Kinder- und hausmärchen der gebrüder Grimm;

Contains Schillers "Der tacuher ... " [with notes] 24 p.

Wenken, herinneringen en aanteekeningen uit de dagen van Nederlands herstelling.

Includes bibliographical references.

Das kalte herz: märchen

Mode of access: Internet.

Nederlands eerste betrekkingen met Oostenrijk toegelicht uit de correspondentie der keizerlijke gezanten te 's Gravenhage, 1658-1678.

Signatures marked: Letterk. verh. der Koninkl. akademie, deel v.

Filip van Marnix, heer van St. Aldegonde, bijzonder aan de hand van Willem I : ter inleiding Margareta van Parma en Katharina de Medicis, Willem I en Hendrik IV /

Mode of access: Internet.

Die Landwirtschaft auf der hamburgischen Geest : Beitrag zur Kenntnis der vorstadtischen Wirtschaft.

Thesis (doctoral)--Vereinigte Friedrichs-Universitat Halle-Wittenberg.

Verslag der handelingen der Staten-Generaal.

1846/47-1875/76: "Bijblad tot de Nederlandsche Staats-Courant."

Quantitatief onderzoek over het bromeeren van toluol.

Thesis (doctoral)--Universitat Van Amsterdam.

De dubbelzouten van kalium- en magnesiumsulfaat : schoniet en Kaliumastrakaniet /

Thesis (doctoral)--Universiteit van Amsterdam, 1893.

Zur kenntniss der dichlorbernsteinsauren und ihrer derivate.

Thesis (doctoral)--

Bijdrage tot de geschiedenis van het natuurgevoel in de middeleeuwsche nederlanden /

Includes bibliographical references (p. 146-153).

Flora batava, afgebeeld door en van wegens J.C. Sepp en zoon; /

Accompanied by "Naamlijst der Nederlandsche gewassen. Afgebeeld en beschreven in deel 1-XXV der Flora batava, door L.Vuyck en H.C. van de Pavord Smits. Met vervolg op deel XXVI en XXVII." (131, 16 p.) Published: s'Gravenhage, M. Nijhoff, 1930.

Catalogue raisonné de la précieuse collection de dessins et d'estampes, au nombre de pres̀ de 30,000, formant le cabinet de M. Ch. van Hulthem ...

Mode of access: Internet.

OMERACT-OARSI Initiative: Osteoarthritis Research Society International set of responder criteria for osteoarthritis clinical trials revisited.

Background: The OARSI Standing Committee for Clinical Trials Response Criteria Initiative had developed two sets of responder criteria to present the results of changes after treatment in three symptomatic domains (pain, function, and patient's global assessment) as a single variable for clinical trials (1). For each domain, a response was defined by both a relative and an absolute change, with different cut-offs with regard to the drug, the route of administration and the OA localization. Objective: To propose a simplified set of responder criteria with a similar cut-off, whatever the drug, the route or the OA localization. Methods: Data driven approach: (1) Two databases were considered The 'elaboration' database with which the formal OARSI sets of responder criteria were elaborated and The 'revisit' database. (2) Six different scenarios were evaluated: The two formal OARSI sets of criteria Four proposed scenarios of simplified sets of criteria Data from clinical randomized blinded placebo controlled trials were used to evaluate the performances of the two formal scenarios with two different databases ('elaboration' versus 'revisit') and those of the four proposed simplified scenarios within the 'revisit' database. The placebo effect, active effect, treatment effect, and the required sample arm size to obtain the placebo effect and the active treatment effect observed were the performances evaluated for each of the six scenarios. Experts' opinion approach: Results were discussed among the participants of the OMERACT VI meeting, who voted to select the definite OMERACT-OARSI set of criteria (one of the six evaluated scenarios). Results: Data driven approach: Fourteen trials totaling 1886 CA patients and fifteen studies involving 8164 CA patients were evaluated in the 'elaboration' and the 'revisit' databases respectively. The variability of the performances observed in the 'revisit' database when using the different simplified scenarios was similar to that observed between the two databases ('elaboration' versus 'revisit') when using the formal scenarios. The treatment effect and the required sample arm size were similar for each set of criteria. Experts' opinion approach: According to the experts, these two previous performances were the most important of an optimal set of responder criteria. They chose the set of criteria considering both pain and function as evaluation domain and requiring an absolute change and a relative change from baseline to define a response, with similar cut-offs whatever the drug, the route of administration or the CA localization. Conclusion: This data driven and experts' opinion approach is the basis for proposing an optimal simplified set of responder criteria for CA clinical trials. Other studies, using other sets of CA patients, are required in order to further validate this proposed OMERACT - OARSI set of criteria. (C) 2004 OsteoArthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

Business processes and knowledge management

Knowledge has been a subject of interest and inquiry for thousands of years since at least the time of the ancient Greeks, and no doubt even before that. “What is knowledge” continues to be an important topic of discussion in philosophy. More recently, interest in managing knowledge has grown in step with the perception that increasingly we live in a knowledge-based economy. Drucker (1969) is usually credited as being the first to popularize the knowledge-based economy concept by linking the importance of knowledge with rapid technological change in Drucker (1969). Karl Wiig coined the term knowledge management (hereafter KM) for a NATO seminar in 1986, and its popularity took off following the publication of Nonaka and Takeuchi’s book “The Knowledge Creating Company” (Nonaka & Takeuchi, 1995). Knowledge creation is in fact just one of many activities involved in KM. Others include sharing, retaining, refining, and using knowledge. There are many such lists of activities (Holsapple & Joshi, 2000; Probst, Raub, & Romhardt, 1999; Skyrme, 1999; Wiig, De Hoog, & Van der Spek, 1997). Both academic and practical interest in KM has continued to increase throughout the last decade. In this article, first the different types of knowledge are outlined, then comes a discussion of various routes by which knowledge management can be implemented, advocating a process-based route. An explanation follows of how people, processes, and technology need to fit together for effective KM, and some examples of this route in use are given. Finally, there is a look towards the future.