Crystal and molecular structure of the quinoxaline antibiotic analog TANDEM (des-N-tetramethyltriostin A)

The crystal structure of TANDEM (des-N-tetramethyltriostin A), a synthetic analogue of the quinoxaline antibiotic triostin A, has been determined independently at -135 and 7 'C and refined to R values of 0.088 and 0.147, respectively. The molecule has approximate 2-fold symmetry, with the quinoxaline chromophores and the disulfide cross-bridge projecting from opposite sides of the peptide ring. The quinoxaline groups are nearly parallel to each other and separated by about 6.5 A. The peptide backbone resembles a distorted antiparallel 13 ribbon joined by intramolecular hydrogen bonds N-H(LVal)--O(L-Ala). At low temperatures, the TANDEM molecule is surrounded by a regular first- and second-order hydration sphere containing 14 independent water molecules. At room temperature, only the first-order hydration shell is maintained. Calculations of the interplanar separation of the quinoxaline groups as a function of their orientation with respect to the peptide ring support the viability of TANDEM to intercalate bifunctionally into DNA.

Eine Erinnerung an den 67. Geburtstag des Herrn Sobernheim (in memory of the 67th birthday of Mr. Sobernheim); Wiesbaden Portraits Groups

Participants include Erna Hirsch, Else Giesenow, Marta Nachmann, Erna Goldschmidt (Goldi), Lotte Strauss, Marta Bruchfeld, Toni Eichenberg, Grete Guthmann, Flora Goldschmidt, Hedwig Trum, Hedel Korhmann, Paula Arendt, Erna Behr and Frl. Minka Friedmann

Students on the steps of the Lehranstalt fuer die Wissenschaft des Judentums (Jewish teachers' seminary); Berlin Institutions; Educational; Schools; Portraits; Groups

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Students on the steps of the Lehranstalt fuer die Wissenschaft des Judentums (Jewish teachers' seminary); Berlin Institutions; Educational; Schools; Portraits; Groups

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Students on the steps of the Lehranstalt fuer die Wissenschaft des Judentums (Jewish teachers' seminary); Berlin Institutions; Educational; Schools; Portraits; Groups

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Students on the steps of the Lehranstalt fuer die Wissenschaft des Judentums (Jewish teachers' seminary); Berlin Institutions; Educational; Schools; Portraits; Groups

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Komplexe Grundlagenforschung Antijudaismus Verunglimpfung des Judentums in Literatur- und Kirchengeschichte.

Manuscript on Antisemitism in Christianity

Das fatale Loch in der Berliner Theatergeschichte : lecture ueber Persoenlichkeiten des Berliner Theaterlebens und ihre NS-Vergangenheit /

Manuscript: "Das fatale Loch in der Berliner Theatergeschichte". Speech exploring the burdens placed on scholarship and the students of the Theatrical Institute of the Free University of Berlin by the presence of professors who were compromised by their activities during the Nazi era.

Kukuruza Raĭony vozdelyvanii︠a︡ kukuruzy : nailuchshie sorta i sredni︠a︡i︠a︡ urozhaĭnost' sukhogo zerna na 1 des. po dannym seti opytnykh uchastkov iuga Rossii i postoi︠a︡nnykh opytnykh uchrezhdenniĭ

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