Sorovacinação antirrabica: aspectos epidemiologicos e implicações para assistência de enfermagem

This study was developed with the purpose to search for relevant knowledge concerning nursing care for individuals exposed to the rabies virus and submitted to post-exposure anti-rabies serovaccination. The authors aimed at evaluating the epidemiological aspects of accidents involving household and wild animals occurring in 2007 and patients assisted at a reference hospital located in the mid-southern region of São Paulo State. They also aimed at identifying the relevance of nurses' actions by describing aspects of care provision. The method adopted was exploratory, retrospective and descriptive of the epidemiological aspects of the accidents and of the care provided to these patients by referring to information in their medical charts. Fifty-one charts of patients aged 17 to 81 years, considered to be at risk and with indication for post-exposure prophylaxis against human rabies were evaluated. It was found that nursing care provision to these patients presents low complexity although it requires properly trained professionals. It was possible to identify the relevance of nurses' actions in care provision and procedures related to anti-rabies prophylaxis; however, consistent information concerning nursing care was not observed.

Effects of primovaccination and booster vaccination on serum cortisol and humoral immune response in cattle

The objective of this study was to evaluate the effect of one or two doses of the anti-rabies vaccination on the serum concentration of cortisol and the humoral immune response in cattle as well as the correlation between serum cortisol concentrations and the titers of rabies-neutralizing antibodies. Nelore cattle were randomly assigned to one of three groups, which were vaccinated with one dose of rabies vaccine (group GVSR, N = 15), two doses of rabies vaccine (group GVR, N = 15) or were not vaccinated (group Gc, N = 15). A commercial liquid inactivated rabies vaccine was used. The stressors imposed on the cattle were vaccination, corral handling and the presence of people. Blood samples were collected on days 0, 30 and 60 post-vaccination. Serum cortisol concentrations were determined using a solid-phase radioimmunoassay, and rabies antibody titers were determined using a serum neutralization test with BHK21 cells (RFFIT). Both serum cortisol concentrations and antibody titers increased after the second (booster) vaccination (P < 0.05). In all the groups, the serum cortisol concentrations increased after the cattle were handled in the corral (P < 0.05). No correlation was observed between the serum cortisol concentrations and the antibody titers with any treatment or on any observation day. In conclusion, booster vaccination is indispensable for primovaccinated cattle in achieving high and protective levels of rabies antibodies. Although booster vaccination and frequent cattle handling in corrals are stressors, the response is not strong enough to cause immunosuppression in cattle.

Avaliação da participação e confiabilidade da população em relação à campanha de vacinação anual contra a raiva de cães e gatos no município de Botucatu, São Paulo, Brasil

The annual vaccination campaign against rabies is the most effective prevention procedure for this disease in dogs and cats and hence for human protection also. However, in 2010 and 2011, this activity was interrupted in Brazil due to the occurrence of adverse events associated with vaccination. Even though cases of canine rabies have been decreasing in the last two decades, vigilance must be strengthened in order to maintain pet owners trust in the vaccines provided in public services. This study aimed to determine pet owners participation in the annual vaccination campaign carried out in Botucatu. During March and April 2012, the period before the 42nd campaign, 312 pet owners, dogs and cats, were interviewed. The homes were randomly drawn in blocks from different sectors of the city; all houses on the same block over the 120 km² of urban area participated in the sampling process. Statistical analysis was performed descriptively. The results showed that the owners main motivation to vaccinate their pets during the campaigns is rabies prevention (36%), followed by the proximity of the vaccination station to the house (20.7%), zero cost (10.9%), and the combination of all three factors (16.1%). When asked if they would take their animals back to be vaccinated in another campaign, 60.1% answered yes, 13.5% would go to a private clinic, 2.2% would not take because they do not trust the vaccine and 1.6% had not decided yet. We conclude that the respondents have realized how dangerous Rabies is, because even after the break period, they still utilized the vaccination campaign demonstrating confidence in its effectiveness, while knowing the campaign goals facilitates understanding and participation.

Prevalence and geographical distribution of Toxoplasma gondii in dogs in the urban area of Botucatu, SP, Brazil

Toxoplasmosis is a worldwide zoonosis caused by Toxoplasma gondii, and can infect a wide variety of animals including humans. Domestic animals can be an important sentinel population for infection in the community. Occurrence of T. gondii infection was assessed in dogs in the urban area of Botucatu city, SP, Brazil. In the sample, 10% rate for error estimate, 95% confidence interval, and 5% significance level were established. Serum samples were collected from dogs during a rabies vaccination campaign, and were processed using modified agglutination test (MAT). Blood samples were collected from 670 dogs, with homogeneous distribution in five regions in the urban area, representing 3.74% of 17,910 animals vaccinated. In this sample, 17.3% (116/670) dogs (68 – 58.6% female and 48 – 41.4% male) were positive for T. gondii infection (p<0.03). Regarding age of the infected dogs 4.6% (4/88) were younger and 95.4% (84/88) were older than one year (p<0.01); the age of 28 positive animals were undetermined. The serum titers of anti-T. gondii antibodies were: 16 (69.8%; 81/116), 64 (13.8%; 16/116), 256 (15.5%; 18/116), and 1024 (0.9%; 1/116). Prevalence was distributed among the North 14.2% (19/134), South 18.0% (31/172), East 15.7% (19/121), West 21.6% (27/125), and Central 16.9% (20/118) regions of the municipality (p=0.5). In all these regions, females and dogs aged more than one year showed a higher occurrence of T. gondii infection (p<0.05).

Observations on Some Natural-Focal Zoonoses in Alaska

In Alaska, as in arctic and subarctic Eurasia, important natural-focal zoonoses are rabies, brucellosis, tularemia, trichinosis, alveolar hydatid disease, cystic hydatid disease, and diphyllobothriasis. Most frequently affected are aboriginal peoples in villages within biocenoses that include the natural parasite-host assemblages. Pathogens are transmitted to man from wild animals and from dogs, which are important as synanthropic hosts. The prevalence and rate of transmission of certain pathogens in natural foci are related to the numerical density of small mammals, especially rodents, which may themselves be involved as hosts, and on which the numbers of their predators ultimately depend, such as is evident in the natural cycles of Echinococcus multilocularis and of rabies virus. Some pathogens in northern regions exhibit biological Characteristics that separate them from morphologically indistinguishable strains at lower latitudes (e.g., Trichinella spiralis and E. granulosus). Host-parasite relationships may also differ, as in the Arctic where rabies virus is maintained in populations of foxes, without significant involvement of mammals of other groups. Faunal interchanges during and after the Pleistocene period have influenced the distribution of parasite-host assemblages in Alaska.

A Field-Test of Rhodamine B as a Biomarker in Raccoons

Rhodamine B is a dye that when ingested results in fluorescent bands in growing hair and whiskers of many mammals. Previous research at Wildlife Services’ (WS) National Wildlife Research Center (NWRC) found that rhodamine B is a successful biomarker in raccoon whiskers and that raccoons do not have a taste aversion to the dye when it comprises ≤ 3% of a bait. Our study assessed the ease of bait distribution, whisker collection, and evaluation of the biomarker for potential use in the Oral Rabies Vaccination (ORV) program administered by the WS National Rabies Management Program (NRMP). In collaboration with WS operations personnel from Ohio and Michigan, 750 fishmeal polymer baits each containing 150 mg of rhodamine B were hand distributed at NASA’s Plum Brook Station, Sandusky, Ohio in the summer of 2008. Four weeks after baits were distributed whiskers from 162 raccoons were collected. Wildlife Services biologists and technicians evaluated the whiskers for fluorescence using a handheld UV magnifying lamp. Biologists then sent the whiskers to the NWRC, Ft. Collins, Colorado for confirmation of fluorescence under a UV microscope. Results suggest a high level of agreement between the two methods of evaluation. Surveys completed by biologists confirmed that the ease of use, less invasive sampling techniques and promptness of results obtained through the use of rhodamine B are advantageous to the tetracycline biomarker presently used by the ORV program. All participants recommended further evaluation of rhodamine B for its inclusion in future efforts requiring biomarker evaluation.

The Probe, Issue 174 – March 1997

Outwitting Urban Beaver, by C. E. "Ki" Faulkner, Regional Director, Region 0, NADCA Bear Gets Attention in Southeast Chinese disease Threatens Rabbits Product Announcements: BEAR BE GONE™ -- a device designed to deter bears from foraging in trash cans. Booklet: "Using Guard Animals to Protect Livestock" Abstracts Published at the 3rd Annual Conference of The Wildlife Society: A case study of black bear movements and survival after landfill closure in the central Adirondacks, by Ann M. Russell and S.L. Simek Ecology of coyotes in a sheep ranching environment, by Ben N. Sacks, J.C.C. Neale, M. Jaeger, and D. R. McCullough Design and analysis of carnivore scent-station surveys, by Glen Sargeant, Douglas H. Johnson, and William Berg Public attitudes toward wildlife damage management, by Robert H. Schmidt, M.W. Brunson, andD. Reiter Human dimensions of wildlife contraception, by Robert H. Schmidt and D. E. Mclvor Economic assessment of rabies control efforts in Texas, by Randy M. Smith Methyl salicylate: a naturally occurring avian repellent, by Shirley Wager-Page A brief historical perspective on wildlife contraception research, by Robert J. Warren Wildlife-caused losses to agriculture in 1994, by Alice P. Wywialowski

The Probe, Issue 190 – July 1998

Research, Cooperation Pays Off for Fish Farmers -- Peter Butchko, District Supervisor, USDA-APHIS-WS, Mississippi and NADCA Vice-President, East Thoughts... Robert H. Giles, Jr., President, NADCA Book Review : The Wildlife Damage Inspection Handbook, by Stephen Vantassel with Tom Olander; Reviewed by Rex E. Marsh British Fox Hunting Ban Fails Passage Recent Coyote Research From Texas: Diets of Coyotes (Canis latrans) in the Edwards Plateau and Trans-Pecos regions of Texas, by J. Harris Glass, S.K. Canon, and D. Rollins Long-time NADCA Member Robert H. Schmidt Featured in Associated Press Article on Nuisance Animal Control Industry Research Continues in New Zealand and Australia on the Efficacy of Rabbit Calicivirus Disease as Rabbit Population Control Method Latest Rabies Trends Subject of Meeting of State and National Health Experts: Keeping Physicians and the Public Informed on Managing Deadly Disease Bogus Gizmos and Gadgets No Help With Homeowners' Wildlife Problems

The Probe, Issue # 155 -- June 1995

Understanding the Eastern Coyote - Part II, by Thomas N. Tomsa, Jr., USDA-APHIS-ADC, Pennsylvania Book Review - "The Dirt Hole and Its Variations" All Texas Counties Quarantined for Rabies Ravenous Vultures Decimating Sheep & Calves on the East Coast Four-Year-Old Dies of Rabies The National Urban Wildlife Management Association (NUWMA) officially merged with NADCA, to create one larger, more effective organization to work for professional Animal Damage Control. State-Endangered Species: Meaningful Management or Preservationist Politics?, by Richard B. Chipman, Wildlife Biologist, USDA-APHIS-ADC, Vermont NADCA Membership Meeting Trapping Weasels
Jack H. Berryman 1995 Leopold Award Winner

The Probe, Issue 210 – May/June 2000

NADCA Election in Progress Berryman Institute Announces 1999 Awards New Probe Editor to be Appointed: Larry Sullivan Ken Garner Retires Book Review: "Master Land Snaring: Canine and Coon Techniques, Effective in All Terrains." by Newt Sterling as told to Bob Noonan. 1999. 58 pages, illustrated. NPCA Gets New Name Lobster Plates: PETA (People for the Ethical Treatment of Animals) is fighting to prevent the return of the lobster to Maine's automobile license plates. Active Antis in the Northwest Animal Rights Violence on Increase Abstracts from the 6th Annual Conference of The Wildlife Society: Monitoring of Sin Nombre Hantavirus in deer mice of the Southwest, USA -- Robinson, Rhonda /., Kathryn D. Bennett, James R. Biggs, Timothy K. Haarmann, David C. Keller, and Mary E. Salisbury Predators in the classroom: A prickly paradigm for educators -- Rollins, Dale Trends in bat rabies in the U.S.: Shaping public health policy -- Rupprecht, Charles E., Sharon B. Messenger, and Jean S. Smith

SCWDS BRIEFS: Volume 18, Number 3 (October 2002)

• Chronic Wasting Disease Update: Wisconsin, Minnesota, South Dakota, Colorado; National CWD Management – USDA & USDI National Plan for Assisting States, Federal Agencies, and Tribes in Managing Chronic Wasting Disease in Free-ranging and Captive Cervids • West Nile virus (WNV) reaches the Pacific coast • West Nile Virus in Blue Jays • Idaho Brucellosis Linked to Wildlife: All of the epidemiological and laboratory information clearly indicates that brucellosis-infected elk transmitted the disease to the cattle herd. • Tularemia caused a die-off of captured wild prairie dogs this summer at a Texas commercial exotic animal facility that distributes the animals for sale as pets. • Raptors can acquire avian vacuolar myelinopathy (AVM) via ingestion of other affected birds. • House Finch Mycoplasmosis: bacterial eye disease of house finches • Raccoon Rabies report • Toxoplasmosis – The newest finding regarding sea otters in California is the importance of toxoplasmosis as a mortality factor. Toxoplasma gondii is a protozoan parasite that can invade visceral organs and the central nervous system to cause acute, disseminated tissue necrosis and fatal meningoencephalitis in susceptible animals. In recent years, 36% of dead sea otters examined have been infected. Another tissue-invading protozoan, Sarcocystis neurona, also was found in 4% of the otters. • Recovery of remnant populations of the endangered black-footed ferret have been hampered by sylvatic plague, which is caused by the bacterium Yersinia pestis. • Dr. Samantha Gibbs received the Wildlife Disease Association’s Student Research Recognition Award. Dr. Cynthia Tate was selected by the American Association of Veterinary Parasitologists to receive the Best Student Presentation Award. Dr. Andrea Varela won second place in the Student Presentation Award for her presentation at the meeting of the American Association Veterinary Parasitologists. Mr. Michael Yabsley received the Wildlife Disease Association Student Scholarship and the S.A. Ewing Vectorborne Parasitology Award from the University of Georgia’s College of Veterinary Medicine.

Neospora caninum as causative agent of bovine encephalitis in Brazil

For supporting the Brazilian bovine encephalitis surveillance program this study examined the differential diagnosis of Neospora caninum in central nervous system (CNS) by histological analysis (HE staining), immunohistochemistry (IHC), and nested-PCR using a set of primers from the Nc5 region of the genomic DNA and ITS1 region of the ribosomal DNA. A sample of 302 cattle presenting neurological syndrome and negative for rabies, aged 0 to 18 years, from herds in 10 Brazilian states was evaluated for N caninum from January 2007 to April 2010. All specimens tested negative with IHC and nested-PCR using primers from the ITS I region of ribosomal DNA, while two positive cases (0.66%) were found using primers from the Nc5 region of genomic DNA: a 20 month-old male and a 72 month-old female, both from Sao Paulo State. Only the male presented severe multifocal necrotizing encephalitis associated with mononuclear cell infiltration, a pathognomonic lesion caused by parasites of the family Sarcocystidae, and only this case was associated with N caninum thus representing 0.33% positivity. Future studies should explore the association of IHC and nested-PCR with real-time PCR, a quantitative method that could be standardized for improving the detection of N. caninum in bovine CNS specimens.

Consolidation of international guidelines for the management of canine populations in urban areas and proposal of performance indicators

Consolidation of international guidelines for the management of canine populations in urban areas and proposal of performance indicators The objective of this study is to propose a generic program for the management of urban canine populations with suggestion of performance indicators. The following international guidelines on canine population management were revised and consolidated: World Health Organization, World Organisation for Animal Health, World Society for the Protection of Animals, International Companion Animal Management Coalition, and the Food and Agriculture Organization. Management programs should cover: situation diagnosis, including estimates of population size; social participation with involvement of various sectors in the planning and execution of strategies; educational actions to promote humane values, animal welfare, community health, and responsible ownership (through purchase or adoption); environmental and waste management to eliminate sources of food and shelter; registration and identification of animals; animal health care, reproductive control; prevention and control of zoonoses; control of animal commerce; management of animal behavior and adequate solutions for abandoned animals; and laws regulating responsible ownership, prevention of abandonment and zoonoses. To monitor these actions, four groups of indicators are suggested: animal population indicators, human/animal interaction indicators, public service indicators, and zoonosis indicators. The management of stray canine populations requires political, sanitary, ethologic, ecologic, and humanitarian strategies that are socially acceptable and environmentally sustainable. Such measures must also include the control of zoonoses such as rabies and leishmaniasis, considering the concept of "one health," which benefits both the animals and people in the community.

Polyganglioradiculoneuritis in a young cat: clinical and histopathological findings

An 18-month-old European shorthair cat was presented with a two week history of progressive decrease in consciousness, ambulatory tetraparesis, moderate ataxia and generalised decreased-to-absent postural reactions. Bilateral facial and nasal hypalgesia, absent menace response and anisocoria were found, and segmental spinal reflexes were normal. Neurological signs progressed to nonambulatory tetraparesis, tremor and spinal hyperalgesia. Histopathological examination revealed a mild-to-moderate lymphoplasmacytic and histiocytic infiltration, predominantly in the dorsal spinal roots, cranial nerves and ganglia in association with marked demyelination and proliferation of Schwann cells. Neurons and axons were preserved. Lesions were multi-focal and varied in severity. A predominantly sensory polyganglioradiculoneuritis was diagnosed. This lesion has not been reported previously in cats. Rabies, herpesviruses, feline infectious peritonitis, feline immunodeficiency virus, Toxoplasma gondii and feline leukaemia virus were excluded as possible aetiologies. Infections by other viruses or an autoimmune disease are discussed.

Serologic vaccination response after solid organ transplantation: a systematic review

BACKGROUND Infectious diseases after solid organ transplantation (SOT) are one of the major complications in transplantation medicine. Vaccination-based prevention is desirable, but data on the response to active vaccination after SOT are conflicting. METHODS In this systematic review, we identify the serologic response rate of SOT recipients to post-transplantation vaccination against tetanus, diphtheria, polio, hepatitis A and B, influenza, Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitides, tick-borne encephalitis, rabies, varicella, mumps, measles, and rubella. RESULTS Of the 2478 papers initially identified, 72 were included in the final review. The most important findings are that (1) most clinical trials conducted and published over more than 30 years have all been small and highly heterogeneous regarding trial design, patient cohorts selected, patient inclusion criteria, dosing and vaccination schemes, follow up periods and outcomes assessed, (2) the individual vaccines investigated have been studied predominately only in one group of SOT recipients, i.e. tetanus, diphtheria and polio in RTX recipients, hepatitis A exclusively in adult LTX recipients and mumps, measles and rubella in paediatric LTX recipients, (3) SOT recipients mount an immune response which is for most vaccines lower than in healthy controls. The degree to which this response is impaired varies with the type of vaccine, age and organ transplanted and (4) for some vaccines antibodies decline rapidly. CONCLUSION Vaccine-based prevention of infectious diseases is far from satisfactory in SOT recipients. Despite the large number of vaccination studies preformed over the past decades, knowledge on vaccination response is still limited. Even though the protection, which can be achieved in SOT recipients through vaccination, appears encouraging on the basis of available data, current vaccination guidelines and recommendations for post-SOT recipients remain poorly supported by evidence. There is an urgent need to conduct appropriately powered vaccination trials in well-defined SOT recipient cohorts.