytic trichite trichobothrium trichobranchia trichobranchiate trichocerous trichodes trichodeum trichodragmata trichogen trichoid trichomes trichophore trichopore trichosors trichostichal trichotomous trichroism tricolumella tricomes tricostate tricrepid tricuspid tricuspidate tridactyl trident tridentate trifid trifurcate triglycerides trignathan trigonal trigoneutism trilabiate trilateral trilobate trilocular trimorphic trimorphism Trinominal triordinal tripartite tripectinate triplet triploblastic triploid triquetral triquetrous triradiate triradiates tritocerebral tritocerebrum tritocerebrum tritonymph tritosternum triturate triungulin triungulinid trivial trivium trivoltine trixenic troch trochal trochalopodous trochantellus trochanter trochanteral trochantin trochi trochiform trochlea trocholophous trochophore trochosphere trochus troglobiont troglodytic troglophile trogloxene tropeic trophal trophallactic trophallaxis trophamnion trophi trophic trophidium trophobiont trophobiont trophobiosis trophobiotic trophocytes trophodisc trophogeny trophoporic trophorhinium trophosome trophotaxis trophothylax trophozooid trophus tropis tropism tropotaxis trumpet truncate truncation trunk trypsin tryptic tryptophan tryptophane T-tubule tube tube-feet tubercle tubercula tuberculate tuberculose tuberiferous tubicolous tubifacient tubule tubulus tubus tuft Tullgren tumefaction tumescence tumid tumulus tunic tunica tunicary tunicate turbinate turgid turreted turriculate tychoparthenogenesis tylasters tylenchoid tyli tyloid tyloides tylosis tylostyle tylote tylus tymbal tympanal tympanal tympanic tympanum Tyndall type typhlosole typologist typolysis typostasis

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In 1893 Ferruccio Busoni transcribed, for the piano, the famous Bach Chaconne for violin solo from the Partita No.2 in D minor. Numerous transcriptions of this piece for different various instruments exist; however Busoni's transcription stands above all others. The purpose of this study was to analyze what the famous, twentieth-century pianist did when he transcribed Bach's Chaconne. What information exists on the topic comes primarily from pianists who dared to learn this exceptionally difficult, beautiful composition. Busoni's accomplishments lie in the new concept, a conceptual transcription, which has two roots: understanding how, historically, we are connected to the music, and how once genres have a special meaning in the twentieth-century. Every generation of musicians brings their own specific point of view and interpretation. Busoni lived on the border of the two centuries and, in his transcription, reveled in several issues overlooked by the previous generation. With his keen understanding of the piece, Busoni highlighted many different genres present in the music, thus allowing recognition of the last movement of the Partita No. 2 in D minor as a Requiem for Bach's wife. By underscoring the genres, Busoni used them as strata. The idea of strata comes from the aesthetics of “play,” and from a different approach to the quality of sound on piano originally intended for a high string instrument. Busoni's arrangement of the texture added both orchestral quality and stereophonic perception. The strata add to a certain reading of Bach's original. Busoni promoted a dramatic approach opening the possibility of reading the chaconne as a multi-layered form. Through Busoni', we see the possibility not only of a tripartite, variation form, but also a composition, with the elements of a concerto, and a sonata. Who could imagine, that a composition written by a young composer at the fin de siecle, intended for practical use by pianists, would subtly influence so many contemporaries and generations, that they will find his findings and music inspiring. Adviser: Dr. Mark K. Clinton