Blood and lymphatic vessel invasion in pT1 colorectal cancer: an international concordance study

AIM This study was performed to evaluate the concordance in pathological assessments of blood and lymphatic vessel invasion (BLI) in pT1 colorectal cancers and to assess the effect of diagnostic criterion on consistency in the assessment of BLI. METHODS Forty consecutive patients undergoing surgical resection of pT1 colorectal cancers were entered into this study. H&E-stained, D2-40-stained and elastica-stained slides from the tumours were examined by 18 pathologists from seven countries. The 40 cases were divided into two cohorts with 20 cases each. In cohort 1, pathologists diagnosed BLI using criteria familiar to them; all Japanese pathologists used a criterion of BLI from the Japanese Society for Cancer of the Colon and Rectum (JSCCR). In cohort 2, all pathologists used the JSCCR diagnostic criterion. RESULTS In cohort 1, diagnostic concordance was moderate in the US/Canadian and European pathologists. There were no differences in the consistency compared with results for Japanese pathologists, and no improvement in the diagnostic concordance was found for using the JSCCR criterion. However, in cohort 2, the JSCCR criterion decreased the consistency of BLI diagnosis in the US/Canadian and European pathologists. The level of decreased consistency in the assessment of BLI was different between the US/Canadian and European pathologists. CONCLUSIONS A uniform criterion strongly influences the diagnostic consistency of BLI but may not always improve the concordance. Further study is required to achieve an objective diagnosis of BLI in colorectal cancer. The varying effects of diagnostic criterion on the pathologists from Japan, the USA/Canada and Europe might reflect varied interpretations of the criterion. Internationally accepted criterion should be developed by participants from around the world.

(Table 1) Isotopic and trace-element composition of ODP Leg 127/128 basalts

The western Pacific includes many volcanic island arc and backarc complexes, yet multi-isotopic studies of them are rare. Basement rocks of the Sea of Japan backarc basin were encountered at Sites 794,795, and 797, and consisted of basaltic sills and lava flows. These rocks exhibit a broad range in isotopic composition, broader than that seen in any other western Pacific arc or backarc system: 87Sr/86Sr = 0.70369 to 0.70499, 143Nd/144Nd = 0.51267 to 0.51317, 206Pb/204Pb = 17.64 to 18.36. The samples form highly correlated arrays between very depleted mid-ocean ridge basalt (MORB) and the Pacific pelagic sediment fields on Pb-Pb plots. Similarly, on plots of Sr-Pb and Nd-Pb, the Sea of Japan samples lie on mixing curves between depleted mantle and enriched mantle ("EM II"), which is interpreted to be of average crustal or pelagic sediment composition. The source of these backarc rocks appears to be a MORB-like mantle source, contaminated by pelagic sediments. Unlike the Mariana and Izu arc/backarc systems, Japanese arc and backarc rocks are indistinguishable from each other in a Sr-Nd isotope plot, and have similar trends in Pb-Pb plots. Thus, sediment contamination of the mantle wedge appears to control the isotopic compositions of both the arc and backarc magmas. Two-component mixing calculations suggest that the percentage of sediments in the magma source varies from 0.5% to 2.5%.

"Contra toda forma de opresión" : Sexo, política y clases medias juveniles en las revistas de humor de los primeros '70

Este artículo explora cómo las revistas de humor político-cultural de los primeros '70 devinieron una fuente de autorreflexión para un público, o espacio social, que se constituyó en torno a ellas. A partir del análisis de la más importante de esas publicaciones, Satiricón, es posible aseverar que en términos socio-demográficos ese espacio social se componía de segmentos juveniles de los sectores medios intelectualizados que podían a la vez reírse y hacer reír, en especial cuando se remarcaban incongruencias en sus experiencias sexuales y políticas. Las revistas de humor elaboraron múltiples incongruencias: los llamados a una educación sexual imbricados con la persistencia de viejas creencias sexuales; el lenguaje "psi" domesticando, antes que ayudando a liberar, las represiones sexuales; los varones temiendo por el fin de privilegios ante la afirmación sexual de las mujeres; y, más en general, la militancia política como forma de opresión. Las incongruencias eran la base de lo risible, mientras que en su centro estaban los y las jóvenes de los sectores medios, a quienes se convocaba a un tipo de reflexión que, en ese contexto político, quizá era solo viable a partir de la exageración y del humor

"Contra toda forma de opresión" : Sexo, política y clases medias juveniles en las revistas de humor de los primeros '70

Este artículo explora cómo las revistas de humor político-cultural de los primeros '70 devinieron una fuente de autorreflexión para un público, o espacio social, que se constituyó en torno a ellas. A partir del análisis de la más importante de esas publicaciones, Satiricón, es posible aseverar que en términos socio-demográficos ese espacio social se componía de segmentos juveniles de los sectores medios intelectualizados que podían a la vez reírse y hacer reír, en especial cuando se remarcaban incongruencias en sus experiencias sexuales y políticas. Las revistas de humor elaboraron múltiples incongruencias: los llamados a una educación sexual imbricados con la persistencia de viejas creencias sexuales; el lenguaje "psi" domesticando, antes que ayudando a liberar, las represiones sexuales; los varones temiendo por el fin de privilegios ante la afirmación sexual de las mujeres; y, más en general, la militancia política como forma de opresión. Las incongruencias eran la base de lo risible, mientras que en su centro estaban los y las jóvenes de los sectores medios, a quienes se convocaba a un tipo de reflexión que, en ese contexto político, quizá era solo viable a partir de la exageración y del humor

"Contra toda forma de opresión" : Sexo, política y clases medias juveniles en las revistas de humor de los primeros '70

Este artículo explora cómo las revistas de humor político-cultural de los primeros '70 devinieron una fuente de autorreflexión para un público, o espacio social, que se constituyó en torno a ellas. A partir del análisis de la más importante de esas publicaciones, Satiricón, es posible aseverar que en términos socio-demográficos ese espacio social se componía de segmentos juveniles de los sectores medios intelectualizados que podían a la vez reírse y hacer reír, en especial cuando se remarcaban incongruencias en sus experiencias sexuales y políticas. Las revistas de humor elaboraron múltiples incongruencias: los llamados a una educación sexual imbricados con la persistencia de viejas creencias sexuales; el lenguaje "psi" domesticando, antes que ayudando a liberar, las represiones sexuales; los varones temiendo por el fin de privilegios ante la afirmación sexual de las mujeres; y, más en general, la militancia política como forma de opresión. Las incongruencias eran la base de lo risible, mientras que en su centro estaban los y las jóvenes de los sectores medios, a quienes se convocaba a un tipo de reflexión que, en ese contexto político, quizá era solo viable a partir de la exageración y del humor

Analogous Cycles with Lagged Co-movement: U.S. and East Asian Business Cycles

In selected East Asian economies, the behavior of detrended macroeconomic variables was found to be similar to that observed in the postwar U.S. economy. Consumption and investment are highly procyclical while the balance of trade and the price level are counter-cyclical in most of them. Labor productivity is procyclical in general. The high coherence between U.S. GDP and that of the East Asian economies suggests that business cycles in terms of frequency are also similar between the United States and East Asia. However, the GDP and consumption of East Asian countries do not necessarily co-move well with current U.S. and Japanese GDP and consumption, while East Asian consumption tends to co-move more with lagged U.S. and Japanese consumption.

Looking Toward the “New Era” Features and Background of the Japan-Thailand Economic Partnership Agreement

This paper examines Thai-Japanese relations through analysis of EPA. There are two questions. The first involves the features of JTEPA as an EPA. By scrutinizing the features of the EPA, we would like to approach the institutional framework of the “new era” which will be brought about by JTEPA. The second question is how did the governments of Thailand and Japan come to conclude JTEPA? By reviewing the focal points of the negotiations, we will describe the background of the formation and aims of JTEPA. Finally, we conclude that JTEPA is a culmination of the existing Thai-Japanese relations, and was built based upon the existing divergence of economic institutions. At the same time it upgrades the bilateral partnership to a framework for multilateral cooperation by considering assistance toward Cambodia, Laos and Myanmar and Vietnam. The author would like to emphasize that JTEPA was designed based on the idea of a further integration of CLMV and Thailand, an original member of ASEAN.

Did Japanese direct investment in Korea suppress indigenous industrialization in the 1930s? : evidence from country-level factory entry patterns

Foreign direct investment (FDI) can deliver both positive and negative spillovers to the local economy. Negative effects such as crowding-out or entry-barrier effects might outweigh the positive ones when the technological gap between foreign and local firms is significant. This paper examines the impact of Japanese direct investment into Korea under colonization in the 1930s on the entry of Korean-owned factories. By using the census of manufacturing factories in Korea, we exploit variations in the share of Japanese factories and their entry rates across counties within the same subsectors. We find that within a subsector, entry rates of Korean factories were higher in counties with higher presence and entry of Japanese factories. Positive correlations are also found between subsectors. The results imply that Japanese direct investment did not suppress the entry of Korean factories and that FDI could exert positive entry spillovers on indigenous firms, even at a very early stage of industrialization.

Chinese Intellectuals and China`s Policy toward Japan

This dissertation aims at integrating two scholarships: state-society relation studies and Chinese foreign policy analysis. I created Two-level Perception Gap Model to analyze different intellectual groups' relations with party-state by confirming Chinese intellectuals play a role in CFP making in general, China's Japan policy in particular. This model is an alternative approach, instead of conventional wisdom patron-client approach, to explain and analyze the pluralized intellectual-state relations in China. This model first analyzed the role of two intellectual groups, namely think tank scholars and popular nationalist, in China's Japan policy making, and then based on these analyses it explains the interactional patterns between these two intellectual groups and party-state. I used three case studies, which represented different types of issue, Chinese attitude toward the U.S.-Japan alliance and the Japanese defense policy, the controversy over the Yasukuni Shrine Visit, and the territorial dispute over the Diaoyu/Senkaku Islands, to examine this model. First, I examined think tank scholar groups and the extent they influenced "core interest issue and sensitive issue (Issue 1)," Chinese attitude toward the U.S.-Japan alliance and the Japanese defense policy, and their international patterns with party-state. Chapter 3 compares the responses of Chinese officials to the changes in the defense policy of Japan to the analyses from the think tank scholars. As the model assumes, results show that think tank scholars' analyses are consistent with China's policy position; nevertheless, it is difficult to confirm their analyses have influence on Chinese attitude toward the U.S.-Japan alliance and the Japanese defense policy. Based on the analysis of journal articles, most articles do not provide policy suggestions or simply provide suggestions that do not deviate from the policy. As Gu's theory of pluralist institutionalism and my hypothesis points out, most think tank scholars are establishment intellectuals so they tend to be self-disciplined. Second, this model provide a new concept "patriotic dilemma" for analyzing the challenge and constraints brought by popular nationalist discourses and public mobilization to Chinese foreign policy decision makers. Chapter 4 investigated the cases study of the controversy over the Yasukuni Shrine Visit, defined as "major/minor interest issue/ sensitive issue (Issue 3)," and the discourses from the popular nationalist, mainly focusing on anti-Japanese activists. The chapter also observes their influence on nationalist public opinions and analyzes how the nationalist public opinions constrain the policy choices among decision makers. Results strongly supported the hypothesis of patriotic dilemma that, although the popular nationalist group and public opinions constrained the policy choices of Chinese decision makers in the short term, they were unable to change the fundamental policy direction. Third, chapter 5 also focuses on anti-Japanese activists and examines the model with the case of the territorial dispute over the Diaoyu/Senkaku Islands. The result supported that hypothesis that China's policy change was not because of the influence from popular nationalist's discourses or public opinions but because of the change of priority of this issue, from major/minor interest issue to core interest issue. These two chapters also indicate that the patron-client model is unable to describe the popular nationalist. An alternative approach, such as the concept "patriotic dilemma" is needed to describe the relations between the popular nationalist and the government.

Wrestling With Tradition: Japanese Activities at Amache, a World War II Incarceration Facility

I employ archaeological analyses, archival research, and oral histories to investigate traditional Japanese practices that were performed at Amache, a World War II Japanese American incarceration facility. I argue that these inter-generational practices helped to bridge a cultural gap that existed between several generations of Japanese Americans. For many incarcerated Japanese Americans, their first exposure to many traditional activities occurred during incarceration. The resulting social environment incorporated aspects of Japanese, Japanese American, and mainstream American influences, all of which were adapted to conditions during incarceration. Similarly, archaeological analyses allow for the investigation of traditional practice features. These provide evidence regarding the significance of the adapted landscape at Amache. Evidence of these practices suggests Amache internees had both a strong desire to maintain and celebrate these aspects of their Japanese heritage but they also incorporated non-traditional elements that reflected the unique living conditions during incarceration. Incarceration, I argue, created an environment in which a unique internee consciousness was formed in which the use of traditional practices was a focal point. The physical remains of traditional practices allow archaeologists to determine aspects of this newly formed consciousness that are not readily apparent in historical documentation.

Samurai Son and Exploring Cultural Myths Through Fantasy Fiction

Samurai Son is a story that captures the beauty, wonder and imagination of Japanese legends and mythology with some modern-day sensibilities and morals against the backdrop of medieval Japan. The story blends Shinto religion and stories about the tengu, bird-like wind spirits with a modern plotline in a Japanese fantasy universe. This world is filled with magic, demons, kami (magical spirits), gods and goddesses, samurai, ninja and martial arts.

Una propuesta de estudio para el humor en la conversación coloquial

En el grupo de investigación GRIALE hemos desarrollado un método teórico que aplicamos a los enunciados irónicos con humor en diferentes géneros textuales, a partir de la violación de principios conversacionales. Además, tendremos en cuenta para el análisis la Teoría General del Humor Verbal propuesta por Attardo. Así pues, estudiamos la ironía y el humor en ejemplos de conversaciones extraídos de corpus de muestras reales del español peninsular (COVJA y Corpus de conversaciones coloquiales). En este trabajo, nos centramos en la aplicación de dichas teorías a los enunciados irónicos humor��sticos que se producen en la conversación y estudiaremos los efectos que desarrollan; y comprobaremos que ironía y humor conviven en un mismo intercambio conversacional con un fin comunicativo.

An approach to verbal humor in interaction

I propose a method to study interactional ironic humorous utterances in Spanish. In GRIALE research group consider this method can be applied to humorous ironic utterances in different textual genres, from the violation of conversational principles. Futhermore, we present the General Theory of Verbal Humor proposed by Attardo that it will be taken in our analysis. Therefore, I study irony and humor in examples of conversations from Peninsular Spanish real sample corpuses (COVJA, Corpus de conversaciones coloquiales [Corpus of Colloquial Conversations] and CREA, Corpus de Referencia del Español Actual [Reference Corpus of Present-Day Spanish]). In this article, I will focus on the application of this theory to humorous ironic statements which arise in conversation and examine the effects caused by them, which will additionally verify if irony and humor coexist in the same conversational exchange with a communicative aim and conversational strategies.

Moya moya disease : literature review and case report

Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2014

The life and adventures of Robinson Crusoe /

The diary of an Englishman shipwrecked for almost thirty years on a small isolated island where, using wit and industry, he manages to build life anew.