National patterns of R & D resources; funds and personnel in the United States.

Mode of access: Internet.

Equitable distribution of R. & D. funds by Government agencies : hearings ... Eighty-ninth Congress, second session.

Pt. 1 not named as such.

Confirmation of Daniel D. Moore to be Collector of Internal Revenue : hearings before the Committee on Finance, United States Senate, Seventy-third Congress, second session, on confirmation of Daniel D. Moore, of New Orleans, La., to be Collector of Internal Revenue, Apr.4-13, 1934.

[Pt. 1] has title: Confirmation of Daniel D. Moore to be Collector of Internal Revenue : hearing before a subcommittee of the Committee on Finance ... Feb. 19, 1934.

Confirmation of Jacob D. Walter to be United States marshal for the state of Connecticut. Hearing before a subcommittee of the Committee on the judiciary, United States Senate, Seventy-first Congress, second session, on the confirmation of Jacob D. Walter to be United States marshal for the state of Connecticut. February 3, 1930.

William E. Borah, chairman of subcommittee.

Senator from West Virginia : hearing before the Committee on Privileges and Elections, United States Senate, Seventy-fourth Congress, first session relative to the contests of Henry D. Hatfield v. Rush D. Holt for the seat in the United States Senate from the state of West Virginia. June l, 1935 ...

Printed for the use of the Committee on Privileges and Elections. Walter F. George, chairman.

Domesday studies: an analysis and digest of the Somerset survey (according to the Exon codex), and of the Somerset gheld inquest of A. D. 1084, as collated with, and illustrated by, Domesday.

v.1. Analysis and digest.--v.2. Tables.

Nomination of William D. Ruckelshaus : hearings before the Committee on Environment and Public Works, United States Senate, Ninety-eighth Congress, first session, on the nomination of William D. Ruckelshaus, to be Administrator of the Environmental Protection Agency, May 3, 4, and 5, 1983.

Includes bibliographical references.

Home of Franklin D. Roosevelt : Roosevelt-Vanderbilt sites, Hyde Park, New York /

"Written 1989."

Prospective evaluation of a D-optimal designed population pharmacokinetic study

Recently, methods for computing D-optimal designs for population pharmacokinetic studies have become available. However there are few publications that have prospectively evaluated the benefits of D-optimality in population or single-subject settings. This study compared a population optimal design with an empirical design for estimating the base pharmacokinetic model for enoxaparin in a stratified randomized setting. The population pharmacokinetic D-optimal design for enoxaparin was estimated using the PFIM function (MATLAB version 6.0.0.88). The optimal design was based on a one-compartment model with lognormal between subject variability and proportional residual variability and consisted of a single design with three sampling windows (0-30 min, 1.5-5 hr and 11 - 12 hr post-dose) for all patients. The empirical design consisted of three sample time windows per patient from a total of nine windows that collectively represented the entire dose interval. Each patient was assigned to have one blood sample taken from three different windows. Windows for blood sampling times were also provided for the optimal design. Ninety six patients were recruited into the study who were currently receiving enoxaparin therapy. Patients were randomly assigned to either the optimal or empirical sampling design, stratified for body mass index. The exact times of blood samples and doses were recorded. Analysis was undertaken using NONMEM (version 5). The empirical design supported a one compartment linear model with additive residual error, while the optimal design supported a two compartment linear model with additive residual error as did the model derived from the full data set. A posterior predictive check was performed where the models arising from the empirical and optimal designs were used to predict into the full data set. This revealed the optimal'' design derived model was superior to the empirical design model in terms of precision and was similar to the model developed from the full dataset. This study suggests optimal design techniques may be useful, even when the optimized design was based on a model that was misspecified in terms of the structural and statistical models and when the implementation of the optimal designed study deviated from the nominal design.

Formation of mononuclear and chloro-bridged binuclear copper(II) complexes of patellamide D, a naturally occurring cyclic peptide: influence of anion and solvent

Patellamide D (patH(4)) is a cyclic octapeptide isolated from the ascidian Lissoclinum patella. The peptide possesses a 24-azacrown-8 macrocyclic structure containing two oxazoline and two thiazole rings, each separated by an amino acid. The present spectrophotometric, electron paramagnetic resonance (EPR) and mass spectral studies show that patellamide D reacts with CuCl, and triethylamine in acetonitrile to form mononuclear and binuclear copper(II) complexes containing chloride. Molecular modelling and EPR studies suggest that the chloride anion bridges the copper(II) ions in the binuclear complex [Cu-2(patH(2))(mu-Cl)](+). These results contrast with a previous study employing both base and methanol, the latter substituting for chloride in the copper(II) complexes en route to the stable mu-carbonato binuclear copper(II) complex [Cu-2 (patH(2))(mu-CO3)]. Solvent clearly plays an important role in both stabilising these metal ion complexes and influencing their chemical reactivities. (C) 2004 Elsevier Inc. All rights reserved.

Behavioural characterization of Vitamin D receptor knockout mice

Vitamin D (calcitriol) is a nuclear transcription regulator acting via a nuclear hormone receptor (VDR). In addition to its role in the regulation of calcium and phosphate horneostasis and in bone formation, Vitamin D is also thought to be involved in brain function. The aim of this study was to behaviourally phenotype VDR knockout mice. We characterized the behaviour of VDR null mutant mice and wildtype littermate controls by subjecting them to a range of tests including a primary behavioural screen (using the SHIRPA protocol), rotarod, gait analysis, Y-maze, marble burying test, bedding test, holeboard test, elevated plus maze, open field test and prepulse inhibition of the acoustic startle response. There were no effects of genotype on most of the scores from the SHIRPA protocol except that VDR -/- mice had alopecia, were shorter and weighed less than VDR +/+ mice. VDR -/- mice had a shorter gait as well as impairments on the rotarod, in the bedding test and impaired habituation in both the open field and on the acoustic startle response. The VDR -/- mice had normal acoustic startle responses but had impaired PPI at long (256 ms) but not short (64 ms) prepulse to pulse intervals. The VDR -/- mice were less active in the open field and buried fewer marbles in the marble burying test. However, there were no differences in the time spent on the open arms of the elevated plus maze or in working memory as assessed by repeat arm entries on the Y-maze. Therefore, it appears that VDR -/- mice have muscular and motor impairments that significantly affects locomotor behaviour but seemingly no impairments in cognition as indicated by exploration, working memory or anxiety. (C) 2004 Elsevier B.V. All rights reserved.